1632719_at
type: EFO_0005072
part of: A-AFFY-35

w UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 3.69358627434164
p value: 3.61050247021585E-5
refers to: w
refers to: 1624393_at
t statistic: 21.6988455261907

TpnC4 DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.24036732165569
p value: 0.00414273209504205
refers to: TpnC4
refers to: 1634310_at
t statistic: -8.83191272876372

CG33468
type: EnsemblDatabaseReference

CG9150
type: EnsemblDatabaseReference

mre11
type: EnsemblDatabaseReference

tilB
type: EnsemblDatabaseReference

Obp56f
type: EnsemblDatabaseReference

Ady43A
type: EnsemblDatabaseReference

1635486_at
type: EFO_0005072
part of: A-AFFY-35

Analysis of 'HEXIM knockdown mutant' vs 'wild type genotype'
type: MicroarrayDifferentialExpressionAnalysis

Hsp23 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.57016919622662
p value: 0.00127719259947735
refers to: Hsp23
refers to: 1641055_at
t statistic: 11.796456957385

Rh5
type: EnsemblDatabaseReference

1625382_at
type: EFO_0005072
part of: A-AFFY-35

CG32553
type: EnsemblDatabaseReference

Met DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.73876140574855
p value: 3.61050247021585E-5
refers to: Met
refers to: 1630521_at
t statistic: -20.8720667781486

CG15117
type: EnsemblDatabaseReference

1634310_at
type: EFO_0005072
part of: A-AFFY-35

1634794_at
type: EFO_0005072
part of: A-AFFY-35

(Assay) GSM1319601
type: Assay
has participant: A-AFFY-35

Obp56f
type: EnsemblDatabaseReference

RFeSP
type: EnsemblDatabaseReference

Cpr92F
type: EnsemblDatabaseReference

Rala
type: EnsemblDatabaseReference

Cpr92F DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.07298080150542
p value: 0.0421118549771607
refers to: Cpr92F
refers to: 1633344_at
t statistic: -5.08486573885698

AttA
type: EnsemblDatabaseReference

(Assay) GSM1319603
type: Assay
has participant: A-AFFY-35

Osi6
type: EnsemblDatabaseReference

CG33468 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 2.57596868061082
p value: 0.00501121843724792
refers to: CG33468
refers to: 1635486_at
t statistic: 8.52700879218575

CG7906
type: EnsemblDatabaseReference

E-GEOD-54590
type: microarray 1colour mrna differential
RO_0002162: Drosophila melanogaster
description: We address the function of HEXIM, an inhibitor of the general transcriptional elongation regulator P-TEFb which regulates the transcriptional status of many developmental genes, during Drosophila development. We showed that HEXIM knockdown mutants display organs development failure. In the wing disc, it induces apoptosis and affects Hh signaling. The continuous death of proliferative cells is compensated by apoptosis-induced cell proliferation, in a manner similar to that of differentiated cells, together with high levels of Hh and Ci. We completed this analysis with microarrays to characterize the molecular phenotype of HEXIM knockdown during eye differentiation. HEXIM knockdown during eye differentiation was carried out with a UAS-Hexim-RNAi strain crossed with a GMR-Gal4 driver strain (Bloomington stock center)). Adult GMR>RNAi Hexim flies display slightly smaller, rough and often necrosed eyes. Total RNA were collected from isolated heads. We then used microarray to compare the transcriptome of HEXIM knockdown mutant with that of wild type flies.

