Myot
type: EnsemblDatabaseReference

Pde1c
type: EnsemblDatabaseReference

Ctgf UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.36711054329838
p value: 4.62762802402984E-4
refers to: Ctgf
refers to: 1416953_at
t statistic: 7.30449994249158

Rtn4
type: EnsemblDatabaseReference

Uck2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.21668045054124
p value: 0.00464993756248313
refers to: Uck2
refers to: 1439740_s_at
t statistic: 5.24366970441537

Ang DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2249931596477
p value: 2.63342737309726E-5
refers to: 1438936_s_at
refers to: Ang
t statistic: -10.459932107238

Synpo2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.20267645034755
p value: 0.0010091000247702
refers to: Synpo2
refers to: 1450828_at
t statistic: 6.47316002657317

Myot UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.78292248228524
p value: 5.365892691713E-7
refers to: 1418155_at
refers to: Myot
t statistic: 16.6309963978458

(Sample) environmental stress/transverse aortic constriction mediated heart pressure overload
type: EFO_0000001
property type: environmental stress
property value: transverse aortic constriction mediated heart pressure overload

Cilp
type: EnsemblDatabaseReference

Fmo2 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1446395772817
p value: 0.0102607467870268
refers to: 1435459_at
refers to: Fmo2
t statistic: 6.75503160215922

Cilp
type: EnsemblDatabaseReference

Synpo2
type: EnsemblDatabaseReference

Rpgrip1
type: EnsemblDatabaseReference

1424010_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) Wildtype_TAC_Rep5
type: Assay
has participant: A-AFFY-45

Rpgrip1
type: EnsemblDatabaseReference

Dio2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.87420439273856
p value: 2.23903520472849E-5
refers to: 1418937_at
refers to: Dio2
t statistic: 10.7755412440592

1433434_at
type: EFO_0005072
part of: A-AFFY-45

1428295_at
type: EFO_0005072
part of: A-AFFY-45

1448595_a_at
type: EFO_0005072
part of: A-AFFY-45

Efnb3 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.43976500450039
p value: 9.28694395062928E-4
refers to: Efnb3
refers to: 1423085_at
t statistic: -6.54483587280581

1434202_a_at
type: EFO_0005072
part of: A-AFFY-45

Colec11 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.21369292535215
p value: 6.16843552286984E-5
refers to: Colec11
refers to: 1458345_s_at
t statistic: -9.45582548697742

Ltbp2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.39818843966053
p value: 0.0177218831738097
refers to: 1418061_at
refers to: Ltbp2
t statistic: 4.15885504166254

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Col12a1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2360920077515
p value: 0.0146950707352423
refers to: 1434411_at
refers to: Col12a1
t statistic: 4.31405949528571

1418155_at
type: EFO_0005072
part of: A-AFFY-45

1448604_at
type: EFO_0005072
part of: A-AFFY-45

Nmrk2
type: EnsemblDatabaseReference

Efnb3
type: EnsemblDatabaseReference

1435459_at
type: EFO_0005072
part of: A-AFFY-45

Mfap5
type: EnsemblDatabaseReference

1433652_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) G4D_Sham_Rep4
type: Assay
has participant: A-AFFY-45

1110034G24Rik UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02466625357203
p value: 0.0484005900424027
refers to: 1110034G24Rik
refers to: 1452888_at
t statistic: 4.47847443357783

Analysis of 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: MicroarrayDifferentialExpressionAnalysis

Fam107a
type: EnsemblDatabaseReference

Col8a1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1396790531342
p value: 0.0254406365390754
refers to: 1418441_at
refers to: Col8a1
t statistic: 3.88051901574008

1419739_at
type: EFO_0005072
part of: A-AFFY-45

1418061_at
type: EFO_0005072
part of: A-AFFY-45

Ctgf
type: EnsemblDatabaseReference

Zbtb16
type: EnsemblDatabaseReference

Ang
type: EnsemblDatabaseReference

1418937_at
type: EFO_0005072
part of: A-AFFY-45

1429637_at
type: EFO_0005072
part of: A-AFFY-45

Ang
type: EnsemblDatabaseReference

Tnfaip2 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.30083226811832
p value: 0.00760297209889545
refers to: 1438855_x_at
refers to: Tnfaip2
t statistic: -7.48387181805914

