PSG4
type: EnsemblDatabaseReference

TCEAL2
type: EnsemblDatabaseReference

TM4SF18
type: EnsemblDatabaseReference

SESN3
type: EnsemblDatabaseReference

8095110
type: EFO_0005072
part of: A-AFFY-141

CDK15
type: EnsemblDatabaseReference

LRRC17 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.46014749881913
p value: 0.00131292341732569
refers to: LRRC17
refers to: 8135218
t statistic: 14.1755987191207

CD274
type: EnsemblDatabaseReference

FAM90A27P
type: EnsemblDatabaseReference

8073062
type: EFO_0005072
part of: A-AFFY-141

GPR126 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.54680618899659
p value: 0.00125074668264361
refers to: GPR126
refers to: 8122365
t statistic: -13.3683104814605

8112342
type: EFO_0005072
part of: A-AFFY-141

HIST2H4A UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.02520048761572
p value: 8.7130915875396E-4
refers to: HIST2H4A
refers to: 7905067
t statistic: 14.8254440357246

PRDM1
type: EnsemblDatabaseReference

SYTL5
type: EnsemblDatabaseReference

SERPINB2
type: EnsemblDatabaseReference

8056285
type: EFO_0005072
part of: A-AFFY-141

USP41
type: EnsemblDatabaseReference

7895105
type: EFO_0005072
part of: A-AFFY-141

8074606
type: EFO_0005072
part of: A-AFFY-141

OAS1
type: EnsemblDatabaseReference

TM6SF1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.06366385666352
p value: 0.00219601965262884
refers to: 7985493
refers to: TM6SF1
t statistic: -11.0063666795319

PRRX1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.29183830069408
p value: 3.20271537909046E-4
refers to: 7907222
refers to: PRRX1
t statistic: -22.2121730371067

8095303
type: EFO_0005072
part of: A-AFFY-141

PAPPA-AS1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04513065025543
p value: 0.00514974315778442
refers to: PAPPA-AS1
refers to: 8163672
t statistic: -8.3258039653381

BTN3A3 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.05569722453773
p value: 0.0122620191701709
refers to: BTN3A3
refers to: 8117476
t statistic: 6.920973540604

8038899
type: EFO_0005072
part of: A-AFFY-141

OAS1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.27280338974415
p value: 8.39206001493926E-4
refers to: 7958884
refers to: OAS1
t statistic: 17.8182315779525

8091678
type: EFO_0005072
part of: A-AFFY-141

GCH1
type: EnsemblDatabaseReference

8121257
type: EFO_0005072
part of: A-AFFY-141

ANGPT2
type: EnsemblDatabaseReference

RP11-1002K11.1
type: EnsemblDatabaseReference

TNC
type: EnsemblDatabaseReference

(Assay) GSM1275855
type: Assay
has participant: A-AFFY-141

PSG4
type: EnsemblDatabaseReference

KIT
type: EnsemblDatabaseReference

PTPRD
type: EnsemblDatabaseReference

8054712
type: EFO_0005072
part of: A-AFFY-141

QRFPR DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.14742414774995
p value: 0.00781491710842529
refers to: QRFPR
refers to: 8102610
t statistic: -8.00022615133644

(Sample) organism/Homo sapiens
type: Homo sapiens
property type: organism
property value: Homo sapiens

(Sample) genotype/wild type genotype
type: EFO_0000001
property type: genotype
property value: wild type genotype

ZSCAN4 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 3.40047484853978
p value: 3.7949190454694E-4
refers to: 8031799
refers to: ZSCAN4
t statistic: 21.0256040708373

SP110
type: EnsemblDatabaseReference

(Sample) genotype/SUZ12 overexpression
type: EFO_0000001
property type: genotype
property value: SUZ12 overexpression

RFPL4AL1
type: EnsemblDatabaseReference

LRRC17
type: EnsemblDatabaseReference

CCDC80 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.23265585897987
p value: 0.00444219118080641
refers to: CCDC80
refers to: 8089544
t statistic: -8.62211864218546

8094441
type: EFO_0005072
part of: A-AFFY-141

CD274
type: EnsemblDatabaseReference

VEPH1
type: EnsemblDatabaseReference

8109752
type: EFO_0005072
part of: A-AFFY-141

LY6K
type: EnsemblDatabaseReference

FPR1
type: EnsemblDatabaseReference

BAMBI
type: EnsemblDatabaseReference

SUZ12
type: EnsemblDatabaseReference

ANGPT1
type: EnsemblDatabaseReference

XAF1
type: EnsemblDatabaseReference

KCNK2
type: EnsemblDatabaseReference

OAS1
type: EnsemblDatabaseReference

GCH1 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.00680899896942
p value: 0.0215904935764365
refers to: GCH1
refers to: 7979269
t statistic: 5.18911901419396

A-AFFY-141
type: EFO_0000269

TNFSF10
type: EnsemblDatabaseReference

PAPPA-AS1
type: EnsemblDatabaseReference

ACADL
type: EnsemblDatabaseReference

HAS2
type: EnsemblDatabaseReference

8024111
type: EFO_0005072
part of: A-AFFY-141

BTN3A2 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.10010641702992
p value: 8.50221433702433E-4
refers to: BTN3A2
refers to: 8117435
t statistic: 16.8015566925045

MPP4
type: EnsemblDatabaseReference

8054344
type: EFO_0005072
part of: A-AFFY-141

PTPRB DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01460412817581
p value: 0.00132677922576724
refers to: PTPRB
refers to: 7964872
t statistic: -13.1664244403615

NFIB
type: EnsemblDatabaseReference

SLC34A2
type: EnsemblDatabaseReference

7909789
type: EFO_0005072
part of: A-AFFY-141

RP11-665E10.5 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00754654475937
p value: 6.27352599659572E-4
refers to: RP11-665E10.5
refers to: 8055494
t statistic: -17.2897786683499

DHRS2
type: EnsemblDatabaseReference

7988414
type: EFO_0005072
part of: A-AFFY-141

PDE1C
type: EnsemblDatabaseReference

(Assay) GSM1275859
type: Assay
has participant: A-AFFY-141

8168892
type: EFO_0005072
part of: A-AFFY-141

PRRX1
type: EnsemblDatabaseReference

7905067
type: EFO_0005072
part of: A-AFFY-141

RHOJ
type: EnsemblDatabaseReference

IFIT2 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.26823033594062
p value: 7.21762657739485E-4
refers to: IFIT2
refers to: 7929047
t statistic: 19.2140828340981

