KIF2C DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
DGKA UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDC6 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
AHNAK2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
LACC1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CEACAM1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
TCF19 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2AI DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2BM DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
FIGNL1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
FAM214A UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
E2F8 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
SASS6 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
WEE1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
DDB2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SYTL2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SPC25 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CYP4F3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
UHRF1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST2H3DP1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
APOBEC3C UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
TLR3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
BARD1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GALNT5 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2BO DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST2H4A DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GPR56 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2AK DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CENPE DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RMI1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RINL UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CEP55 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MSH6 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CD82 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
TICRR DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PAPPA-AS1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
ANKRA2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
ARL6IP6 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PLK3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
ZNF367 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
TTK DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CCNE2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CENPU DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GJB5 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
EFCAB10 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H3J DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ANKRD32 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ESCO2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
SPDL1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ACER2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
MYBL1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDC7 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
FOXM1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
NEIL3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
NUF2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
WDHD1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HCT116 microarray done 12 hours after treatment with DMSO (control) or Nutlin Total RNA from HCT116 cells was harvested with an RNeasy kit (Qiagen) and analyzed on Affymetrix HuGene 1.0 ST arrays following the manufacturerâÂÂs instructions. Microarray data were processed using Partek Genomics Suite 6.6. Anova was used to call differentially expressed genes for which any isoform showed a fold change > |+/-1.5| with FDR <0.05. There were 362 genes called as upregulated and 367 genes as downregulated.
TSPAN1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
RAD54L DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF18A DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF24 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RBL1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PLCXD2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
TMEM63B UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDT1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
SESN1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
MCM3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
FANCB DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
EXO1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
FAS UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CLN8 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2BF DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HMMR DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
NADSYN1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CLSPN DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
LRP10 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CMBL UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
IL17RB DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
FBXO5 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
C12orf5 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
YPEL2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
UNG DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PCMTD1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
POLE2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PTAFR UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
RRM2B UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDKN1A UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CH507-42P11.1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
POLD3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PSTPIP2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
FAM111B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIFC1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
SULF2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2BH DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
EME1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MCM4 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
DSN1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
BUB1B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
TP53INP1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
ZNF724P DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF18B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H4H DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H3H DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
C5orf34 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ATAD2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CCNF DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MYBL2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDCA8 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDCA5 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ZMAT3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2BC DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF20B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MCM8 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
XRCC2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
E2F2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PRIM1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
SKA3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2BL DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ALOX5 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PHLDA3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
NCAPG DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
TAP1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HELLS DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2AD DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
DDIAS DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2BN DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RPS27L UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
BUB1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
LMNB1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
POLH UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST2H2BE DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ABHD4 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
MTFR2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GINS2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MAP3K12 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDKN3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
BRCA2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PSMC3IP DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF14 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MTBP DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KRT15 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
KRTAP2-4 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDCA3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MYB DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST4H4 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
IKBIP UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
DSCC1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CHAF1B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIAA1524 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
INSIG1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
BRIP1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
C1orf116 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
NTPCR UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
FDXR UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
GADD45A UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PARD6G UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
BTG2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SKA1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CENPI DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
BLOC1S2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
MASTL DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H2AJ DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GPR87 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PTPRE UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
ORC6 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PTCHD4 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
BRCA1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PLK2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PGAP1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SERPINB5 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CASC5 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CENPL DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF15 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF11 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
FAM111A DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KRTAP2-3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PORCN UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
C18orf54 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
AUNIP DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
PLEKHG1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
ZGRF1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
EPS8L2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
RFC4 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RAD51 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GPSM2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CENPQ DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RAD51AP1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDCA2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ASPM DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RTKN2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
Analysis of '10 micromolar; Nutlin-3' vs 'DMSO control'
ABCA12 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
TNFRSF10C UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SGOL1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GDF15 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PLK4 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
STIL DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ANLN DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MKI67 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CCNA2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H3A DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
GINS3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ESPL1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
TMEM40 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SERPINE1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
WDR63 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
ERCC6L DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KDM5B UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PRDM1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CKAP2L DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
TP53I3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H3B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
STAT4 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
PBX3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
DEPDC1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
WDR76 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF20A DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ARHGAP11A DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ASF1B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
LAMP3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
TCP11L2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
MCM2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
TNFRSF10B UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CDC25A DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ACTA2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
DSC3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
GAS2L3 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
HIST1H4B DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CENPK DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
DRAM1 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
NEK2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
SGOL2 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MDM2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SHCBP1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
USP1 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CENPO DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ADCK3 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CEP85L UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
KIF23 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
MCM10 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ATAD5 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
RFX5 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
SLC44A5 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
CYFIP2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
NDC80 DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
ANKRD29 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
DONSON DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
BLM DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
CES2 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
DDIT4 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
HJURP DOWN in '10 micromolar; Nutlin-3' vs 'DMSO control'
TNFSF18 UP in '10 micromolar; Nutlin-3' vs 'DMSO control'
INPP5D UP in '10 micromolar; Nutlin-3' vs 'DMSO control'