Epas1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ceacam12 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ifi27l2a DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Nov DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ace DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Enpep UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fam57a UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ace2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
St8sia5 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Bcl2l15 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Analysis of 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Prss23 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
H2-T3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
H2-Ab1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cbr3 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gbp4 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ythdf1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Krtap13 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sp100 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Prap1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
2010106E10Rik UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Phlda1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ereg UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
St3gal1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slc25a45 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Abcg8 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Scd1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
S100a8 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Nlrc5 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Zfp385b DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gpr110 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Clec14a DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Areg UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cox18 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slc37a2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Xdh DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Hspa9 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ces2f DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
H2-Q6 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Oaz3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Prdm1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Nts UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
The development and severity of inflammatory bowel diseases (IBD) and other chronic inflammatory conditions can be influenced by host genetic and environmental factors, including signals derived from commensal bacteria. However, the mechanisms that integrate these diverse cues remain undefined. Here we demonstrate that intestinal epithelial cells (IECs) isolated from IBD patients exhibit decreased expression of the epigenome-modifying enzyme histone deacetylase 3 (HDAC3). Further, genome-wide analyses of murine IECs that lack HDAC3 (HDAC3ÃÂIEC) revealed that HDAC3 deficiency resulted in dysregulated gene expression coupled with alterations in histone acetylation. Critically, conventionally-housed HDAC3ÃÂIEC mice demonstrated loss of Paneth cells, impaired IEC function and alterations in the composition of intestinal commensal bacteria. In addition, HDAC3ÃÂIEC mice exhibited significantly increased susceptibility to intestinal damage and inflammation, indicating that epithelial expression of HDAC3 plays a central role in maintaining intestinal homeostasis. Strikingly, rederivation of HDAC3ÃÂIEC mice into germ-free conditions revealed that dysregulated IEC gene expression, Paneth cell homeostasis, and intestinal barrier function were largely restored in the absence of commensal bacteria. Collectively, these data indicate that the HDAC3 is a critical factor that integrates commensal bacteria-derived signals to calibrate epithelial cell responses required to establish normal host-commensal relationships and maintain intestinal homeostasis. In this study, we performed gene expression profiling to examine how the transcriptional profiles in primary live, EpCAM+ IECs from the large intestine differed between control HDAC3FF mice (3 biological replicates) and IEC-intrinsic knockout HDAC3ÃÂIEC mice (3 biological replicates).
Pbp2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Apoa1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cyp2d10 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ckb UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Iigp1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ciita DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Osmr DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Lrrc8b UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cd14 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Apoc2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sst UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Dio1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Trim30a DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Naaladl1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Creb3l3 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
H2-DMb2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Rgs2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Akr1c19 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ccdc58 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Il18bp DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Npc1l1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cst6 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Mucl1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Reg3a UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Smim5 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Mier3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Mttp UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Apobec2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Aadac DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fabp6 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Suox UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Tap1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cdc42ep2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Edn1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gsdmc4 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fam126a DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Il18 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
(Factor value) GENOTYPE/IEC-specific HDAC3 deletion
Lpcat4 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Tppp DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cyp2d26 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
H2-DMa DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cldn8 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Myof DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Wfdc17 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fgfr2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ces2g DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Abcc2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gsta3 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Asns UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Anpep UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Tat DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gm12250 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sult1a1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Thsd4 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gm10680 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gsta4 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
St3gal5 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ccl25 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slpi DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Bend7 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Insl5 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Derl1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gpt UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Lpo UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slfn2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gbp2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gjb5 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Apol10a DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Hdac3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
2310079G19Rik UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Clca2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sdc2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sh3d21 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gna14 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Clca1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cps1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gcg UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cldn4 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Tm4sf5 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ehhadh UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cdv3 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Qsox1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Oas2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slc13a2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Lama3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Pik3r3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sis UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Herc6 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gdf15 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Irgm2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Defb37 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
A330023F24Rik DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fam213b UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Pla2g16 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gbp7 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Pck1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slc4a4 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gm4951 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Samhd1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Myrfl UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slc51a UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Trpv3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cers4 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Mptx1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Apol7a DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
(Factor value) GENOTYPE/floxed HDAC3 (wild type)
Lrpprc UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cpq DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Apoa4 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Tnfsf10 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fabp1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slc7a9 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
(Sample) genotype/IEC-specific HDAC3 deletion
Gbp3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Zbp1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gstm3 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Steap4 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Igsf23 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gm8074 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Tnip3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Muc1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Rbp1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Tomm5 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Hmgcs2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gramd1b DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cfh DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gbp8 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Mrps18b UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cd177 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ifi47 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Eif5 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ada UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Vsig2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gclc UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Wfdc2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ttyh1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Depdc7 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sycn DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Abce1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Khdc1a UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cyp2d22 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Slc6a19 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ceacam10 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Mt1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Prss23os UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Mal DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Adm DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Vnn1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fbxo32 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Znhit3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
H2-Eb1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Pyy UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ano1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Naa60 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gpd1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ccl8 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Lrg1 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Cubn UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ppy UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Nos2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Lbp DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Fads1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
(Sample) cell type/intestinal epithelial cell
Me1 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Akt3 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Ces1g DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Scd2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
G530012D18Rik DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
(Sample) genotype/floxed HDAC3 (wild type)
Lgals2 UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
1700057G04Rik UP in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Gsdmc2 DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'
Sprr2h DOWN in 'IEC-specific HDAC3 deletion' vs 'floxed HDAC3 (wild type)'