MARCH8 UP in '10 micromolar doxorubicin' vs 'vehicle'
TNFRSF10C UP in '10 micromolar doxorubicin' vs 'vehicle'
GABBR2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
RAB27B DOWN in '10 micromolar doxorubicin' vs 'vehicle'
HSD17B11 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SLC7A5 UP in '10 micromolar doxorubicin' vs 'vehicle'
More than two thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen for growth and survival. Therapies targeting ER function including aromatase inhibitors that block the production of estrogens and ER antagonists that alter ER transcriptional activity play a central role in the treatment of ER+ breast cancers of all stages. In contrast to ER- breast cancers, which frequently harbor mutations in the p53 tumor suppressor, ER+ breast cancers are predominantly wild type for p53. Despite harboring wild type p53, ER+ breast cancer cells are resistant to chemotherapy-induced apoptosis in the presence of estrogen. Using genome-wide approaches we have addressed the mechanism by which ER antagonizes the pro-apoptotic function of p53. Interestingly both ER agonists such as estradiol and selective ER modulators (SERM) such as tamoxifen promote p53 antagonism. In contrast the full ER antagonist fulvestrant blocks the ability of ER to inhibit p53-mediated cell death. This suggests an improved strategy for the treatment of ER+ breast cancer utilizing antagonists that completely block ER action together with drugs that activate p53-mediated cell death. MCF7 cells were hormone-depleted for 3 days and then treated with 10 uM doxorubicin for 12 hours
SAT1 UP in '10 micromolar doxorubicin' vs 'vehicle'
GDF15 UP in '10 micromolar doxorubicin' vs 'vehicle'
FSCN1 UP in '10 micromolar doxorubicin' vs 'vehicle'
TIPIN DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CDC20 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CCNG1 UP in '10 micromolar doxorubicin' vs 'vehicle'
H2AFX DOWN in '10 micromolar doxorubicin' vs 'vehicle'
E2F8 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CDKN1A UP in '10 micromolar doxorubicin' vs 'vehicle'
PBK DOWN in '10 micromolar doxorubicin' vs 'vehicle'
HOXC6 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
PLK1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
TLR5 UP in '10 micromolar doxorubicin' vs 'vehicle'
NCAPG DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SESN1 UP in '10 micromolar doxorubicin' vs 'vehicle'
ASPM DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SLC19A1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
ATF3 UP in '10 micromolar doxorubicin' vs 'vehicle'
TTK DOWN in '10 micromolar doxorubicin' vs 'vehicle'
KCNJ8 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
PLCB1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SRSF3 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CCNA2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
BTG2 UP in '10 micromolar doxorubicin' vs 'vehicle'
TP53I3 UP in '10 micromolar doxorubicin' vs 'vehicle'
MDM2 UP in '10 micromolar doxorubicin' vs 'vehicle'
BORA DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CXCL12 UP in '10 micromolar doxorubicin' vs 'vehicle'
LHX2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
KIF14 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CYFIP2 UP in '10 micromolar doxorubicin' vs 'vehicle'
RPS27L UP in '10 micromolar doxorubicin' vs 'vehicle'
MAFB UP in '10 micromolar doxorubicin' vs 'vehicle'
MCM10 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
IER5 UP in '10 micromolar doxorubicin' vs 'vehicle'
FAS UP in '10 micromolar doxorubicin' vs 'vehicle'
AKR1C3 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
WISP2 UP in '10 micromolar doxorubicin' vs 'vehicle'
DPYSL4 UP in '10 micromolar doxorubicin' vs 'vehicle'
TNFRSF10B UP in '10 micromolar doxorubicin' vs 'vehicle'
F8 UP in '10 micromolar doxorubicin' vs 'vehicle'
PMAIP1 UP in '10 micromolar doxorubicin' vs 'vehicle'
HNRNPD DOWN in '10 micromolar doxorubicin' vs 'vehicle'
C2CD2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
WSB1 UP in '10 micromolar doxorubicin' vs 'vehicle'
GPR87 UP in '10 micromolar doxorubicin' vs 'vehicle'
HSPA4L UP in '10 micromolar doxorubicin' vs 'vehicle'
PTP4A1 UP in '10 micromolar doxorubicin' vs 'vehicle'
