Ldb3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Tnnc2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ppp2r3a DOWN in 'PolgD257A/D257A' vs 'wild type'
Nupr1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Crim1 UP in 'PolgD257A/D257A' vs 'wild type'
Mbp UP in 'PolgD257A/D257A' vs 'wild type'
Ddit4l DOWN in 'PolgD257A/D257A' vs 'wild type'
Dfna5 DOWN in 'PolgD257A/D257A' vs 'wild type'
Art1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Apobec2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cacna1s DOWN in 'PolgD257A/D257A' vs 'wild type'
Wfdc2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pigr DOWN in 'PolgD257A/D257A' vs 'wild type'
Clca2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Nbeal1 UP in 'PolgD257A/D257A' vs 'wild type'
H2-Aa DOWN in 'PolgD257A/D257A' vs 'wild type'
Krt6a DOWN in 'PolgD257A/D257A' vs 'wild type'
Ccl3 UP in 'PolgD257A/D257A' vs 'wild type'
Krt14 DOWN in 'PolgD257A/D257A' vs 'wild type'
Mylk4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Zbtb16 DOWN in 'PolgD257A/D257A' vs 'wild type'
Iqgap1 UP in 'PolgD257A/D257A' vs 'wild type'
Dnajb14 UP in 'PolgD257A/D257A' vs 'wild type'
Cdh7 DOWN in 'PolgD257A/D257A' vs 'wild type'
Sbsn DOWN in 'PolgD257A/D257A' vs 'wild type'
Mobp UP in 'PolgD257A/D257A' vs 'wild type'
Stmnd1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Gpm6a DOWN in 'PolgD257A/D257A' vs 'wild type'
Snx6 UP in 'PolgD257A/D257A' vs 'wild type'
Igkc DOWN in 'PolgD257A/D257A' vs 'wild type'
Nrep DOWN in 'PolgD257A/D257A' vs 'wild type'
Dmbt1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ttr UP in 'PolgD257A/D257A' vs 'wild type'
Myoz1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Rorb UP in 'PolgD257A/D257A' vs 'wild type'
Map1b UP in 'PolgD257A/D257A' vs 'wild type'
Fmo3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Gm10482 UP in 'PolgD257A/D257A' vs 'wild type'
Pycr1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ctsg UP in 'PolgD257A/D257A' vs 'wild type'
Irg1 UP in 'PolgD257A/D257A' vs 'wild type'
Tfap2c DOWN in 'PolgD257A/D257A' vs 'wild type'
Asb2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Hspb6 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ampd1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Sfpq UP in 'PolgD257A/D257A' vs 'wild type'
Car8 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ccdc153 DOWN in 'PolgD257A/D257A' vs 'wild type'
Diras2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cfd DOWN in 'PolgD257A/D257A' vs 'wild type'
Ankrd23 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lce1m DOWN in 'PolgD257A/D257A' vs 'wild type'
Ifitm6 UP in 'PolgD257A/D257A' vs 'wild type'
Pdlim3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Dsc3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Dhrs7c DOWN in 'PolgD257A/D257A' vs 'wild type'
Ttc29 DOWN in 'PolgD257A/D257A' vs 'wild type'
Gabra1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Paip1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Des DOWN in 'PolgD257A/D257A' vs 'wild type'
Eno3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Rsph4a DOWN in 'PolgD257A/D257A' vs 'wild type'
Cox6a2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Myl1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Neurod1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Malat1 UP in 'PolgD257A/D257A' vs 'wild type'
Ryr1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cnpy1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Myom1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ddit4 UP in 'PolgD257A/D257A' vs 'wild type'
Tpm1 DOWN in 'PolgD257A/D257A' vs 'wild type'
(Factor value) GENOTYPE/wild type genotype
Adrb3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ggnbp2 UP in 'PolgD257A/D257A' vs 'wild type'
Cbln4 UP in 'PolgD257A/D257A' vs 'wild type'
Col1a2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Trim34a DOWN in 'PolgD257A/D257A' vs 'wild type'
1700007K13Rik DOWN in 'PolgD257A/D257A' vs 'wild type'
Bicd2 UP in 'PolgD257A/D257A' vs 'wild type'
Trim62 DOWN in 'PolgD257A/D257A' vs 'wild type'
Hhip UP in 'PolgD257A/D257A' vs 'wild type'
Hfe2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lpgat1 UP in 'PolgD257A/D257A' vs 'wild type'
Col1a1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Abi3bp DOWN in 'PolgD257A/D257A' vs 'wild type'
Tcap DOWN in 'PolgD257A/D257A' vs 'wild type'
Ighm DOWN in 'PolgD257A/D257A' vs 'wild type'
Capsl DOWN in 'PolgD257A/D257A' vs 'wild type'
Enpp2 UP in 'PolgD257A/D257A' vs 'wild type'
Gng13 DOWN in 'PolgD257A/D257A' vs 'wild type'
Itgb1bp2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lhx1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Trim12a DOWN in 'PolgD257A/D257A' vs 'wild type'