Klhdc8a
type: EnsemblDatabaseReference

(Assay) Wildtype_Sham_Rep2
type: Assay
has participant: A-AFFY-45

Fgl2
type: EnsemblDatabaseReference

Ces1d
type: EnsemblDatabaseReference

1419527_at
type: EFO_0005072
part of: A-AFFY-45

Klhdc8a
type: EnsemblDatabaseReference

Uck2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.04144556914095
p value: 1.64115484348425E-4
refers to: Uck2
refers to: 1448604_at
t statistic: 8.51474159095341

Ces1d
type: EnsemblDatabaseReference

(Assay) Wildtype_TAC_Rep6
type: Assay
has participant: A-AFFY-45

Fgl2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.06421915066146
p value: 0.0488288295612485
refers to: Fgl2
refers to: 1421854_at
t statistic: 3.38885281663672

1443866_at
type: EFO_0005072
part of: A-AFFY-45

Rcan1
type: EnsemblDatabaseReference

Tgfb2
type: EnsemblDatabaseReference

1439740_s_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) G4D_TAC_Rep1
type: Assay
has participant: A-AFFY-45

1438936_s_at
type: EFO_0005072
part of: A-AFFY-45

Col8a1
type: EnsemblDatabaseReference

Analysis of 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: MicroarrayDifferentialExpressionAnalysis

1418440_at
type: EFO_0005072
part of: A-AFFY-45

Rpgrip1 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -2.28398198120722
p value: 1.33833394417671E-8
refers to: 1421144_at
refers to: Rpgrip1
t statistic: -23.0645242904466

Pah UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.23360864813454
p value: 0.028170223097296
refers to: 1454638_a_at
refers to: Pah
t statistic: 3.80313721652853

Mfap4
type: EnsemblDatabaseReference

Tfrc
type: EnsemblDatabaseReference

Snap91 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08382417644404
p value: 0.00173613413006441
refers to: Snap91
refers to: 1416688_at
t statistic: 5.99930393538394

Mfap4
type: EnsemblDatabaseReference

Synpo2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.30360530420858
p value: 6.71801717281627E-7
refers to: Synpo2
refers to: 1452879_at
t statistic: 15.8100336707055

(Assay) G4D_TAC_Rep4
type: Assay
has participant: A-AFFY-45

AW551984
type: EnsemblDatabaseReference

Gpr22
type: EnsemblDatabaseReference

1449082_at
type: EFO_0005072
part of: A-AFFY-45

Fam107a UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.20230315865234
p value: 0.0437424556329014
refers to: Fam107a
refers to: 1434202_a_at
t statistic: 4.57480301465332

Gpr22
type: EnsemblDatabaseReference

Pah
type: EnsemblDatabaseReference

Lmcd1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02698226399797
p value: 2.96444689745119E-5
refers to: Lmcd1
refers to: 1424596_s_at
t statistic: 10.2642085920604

Snap91
type: EnsemblDatabaseReference

Fhl1
type: EnsemblDatabaseReference

1425213_at
type: EFO_0005072
part of: A-AFFY-45

Rcan1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.32928261953441
p value: 0.00109577277715266
refers to: Rcan1
refers to: 1416600_a_at
t statistic: 6.38926916428443

(Assay) Wildtype_TAC_Rep1
type: Assay
has participant: A-AFFY-45

Bex1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.97142209371825
p value: 1.81115093632452E-5
refers to: Bex1
refers to: 1448595_a_at
t statistic: 11.2856270794463

Uck2
type: EnsemblDatabaseReference

1439163_at
type: EFO_0005072
part of: A-AFFY-45

(Factor value) ENVIRONMENTAL_STRESS/none
type: EFO_0001461
property type: ENVIRONMENTAL_STRESS
property value: none

Igsf1
type: EnsemblDatabaseReference

1453898_at
type: EFO_0005072
part of: A-AFFY-45

1421855_at
type: EFO_0005072
part of: A-AFFY-45

Bex1
type: EnsemblDatabaseReference

1440374_at
type: EFO_0005072
part of: A-AFFY-45

Synpo2l
type: EnsemblDatabaseReference

Mfap4 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.11718610042443
p value: 0.00492788121833099
refers to: Mfap4
refers to: 1424010_at
t statistic: 5.20614691079449

Uchl1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.34405324156584
p value: 0.00240954598224232
refers to: Uchl1
refers to: 1448260_at
t statistic: 5.72901823884502