8096050
type: EFO_0005072
part of: A-AFFY-141

IL7R DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.79854773988246
p value: 9.51442896036089E-5
refers to: IL7R
refers to: 8104901
t statistic: -31.8841083934723

TGFB2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.43341911696037
p value: 8.7130915875396E-4
refers to: TGFB2
refers to: 7909789
t statistic: -14.9982744302982

(Sample) disease/malignant peripheral nerve sheath tumor
type: EFO_0000760
property type: disease
property value: malignant peripheral nerve sheath tumor

SP110
type: EnsemblDatabaseReference

SUZ12 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 4.19916538200317
p value: 2.76373741096528E-5
refers to: 8006325
refers to: SUZ12
t statistic: 53.6356547128711

RFPL4AL1
type: EnsemblDatabaseReference

8091402
type: EFO_0005072
part of: A-AFFY-141

TCEAL2
type: EnsemblDatabaseReference

ACADL DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03188753938292
p value: 0.0172061474874841
refers to: ACADL
refers to: 8058591
t statistic: -6.18760420826766

8102232
type: EFO_0005072
part of: A-AFFY-141

LIFR
type: EnsemblDatabaseReference

7902452
type: EFO_0005072
part of: A-AFFY-141

8047763
type: EFO_0005072
part of: A-AFFY-141

SESN3
type: EnsemblDatabaseReference

SUZ12
type: EnsemblDatabaseReference

7909730
type: EFO_0005072
part of: A-AFFY-141

8047467
type: EFO_0005072
part of: A-AFFY-141

8056877
type: EFO_0005072
part of: A-AFFY-141

8124448
type: EFO_0005072
part of: A-AFFY-141

S100A2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.30804520024879
p value: 0.00180455762562728
refers to: S100A2
refers to: 7920285
t statistic: -11.7361279105396

8145361
type: EFO_0005072
part of: A-AFFY-141

CNN2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00397600091622
p value: 0.00322539499620789
refers to: CNN2
refers to: 8024111
t statistic: -9.60372306201434

MAMDC2
type: EnsemblDatabaseReference

7953200
type: EFO_0005072
part of: A-AFFY-141

ATP8B1
type: EnsemblDatabaseReference

TNFSF10
type: EnsemblDatabaseReference

PNP UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.48986924050661
p value: 0.00385335979333829
refers to: PNP
refers to: 7973067
t statistic: 9.17520049432747

AK5
type: EnsemblDatabaseReference

ANO1
type: EnsemblDatabaseReference

SYTL5
type: EnsemblDatabaseReference

SERPINB2
type: EnsemblDatabaseReference

SAMD9
type: EnsemblDatabaseReference

TMEM244 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.88558615269509
p value: 0.00166738231317259
refers to: TMEM244
refers to: 8129476
t statistic: -11.9980307526084

CCDC84
type: EnsemblDatabaseReference

NMU
type: EnsemblDatabaseReference

8040080
type: EFO_0005072
part of: A-AFFY-141

HIST1H4H UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.10978110374274
p value: 0.0190710191867562
refers to: HIST1H4H
refers to: 8124448
t statistic: 5.37268250315104

SLC14A1
type: EnsemblDatabaseReference

8100026
type: EFO_0005072
part of: A-AFFY-141

Analysis of 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: MicroarrayDifferentialExpressionAnalysis

GPM6B DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13584662786738
p value: 0.00151098503816475
refers to: 8171359
refers to: GPM6B
t statistic: -13.5026117857129

8105302
type: EFO_0005072
part of: A-AFFY-141

PDE1C DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3359120080139
p value: 6.27352599659572E-4
refers to: 8138888
refers to: PDE1C
t statistic: -17.962681454396

PRDM1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.80424425413109
p value: 0.00402988461276099
refers to: 8121257
refers to: PRDM1
t statistic: -8.97805491342214

RNY3P11
type: EnsemblDatabaseReference

TCEAL2 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17261478899507
p value: 0.00232956439534714
refers to: 8168892
refers to: TCEAL2
t statistic: -12.008049035019

PARP14 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.16901507363314
p value: 0.00154891023862115
refers to: PARP14
refers to: 8082100
t statistic: -12.2891978831633

IL6
type: EnsemblDatabaseReference

LEF1
type: EnsemblDatabaseReference

PARP14 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.15698414130972
p value: 8.50221433702433E-4
refers to: 8082100
refers to: PARP14
t statistic: 16.8459228184535

8120468
type: EFO_0005072
part of: A-AFFY-141

8146863
type: EFO_0005072
part of: A-AFFY-141

KIT
type: EnsemblDatabaseReference

PTPRD
type: EnsemblDatabaseReference

RBP7
type: EnsemblDatabaseReference

ANXA3 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.99539941996357
p value: 0.00263794167443106
refers to: 8095986
refers to: ANXA3
t statistic: -10.2997949916119

CYP1B1 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.12175444293185
p value: 0.0352731788502252
refers to: CYP1B1
refers to: 8051583
t statistic: -4.83898446188108

NPY DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19238630806041
p value: 7.21762657739485E-4
refers to: NPY
refers to: 8131919
t statistic: -19.371328958836

C7orf69 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.61829160687556
p value: 0.00102139286469475
refers to: 8132710
refers to: C7orf69
t statistic: 15.8105614570347

LRRC17
type: EnsemblDatabaseReference

NFIB DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.36721554979607
p value: 0.00132640978394201
refers to: NFIB
refers to: 8160138
t statistic: -14.0168305031235

HIST1H4H
type: EnsemblDatabaseReference

8138888
type: EFO_0005072
part of: A-AFFY-141

SAMD9L DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.05329367080754
p value: 0.00937377188652752
refers to: SAMD9L
refers to: 8140971
t statistic: -6.76881235352848

VEPH1
type: EnsemblDatabaseReference

NEFM
type: EnsemblDatabaseReference

FPR1
type: EnsemblDatabaseReference

MAMDC2
type: EnsemblDatabaseReference

NMU
type: EnsemblDatabaseReference

XAF1
type: EnsemblDatabaseReference

FPR1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.04465983343672
p value: 0.00365428533751719
refers to: 8038899
refers to: FPR1
t statistic: 10.3513452657409