CG10407 DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.23349863194411
p value: 0.00354236715838378
refers to: CG10407
refers to: 1623852_at
t statistic: -9.3499645706401

Rala
type: EnsemblDatabaseReference

Rala UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.11812267810166
p value: 0.00141884444901868
refers to: Rala
refers to: 1640377_s_at
t statistic: 11.2377930110543

Cpr49Af
type: EnsemblDatabaseReference

Ady43A DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03099980068462
p value: 0.00527484247649897
refers to: Ady43A
refers to: 1641062_at
t statistic: -8.33603451763064

1636168_s_at
type: EFO_0005072
part of: A-AFFY-35

CG8620
type: EnsemblDatabaseReference

1628806_at
type: EFO_0005072
part of: A-AFFY-35

(Assay) GSM1319599
type: Assay
has participant: A-AFFY-35

1640477_at
type: EFO_0005072
part of: A-AFFY-35

(Sample) genotype/wild type genotype
type: EFO_0000001
property type: genotype
property value: wild type genotype

CG32553 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.87500982607158
p value: 0.00141884444901868
refers to: CG32553
refers to: 1635251_at
t statistic: 10.9190657560903

Cpr49Af
type: EnsemblDatabaseReference

mre11
type: EnsemblDatabaseReference

Ady43A
type: EnsemblDatabaseReference

CG10407
type: EnsemblDatabaseReference

1628884_at
type: EFO_0005072
part of: A-AFFY-35

CG32553
type: EnsemblDatabaseReference

1623714_at
type: EFO_0005072
part of: A-AFFY-35

CG15117
type: EnsemblDatabaseReference

A-AFFY-35
type: EFO_0000269

(Assay) GSM1319602
type: Assay
has participant: A-AFFY-35

CG13101 DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10949406440453
p value: 0.00141884444901868
refers to: CG13101
refers to: 1636168_s_at
t statistic: -11.1995627521764

Met
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/wild type genotype
type: EFO_0000001
property type: GENOTYPE
property value: wild type genotype

1635251_at
type: EFO_0005072
part of: A-AFFY-35

rst
type: EnsemblDatabaseReference

rst DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.32969900336952
p value: 0.0119296438974377
refers to: 1625366_at
refers to: rst
t statistic: -6.97038599110015

Osi6 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.9210226401653
p value: 0.0119296438974377
refers to: 1625382_at
refers to: Osi6
t statistic: 6.99141668872097

CG10924
type: EnsemblDatabaseReference

Cpr92F
type: EnsemblDatabaseReference

1629161_at
type: EFO_0005072
part of: A-AFFY-35

1635331_at
type: EFO_0005072
part of: A-AFFY-35

AttA UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 5.02307115849141
p value: 0.00760137427481617
refers to: AttA
refers to: 1625124_at
t statistic: 7.62191504346307

CG10924 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 2.13834925413277
p value: 0.0128192393584615
refers to: CG10924
refers to: 1634794_at
t statistic: 6.66641185645748

(Sample) genotype/HEXIM knockdown mutant
type: EFO_0000001
property type: genotype
property value: HEXIM knockdown mutant

Osi6
type: EnsemblDatabaseReference

(Assay) GSM1319597
type: Assay
has participant: A-AFFY-35

CecC
type: EnsemblDatabaseReference

Met
type: EnsemblDatabaseReference

rst
type: EnsemblDatabaseReference

1633344_at
type: EFO_0005072
part of: A-AFFY-35

w
type: EnsemblDatabaseReference

Hsp23
type: EnsemblDatabaseReference

(Assay) GSM1319600
type: Assay
has participant: A-AFFY-35

Cpr49Af DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13797269216201
p value: 0.0361313057605175
refers to: Cpr49Af
refers to: 1635331_at
t statistic: -5.31774480636969

(Factor value) GENOTYPE/HEXIM knockdown mutant
type: EFO_0000001
property type: GENOTYPE
property value: HEXIM knockdown mutant

1634005_at
type: EFO_0005072
part of: A-AFFY-35

CecC
type: EnsemblDatabaseReference

CG9150 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 3.02808376620091
p value: 0.00354236715838378
refers to: CG9150
refers to: 1623971_at
t statistic: 9.39376476469625

CG8620
type: EnsemblDatabaseReference

Obp56f DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.37028478779974
p value: 0.00354236715838378
refers to: Obp56f
refers to: 1629161_at
t statistic: -9.31053444114749