1416601_a_at
type: EFO_0005072
part of: A-AFFY-45

1455665_at
type: EFO_0005072
part of: A-AFFY-45

Slc41a3
type: EnsemblDatabaseReference

Thbs4 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 2.61072500317273
p value: 3.36220325064592E-6
refers to: 1449388_at
refers to: Thbs4
t statistic: 13.2929190954003

Per2 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.07292070231251
p value: 0.0339766821740723
refers to: 1417602_at
refers to: Per2
t statistic: 4.88947215667012

Nmrk2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.82245475701096
p value: 3.59442079289534E-5
refers to: Nmrk2
refers to: 1453898_at
t statistic: 10.0588776445507

Rhobtb1 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1447645752239
p value: 0.0409479896188534
refers to: Rhobtb1
refers to: 1429656_at
t statistic: 4.65124403910175

1456084_x_at
type: EFO_0005072
part of: A-AFFY-45

Rbp1
type: EnsemblDatabaseReference

Fmod
type: EnsemblDatabaseReference

Enah UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.239239566818
p value: 5.55612715450656E-4
refers to: Enah
refers to: 1421624_a_at
t statistic: 7.05841344171933

Fmod
type: EnsemblDatabaseReference

1437224_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) G4D_Sham_Rep1
type: Assay
has participant: A-AFFY-45

Dio2
type: EnsemblDatabaseReference

Fmo2
type: EnsemblDatabaseReference

1416953_at
type: EFO_0005072
part of: A-AFFY-45

Ltbp2
type: EnsemblDatabaseReference

1452879_at
type: EFO_0005072
part of: A-AFFY-45

Fgl2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.00124512645333
p value: 0.00868815396405823
refers to: 1421855_at
refers to: Fgl2
t statistic: 4.72940591149687

Gdf15
type: EnsemblDatabaseReference

Rnf207 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17486991393959
p value: 0.00144980783077479
refers to: Rnf207
refers to: 1436277_at
t statistic: -6.16013373442013

Tnfaip2
type: EnsemblDatabaseReference

Uck2
type: EnsemblDatabaseReference

Ces1d DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.55682660802728
p value: 0.011271420127543
refers to: 1435370_a_at
refers to: Ces1d
t statistic: -4.52305967222798

Per2
type: EnsemblDatabaseReference

(Assay) Wildtype_Sham_Rep3
type: Assay
has participant: A-AFFY-45

Thbs4
type: EnsemblDatabaseReference

Col8a1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1672391541077
p value: 0.00187458915604583
refers to: Col8a1
refers to: 1418440_at
t statistic: 5.9421744618845

1448754_at
type: EFO_0005072
part of: A-AFFY-45

Lonrf1 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.13333578797113
p value: 0.0175541153923686
refers to: 1455665_at
refers to: Lonrf1
t statistic: 5.77803979214746

Rhobtb1
type: EnsemblDatabaseReference

Amot
type: EnsemblDatabaseReference

1435370_a_at
type: EFO_0005072
part of: A-AFFY-45

Colec11
type: EnsemblDatabaseReference

(Assay) Wildtype_Sham_Rep1
type: Assay
has participant: A-AFFY-45

Rhobtb1 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.16870635401398
p value: 0.0249689836813774
refers to: Rhobtb1
refers to: 1429206_at
t statistic: 5.36585102282266

Amot
type: EnsemblDatabaseReference

(Sample) genotype/wild type genotype
type: EFO_0000001
property type: genotype
property value: wild type genotype

1448260_at
type: EFO_0005072
part of: A-AFFY-45

(Sample) environmental stress/none
type: EFO_0001461
property type: environmental stress
property value: none

Rtn4
type: EnsemblDatabaseReference

Ctgf UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3240607848715
p value: 0.0331211888229297
refers to: 1416953_at
refers to: Ctgf
t statistic: 5.00935179510041

Comp
type: EnsemblDatabaseReference

Fam198b UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.11051880993507
p value: 0.00155262893310699
refers to: Fam198b
refers to: 1429637_at
t statistic: 6.08617343018041

Fam81a
type: EnsemblDatabaseReference

Tgfb2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 2.101714297899
p value: 3.24687015823107E-4
refers to: Tgfb2
refers to: 1450922_a_at
t statistic: 7.71061374806718

1424596_s_at
type: EFO_0005072
part of: A-AFFY-45

1452661_at
type: EFO_0005072
part of: A-AFFY-45

Lrtm1
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/wild type genotype
type: EFO_0000001
property type: GENOTYPE
property value: wild type genotype

