Lgals1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Tspan8 UP in 'Western diet' vs 'control diet'
Clec4a3 UP in 'Western diet' vs 'control diet'
Clec2h DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Cd24a UP in 'Western diet' vs 'control diet'
Ms4a6d UP in 'Western diet' vs 'control diet'
Idi1 DOWN in 'Western diet' vs 'control diet'
Limk1 UP in 'Western diet' vs 'control diet'
Nid1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Arhgap25 UP in 'Western diet' vs 'control diet'
Spink3 UP in 'Western diet' vs 'control diet'
B4galt6 UP in 'Western diet' vs 'control diet'
Lipo1 UP in 'Western diet' vs 'control diet'
Cyp51 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Prlr DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Sqle DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Capg UP in 'Western diet' vs 'control diet'
Hspa1b UP in 'Western diet' vs 'control diet'
Clec2h DOWN in 'Western diet' vs 'control diet'
Csad UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Idi1 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Mmp12 UP in 'Western diet' vs 'control diet'
Cidec UP in 'Western diet' vs 'control diet'
Hist1h2ap UP in 'Western diet' vs 'control diet'
Prlr DOWN in 'Western diet' vs 'control diet'
Col3a1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Ccdc120 UP in 'Western diet' vs 'control diet'
Sirpa UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Plek UP in 'Western diet' vs 'control diet'
Krt8 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Tm6sf1 UP in 'Western diet' vs 'control diet'
Kbtbd11 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cxcl13 DOWN in 'Western diet' vs 'control diet'
Cxcl14 UP in 'Western diet' vs 'control diet'
Abcb1a UP in 'Western diet' vs 'control diet'
Pyhin1 UP in 'Western diet' vs 'control diet'
Col1a2 UP in 'Western diet' vs 'control diet'
Tmem86a UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Etnppl DOWN in 'Western diet' vs 'control diet'
Ephb2 UP in 'Western diet' vs 'control diet'
Gpr98 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Smpd3 UP in 'Western diet' vs 'control diet'
Ntrk2 UP in 'Western diet' vs 'control diet'
Rdh11 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Axl UP in 'Western diet' vs 'control diet'
Bhlhb9 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Ttc39a UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Rgs1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Kbtbd11 UP in 'Western diet' vs 'control diet'
Lgals3 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cybb UP in 'Western diet' vs 'control diet'
Ccr2 UP in 'Western diet' vs 'control diet'
Slc25a24 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Ly6d UP in 'Western diet' vs 'control diet'
Ifi27l2b UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Serpinh1 UP in 'Western diet' vs 'control diet'
S100a6 UP in 'Western diet' vs 'control diet'
Col3a1 UP in 'Western diet' vs 'control diet'
Cd48 UP in 'Western diet' vs 'control diet'
Cbr3 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Ccdc80 UP in 'Western diet' vs 'control diet'
Ifi27l2a UP in 'Western diet' vs 'control diet'
Hspa1a UP in 'Western diet' vs 'control diet'
Haus8 UP in 'Western diet' vs 'control diet'
Sqle DOWN in 'Western diet' vs 'control diet'
Apoa4 UP in 'Western diet' vs 'control diet'
Cd44 UP in 'Western diet' vs 'control diet'
Csad UP in 'Western diet' vs 'control diet'
Oasl2 UP in 'Western diet' vs 'control diet'
Enho DOWN in 'Western diet' vs 'control diet'
Nipal1 DOWN in 'Western diet' vs 'control diet'
Mcm5 UP in 'Western diet' vs 'control diet'
Prss23 UP in 'Western diet' vs 'control diet'
Basp1 UP in 'Western diet' vs 'control diet'
Col4a5 UP in 'Western diet' vs 'control diet'
Gstm3 UP in 'Western diet' vs 'control diet'
Gpr137b UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Bicc1 UP in 'Western diet' vs 'control diet'
Sox4 UP in 'Western diet' vs 'control diet'
Fam129a UP in 'Western diet' vs 'control diet'
Sprr1a UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Krt8 UP in 'Western diet' vs 'control diet'
Mcm2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Agxt DOWN in 'Western diet' vs 'control diet'
Orm2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Sdcbp2 UP in 'Western diet' vs 'control diet'
Analysis of 'Western diet' vs 'control diet'
Plagl1 UP in 'Western diet' vs 'control diet'