Cbln3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Myh2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Adipoq DOWN in 'PolgD257A/D257A' vs 'wild type'
Adck3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Nfkbia UP in 'PolgD257A/D257A' vs 'wild type'
Fkrp UP in 'PolgD257A/D257A' vs 'wild type'
4933434E20Rik DOWN in 'PolgD257A/D257A' vs 'wild type'
Ppp1r17 DOWN in 'PolgD257A/D257A' vs 'wild type'
Tpm2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Car4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pdk4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cmya5 DOWN in 'PolgD257A/D257A' vs 'wild type'
Apol11b DOWN in 'PolgD257A/D257A' vs 'wild type'
Taok1 UP in 'PolgD257A/D257A' vs 'wild type'
Analysis of 'PolgD257A/D257A' vs 'wild type'
Obscn DOWN in 'PolgD257A/D257A' vs 'wild type'
Lmod3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lce1a2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Calm4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Dsp DOWN in 'PolgD257A/D257A' vs 'wild type'
Pon1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Thbs4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pcp2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pde7a DOWN in 'PolgD257A/D257A' vs 'wild type'
Tspan1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Oit1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Hist1h2ap UP in 'PolgD257A/D257A' vs 'wild type'
Tnnt3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cd36 DOWN in 'PolgD257A/D257A' vs 'wild type'
Dst DOWN in 'PolgD257A/D257A' vs 'wild type'
Ifi202b UP in 'PolgD257A/D257A' vs 'wild type'
Gria1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Hrc DOWN in 'PolgD257A/D257A' vs 'wild type'
Lmod2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cbr2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Klhl41 DOWN in 'PolgD257A/D257A' vs 'wild type'
Trdn DOWN in 'PolgD257A/D257A' vs 'wild type'
Dmpk DOWN in 'PolgD257A/D257A' vs 'wild type'
Ch25h UP in 'PolgD257A/D257A' vs 'wild type'
Aoc3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Synpo2l DOWN in 'PolgD257A/D257A' vs 'wild type'
Comp DOWN in 'PolgD257A/D257A' vs 'wild type'
Ermn UP in 'PolgD257A/D257A' vs 'wild type'
Calb1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Srl DOWN in 'PolgD257A/D257A' vs 'wild type'
Lyz2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Rgs5 UP in 'PolgD257A/D257A' vs 'wild type'
Rbm39 UP in 'PolgD257A/D257A' vs 'wild type'
Slc1a6 DOWN in 'PolgD257A/D257A' vs 'wild type'
Neb DOWN in 'PolgD257A/D257A' vs 'wild type'
Ttn DOWN in 'PolgD257A/D257A' vs 'wild type'
Kcnj10 UP in 'PolgD257A/D257A' vs 'wild type'
2310002L09Rik DOWN in 'PolgD257A/D257A' vs 'wild type'
Mypn DOWN in 'PolgD257A/D257A' vs 'wild type'
Krt5 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cyp2f2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Aldh3a1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Sfrp2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Aplnr DOWN in 'PolgD257A/D257A' vs 'wild type'
Muc16 DOWN in 'PolgD257A/D257A' vs 'wild type'
Hspb7 DOWN in 'PolgD257A/D257A' vs 'wild type'
Agr2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Chn2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Synpo2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Vgll2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Anxa8 DOWN in 'PolgD257A/D257A' vs 'wild type'
Fam81a UP in 'PolgD257A/D257A' vs 'wild type'
Gm94 DOWN in 'PolgD257A/D257A' vs 'wild type'
S100a8 UP in 'PolgD257A/D257A' vs 'wild type'
Actc1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Postn DOWN in 'PolgD257A/D257A' vs 'wild type'
Crct1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Smtnl1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Mfsd4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Atp2a1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Asb5 DOWN in 'PolgD257A/D257A' vs 'wild type'
Tnni2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Casq1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Foxa1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ankrd33b UP in 'PolgD257A/D257A' vs 'wild type'
Trpm1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pgam2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cidea DOWN in 'PolgD257A/D257A' vs 'wild type'
Gdf10 DOWN in 'PolgD257A/D257A' vs 'wild type'
Chic1 UP in 'PolgD257A/D257A' vs 'wild type'
Krt1 DOWN in 'PolgD257A/D257A' vs 'wild type'
RP24-439I22.1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cytl1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Rpl3l DOWN in 'PolgD257A/D257A' vs 'wild type'
Fam57b UP in 'PolgD257A/D257A' vs 'wild type'
Slfn4 UP in 'PolgD257A/D257A' vs 'wild type'
Wnt5a UP in 'PolgD257A/D257A' vs 'wild type'