MICB UP in '10 micromolar doxorubicin' vs 'vehicle'
MORC4 UP in '10 micromolar doxorubicin' vs 'vehicle'
PATZ1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SPC25 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
EI24 UP in '10 micromolar doxorubicin' vs 'vehicle'
GEMIN2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SLC6A8 UP in '10 micromolar doxorubicin' vs 'vehicle'
GPR37 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CENPA DOWN in '10 micromolar doxorubicin' vs 'vehicle'
GLS2 UP in '10 micromolar doxorubicin' vs 'vehicle'
HNRNPDL DOWN in '10 micromolar doxorubicin' vs 'vehicle'
BUB1B DOWN in '10 micromolar doxorubicin' vs 'vehicle'
PHYH UP in '10 micromolar doxorubicin' vs 'vehicle'
CENPE DOWN in '10 micromolar doxorubicin' vs 'vehicle'
FGF13 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
ZMAT3 UP in '10 micromolar doxorubicin' vs 'vehicle'
CASD1 UP in '10 micromolar doxorubicin' vs 'vehicle'
PRC1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
ACTA2 UP in '10 micromolar doxorubicin' vs 'vehicle'
FOS UP in '10 micromolar doxorubicin' vs 'vehicle'
NDC80 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
PGF UP in '10 micromolar doxorubicin' vs 'vehicle'
LMNB1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CENPI DOWN in '10 micromolar doxorubicin' vs 'vehicle'
LYN DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CTNND2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
DDB2 UP in '10 micromolar doxorubicin' vs 'vehicle'
KIF23 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
XPC UP in '10 micromolar doxorubicin' vs 'vehicle'
ZMYND8 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
FZD2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
GREB1 UP in '10 micromolar doxorubicin' vs 'vehicle'
LIMK2 UP in '10 micromolar doxorubicin' vs 'vehicle'
BAX UP in '10 micromolar doxorubicin' vs 'vehicle'
MECOM DOWN in '10 micromolar doxorubicin' vs 'vehicle'
IL1R1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
FDXR UP in '10 micromolar doxorubicin' vs 'vehicle'
LXN DOWN in '10 micromolar doxorubicin' vs 'vehicle'
THBD UP in '10 micromolar doxorubicin' vs 'vehicle'
MCM6 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SOCS2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
ANP32E DOWN in '10 micromolar doxorubicin' vs 'vehicle'
TAP1 UP in '10 micromolar doxorubicin' vs 'vehicle'
SLC7A11 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
DNAJC22 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CENPF DOWN in '10 micromolar doxorubicin' vs 'vehicle'
STOM UP in '10 micromolar doxorubicin' vs 'vehicle'
SFN UP in '10 micromolar doxorubicin' vs 'vehicle'
DEPDC1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
AMIGO2 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
GLS UP in '10 micromolar doxorubicin' vs 'vehicle'
SRSF10 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
BUB1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
GADD45A UP in '10 micromolar doxorubicin' vs 'vehicle'
RNF43 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
C12orf5 UP in '10 micromolar doxorubicin' vs 'vehicle'
GPER1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
AHNAK2 UP in '10 micromolar doxorubicin' vs 'vehicle'
KIF20A DOWN in '10 micromolar doxorubicin' vs 'vehicle'
INPP1 UP in '10 micromolar doxorubicin' vs 'vehicle'
EPHA2 UP in '10 micromolar doxorubicin' vs 'vehicle'
ANKRA2 UP in '10 micromolar doxorubicin' vs 'vehicle'
PFKFB3 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SRSF1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
NPY1R UP in '10 micromolar doxorubicin' vs 'vehicle'
PPP1R3C DOWN in '10 micromolar doxorubicin' vs 'vehicle'
ZNF165 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
SPTBN1 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
MSMB UP in '10 micromolar doxorubicin' vs 'vehicle'
KLF10 UP in '10 micromolar doxorubicin' vs 'vehicle'
DLGAP5 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
CUTC DOWN in '10 micromolar doxorubicin' vs 'vehicle'
GRIN2C UP in '10 micromolar doxorubicin' vs 'vehicle'
ISCU UP in '10 micromolar doxorubicin' vs 'vehicle'
DBF4 DOWN in '10 micromolar doxorubicin' vs 'vehicle'
Analysis of '10 micromolar doxorubicin' vs 'vehicle'