Chic1 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Mcm6 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Gpnmb UP in 'Western diet' vs 'control diet'
Capg UP in 'Western diet with 0.05% quercetin' vs 'control diet'
H19 UP in 'Western diet' vs 'control diet'
Lpin1 DOWN in 'Western diet' vs 'control diet'
Slc22a7 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Itgb2 UP in 'Western diet' vs 'control diet'
Mogat1 UP in 'Western diet' vs 'control diet'
Apoa4 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Chil3 UP in 'Western diet' vs 'control diet'
Fam102a UP in 'Western diet' vs 'control diet'
Ubd UP in 'Western diet' vs 'control diet'
Ccl6 UP in 'Western diet' vs 'control diet'
Hamp2 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Lgals3 UP in 'Western diet' vs 'control diet'
Saa2 UP in 'Western diet' vs 'control diet'
Gpr65 UP in 'Western diet' vs 'control diet'
Cd52 UP in 'Western diet' vs 'control diet'
1810046K07Rik DOWN in 'Western diet' vs 'control diet'
Slamf8 UP in 'Western diet' vs 'control diet'
Oxct1 UP in 'Western diet' vs 'control diet'
Rragd UP in 'Western diet' vs 'control diet'
Rassf4 UP in 'Western diet' vs 'control diet'
Hsd3b5 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Gipc2 UP in 'Western diet' vs 'control diet'
B930041F14Rik UP in 'Western diet' vs 'control diet'
Filip1l UP in 'Western diet' vs 'control diet'
Mtmr11 UP in 'Western diet' vs 'control diet'
Gnai1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Mmp13 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Col1a2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cela1 DOWN in 'Western diet' vs 'control diet'
Gpr64 UP in 'Western diet' vs 'control diet'
Slc15a3 UP in 'Western diet' vs 'control diet'
Gm13855 DOWN in 'Western diet' vs 'control diet'
Limk1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Col5a2 UP in 'Western diet' vs 'control diet'
H19 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Egr2 UP in 'Western diet' vs 'control diet'
Tnc UP in 'Western diet' vs 'control diet'
Cd83 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cfd UP in 'Western diet' vs 'control diet'
Fabp4 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Lepr UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cd93 UP in 'Western diet' vs 'control diet'
Gpr137b UP in 'Western diet' vs 'control diet'
Acot9 UP in 'Western diet' vs 'control diet'
Gpx6 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Scd2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Mcm5 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
(Sample) diet/Western diet with 0.05% quercetin
Casp12 UP in 'Western diet' vs 'control diet'
Gpx6 DOWN in 'Western diet' vs 'control diet'
Evi2a UP in 'Western diet' vs 'control diet'
Csf2rb2 UP in 'Western diet' vs 'control diet'
Cidea UP in 'Western diet' vs 'control diet'
Fstl1 UP in 'Western diet' vs 'control diet'
Plin4 UP in 'Western diet' vs 'control diet'
Ifi204 UP in 'Western diet' vs 'control diet'
Cbr3 UP in 'Western diet' vs 'control diet'
Chic1 DOWN in 'Western diet' vs 'control diet'
Fscn1 UP in 'Western diet' vs 'control diet'
Emp1 UP in 'Western diet' vs 'control diet'
Gnai1 UP in 'Western diet' vs 'control diet'
Acot9 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Fos UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Bhlhb9 UP in 'Western diet' vs 'control diet'
Ttc39a UP in 'Western diet' vs 'control diet'
Lpl UP in 'Western diet' vs 'control diet'
Ntrk2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Clec7a UP in 'Western diet' vs 'control diet'
Mmp12 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Serpina7 UP in 'Western diet' vs 'control diet'
Ccl6 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Vim UP in 'Western diet' vs 'control diet'
Dct DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Serpinb6b UP in 'Western diet' vs 'control diet'
Saa1 UP in 'Western diet' vs 'control diet'
Cd300lb UP in 'Western diet with 0.05% quercetin' vs 'control diet'
(Factor value) DIET/Western diet with 0.05% quercetin
Hsd3b5 DOWN in 'Western diet' vs 'control diet'
Anxa2 UP in 'Western diet' vs 'control diet'
Mtmr11 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Pdk4 UP in 'Western diet' vs 'control diet'
Ubd UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cybb UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cd48 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