8082100
type: EFO_0005072
part of: A-AFFY-141

RSAD2
type: EnsemblDatabaseReference

ATP8B1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.27244355218709
p value: 7.4806872155653E-4
refers to: ATP8B1
refers to: 8023497
t statistic: -16.3348801352323

ACADL
type: EnsemblDatabaseReference

IL1B DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.6119287788428
p value: 2.13647880643273E-4
refers to: IL1B
refers to: 8054722
t statistic: -25.5352377405976

RNY3P11
type: EnsemblDatabaseReference

HAS2
type: EnsemblDatabaseReference

HIST2H4A
type: EnsemblDatabaseReference

PROM1
type: EnsemblDatabaseReference

IL6
type: EnsemblDatabaseReference

POSTN
type: EnsemblDatabaseReference

8051583
type: EFO_0005072
part of: A-AFFY-141

7950933
type: EFO_0005072
part of: A-AFFY-141

MX2 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.85796362883992
p value: 0.00146143722316699
refers to: MX2
refers to: 8068697
t statistic: 13.7237470759054

IFI44L DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.67308217041376
p value: 3.40382114833493E-4
refers to: IFI44L
refers to: 7902541
t statistic: -21.6830995972543

FST
type: EnsemblDatabaseReference

RBBP6
type: EnsemblDatabaseReference

NFIB
type: EnsemblDatabaseReference

ANO1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01441524966151
p value: 0.00110366182604212
refers to: 7942135
refers to: ANO1
t statistic: -13.8403851960148

LEF1
type: EnsemblDatabaseReference

8131803
type: EFO_0005072
part of: A-AFFY-141

LPXN
type: EnsemblDatabaseReference

DHRS2
type: EnsemblDatabaseReference

NRP2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00430413090764
p value: 0.00110416281645427
refers to: 8047763
refers to: NRP2
t statistic: -13.7995077738746

Analysis of 'SUZ12 overexpression' vs 'wild type'
type: MicroarrayDifferentialExpressionAnalysis

PDE1C
type: EnsemblDatabaseReference

RBP7 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00663932527873
p value: 0.00319803824156507
refers to: RBP7
refers to: 7897522
t statistic: -10.8927977413821

ELOVL2
type: EnsemblDatabaseReference

IFIT1
type: EnsemblDatabaseReference

8058591
type: EFO_0005072
part of: A-AFFY-141

8021623
type: EFO_0005072
part of: A-AFFY-141

RHOJ
type: EnsemblDatabaseReference

8160040
type: EFO_0005072
part of: A-AFFY-141

OAS2 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.77678805281189
p value: 3.99457279185092E-4
refers to: 7958913
refers to: OAS2
t statistic: 24.2370453108177

7964872
type: EFO_0005072
part of: A-AFFY-141

7951077
type: EFO_0005072
part of: A-AFFY-141

FGF5
type: EnsemblDatabaseReference

8099476
type: EFO_0005072
part of: A-AFFY-141

PARP14
type: EnsemblDatabaseReference

7926875
type: EFO_0005072
part of: A-AFFY-141

BAI3 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10420781313709
p value: 0.00689523281986419
refers to: 8120468
refers to: BAI3
t statistic: -7.55952127590044

7971461
type: EFO_0005072
part of: A-AFFY-141

ALDH1A1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.4803136933469
p value: 0.00180455762562728
refers to: ALDH1A1
refers to: 8161755
t statistic: -11.7025549537884

KIAA1324L UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.01437304685665
p value: 0.00668056833322973
refers to: KIAA1324L
refers to: 8140709
t statistic: 7.65182824770657

CD274 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.88389092355171
p value: 0.00103465696195946
refers to: CD274
refers to: 8154233
t statistic: -14.115048016008

LIFR
type: EnsemblDatabaseReference

8047300
type: EFO_0005072
part of: A-AFFY-141

7973433
type: EFO_0005072
part of: A-AFFY-141

8130211
type: EFO_0005072
part of: A-AFFY-141

7982366
type: EFO_0005072
part of: A-AFFY-141

ELOVL6
type: EnsemblDatabaseReference

8095986
type: EFO_0005072
part of: A-AFFY-141

TMEM47 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.29582046720151
p value: 0.00466184625162707
refers to: TMEM47
refers to: 8172022
t statistic: -9.48968777598642

RP11-432M8.8 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.81540200168378
p value: 0.00196164078631394
refers to: 8104617
refers to: RP11-432M8.8
t statistic: 11.3933470342046

8021635
type: EFO_0005072
part of: A-AFFY-141

(Factor value) GENOTYPE/wild type genotype
type: EFO_0000001
property type: GENOTYPE
property value: wild type genotype

RASGRP3
type: EnsemblDatabaseReference

ANXA3
type: EnsemblDatabaseReference

7948332
type: EFO_0005072
part of: A-AFFY-141

RSAD2
type: EnsemblDatabaseReference

CHRNA1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.25038408642794
p value: 0.0011786639610869
refers to: CHRNA1
refers to: 8056877
t statistic: 14.9379419931284

(Factor value) GENOTYPE/SUZ12 overexpression
type: EFO_0000001
property type: GENOTYPE
property value: SUZ12 overexpression

ATP8B1
type: EnsemblDatabaseReference

7907222
type: EFO_0005072
part of: A-AFFY-141

8121416
type: EFO_0005072
part of: A-AFFY-141

LPHN3
type: EnsemblDatabaseReference

AK5
type: EnsemblDatabaseReference

HIST2H4A
type: EnsemblDatabaseReference

IFIT2
type: EnsemblDatabaseReference

SAMD9
type: EnsemblDatabaseReference

ANO1
type: EnsemblDatabaseReference

CCDC84
type: EnsemblDatabaseReference

SLC14A1
type: EnsemblDatabaseReference

KLHL24 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.05363654076307
p value: 0.00263794167443106
refers to: 8084219
refers to: KLHL24
t statistic: 10.3451018557076

FST
type: EnsemblDatabaseReference

LPXN DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19916104544647
p value: 0.00540960290001583
refers to: LPXN
refers to: 7948332
t statistic: -8.1979466090785

RBBP6
type: EnsemblDatabaseReference

FABP4
type: EnsemblDatabaseReference

FBXL21 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.179147362779
p value: 0.0047868024626549
refers to: 8108205
refers to: FBXL21
t statistic: -9.41580058685332

