Adam8 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Plod2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mthfd2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tmem178a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Pdk4 DOWN in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Slamf9 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tyrobp UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Bub1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Gja1 DOWN in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mboat1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Arhgap22 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Spp1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Timp1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Asns UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mki67 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tes UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Asf1b UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Aspm UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mustn1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cst7 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
LOC100909901 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccdc93 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cdk1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Adamts4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Shcbp1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Vcan UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Uhrf1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mybpc2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fkbp11 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cdca3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Sdc1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ncf4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fam167a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Inhbb UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Btk UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Dusp2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fcnb UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Kdm1a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Lgals3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Nuf2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Aurkb UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
(Factor value) GENOTYPE/Constitutively active MKK3bE and wild-type p38?
Constitutively active MKK3bE and wild-type p38?
Hmox1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Prc1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Sele UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fam64a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Kcnn4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Htatip2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tgm1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fam46a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cenpf UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Spc25 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
RT1-CE5 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Plscr1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fcgr2b UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cbln2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Aldh1a2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tnfrsf12a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Coro1a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Myc UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fam111a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tmem97 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tgfb2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Aurka UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
LOC100362620 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Plk4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Serpine1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
LOC100359539 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mllt11 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
LOC100911267 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Rnd1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Rab32 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccl27 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cd33 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tubb3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ckap2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tgif1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fcrl2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fosl1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ifitm1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Myl1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Glipr1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Idi1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Apobec1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccdc109b UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ripk3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Srrt UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Il33 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
PVR UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Plk2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Gng2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by using local adenovirus-mediated gene transfer of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38ÃÂÃÂ± in rats. DNA microarray analysis of animals with cardiac-specific overexpression of p38 MAPK revealed that 264 genes were upregulated more than 2-fold including multiple genes controlling cell division, cell signaling, inflammation, adhesion and transcription. Several previously unknown p38 target genes were found. Using gel mobility shift assays we identified several cardiac transcription factors that were directly activated by p38 MAPK. Finally, we determined the functional significance of the altered cardiac gene expression profile by histological analysis and echocardiographic measurements, which indicated that p38 MAPK overexpression induced gene expression results in cell proliferation, myocardial inflammation and fibrosis. In conclusion, we defined the novel target genes and transcription factors as well as the functional effects of p38 MAPK in the heart. Expression profiling of p38 MAPK overexpression identified cell cycle regulatory and inflammatory genes critical for pathological processes in the adult heart. Experiment Overall Design: Left ventricular gene expression profiles three days after MKK3bE + WT p38ÃÂÃÂ± gene transfer were compared with those of Lac Z ÃÂ¢ÃÂÃÂtreated animals by screening Affymetrix Rat Expression Set 230_2.0 Arrays (there are 5 samples in both group).
Gprc5a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Smc2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Areg UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
S100a4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Reg3g UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Il6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Serpinb1a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccna2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Evi2a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
S100a6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Hist1h2ail1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Slc1a3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Col12a1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Dok2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Pak1ip1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cd14 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fxyd5 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mmp12 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Kif11 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tnfaip6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Thy1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
(Sample) genotype/Constitutively active MKK3bE and wild-type p38?
Angptl4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mmp10 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Eif1a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tnc UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Kif23 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Slc41a2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ctsz UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ube2c UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Analysis of 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Gch1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ptgs2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tmem106a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccnb2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Knstrn UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Slc39a6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
AABR06014093.1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tacc3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Lilrb4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Atf3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Exo5 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
AABR06033633.1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Dscc1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Igsf6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ly86 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tnfrsf11b UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fn1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cnn1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Egr1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Clec7a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Edem1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Arg1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Gpnmb UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Glipr2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Melk UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ttk UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Nppa UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Rasd1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccnb1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Plaur UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Slc37a2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ctgf UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Clec4a3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccl7 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Orc6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Akr1b8 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Srpx2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Hbegf UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Lpxn UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Il18 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Neurl3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Prnd UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fcgr1a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fcgr3a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Depdc7 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Runx1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Lmcd1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mx1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Trim59 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Actn1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Olr1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Bcat1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Slc30a7 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Nipsnap3b UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ankrd23 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cd44 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Hamp UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mad2l1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Enpp1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Nptx2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ska1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Bcl2a1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cdkn3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Nfkbiz UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cdkn1a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Nabp1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Klhl41 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Rai14 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ms4a6a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Kif22 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mcm6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Reg3b UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Pqlc3 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Top2a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ns5atp9 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Cenpw UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ass1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ch25h UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Abhd2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Enah UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Egr2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Kif20a UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Sowahc UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tubb6 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Zfp367 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Aif1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Arl11 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Rad18 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Pttg1 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Plau UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ect2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Emb UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Mir221 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Ccl2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Tlr2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Lcn2 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Irf7 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Fst UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'
Acsl4 UP in 'constitutively active MKK3bE and wild-type p38-alpha' vs 'control'