B4galt6 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Msmo1 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Aldh18a1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cd68 UP in 'Western diet' vs 'control diet'
Anxa2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cyr61 UP in 'Western diet' vs 'control diet'
Etnppl DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Orm3 UP in 'Western diet' vs 'control diet'
Osbpl3 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
2010003K11Rik UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Nsdhl DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Tubb6 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Lcn2 UP in 'Western diet' vs 'control diet'
Lum UP in 'Western diet' vs 'control diet'
Tlr1 UP in 'Western diet' vs 'control diet'
To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression, C56BL/6J mice were fed for 20 weeks on control or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Chronic dietary intake of quercetin reduced body weight gain and visceral and liver fat accumulation, and improved hyperglyceamia, hyperinsulinaemia, dyslipidaemia in mice fed a Western-style diet. Feeding a Western-style diet altered expression of genes related to inflammatory responses, lipid metabolism and oxidative phosphorylation in C57BL/6J mice after 20 weeks. The results from exhaustive gene expression analysis showed that quercetin minimally influenced hepatic gene expression in mice fed the Western diet. The gene screening results (GSEA) were consistent with the notion that it did improve mitochondrial function to some extent. Quantitative RT-PCR analysis indicated that quercetin did influence important regulators of fat accumulation and metabolic disorders. Our results suggest that quercetin reduces fat accumulation presumably through decreasing oxidative stress and increasing PPARÃÂ± expression, and the following improvement of gene expression related to steatosis in the liver. C56BL/6J mice were fed for 20 weeks on AIN93G (con) or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin for 20 weeks.
C3ar1 UP in 'Western diet' vs 'control diet'
Cd300lb UP in 'Western diet' vs 'control diet'
Anxa1 UP in 'Western diet' vs 'control diet'
Ddr1 UP in 'Western diet' vs 'control diet'
Rragd UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Dpt UP in 'Western diet' vs 'control diet'
Cd83 UP in 'Western diet' vs 'control diet'
Sirpa UP in 'Western diet' vs 'control diet'
Osbpl3 UP in 'Western diet' vs 'control diet'
Fcgr1 UP in 'Western diet' vs 'control diet'
Hspa1a UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Mapt UP in 'Western diet' vs 'control diet'
Cfd UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Mcm6 UP in 'Western diet' vs 'control diet'
Slc22a7 DOWN in 'Western diet' vs 'control diet'
Rgs2 UP in 'Western diet' vs 'control diet'
Anxa5 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Avpr1a DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Tlr1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Btg2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Lpl UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Thbs1 UP in 'Western diet' vs 'control diet'
Cd44 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Rdh11 DOWN in 'Western diet' vs 'control diet'
Cyp51 DOWN in 'Western diet' vs 'control diet'
Wfdc2 UP in 'Western diet' vs 'control diet'
Analysis of 'Western diet with 0.05% quercetin' vs 'control diet'
Col1a1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Pla2g7 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Lgals1 UP in 'Western diet' vs 'control diet'
Anxa5 UP in 'Western diet' vs 'control diet'
Myo1f UP in 'Western diet' vs 'control diet'
Adcy7 UP in 'Western diet' vs 'control diet'
Cd53 UP in 'Western diet' vs 'control diet'
Il1rn UP in 'Western diet' vs 'control diet'
Synpo UP in 'Western diet' vs 'control diet'
Fabp7 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Soat1 UP in 'Western diet' vs 'control diet'
Col6a3 UP in 'Western diet' vs 'control diet'
Orm2 UP in 'Western diet' vs 'control diet'
Cxcl13 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Spp1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Pla2g7 UP in 'Western diet' vs 'control diet'
Gstm3 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Tnfrsf19 UP in 'Western diet' vs 'control diet'