1429206_at
type: EFO_0005072
part of: A-AFFY-45

Lmcd1
type: EnsemblDatabaseReference

Lmcd1
type: EnsemblDatabaseReference

1424885_at
type: EFO_0005072
part of: A-AFFY-45

Enah
type: EnsemblDatabaseReference

Mfap5 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.13033106799626
p value: 0.00594361891557621
refers to: 1449082_at
refers to: Mfap5
t statistic: 5.0491375242655

Svep1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12233804934377
p value: 1.47744380409199E-4
refers to: Svep1
refers to: 1419182_at
t statistic: 8.63955960734201

Col8a1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.14785227091523
p value: 0.00689805728106729
refers to: Col8a1
refers to: 1455627_at
t statistic: 4.91722244709459

Efnb3
type: EnsemblDatabaseReference

Col12a1
type: EnsemblDatabaseReference

Mfap5
type: EnsemblDatabaseReference

1434411_at
type: EFO_0005072
part of: A-AFFY-45

Pde1c DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09474180430203
p value: 0.00116695339050906
refers to: Pde1c
refers to: 1440374_at
t statistic: -6.32496265701538

(Sample) sex/male
type: EFO_0001266
property type: sex
property value: male

Cilp UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 2.68877094981487
p value: 5.06879805685081E-5
refers to: 1457296_at
refers to: Cilp
t statistic: 9.66399986765545

Lonrf1
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/Gata4+/-
type: EFO_0000001
property type: GENOTYPE
property value: Gata4+/-

Myot
type: EnsemblDatabaseReference

Pde1c
type: EnsemblDatabaseReference

E-GEOD-5500
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: An important event in the pathogenesis of heart failure is the development of pathological cardiac hypertrophy. In cultured cardiac cardiomyocytes, the transcription factor Gata4 is required for agonist-induced cardiomyocyte hypertrophy. We hypothesized that in the intact organism Gata4 is an important regulator of postnatal heart function and of the hypertrophic response of the heart to pathological stress. To test this hypothesis, we studied mice heterozygous for deletion of the second exon of Gata4 (G4D). At baseline, G4D mice had mild systolic and diastolic dysfunction associated with reduced heart weight and decreased cardiomyocyte number. After transverse aortic constriction (TAC), G4D mice developed overt heart failure and eccentric cardiac hypertrophy, associated with significantly increased fibrosis and cardiomyocyte apoptosis. Inhibition of apoptosis by overexpression of the insulin-like growth factor 1 receptor prevented TAC-induced heart failure in G4D mice. Unlike WT-TAC controls, G4D-TAC cardiomyocytes hypertrophied by increasing in length more than width. Gene expression profiling revealed upregulation of genes associated with apoptosis and fibrosis, including members of the TGF? pathway. Our data demonstrate that Gata4 is essential for cardiac function in the postnatal heart. After pressure overload, Gata4 regulates the pattern of cardiomyocyte hypertrophy and protects the heart from load-induced failure. Experiment Overall Design: We reasoned that if Gata4 was a crucial regulator of pathways necessary for cardiac hypertrophy, then modest reductions of Gata4 activity should result in an observable cardiac phenotype. To test this hypothesis, we used gene targeted mice that express reduced levels of Gata4. We characterized these mice at baseline and after pressure Experiment Overall Design: overload.
uses data from: http://identifiers.org/pubmed/16983087

1110034G24Rik
type: EnsemblDatabaseReference

1110034G24Rik
type: EnsemblDatabaseReference

Ctgf
type: EnsemblDatabaseReference

Zbtb16
type: EnsemblDatabaseReference

1449081_at
type: EFO_0005072
part of: A-AFFY-45

Synpo2
type: EnsemblDatabaseReference

1418949_at
type: EFO_0005072
part of: A-AFFY-45

1416688_at
type: EFO_0005072
part of: A-AFFY-45

1417602_at
type: EFO_0005072
part of: A-AFFY-45

Tfrc DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.07013475270219
p value: 0.0498677929749896
refers to: 1452661_at
refers to: Tfrc
t statistic: -4.42910151003222

Zbtb16 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.13984791504566
p value: 0.0331211888229297
refers to: Zbtb16
refers to: 1439163_at
t statistic: 5.00011036572247

Fam81a UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0152712811792
p value: 7.62463949856348E-4
refers to: 1425213_at
refers to: Fam81a
t statistic: 6.74753726417587

