Sdpr UP in '22 to 23 month' vs '2 to 3 month'
Igj DOWN in '22 to 23 month' vs '2 to 3 month'
Ndnf DOWN in '22 to 23 month' vs '2 to 3 month'
Fam46a DOWN in '22 to 23 month' vs '2 to 3 month'
Sdc1 DOWN in '22 to 23 month' vs '2 to 3 month'
Slc16a12 UP in '22 to 23 month' vs '2 to 3 month'
Selp UP in '22 to 23 month' vs '2 to 3 month'
Tnfaip2 UP in '22 to 23 month' vs '2 to 3 month'
Mmp2 DOWN in '22 to 23 month' vs '2 to 3 month'
Zg16 UP in '22 to 23 month' vs '2 to 3 month'
Analysis of '22 to 23 month' vs '2 to 3 month'
Lsp1 DOWN in '22 to 23 month' vs '2 to 3 month'
Sox4 DOWN in '22 to 23 month' vs '2 to 3 month'
Itgb5 DOWN in '22 to 23 month' vs '2 to 3 month'
Ms4a4b DOWN in '22 to 23 month' vs '2 to 3 month'
Igf1 DOWN in '22 to 23 month' vs '2 to 3 month'
Hist1h1c UP in '22 to 23 month' vs '2 to 3 month'
Mn1 DOWN in '22 to 23 month' vs '2 to 3 month'
Rassf10 UP in '22 to 23 month' vs '2 to 3 month'
Ctss DOWN in '22 to 23 month' vs '2 to 3 month'
S100a8 DOWN in '22 to 23 month' vs '2 to 3 month'
Klhl4 UP in '22 to 23 month' vs '2 to 3 month'
Cenpa DOWN in '22 to 23 month' vs '2 to 3 month'
Tc2n UP in '22 to 23 month' vs '2 to 3 month'
Tmem158 UP in '22 to 23 month' vs '2 to 3 month'
Wwtr1 UP in '22 to 23 month' vs '2 to 3 month'
Ap2a2 DOWN in '22 to 23 month' vs '2 to 3 month'
Gas2l3 UP in '22 to 23 month' vs '2 to 3 month'
4930426D05Rik DOWN in '22 to 23 month' vs '2 to 3 month'
Car1 DOWN in '22 to 23 month' vs '2 to 3 month'
Tnfrsf13c DOWN in '22 to 23 month' vs '2 to 3 month'
9030619P08Rik DOWN in '22 to 23 month' vs '2 to 3 month'
Timp3 UP in '22 to 23 month' vs '2 to 3 month'
Nav1 UP in '22 to 23 month' vs '2 to 3 month'
Igf2bp2 DOWN in '22 to 23 month' vs '2 to 3 month'
Jam2 UP in '22 to 23 month' vs '2 to 3 month'
Synm UP in '22 to 23 month' vs '2 to 3 month'
Fermt2 UP in '22 to 23 month' vs '2 to 3 month'
Rnase6 DOWN in '22 to 23 month' vs '2 to 3 month'
Camk1d DOWN in '22 to 23 month' vs '2 to 3 month'
Bank1 DOWN in '22 to 23 month' vs '2 to 3 month'
Ahnak2 UP in '22 to 23 month' vs '2 to 3 month'
Ndrg1 UP in '22 to 23 month' vs '2 to 3 month'
Mpo DOWN in '22 to 23 month' vs '2 to 3 month'
Ablim1 DOWN in '22 to 23 month' vs '2 to 3 month'
Sbspon UP in '22 to 23 month' vs '2 to 3 month'
Trpc1 UP in '22 to 23 month' vs '2 to 3 month'
Ngp DOWN in '22 to 23 month' vs '2 to 3 month'
Trim2 UP in '22 to 23 month' vs '2 to 3 month'
Rnf128 UP in '22 to 23 month' vs '2 to 3 month'
Pbx3 UP in '22 to 23 month' vs '2 to 3 month'
Hspa1b UP in '22 to 23 month' vs '2 to 3 month'
Fhl1 UP in '22 to 23 month' vs '2 to 3 month'
Alcam UP in '22 to 23 month' vs '2 to 3 month'
Vldlr UP in '22 to 23 month' vs '2 to 3 month'
Abcb1a UP in '22 to 23 month' vs '2 to 3 month'
Efemp1 UP in '22 to 23 month' vs '2 to 3 month'
Marveld1 UP in '22 to 23 month' vs '2 to 3 month'
Ms4a6b DOWN in '22 to 23 month' vs '2 to 3 month'