8068713
type: EFO_0005072
part of: A-AFFY-141

RNVU1-15
type: EnsemblDatabaseReference

IL7R
type: EnsemblDatabaseReference

8140967
type: EFO_0005072
part of: A-AFFY-141

C7orf69
type: EnsemblDatabaseReference

ANGPT2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3766797328235
p value: 7.74094924610308E-4
refers to: ANGPT2
refers to: 8149071
t statistic: -15.5967643081347

8149071
type: EFO_0005072
part of: A-AFFY-141

8145766
type: EFO_0005072
part of: A-AFFY-141

(Sample) cell line/90-8TL
type: EFO_0000001
property type: cell line
property value: 90-8TL

C14orf23 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.46156299958658
p value: 0.00102139286469475
refers to: C14orf23
refers to: 7973748
t statistic: 15.7631203713971

TRIM51BP
type: EnsemblDatabaseReference

DDX58 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.30078280322745
p value: 5.2769564231607E-4
refers to: DDX58
refers to: 8160559
t statistic: 22.2561092812061

CXCL12
type: EnsemblDatabaseReference

8056257
type: EFO_0005072
part of: A-AFFY-141

FGF5
type: EnsemblDatabaseReference

QRFPR
type: EnsemblDatabaseReference

VEPH1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.30349370942691
p value: 0.00456190431469743
refers to: VEPH1
refers to: 8091678
t statistic: -8.54251032444363

POSTN DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15317550471448
p value: 8.50221433702433E-4
refers to: POSTN
refers to: 7971077
t statistic: -16.8821400450193

8102342
type: EFO_0005072
part of: A-AFFY-141

HERC6 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.39028841516983
p value: 0.00130624055631929
refers to: 8096335
refers to: HERC6
t statistic: 14.274129874172

SESN3 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.29812019112359
p value: 7.74094924610308E-4
refers to: SESN3
refers to: 7951077
t statistic: 15.9179889759725

IL1B
type: EnsemblDatabaseReference

PTPRB
type: EnsemblDatabaseReference

FGF5 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.57850630704236
p value: 0.00444219118080641
refers to: FGF5
refers to: 8096050
t statistic: -8.65894153273535

RBP7
type: EnsemblDatabaseReference

(Assay) GSM1275858
type: Assay
has participant: A-AFFY-141

OAS1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09831494136296
p value: 0.0119717936394917
refers to: OAS1
refers to: 7958884
t statistic: -6.24992992855449

PDCD1LG2
type: EnsemblDatabaseReference

8114805
type: EFO_0005072
part of: A-AFFY-141

RP11-665E10.5
type: EnsemblDatabaseReference

IL6 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.12371215024655
p value: 0.0144561161140231
refers to: IL6
refers to: 8131803
t statistic: -5.84673957500293

HIST1H4H
type: EnsemblDatabaseReference

NRP2
type: EnsemblDatabaseReference

ANXA3
type: EnsemblDatabaseReference

XAF1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.80175402211171
p value: 7.95398902278678E-4
refers to: XAF1
refers to: 8004184
t statistic: -15.4135533851544

8023497
type: EFO_0005072
part of: A-AFFY-141

LEF1 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.37082198239421
p value: 0.0011786639610869
refers to: LEF1
refers to: 8102232
t statistic: -15.1041235084281

ELOVL7
type: EnsemblDatabaseReference

7979269
type: EFO_0005072
part of: A-AFFY-141

CCL2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.50344369925463
p value: 8.7130915875396E-4
refers to: CCL2
refers to: 8006433
t statistic: -14.9595194114036

SP110 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.04314590562294
p value: 0.00465464246923047
refers to: SP110
refers to: 8059650
t statistic: 9.50237885815343

NEFM
type: EnsemblDatabaseReference

LPHN3
type: EnsemblDatabaseReference

TENM2
type: EnsemblDatabaseReference

8123920
type: EFO_0005072
part of: A-AFFY-141

BAI3
type: EnsemblDatabaseReference

SAMD9L
type: EnsemblDatabaseReference

TNFSF10 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.40214989549983
p value: 0.00353771748105691
refers to: TNFSF10
refers to: 8092169
t statistic: 10.5027813518785

SNORD116-14 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.04133986614309
p value: 0.0125590572017469
refers to: 7981976
refers to: SNORD116-14
t statistic: 6.84037158801173

RP11-432M8.8
type: EnsemblDatabaseReference

AOX1
type: EnsemblDatabaseReference

8096335
type: EFO_0005072
part of: A-AFFY-141

8006433
type: EFO_0005072
part of: A-AFFY-141

IL1A DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.91732868593649
p value: 2.02899996173565E-4
refers to: 8054712
refers to: IL1A
t statistic: -26.4033109018737

SNORD116-14
type: EnsemblDatabaseReference

PROM1
type: EnsemblDatabaseReference

C7orf69
type: EnsemblDatabaseReference

POSTN
type: EnsemblDatabaseReference

GPR126
type: EnsemblDatabaseReference

CCDC84 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17926463385275
p value: 0.020776034231782
refers to: CCDC84
refers to: 7895105
t statistic: -5.25776986994042

S100A2
type: EnsemblDatabaseReference

7937335
type: EFO_0005072
part of: A-AFFY-141

CXCL12
type: EnsemblDatabaseReference

FAP DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20475174823508
p value: 0.00429478715849105
refers to: FAP
refers to: 8056257
t statistic: -8.80869040959439

IFIH1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.22973503051204
p value: 2.76203129327346E-4
refers to: IFIH1
refers to: 8056285
t statistic: 28.3418573853525

BTN3A2
type: EnsemblDatabaseReference

8126428
type: EFO_0005072
part of: A-AFFY-141

LPXN
type: EnsemblDatabaseReference

CYP1B1
type: EnsemblDatabaseReference

8148553
type: EFO_0005072
part of: A-AFFY-141

8058857
type: EFO_0005072
part of: A-AFFY-141

TMEM244
type: EnsemblDatabaseReference

FGF1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.14621648718438
p value: 0.00140811717343556
refers to: FGF1
refers to: 8114805
t statistic: -12.815353173335

ELOVL2
type: EnsemblDatabaseReference

8021081
type: EFO_0005072
part of: A-AFFY-141

IFIT1
type: EnsemblDatabaseReference

7943019
type: EFO_0005072
part of: A-AFFY-141

8031799
type: EFO_0005072
part of: A-AFFY-141

(Factor value) COMPOUND/JQ1 100
type: EFO_0000001
property type: COMPOUND
property value: JQ1 100

