Decr1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
(Assay) Rat_Ventricle_Diabetic_28days_rep3
Slc2a1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Control_42days_rep4
Pfkp UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Higd1a DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Control_28days_rep3
Acot2 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
(Assay) Rat_Ventricle_Control_28days_rep2
Hadha UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Control_03days_rep1
Igfbp3 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Ech1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Decr1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Col1a1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Hk2 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Cd74 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Cyp2e1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Cd36 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Gstm1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Ucp3 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Myh7 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
(Assay) Rat_Ventricle_Diabetic_42days_rep1
RT1-Da DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Diabetic_42days_rep2
(Assay) Rat_Ventricle_Diabetic_42days_rep3
Hmgcs2 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Lum DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Sult1a1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
Ckb DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
Pla2g2a UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Alox15 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Ckb DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Tgm1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Nppa UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Tfrc DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
Pdk4 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Hadha UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
(Assay) Rat_Ventricle_Control_03days_rep3
Slc41a3 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Diabetic_03days_rep3
Decr1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
LOC688090 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Aqp1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Hmgcs2 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
Dbp DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Myh7 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Eno3 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Analysis of 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
(Sample) disease/streptozotocin induced diabetes mellitus
streptozotocin induced diabetes mellitus
Cpt1a UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
LOC100912469 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Nr4a1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Bdh1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Insig1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Hmgcs2 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Control_03days_rep2
Cardiomyopathy in type 1 diabetic patients is characterized by early onset diastolic and late onset systolic dysfunction. The mechanism underlying development of diastolic and systolic dysfunction in diabetes remains unknown. We used microarrays to detail the ventricle gene expression changes that underly development of diabetic cardiomyopathy. We identified distinct classes of up-regulated genes during this process. Experiment Overall Design: 150g male Wistar rats (Harlan) we injected with 65 mg/kg streptozotocin to induce Type 1 diabetes. Four replicates of Control and Diabetic rat ventricles were removed and frozen at Three time points for total RNA isolation and hybridization on the Affymetrix RG-U34A microarray. The 3 day samples show a baseline for initial diabetic changes in the ventricle. The 28 day samples show changes associated with diastolic dysfunction in diabetes. The 42 day samples show changes associated with both diastolic and systolic dysfunction in type 1 diabetic rat ventricles.
Ngfrap1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Col3a1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Sample) clinical information/streptozotocin induced systolic and diastolic dysfunction
streptozotocin induced systolic and diastolic dysfunction
(Assay) Rat_Ventricle_Diabetic_28days_rep2
Vamp5 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Hsph1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Ckb DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Acot2 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
G0s2 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Pdk4 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
Myh7 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
Slc2a4 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Control_03days_rep4
Txnip UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Penk UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
(Assay) Rat_Ventricle_Diabetic_03days_rep4
LOC100909441 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Analysis of 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Analysis of 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Pxmp2 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Control_28days_rep1
Kdr UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Sparc DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Diabetic_03days_rep2
Sult1a1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Hspa1a DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Acot1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Diabetic_28days_rep1
(Sample) clinical information/streptozotocin induced diastolic dysfunction
streptozotocin induced diastolic dysfunction
Cd36 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Pdk4 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
(Assay) Rat_Ventricle_Diabetic_42days_rep4
(Assay) Rat_Ventricle_Control_28days_rep4
(Assay) Rat_Ventricle_Control_42days_rep1
(Assay) Rat_Ventricle_Diabetic_03days_rep1
Maoa DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
(Assay) Rat_Ventricle_Control_42days_rep2
Dnaja1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Dusp1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Dnajb1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Acot1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '3 days'
(Factor value) COMPOUND/streptozotocin 65
Nr4a3 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Hk2 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
(Assay) Rat_Ventricle_Diabetic_28days_rep4
Aqp7 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
(Assay) Rat_Ventricle_Control_42days_rep3
Impa2 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Txnip UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Acot1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Penk UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Bdh1 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Penk UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Bcat2 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Col1a2 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Slc2a4 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '28 days'
Acsl6 DOWN in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'
Mgst1 UP in 'streptozotocin 65 milligram per kilogram' vs 'none' at '48 days'