(Sample) organism part/head
type: UBERON_0000033
property type: organism part
property value: head

CG33468
type: EnsemblDatabaseReference

Hsp23
type: EnsemblDatabaseReference

w
type: EnsemblDatabaseReference

1624393_at
type: EFO_0005072
part of: A-AFFY-35

1641055_at
type: EFO_0005072
part of: A-AFFY-35

1624466_a_at
type: EFO_0005072
part of: A-AFFY-35

1625124_at
type: EFO_0005072
part of: A-AFFY-35

1625366_at
type: EFO_0005072
part of: A-AFFY-35

Drosophila melanogaster
type: OBI_0100026

mre11 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4790831901606
p value: 2.656548694319E-4
refers to: mre11
refers to: 1637151_at
t statistic: 15.5984713584173

CG15117 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.01123605899931
p value: 0.0128192393584615
refers to: 1624466_a_at
refers to: CG15117
t statistic: 6.65855396445681

CG10407
type: EnsemblDatabaseReference

(Sample) organism/Drosophila melanogaster
type: Drosophila melanogaster
property type: organism
property value: Drosophila melanogaster

tilB UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0646626725843
p value: 0.0128192393584615
refers to: 1640477_at
refers to: tilB
t statistic: 6.63972809050433

RFeSP
type: EnsemblDatabaseReference

PGRP-SA
type: EnsemblDatabaseReference

AttA
type: EnsemblDatabaseReference

CG13101
type: EnsemblDatabaseReference

RFeSP DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -1.369376343957
p value: 0.00689611163738578
refers to: 1641174_at
refers to: RFeSP
t statistic: -7.79313189503199

CG7906 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.55649394147515
p value: 0.0125137174087072
refers to: CG7906
refers to: 1634005_at
t statistic: 6.72252792675733

CG10924
type: EnsemblDatabaseReference

PGRP-SA UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.73561752987742
p value: 0.0454394876941885
refers to: PGRP-SA
refers to: 1628884_at
t statistic: 4.94845217995033

1641062_at
type: EFO_0005072
part of: A-AFFY-35

1630521_at
type: EFO_0005072
part of: A-AFFY-35

CG7906
type: EnsemblDatabaseReference

PGRP-SA
type: EnsemblDatabaseReference

1623971_at
type: EFO_0005072
part of: A-AFFY-35

1640377_s_at
type: EFO_0005072
part of: A-AFFY-35

(Assay) GSM1319598
type: Assay
has participant: A-AFFY-35

TpnC4
type: EnsemblDatabaseReference

(Assay) GSM1319604
type: Assay
has participant: A-AFFY-35

CG13101
type: EnsemblDatabaseReference

(Sample) developmental stage/adult
type: EFO_0001272
property type: developmental stage
property value: adult

(Sample) strain/W118
type: EFO_0000001
property type: strain
property value: W118

1641174_at
type: EFO_0005072
part of: A-AFFY-35

1623852_at
type: EFO_0005072
part of: A-AFFY-35

CecC UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 3.79180195131229
p value: 0.0302760088702165
refers to: 1632719_at
refers to: CecC
t statistic: 5.50642111153281

CG9150
type: EnsemblDatabaseReference

1637151_at
type: EFO_0005072
part of: A-AFFY-35

tilB
type: EnsemblDatabaseReference

CG8620 UP in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4286513235792
p value: 0.00501121843724792
refers to: CG8620
refers to: 1623714_at
t statistic: 8.47597313966816

Rh5 DOWN in 'HEXIM knockdown mutant' vs 'wild type genotype'
type: DecreasedDifferentialExpressionRatio
fold change: -2.51535908665816
p value: 0.0403350675591419
refers to: Rh5
refers to: 1628806_at
t statistic: -5.16104305751795

Rh5
type: EnsemblDatabaseReference

TpnC4
type: EnsemblDatabaseReference