RSAD2 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.87047878617086
p value: 7.34307203138049E-4
refers to: 8040080
refers to: RSAD2
t statistic: 18.6141756445495

PARP14
type: EnsemblDatabaseReference

KLHL24
type: EnsemblDatabaseReference

E-GEOD-52777
type: microarray 1colour mrna differential
RO_0002162: Homo sapiens
description: The polycomb repressive complex 2 (PRC2) plays an oncogenic role in several cancers. However, loss-of-function mutations in PRC2 components have been detected in a subset of hematopoietic malignancies, suggesting that different epigenetic landscapes are required in different tumor types. In this study we provide genomic, cellular, and mouse modeling data to demonstrate that loss-of-function mutations in the polycomb gene, SUZ12, and NF1 cooperate in peripheral nervous system tumors, glioblastomas, and melanomas. NF1 encodes a Ras GTPase-activating protein and its loss triggers moderate levels of Ras activation. We show that SUZ12-loss enhances the effects of NF1 mutations, in part, by amplifying Ras transcriptional signatures. Moreover, SUZ12-loss triggers an epigenetic switch that confers sensitivity to combined bromodomain and MEK inhibitors in vivo. Collectively these studies demonstrate an unexpected role for polycomb group genes in NF1 mutant tumors and reveal an epigenetic-based therapeutic strategy that may be exploited for a variety of cancers. 9 samples in triplicates, 3x LacZ control, 3x SUZ12 over expression, 3x JQ1 treatment

PRKAA2
type: EnsemblDatabaseReference

8160559
type: EFO_0005072
part of: A-AFFY-141

SAMD9 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.20268987333414
p value: 0.00266848069937523
refers to: 8140967
refers to: SAMD9
t statistic: 11.5507056973797

PARP9 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.49120151289493
p value: 7.21762657739485E-4
refers to: PARP9
refers to: 8090018
t statistic: 19.1392150654482

ELOVL7
type: EnsemblDatabaseReference

DDX58
type: EnsemblDatabaseReference

ALDH1A1 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.38950049477558
p value: 0.00181922470825167
refers to: ALDH1A1
refers to: 8161755
t statistic: -12.6603288584328

8092169
type: EFO_0005072
part of: A-AFFY-141

7958913
type: EFO_0005072
part of: A-AFFY-141

ELOVL6
type: EnsemblDatabaseReference

LCP1
type: EnsemblDatabaseReference

SULF1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.38299683310741
p value: 0.00132677922576724
refers to: 8146863
refers to: SULF1
t statistic: -13.0089259497443

MPP4 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01492897981029
p value: 0.00159351838670553
refers to: MPP4
refers to: 8058273
t statistic: -12.1738829600277

7929065
type: EFO_0005072
part of: A-AFFY-141

CHRNA1
type: EnsemblDatabaseReference

ALDH1A1
type: EnsemblDatabaseReference

RASGRP3
type: EnsemblDatabaseReference

BAI3
type: EnsemblDatabaseReference

RHOJ DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.64494626170155
p value: 1.93239527857318E-4
refers to: 7974902
refers to: RHOJ
t statistic: -27.4129458959055

RBBP6 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.36791394674217
p value: 0.00132677922576724
refers to: RBBP6
refers to: 7994161
t statistic: 13.0541979316779

MAMDC2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.05983553146327
p value: 0.00529861687302709
refers to: MAMDC2
refers to: 8155754
t statistic: -8.24601003434679

8166747
type: EFO_0005072
part of: A-AFFY-141

AOX1
type: EnsemblDatabaseReference

IFIT2
type: EnsemblDatabaseReference

(Factor value) COMPOUND/DMSO
type: CHEBI_28262
property type: COMPOUND
property value: DMSO

7965941
type: EFO_0005072
part of: A-AFFY-141

SYNE1
type: EnsemblDatabaseReference

IFITM1
type: EnsemblDatabaseReference

PNP
type: EnsemblDatabaseReference

FABP4
type: EnsemblDatabaseReference

Homo sapiens
type: OBI_0100026

MPP4 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0107225015807
p value: 3.04701927669177E-4
refers to: 8058273
refers to: MPP4
t statistic: 26.6184807049778

RNVU1-15
type: EnsemblDatabaseReference

IL7R
type: EnsemblDatabaseReference

CYP1B1
type: EnsemblDatabaseReference

7929047
type: EFO_0005072
part of: A-AFFY-141

CCND2 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.05149068227525
p value: 0.00447684553274115
refers to: 7953200
refers to: CCND2
t statistic: -9.58830113461457

SYNE1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.30067044149803
p value: 7.74094924610308E-4
refers to: SYNE1
refers to: 8130211
t statistic: -15.5603055698336

SULF1
type: EnsemblDatabaseReference

IFI44
type: EnsemblDatabaseReference

TRIM51BP
type: EnsemblDatabaseReference

SCG5 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09787371847099
p value: 0.0160380607501766
refers to: 7982366
refers to: SCG5
t statistic: -5.64984007335139

FGF1
type: EnsemblDatabaseReference

QRFPR
type: EnsemblDatabaseReference

FBXL21
type: EnsemblDatabaseReference

CCDC80
type: EnsemblDatabaseReference

NOX4 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.30306773336881
p value: 0.0024322671718242
refers to: 7950933
refers to: NOX4
t statistic: -10.5793493787407

IL1B
type: EnsemblDatabaseReference

XAF1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.75799772798477
p value: 9.64093531143016E-4
refers to: XAF1
refers to: 8004184
t statistic: 16.1307629768654

8163672
type: EFO_0005072
part of: A-AFFY-141

8030974
type: EFO_0005072
part of: A-AFFY-141

OAS2
type: EnsemblDatabaseReference

8006325
type: EFO_0005072
part of: A-AFFY-141

PTPRB
type: EnsemblDatabaseReference

DDX58
type: EnsemblDatabaseReference

PDCD1LG2
type: EnsemblDatabaseReference

RP11-665E10.5
type: EnsemblDatabaseReference

RNVU1-15 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.51189943178144
p value: 0.0166842593296711
refers to: RNVU1-15
refers to: 7919560
t statistic: 5.58807159195804