Igj DOWN in 'PolgD257A/D257A' vs 'wild type'
Lor DOWN in 'PolgD257A/D257A' vs 'wild type'
Gfap UP in 'PolgD257A/D257A' vs 'wild type'
Nmrk2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Med1 UP in 'PolgD257A/D257A' vs 'wild type'
Dmkn DOWN in 'PolgD257A/D257A' vs 'wild type'
Tff2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Txlnb DOWN in 'PolgD257A/D257A' vs 'wild type'
Nrap DOWN in 'PolgD257A/D257A' vs 'wild type'
Jph1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Igha DOWN in 'PolgD257A/D257A' vs 'wild type'
Mylpf DOWN in 'PolgD257A/D257A' vs 'wild type'
Cp UP in 'PolgD257A/D257A' vs 'wild type'
Itpr1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Rnf112 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lce1f DOWN in 'PolgD257A/D257A' vs 'wild type'
Mapre2 UP in 'PolgD257A/D257A' vs 'wild type'
Sgcg DOWN in 'PolgD257A/D257A' vs 'wild type'
Scd1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lce1c DOWN in 'PolgD257A/D257A' vs 'wild type'
Prrc2c UP in 'PolgD257A/D257A' vs 'wild type'
Ckmt2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Bpifb1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Aqp6 DOWN in 'PolgD257A/D257A' vs 'wild type'
Mybpc1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Luc7l2 UP in 'PolgD257A/D257A' vs 'wild type'
Slc15a2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lipf DOWN in 'PolgD257A/D257A' vs 'wild type'
Lamp5 UP in 'PolgD257A/D257A' vs 'wild type'
Dnaic2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Sec14l3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Hapln2 UP in 'PolgD257A/D257A' vs 'wild type'
1700026D08Rik DOWN in 'PolgD257A/D257A' vs 'wild type'
Trim63 DOWN in 'PolgD257A/D257A' vs 'wild type'
Chil3 UP in 'PolgD257A/D257A' vs 'wild type'
Gas2l3 UP in 'PolgD257A/D257A' vs 'wild type'
Krt10 DOWN in 'PolgD257A/D257A' vs 'wild type'
H19 DOWN in 'PolgD257A/D257A' vs 'wild type'
Psg28 UP in 'PolgD257A/D257A' vs 'wild type'
2310057J18Rik DOWN in 'PolgD257A/D257A' vs 'wild type'
Myl2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Flg DOWN in 'PolgD257A/D257A' vs 'wild type'
Mipol1 UP in 'PolgD257A/D257A' vs 'wild type'
Gsta3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Ngp UP in 'PolgD257A/D257A' vs 'wild type'
Serpinb11 DOWN in 'PolgD257A/D257A' vs 'wild type'
Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related disorders. Previously, we created mice expressing a proofreading-deficient version of the mtDNA polymerase gamma (Polg) which accumulate age-related mtDNA mutations and display premature aging. Here we performed microarray gene expression profiling to identify mtDNA mutation-responsive genes in the cochlea of aged mitochondrial mutator mice. Age-related accumulation of mtDNA mutations was associated with transcriptional alternations consistent with reduced inner ear function, mitochondrial dysfunction, neurodegeneration, and reduced cell structural modulation. Hearing assessment and histopathological results confirmed that aged PolgD257A/D257A (D257A) mice exhibited moderate hearing loss and severe cochlear degenerations. Age-related accumulation of mtDNA mutations also resulted in alternations in gene expression consistent with induction of apoptosis, proteolysis, stress response, and reduced DNA repair. TUNEL (Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling) assay confirmed that the cochleae from aged D257A mice showed significantly more TUNEL positive cells compared to wild-type (WT) mice. The levels of cleaved caspase-3 were also found to increase in the cochleae of aged D257A mice. These observations provide evidence that age-related accumulation of mtDNA mutations is associated with apoptotic cell death in aged cochlea. Our results provide the first global view of molecular events associated with mtDNA mutations in postmitotic tissue, and suggest that apoptosis is the major mechanism of mtDNA mediated cell death in the development of age-related hearing disorder. Experiment Overall Design: To determine the effects of age-related accumulation of mtDNA mutations, each WT sample (n = 5) was compared to each D257A sample (n = 5), generating a total of twenty-five pairwise comparisons. Genes with significantly altered expression levels were sorted into gene ontology biological process categories. Experiment Overall Design: Gene expression change was called statistically significant when at least one gene was called present in a group, the P value was < 0.0500, FC was > 1.1, and FDR was > 30.00 for identification of mtDNA mutations-induced genes. Experiment Overall Design: Affymetrix standard spike controls were used in all experiments (eukaryotic hybridization control kit). Quality control measures were not used. No replicates were done. Dye swap was not used.