Gimap7 DOWN in '22 to 23 month' vs '2 to 3 month'
Cebpd UP in '22 to 23 month' vs '2 to 3 month'
Serpinb9 DOWN in '22 to 23 month' vs '2 to 3 month'
Gpr183 UP in '22 to 23 month' vs '2 to 3 month'
Klrb1c UP in '22 to 23 month' vs '2 to 3 month'
Ncf4 DOWN in '22 to 23 month' vs '2 to 3 month'
(Sample) cell type/long-term hematopoietic stem cell
Itgb3 UP in '22 to 23 month' vs '2 to 3 month'
Nptn UP in '22 to 23 month' vs '2 to 3 month'
Clec1a UP in '22 to 23 month' vs '2 to 3 month'
RP23-362B7.1 DOWN in '22 to 23 month' vs '2 to 3 month'
Dusp22 DOWN in '22 to 23 month' vs '2 to 3 month'
Cldn5 UP in '22 to 23 month' vs '2 to 3 month'
Spon1 UP in '22 to 23 month' vs '2 to 3 month'
Prkcb DOWN in '22 to 23 month' vs '2 to 3 month'
Iigp1 DOWN in '22 to 23 month' vs '2 to 3 month'
Dnajc3 UP in '22 to 23 month' vs '2 to 3 month'
Limch1 UP in '22 to 23 month' vs '2 to 3 month'
Tsc22d3 UP in '22 to 23 month' vs '2 to 3 month'
Sema4f UP in '22 to 23 month' vs '2 to 3 month'
Dntt DOWN in '22 to 23 month' vs '2 to 3 month'
Slco4a1 UP in '22 to 23 month' vs '2 to 3 month'
Gclm UP in '22 to 23 month' vs '2 to 3 month'
P2ry14 DOWN in '22 to 23 month' vs '2 to 3 month'
Ntf3 UP in '22 to 23 month' vs '2 to 3 month'
Runx1t1 UP in '22 to 23 month' vs '2 to 3 month'
Arhgap4 DOWN in '22 to 23 month' vs '2 to 3 month'
Antxr2 DOWN in '22 to 23 month' vs '2 to 3 month'
Flt3 DOWN in '22 to 23 month' vs '2 to 3 month'
Abhd17b UP in '22 to 23 month' vs '2 to 3 month'
Dyrk3 UP in '22 to 23 month' vs '2 to 3 month'
Plagl1 DOWN in '22 to 23 month' vs '2 to 3 month'
Ebi3 DOWN in '22 to 23 month' vs '2 to 3 month'
Rab40b UP in '22 to 23 month' vs '2 to 3 month'
Chil3 DOWN in '22 to 23 month' vs '2 to 3 month'
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties of highly purified long-term hematopoietic stem cells (LT-HSCs) from young and old mice. We found that LT-HSC aging was accompanied by cell autonomous changes, including increased stem cell self-renewal, differential capacity to generate committed myeloid and lymphoid progenitors, and diminished lymphoid potential. Expression profiling revealed that LT-HSC aging was accompanied by the systemic down-regulation of genes mediating lymphoid specification and function and up-regulation of genes involved in specifying myeloid fate and function. Moreover, LT-HSCs from old mice expressed elevated levels of many genes involved in leukemic transformation. These data support a model in which age-dependent alterations in gene expression at the stem cell level presage downstream developmental potential and thereby contribute to age-dependent immune decline, and perhaps also to the increased incidence of leukemia in the elderly. 3 old mice and 5 young mice were assayed
Tyrobp DOWN in '22 to 23 month' vs '2 to 3 month'
Evl DOWN in '22 to 23 month' vs '2 to 3 month'
Bcl11b DOWN in '22 to 23 month' vs '2 to 3 month'