ELOVL7 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15050085166742
p value: 0.00480857982145081
refers to: 8112274
refers to: ELOVL7
t statistic: -9.35056388385036

LCP1
type: EnsemblDatabaseReference

LY6K DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.85804872289409
p value: 7.4806872155653E-4
refers to: LY6K
refers to: 8148553
t statistic: -16.5155091654812

ATP8A1 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.11760455136684
p value: 6.27352599659572E-4
refers to: ATP8A1
refers to: 8100026
t statistic: 17.2913026393139

CHRNA1
type: EnsemblDatabaseReference

ALDH1A1
type: EnsemblDatabaseReference

8004184
type: EFO_0005072
part of: A-AFFY-141

NRP2
type: EnsemblDatabaseReference

CCL2
type: EnsemblDatabaseReference

8172022
type: EFO_0005072
part of: A-AFFY-141

C15orf54 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.40161073452164
p value: 3.89731256132718E-4
refers to: C15orf54
refers to: 7982593
t statistic: -20.6828196250417

TGFB2
type: EnsemblDatabaseReference

TENM2
type: EnsemblDatabaseReference

GPM6B
type: EnsemblDatabaseReference

SAMD9L
type: EnsemblDatabaseReference

RFX8 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.12245932388338
p value: 0.0136217581379733
refers to: RFX8
refers to: 8054344
t statistic: -6.0205809832215

8140709
type: EFO_0005072
part of: A-AFFY-141

7919560
type: EFO_0005072
part of: A-AFFY-141

RP11-432M8.8
type: EnsemblDatabaseReference

FST DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.35892174224628
p value: 0.0024322671718242
refers to: FST
refers to: 8105302
t statistic: -10.6108388413163

TRERF1
type: EnsemblDatabaseReference

SNORD116-14
type: EnsemblDatabaseReference

8058273
type: EFO_0005072
part of: A-AFFY-141

8108205
type: EFO_0005072
part of: A-AFFY-141

TRIM51BP UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4892880548013
p value: 5.15126184730931E-4
refers to: TRIM51BP
refers to: 7943019
t statistic: 19.1443235598198

IFI44L
type: EnsemblDatabaseReference

7920285
type: EFO_0005072
part of: A-AFFY-141

7981976
type: EFO_0005072
part of: A-AFFY-141

IFIH1
type: EnsemblDatabaseReference

GPR126
type: EnsemblDatabaseReference

SULF1
type: EnsemblDatabaseReference

C15orf54
type: EnsemblDatabaseReference

7973748
type: EFO_0005072
part of: A-AFFY-141

S100A2
type: EnsemblDatabaseReference

IFI44
type: EnsemblDatabaseReference

8131919
type: EFO_0005072
part of: A-AFFY-141

8117476
type: EFO_0005072
part of: A-AFFY-141

NPY
type: EnsemblDatabaseReference

LCP1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09041720105797
p value: 0.00266435204403711
refers to: LCP1
refers to: 7971461
t statistic: -10.2047144241249

FBXL21
type: EnsemblDatabaseReference

8104901
type: EFO_0005072
part of: A-AFFY-141

ELOVL2 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.60258658388117
p value: 8.39206001493926E-4
refers to: ELOVL2
refers to: 8123920
t statistic: -17.5073443786697

APOBEC3B
type: EnsemblDatabaseReference

CNN2
type: EnsemblDatabaseReference

TMEM244
type: EnsemblDatabaseReference

LIFR UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.34189048474231
p value: 0.00145784568062672
refers to: LIFR
refers to: 8111677
t statistic: 12.653959488489

BTN3A2
type: EnsemblDatabaseReference

ATP8A1
type: EnsemblDatabaseReference

C15orf54 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08446270331624
p value: 7.34307203138049E-4
refers to: C15orf54
refers to: 7982593
t statistic: 18.5930669213983

TNC DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.07054636457346
p value: 0.00263794167443106
refers to: TNC
refers to: 8163637
t statistic: -10.365650200616

HAS2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.24360501584692
p value: 2.16814046569073E-4
refers to: HAS2
refers to: 8152617
t statistic: -24.9273025363945

ADAMTS6
type: EnsemblDatabaseReference

8132710
type: EFO_0005072
part of: A-AFFY-141

MX1
type: EnsemblDatabaseReference

KLHL24
type: EnsemblDatabaseReference

PRKAA2
type: EnsemblDatabaseReference

CCL2
type: EnsemblDatabaseReference

RFX8
type: EnsemblDatabaseReference

MX1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.98077562053929
p value: 5.2769564231607E-4
refers to: MX1
refers to: 8068713
t statistic: 22.6073422873112

CCND2
type: EnsemblDatabaseReference

PARP9
type: EnsemblDatabaseReference

SLC14A1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.26401471990832
p value: 2.41985179291034E-4
refers to: 8021081
refers to: SLC14A1
t statistic: -24.0214222709755

SAMD9L UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.25616019812363
p value: 0.00122883976694966
refers to: SAMD9L
refers to: 8140971
t statistic: 14.7053021284858

8089544
type: EFO_0005072
part of: A-AFFY-141

8104617
type: EFO_0005072
part of: A-AFFY-141

IL1A
type: EnsemblDatabaseReference

IGFBP5
type: EnsemblDatabaseReference

(Assay) GSM1275853
type: Assay
has participant: A-AFFY-141

FAP
type: EnsemblDatabaseReference

8160138
type: EFO_0005072
part of: A-AFFY-141

GATM
type: EnsemblDatabaseReference

C14orf23
type: EnsemblDatabaseReference

8041422
type: EFO_0005072
part of: A-AFFY-141

IFIT1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.07175470772238
p value: 8.39206001493926E-4
refers to: IFIT1
refers to: 7929065
t statistic: 17.3677031376688

TENM2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03022655659915
p value: 0.00851062228923404
refers to: 8109752
refers to: TENM2
t statistic: -7.07589828135835

8135218
type: EFO_0005072
part of: A-AFFY-141

PTPRD DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00142265977844
p value: 8.39206001493926E-4
refers to: 8160040
refers to: PTPRD
t statistic: -17.2115697773496

(Assay) GSM1275860
type: Assay
has participant: A-AFFY-141

TM6SF1
type: EnsemblDatabaseReference

IFI44L
type: EnsemblDatabaseReference

RAB27B UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.05758078433561
p value: 0.00380877072136173
refers to: RAB27B
refers to: 8021301
t statistic: 10.0821945586321