(Assay) Wildtype_TAC_Rep2
type: Assay
has participant: A-AFFY-45

(Factor value) ENVIRONMENTAL_STRESS/TAC-mediated heart pressure overload
type: EFO_0000001
property type: ENVIRONMENTAL_STRESS
property value: TAC-mediated heart pressure overload

1421854_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) G4D_TAC_Rep6
type: Assay
has participant: A-AFFY-45

(Assay) G4D_TAC_Rep3
type: Assay
has participant: A-AFFY-45

Nmrk2
type: EnsemblDatabaseReference

1438855_x_at
type: EFO_0005072
part of: A-AFFY-45

Tfrc
type: EnsemblDatabaseReference

Fmo2 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.18997602306841
p value: 0.0102607467870268
refers to: Fmo2
refers to: 1453435_a_at
t statistic: 6.37039891772234

Fam107a
type: EnsemblDatabaseReference

(Assay) G4D_Sham_Rep5
type: Assay
has participant: A-AFFY-45

Slc41a3 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.22908376265402
p value: 0.0339766821740723
refers to: Slc41a3
refers to: 1451707_s_at
t statistic: -4.91573764866224

(Sample) organism part/heart
type: UBERON_0000948
property type: organism part
property value: heart

1434672_at
type: EFO_0005072
part of: A-AFFY-45

Lrtm1 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0133400790864
p value: 0.0274316305442937
refers to: 1443866_at
refers to: Lrtm1
t statistic: -3.82258665924751

1421624_a_at
type: EFO_0005072
part of: A-AFFY-45

Pah
type: EnsemblDatabaseReference

Ces1d DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.234864371909
p value: 0.00493295340447689
refers to: Ces1d
refers to: 1449081_at
t statistic: -5.20284836206471

Gdf15 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 2.43861621926298
p value: 6.16843552286984E-5
refers to: 1418949_at
refers to: Gdf15
t statistic: 9.4412547972224

Snap91
type: EnsemblDatabaseReference

(Assay) Wildtype_Sham_Rep4
type: Assay
has participant: A-AFFY-45

Tpm2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.20713315602508
p value: 3.86823143160173E-4
refers to: Tpm2
refers to: 1419739_at
t statistic: 7.48729460735915

1423085_at
type: EFO_0005072
part of: A-AFFY-45

1449388_at
type: EFO_0005072
part of: A-AFFY-45

1450923_at
type: EFO_0005072
part of: A-AFFY-45

Uck2
type: EnsemblDatabaseReference

Fgl2
type: EnsemblDatabaseReference

(Assay) G4D_Sham_Rep2
type: Assay
has participant: A-AFFY-45

1453435_a_at
type: EFO_0005072
part of: A-AFFY-45

Gpr22 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0483642920761
p value: 0.0118734022596309
refers to: Gpr22
refers to: 1434672_at
t statistic: -4.47919203308062

Amot UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.19549811506619
p value: 3.03323324059717E-4
refers to: Amot
refers to: 1454890_at
t statistic: 7.77767948843581

Rcan1
type: EnsemblDatabaseReference

Tgfb2
type: EnsemblDatabaseReference

A-AFFY-45
type: EFO_0000269

1454638_a_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) G4D_TAC_Rep5
type: Assay
has participant: A-AFFY-45

(Assay) Wildtype_TAC_Rep3
type: Assay
has participant: A-AFFY-45

Col8a1
type: EnsemblDatabaseReference

Comp UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4177189834942
p value: 0.013549560487207
refers to: Comp
refers to: 1419527_at
t statistic: 4.36948828021156

1450922_a_at
type: EFO_0005072
part of: A-AFFY-45

Tgfb2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.38960166240334
p value: 4.6760279077447E-4
refers to: Tgfb2
refers to: 1450923_at
t statistic: 7.27763364703843

Fmo2
type: EnsemblDatabaseReference

1429656_at
type: EFO_0005072
part of: A-AFFY-45

AW551984
type: EnsemblDatabaseReference

Rcan1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4036168807964
p value: 0.0262588506166168
refers to: Rcan1
refers to: 1416601_a_at
t statistic: 3.86013831291111

Gdf15
type: EnsemblDatabaseReference

Mus musculus
type: OBI_0100026

1417872_at
type: EFO_0005072
part of: A-AFFY-45

1454890_at
type: EFO_0005072
part of: A-AFFY-45

Igsf1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.33010643052664
p value: 4.03104222316495E-4
refers to: Igsf1
refers to: 1433652_at
t statistic: 7.44866759289518

