Ctgf UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Uck2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Ang DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Synpo2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Myot UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
(Sample) environmental stress/transverse aortic constriction mediated heart pressure overload
transverse aortic constriction mediated heart pressure overload
Fmo2 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Dio2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Efnb3 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Colec11 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Ltbp2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Col12a1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
1110034G24Rik UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Analysis of 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Col8a1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Tnfaip2 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Fgl2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Analysis of 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Rpgrip1 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Pah UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Snap91 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Fam107a UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Lmcd1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Rcan1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Bex1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
(Factor value) ENVIRONMENTAL_STRESS/none
Mfap4 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Uchl1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Thbs4 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Per2 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Nmrk2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Rhobtb1 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Enah UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Rnf207 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Ces1d DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Lonrf1 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Ctgf UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Fam198b UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Tgfb2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
(Factor value) GENOTYPE/wild type genotype
Mfap5 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Svep1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Pde1c DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Cilp UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
An important event in the pathogenesis of heart failure is the development of pathological cardiac hypertrophy. In cultured cardiac cardiomyocytes, the transcription factor Gata4 is required for agonist-induced cardiomyocyte hypertrophy. We hypothesized that in the intact organism Gata4 is an important regulator of postnatal heart function and of the hypertrophic response of the heart to pathological stress. To test this hypothesis, we studied mice heterozygous for deletion of the second exon of Gata4 (G4D). At baseline, G4D mice had mild systolic and diastolic dysfunction associated with reduced heart weight and decreased cardiomyocyte number. After transverse aortic constriction (TAC), G4D mice developed overt heart failure and eccentric cardiac hypertrophy, associated with significantly increased fibrosis and cardiomyocyte apoptosis. Inhibition of apoptosis by overexpression of the insulin-like growth factor 1 receptor prevented TAC-induced heart failure in G4D mice. Unlike WT-TAC controls, G4D-TAC cardiomyocytes hypertrophied by increasing in length more than width. Gene expression profiling revealed upregulation of genes associated with apoptosis and fibrosis, including members of the TGF? pathway. Our data demonstrate that Gata4 is essential for cardiac function in the postnatal heart. After pressure overload, Gata4 regulates the pattern of cardiomyocyte hypertrophy and protects the heart from load-induced failure. Experiment Overall Design: We reasoned that if Gata4 was a crucial regulator of pathways necessary for cardiac hypertrophy, then modest reductions of Gata4 activity should result in an observable cardiac phenotype. To test this hypothesis, we used gene targeted mice that express reduced levels of Gata4. We characterized these mice at baseline and after pressure Experiment Overall Design: overload.
Tfrc DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Zbtb16 UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Fam81a UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
(Factor value) ENVIRONMENTAL_STRESS/TAC-mediated heart pressure overload
Slc41a3 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Lrtm1 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Gdf15 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Tpm2 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Gpr22 DOWN in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Amot UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Comp UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Igsf1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Synpo2l UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Rbp1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Myot UP in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
Rtn4 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Fhl1 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Klhdc8a DOWN in 'Gata4+/-' vs 'wild type genotype' in 'no pressure overload'
AW551984 UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'
Fmod UP in 'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'