SYNE1
type: EnsemblDatabaseReference

IFITM1
type: EnsemblDatabaseReference

PNP
type: EnsemblDatabaseReference

7901720
type: EFO_0005072
part of: A-AFFY-141

RFPL4AL1 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 3.49631567354866
p value: 7.74094924610308E-4
refers to: 8031573
refers to: RFPL4AL1
t statistic: 15.6433473207765

NPY
type: EnsemblDatabaseReference

PRKAA2 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20313576644489
p value: 0.00162808402207833
refers to: PRKAA2
refers to: 7901720
t statistic: -13.0460033910773

RAB27B
type: EnsemblDatabaseReference

PDCD1LG2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.85955829370011
p value: 2.64015191958899E-4
refers to: 8154245
refers to: PDCD1LG2
t statistic: -23.280624148463

APOBEC3B
type: EnsemblDatabaseReference

NOX4
type: EnsemblDatabaseReference

IFIH1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.22075480547319
p value: 0.00444219118080641
refers to: IFIH1
refers to: 8056285
t statistic: -8.67401118036163

8054722
type: EFO_0005072
part of: A-AFFY-141

BTN3A3
type: EnsemblDatabaseReference

8161755
type: EFO_0005072
part of: A-AFFY-141

IFI44L UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 2.91927240861284
p value: 1.65116465971107E-4
refers to: IFI44L
refers to: 7902541
t statistic: 34.3851513010937

7897522
type: EFO_0005072
part of: A-AFFY-141

FGF1
type: EnsemblDatabaseReference

CCDC80
type: EnsemblDatabaseReference

8122365
type: EFO_0005072
part of: A-AFFY-141

ELOVL6 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.06828522896114
p value: 0.0137486180435754
refers to: ELOVL6
refers to: 8102342
t statistic: -5.99832064868308

ANGPT1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.55796621996107
p value: 7.74094924610308E-4
refers to: ANGPT1
refers to: 8152297
t statistic: -16.0264644186901

OAS2
type: EnsemblDatabaseReference

SERPINB7 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.92476702781585
p value: 0.00290450252111461
refers to: 8021623
refers to: SERPINB7
t statistic: -9.97345154100655

SLC34A2 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.11862028163444
p value: 0.00788795741169965
refers to: 8094441
refers to: SLC34A2
t statistic: 7.24832795520612

PARP9
type: EnsemblDatabaseReference

7973067
type: EFO_0005072
part of: A-AFFY-141

8037283
type: EFO_0005072
part of: A-AFFY-141

7958884
type: EFO_0005072
part of: A-AFFY-141

DHRS2 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.27464800729674
p value: 0.0027713999689499
refers to: DHRS2
refers to: 7973433
t statistic: 10.0870979625076

LPHN3 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.09794295856916
p value: 0.0018430200610286
refers to: 8095303
refers to: LPHN3
t statistic: 11.5417831432405

PSG4 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.34039454037269
p value: 0.00264231170730393
refers to: 8037283
refers to: PSG4
t statistic: -10.276291842631

BAMBI UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.15482174043625
p value: 0.00415449506016556
refers to: BAMBI
refers to: 7926875
t statistic: 8.90872879889748

8154233
type: EFO_0005072
part of: A-AFFY-141

7994161
type: EFO_0005072
part of: A-AFFY-141

8102610
type: EFO_0005072
part of: A-AFFY-141

ADAMTS6 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08532334217845
p value: 0.00263794167443106
refers to: 8112342
refers to: ADAMTS6
t statistic: -10.3102733000923

KIAA1324L
type: EnsemblDatabaseReference

8171359
type: EFO_0005072
part of: A-AFFY-141

HERC6
type: EnsemblDatabaseReference

TGFB2
type: EnsemblDatabaseReference

TM6SF1
type: EnsemblDatabaseReference

KIT DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.35872415658554
p value: 0.00335942423607138
refers to: 8095110
refers to: KIT
t statistic: -10.7330478702959

GPM6B
type: EnsemblDatabaseReference

RNY3P11 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01901588307397
p value: 0.0229417074226608
refers to: RNY3P11
refers to: 8121416
t statistic: -5.63857925751499

ZSCAN4
type: EnsemblDatabaseReference

8100464
type: EFO_0005072
part of: A-AFFY-141

TMEM47
type: EnsemblDatabaseReference

7971077
type: EFO_0005072
part of: A-AFFY-141

MX2
type: EnsemblDatabaseReference

8112274
type: EFO_0005072
part of: A-AFFY-141

8084219
type: EFO_0005072
part of: A-AFFY-141

SERPINB7
type: EnsemblDatabaseReference

8090018
type: EFO_0005072
part of: A-AFFY-141

8154245
type: EFO_0005072
part of: A-AFFY-141

RAB27B
type: EnsemblDatabaseReference

TRERF1
type: EnsemblDatabaseReference

NOX4
type: EnsemblDatabaseReference

IFIH1
type: EnsemblDatabaseReference

8117435
type: EFO_0005072
part of: A-AFFY-141

C15orf54
type: EnsemblDatabaseReference

7985493
type: EFO_0005072
part of: A-AFFY-141

GLT8D2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13787026977241
p value: 0.00372722355780816
refers to: GLT8D2
refers to: 7965941
t statistic: -9.24463942602352

8111677
type: EFO_0005072
part of: A-AFFY-141

CNN2
type: EnsemblDatabaseReference

PROM1 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.46929408921168
p value: 8.50221433702433E-4
refers to: 8099476
refers to: PROM1
t statistic: -16.9449952837103

RASGRP3 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.5864885887474
p value: 4.86404982624336E-5
refers to: RASGRP3
refers to: 8041422
t statistic: -40.0783264789567

ATP8A1
type: EnsemblDatabaseReference

8152617
type: EFO_0005072
part of: A-AFFY-141

FAM90A27P
type: EnsemblDatabaseReference

8163637
type: EFO_0005072
part of: A-AFFY-141

8055494
type: EFO_0005072
part of: A-AFFY-141

SYTL5 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.16966161236241
p value: 0.00351477565575555
refers to: SYTL5
refers to: 8166747
t statistic: 10.5851342665037