Synpo2l UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.39604485466481
p value: 0.00495574824645143
refers to: 1428295_at
refers to: Synpo2l
t statistic: 5.19488948319963

Tnfaip2
type: EnsemblDatabaseReference

1416600_a_at
type: EFO_0005072
part of: A-AFFY-45

Fhl1
type: EnsemblDatabaseReference

1451707_s_at
type: EFO_0005072
part of: A-AFFY-45

Per2
type: EnsemblDatabaseReference

Svep1
type: EnsemblDatabaseReference

Thbs4
type: EnsemblDatabaseReference

Igsf1
type: EnsemblDatabaseReference

Rbp1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1709062830245
p value: 2.41568660454031E-4
refers to: Rbp1
refers to: 1448754_at
t statistic: 8.11409345635381

Svep1
type: EnsemblDatabaseReference

(Assay) G4D_Sham_Rep3
type: Assay
has participant: A-AFFY-45

1457296_at
type: EFO_0005072
part of: A-AFFY-45

Tgfb2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 2.08698835286279
p value: 7.14367099487097E-6
refers to: Tgfb2
refers to: 1423250_a_at
t statistic: 12.309172108099

1419182_at
type: EFO_0005072
part of: A-AFFY-45

1436277_at
type: EFO_0005072
part of: A-AFFY-45

1452888_at
type: EFO_0005072
part of: A-AFFY-45

1458345_s_at
type: EFO_0005072
part of: A-AFFY-45

Bex1
type: EnsemblDatabaseReference

Synpo2l
type: EnsemblDatabaseReference

Slc41a3
type: EnsemblDatabaseReference

1418441_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) G4D_TAC_Rep2
type: Assay
has participant: A-AFFY-45

Myot UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.42357240344542
p value: 0.0347011363788558
refers to: Myot
refers to: 1418155_at
t statistic: 4.83371103469291

Rnf207
type: EnsemblDatabaseReference

Rtn4 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.04121165361728
p value: 0.00265444479182843
refers to: Rtn4
refers to: 1437224_at
t statistic: 5.6562598653019

Rbp1
type: EnsemblDatabaseReference

Rnf207
type: EnsemblDatabaseReference

Comp
type: EnsemblDatabaseReference

Fam81a
type: EnsemblDatabaseReference

Dio2
type: EnsemblDatabaseReference

Fhl1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.44626395461589
p value: 6.71801717281627E-7
refers to: Fhl1
refers to: 1417872_at
t statistic: 15.5141627590001

Ltbp2
type: EnsemblDatabaseReference

Lrtm1
type: EnsemblDatabaseReference

1421144_at
type: EFO_0005072
part of: A-AFFY-45

Klhdc8a DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
type: DecreasedDifferentialExpressionRatio
fold change: -1.16956254876473
p value: 0.00760297209889545
refers to: Klhdc8a
refers to: 1424885_at
t statistic: -7.64436632233774

1455627_at
type: EFO_0005072
part of: A-AFFY-45

1423250_a_at
type: EFO_0005072
part of: A-AFFY-45

AW551984 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.28332429882452
p value: 7.14367099487097E-6
refers to: 1433434_at
refers to: AW551984
t statistic: 12.2579671825837

Fmod UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
type: IncreasedDifferentialExpressionRatio
fold change: 1.61006562869342
p value: 0.0376021396736725
refers to: Fmod
refers to: 1456084_x_at
t statistic: 3.5955743440197

Enah
type: EnsemblDatabaseReference

(Sample) genotype/Gata4+/-
type: EFO_0000001
property type: genotype
property value: Gata4+/-

Uck2
type: EnsemblDatabaseReference

(Assay) Wildtype_TAC_Rep4
type: Assay
has participant: A-AFFY-45

1450828_at
type: EFO_0005072
part of: A-AFFY-45

Tpm2
type: EnsemblDatabaseReference

Uchl1
type: EnsemblDatabaseReference

Rhobtb1
type: EnsemblDatabaseReference

Tpm2
type: EnsemblDatabaseReference

Uchl1
type: EnsemblDatabaseReference

Colec11
type: EnsemblDatabaseReference

Col12a1
type: EnsemblDatabaseReference

Fam198b
type: EnsemblDatabaseReference

Fam198b
type: EnsemblDatabaseReference

Lonrf1
type: EnsemblDatabaseReference