Ly6d UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Fabp4 UP in 'Western diet' vs 'control diet'
Gpr98 UP in 'Western diet' vs 'control diet'
Mvd DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Cidea UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Ms4a4c UP in 'Western diet' vs 'control diet'
Endod1 UP in 'Western diet' vs 'control diet'
Cd163 DOWN in 'Western diet' vs 'control diet'
Evl UP in 'Western diet' vs 'control diet'
Nid1 UP in 'Western diet' vs 'control diet'
Tnfrsf19 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Epha3 UP in 'Western diet' vs 'control diet'
Gpnmb UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Mmp13 UP in 'Western diet' vs 'control diet'
Iqgap1 UP in 'Western diet' vs 'control diet'
Uap1l1 UP in 'Western diet' vs 'control diet'
1810046K07Rik DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Slc39a4 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Clec4n UP in 'Western diet' vs 'control diet'
Fos UP in 'Western diet' vs 'control diet'
Aldh18a1 UP in 'Western diet' vs 'control diet'
Spink3 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Oxct1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Gpx3 UP in 'Western diet' vs 'control diet'
Spp1 UP in 'Western diet' vs 'control diet'
Ifi27l2b UP in 'Western diet' vs 'control diet'
Cd68 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Tspan8 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Ms4a7 UP in 'Western diet' vs 'control diet'
Marcks UP in 'Western diet' vs 'control diet'
Susd4 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Evl UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Scd2 UP in 'Western diet' vs 'control diet'
Thbs1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Lyz2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Mcm4 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Hao2 DOWN in 'Western diet' vs 'control diet'
Hao2 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Fabp7 UP in 'Western diet' vs 'control diet'
Cidec UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Pparg UP in 'Western diet' vs 'control diet'
Tm7sf2 DOWN in 'Western diet' vs 'control diet'
Tmem86a UP in 'Western diet' vs 'control diet'
Lepr UP in 'Western diet' vs 'control diet'
2010003K11Rik UP in 'Western diet' vs 'control diet'
Col1a1 UP in 'Western diet' vs 'control diet'
Lcn2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Esm1 UP in 'Western diet' vs 'control diet'
Nnmt DOWN in 'Western diet' vs 'control diet'
Msmo1 DOWN in 'Western diet' vs 'control diet'
BC089597 DOWN in 'Western diet' vs 'control diet'
Slc25a24 UP in 'Western diet' vs 'control diet'
Slc39a4 UP in 'Western diet' vs 'control diet'
Lyz2 UP in 'Western diet' vs 'control diet'
Lgmn UP in 'Western diet' vs 'control diet'
Cyp2c54 DOWN in 'Western diet' vs 'control diet'
BC089597 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Uap1l1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Hamp2 DOWN in 'Western diet' vs 'control diet'
Pdgfrb UP in 'Western diet' vs 'control diet'
Rgs2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Pkm UP in 'Western diet' vs 'control diet'
Plek UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Haus8 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cela1 DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Serpinb6b UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Slc43a1 DOWN in 'Western diet' vs 'control diet'
Plin4 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cd14 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Sdcbp2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Enho DOWN in 'Western diet with 0.05% quercetin' vs 'control diet'
Glipr1 UP in 'Western diet' vs 'control diet'
Sox4 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Clec7a UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Orm3 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Cd14 UP in 'Western diet' vs 'control diet'
Clec4a3 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Ephb2 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Mogat1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Sprr1a UP in 'Western diet' vs 'control diet'
Acyp2 UP in 'Western diet' vs 'control diet'
Cgref1 UP in 'Western diet' vs 'control diet'
Esm1 UP in 'Western diet with 0.05% quercetin' vs 'control diet'
Tubb6 UP in 'Western diet' vs 'control diet'
Ms4a7 UP in 'Western diet with 0.05% quercetin' vs 'control diet'