ADAMTS6
type: EnsemblDatabaseReference

GLT8D2
type: EnsemblDatabaseReference

MX1
type: EnsemblDatabaseReference

7942135
type: EFO_0005072
part of: A-AFFY-141

8068697
type: EFO_0005072
part of: A-AFFY-141

8152297
type: EFO_0005072
part of: A-AFFY-141

KIAA1324L
type: EnsemblDatabaseReference

7933194
type: EFO_0005072
part of: A-AFFY-141

RFX8
type: EnsemblDatabaseReference

USP41 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.19255322329605
p value: 0.0011786639610869
refers to: USP41
refers to: 8074606
t statistic: 14.9714682640572

NEFM UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.66640826523312
p value: 0.00150575302423925
refers to: NEFM
refers to: 8145361
t statistic: 12.4759653706995

CCND2
type: EnsemblDatabaseReference

USP41
type: EnsemblDatabaseReference

8151532
type: EFO_0005072
part of: A-AFFY-141

7974902
type: EFO_0005072
part of: A-AFFY-141

IL1A
type: EnsemblDatabaseReference

HERC6
type: EnsemblDatabaseReference

IGFBP5
type: EnsemblDatabaseReference

FAP
type: EnsemblDatabaseReference

AOX1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.32632425605904
p value: 7.4806872155653E-4
refers to: AOX1
refers to: 8047300
t statistic: -16.3946910639642

ZSCAN4
type: EnsemblDatabaseReference

SERPINB2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.44522208645429
p value: 7.4806872155653E-4
refers to: SERPINB2
refers to: 8021635
t statistic: -16.3187076856965

GATM
type: EnsemblDatabaseReference

SCG5
type: EnsemblDatabaseReference

TRERF1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15239563054912
p value: 0.00442376612122743
refers to: TRERF1
refers to: 8126428
t statistic: -8.71393561019692

C14orf23
type: EnsemblDatabaseReference

TMEM47 UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.53412096185648
p value: 0.00132677922576724
refers to: TMEM47
refers to: 8172022
t statistic: 13.01715263411

SERPINB7
type: EnsemblDatabaseReference

(Assay) GSM1275861
type: Assay
has participant: A-AFFY-141

8059650
type: EFO_0005072
part of: A-AFFY-141

AK5 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.6535419510267
p value: 0.00112653332625726
refers to: AK5
refers to: 7902452
t statistic: -13.7147720499523

GCH1
type: EnsemblDatabaseReference

ANGPT2
type: EnsemblDatabaseReference

8129476
type: EFO_0005072
part of: A-AFFY-141

(Assay) GSM1275857
type: Assay
has participant: A-AFFY-141

7902541
type: EFO_0005072
part of: A-AFFY-141

8021301
type: EFO_0005072
part of: A-AFFY-141

CDK15 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.12310922687528
p value: 8.7130915875396E-4
refers to: 8047467
refers to: CDK15
t statistic: -14.7560124495874

BTN3A3
type: EnsemblDatabaseReference

CXCL12 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.10923556201503
p value: 4.86404982624336E-5
refers to: CXCL12
refers to: 7933194
t statistic: -38.7571975811197

(Assay) GSM1275856
type: Assay
has participant: A-AFFY-141

8031573
type: EFO_0005072
part of: A-AFFY-141

GLT8D2
type: EnsemblDatabaseReference

TM4SF18
type: EnsemblDatabaseReference

GATM UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08003021975308
p value: 0.00394675762506947
refers to: GATM
refers to: 7988414
t statistic: 9.10461835580444

LY6K
type: EnsemblDatabaseReference

APOBEC3B DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01503746096465
p value: 0.00931110425403271
refers to: 8073062
refers to: APOBEC3B
t statistic: -6.78819404916082

BAMBI
type: EnsemblDatabaseReference

7902553
type: EFO_0005072
part of: A-AFFY-141

CDK15
type: EnsemblDatabaseReference

IGFBP5 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.48622568974592
p value: 0.00213856551152677
refers to: 8058857
refers to: IGFBP5
t statistic: -11.1057716936807

ANGPT1
type: EnsemblDatabaseReference

KCNK2
type: EnsemblDatabaseReference

7982593
type: EFO_0005072
part of: A-AFFY-141

PAPPA-AS1
type: EnsemblDatabaseReference

SCG5
type: EnsemblDatabaseReference

PRDM1
type: EnsemblDatabaseReference

MPP4
type: EnsemblDatabaseReference

8140971
type: EFO_0005072
part of: A-AFFY-141

SLC34A2
type: EnsemblDatabaseReference

TMEM47
type: EnsemblDatabaseReference

MX2
type: EnsemblDatabaseReference

(Assay) GSM1275854
type: Assay
has participant: A-AFFY-141

RP11-1002K11.1 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -2.15179543714015
p value: 4.86404982624336E-5
refers to: RP11-1002K11.1
refers to: 8145766
t statistic: -37.2374320523505

NMU DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.38417984267801
p value: 2.76203129327346E-4
refers to: NMU
refers to: 8100464
t statistic: -27.9002021755355

TM4SF18 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -3.00424700526719
p value: 5.66781785690311E-4
refers to: TM4SF18
refers to: 8091402
t statistic: -18.5073449001793

IFI44 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.02327140346927
p value: 0.00816810462128701
refers to: 7902553
refers to: IFI44
t statistic: -7.17146753243338

8155754
type: EFO_0005072
part of: A-AFFY-141

IFITM1 UP in 'SUZ12 overexpression' vs 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.49598592161911
p value: 0.00103906919279395
refers to: IFITM1
refers to: 7937335
t statistic: 15.6476967025093

FABP4 DOWN in 'SUZ12 overexpression' vs 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.27984603756097
p value: 1.65116465971107E-4
refers to: 8151532
refers to: FABP4
t statistic: -33.1251122415574

KCNK2 DOWN in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: DecreasedDifferentialExpressionRatio
fold change: -1.74183041521093
p value: 8.13052792696365E-4
refers to: 7909730
refers to: KCNK2
t statistic: -15.2519304219643

PRRX1
type: EnsemblDatabaseReference

FAM90A27P UP in 'JQ1 100 nanomolar' vs 'DMSO' in 'wild type'
type: IncreasedDifferentialExpressionRatio
fold change: 1.40437911885867
p value: 0.00652687335267558
refers to: FAM90A27P
refers to: 8030974
t statistic: 7.69446948125741

RP11-1002K11.1
type: EnsemblDatabaseReference

TNC
type: EnsemblDatabaseReference