Klhl30 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cyp2e1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Muc5b DOWN in 'PolgD257A/D257A' vs 'wild type'
Tmem38a DOWN in 'PolgD257A/D257A' vs 'wild type'
Dpt DOWN in 'PolgD257A/D257A' vs 'wild type'
Myom2 DOWN in 'PolgD257A/D257A' vs 'wild type'
1110002E22Rik DOWN in 'PolgD257A/D257A' vs 'wild type'
Acta1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Krtdap DOWN in 'PolgD257A/D257A' vs 'wild type'
Shisa6 DOWN in 'PolgD257A/D257A' vs 'wild type'
Tmem45b DOWN in 'PolgD257A/D257A' vs 'wild type'
S100a9 UP in 'PolgD257A/D257A' vs 'wild type'
Actn2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pdlim5 DOWN in 'PolgD257A/D257A' vs 'wild type'
Gp2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Krt17 DOWN in 'PolgD257A/D257A' vs 'wild type'
Dynlrb2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Bbip1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lgals7 DOWN in 'PolgD257A/D257A' vs 'wild type'
Tagln DOWN in 'PolgD257A/D257A' vs 'wild type'
Scn2a1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Slc39a12 UP in 'PolgD257A/D257A' vs 'wild type'
Cilp DOWN in 'PolgD257A/D257A' vs 'wild type'
Zfp871 UP in 'PolgD257A/D257A' vs 'wild type'
Ranbp3l UP in 'PolgD257A/D257A' vs 'wild type'
Rgs8 DOWN in 'PolgD257A/D257A' vs 'wild type'
Myoz2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pclo DOWN in 'PolgD257A/D257A' vs 'wild type'
Msi2 UP in 'PolgD257A/D257A' vs 'wild type'
Them5 DOWN in 'PolgD257A/D257A' vs 'wild type'
BC005624 DOWN in 'PolgD257A/D257A' vs 'wild type'
Fam154b DOWN in 'PolgD257A/D257A' vs 'wild type'
Fzd4 UP in 'PolgD257A/D257A' vs 'wild type'
Ces1d DOWN in 'PolgD257A/D257A' vs 'wild type'
Lce1b DOWN in 'PolgD257A/D257A' vs 'wild type'
Csrp3 DOWN in 'PolgD257A/D257A' vs 'wild type'
Tmem182 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cxcl2 UP in 'PolgD257A/D257A' vs 'wild type'
Asb15 DOWN in 'PolgD257A/D257A' vs 'wild type'
Sh3bgr DOWN in 'PolgD257A/D257A' vs 'wild type'
Aspn DOWN in 'PolgD257A/D257A' vs 'wild type'
Camk4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Dnali1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Rbfox2 UP in 'PolgD257A/D257A' vs 'wild type'
Upk1b DOWN in 'PolgD257A/D257A' vs 'wild type'
Smyd1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Col17a1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Lce1a1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Mss51 DOWN in 'PolgD257A/D257A' vs 'wild type'
Wdr96 DOWN in 'PolgD257A/D257A' vs 'wild type'
Impad1 UP in 'PolgD257A/D257A' vs 'wild type'
Mb DOWN in 'PolgD257A/D257A' vs 'wild type'
Tmod4 DOWN in 'PolgD257A/D257A' vs 'wild type'
Frrs1l DOWN in 'PolgD257A/D257A' vs 'wild type'
Mn1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Perm1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Cadps2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Fpr2 UP in 'PolgD257A/D257A' vs 'wild type'
Scn2b DOWN in 'PolgD257A/D257A' vs 'wild type'
Ehf DOWN in 'PolgD257A/D257A' vs 'wild type'
Smoc2 DOWN in 'PolgD257A/D257A' vs 'wild type'
Pnkp UP in 'PolgD257A/D257A' vs 'wild type'
Cd244 UP in 'PolgD257A/D257A' vs 'wild type'
Fam25c DOWN in 'PolgD257A/D257A' vs 'wild type'
Krt77 DOWN in 'PolgD257A/D257A' vs 'wild type'
Odam DOWN in 'PolgD257A/D257A' vs 'wild type'
Wfdc18 DOWN in 'PolgD257A/D257A' vs 'wild type'
Chad DOWN in 'PolgD257A/D257A' vs 'wild type'
Aqp5 DOWN in 'PolgD257A/D257A' vs 'wild type'
Etv5 DOWN in 'PolgD257A/D257A' vs 'wild type'
Mlf1 DOWN in 'PolgD257A/D257A' vs 'wild type'
Gabra6 DOWN in 'PolgD257A/D257A' vs 'wild type'
Myot DOWN in 'PolgD257A/D257A' vs 'wild type'
Ltf DOWN in 'PolgD257A/D257A' vs 'wild type'
Krt15 DOWN in 'PolgD257A/D257A' vs 'wild type'
Myh1 DOWN in 'PolgD257A/D257A' vs 'wild type'