Cxcl1 UP in '1.0% quercetin diet' vs 'control'
Gpr146 UP in '1.0% quercetin diet' vs 'control'
Id1 UP in '1.0% quercetin diet' vs 'control'
B3galt1 DOWN in '0.1% quercetin diet' vs 'control'
Tsc22d1 DOWN in '0.5% quercetin diet' vs 'control'
5033430I15Rik UP in '0.5% quercetin diet' vs 'control'
S100a8 UP in '0.5% quercetin diet' vs 'control'
Zbtb16 UP in '0.5% quercetin diet' vs 'control'
Celsr1 DOWN in '1.0% quercetin diet' vs 'control'
Saa1 UP in '0.5% quercetin diet' vs 'control'
Scd1 DOWN in '1.0% quercetin diet' vs 'control'
Arhgef26 UP in '0.5% quercetin diet' vs 'control'
2810474O19Rik UP in '0.5% quercetin diet' vs 'control'
Grem2 UP in '0.5% quercetin diet' vs 'control'
Lpin1 UP in '0.5% quercetin diet' vs 'control'
Socs3 UP in '1.0% quercetin diet' vs 'control'
Map3k5 UP in '1.0% quercetin diet' vs 'control'
Foxq1 UP in '0.5% quercetin diet' vs 'control'
Wsb1 UP in '0.5% quercetin diet' vs 'control'
Steap4 UP in '0.5% quercetin diet' vs 'control'
Cish UP in '0.5% quercetin diet' vs 'control'
Dbp UP in '1.0% quercetin diet' vs 'control'
Lcn2 UP in '1.0% quercetin diet' vs 'control'
Gprin3 DOWN in '0.1% quercetin diet' vs 'control'
Csad UP in '1.0% quercetin diet' vs 'control'
Mt1 UP in '1.0% quercetin diet' vs 'control'
Cebpb UP in '0.5% quercetin diet' vs 'control'
Rgs16 DOWN in '0.1% quercetin diet' vs 'control'
Il1r1 UP in '0.5% quercetin diet' vs 'control'
Tbx3 DOWN in '0.5% quercetin diet' vs 'control'
Mbd1 UP in '0.5% quercetin diet' vs 'control'
3110082I17Rik UP in '0.5% quercetin diet' vs 'control'
Saa2 UP in '1.0% quercetin diet' vs 'control'
Zbtb16 UP in '1.0% quercetin diet' vs 'control'
Klf10 DOWN in '0.1% quercetin diet' vs 'control'
Arid5b UP in '0.5% quercetin diet' vs 'control'
Tmprss2 UP in '1.0% quercetin diet' vs 'control'
Mafb UP in '0.5% quercetin diet' vs 'control'
Steap4 UP in '1.0% quercetin diet' vs 'control'
Plk3 UP in '0.5% quercetin diet' vs 'control'
Nabp1 UP in '0.5% quercetin diet' vs 'control'
Analysis of '0.1% quercetin diet' vs 'control'
Sesn3 DOWN in '1.0% quercetin diet' vs 'control'
Usp2 UP in '1.0% quercetin diet' vs 'control'
Socs3 UP in '0.5% quercetin diet' vs 'control'
Abhd17b UP in '0.5% quercetin diet' vs 'control'
Analysis of '1.0% quercetin diet' vs 'control'
Dnajb1 DOWN in '1.0% quercetin diet' vs 'control'
Arntl DOWN in '1.0% quercetin diet' vs 'control'
Hsph1 UP in '0.5% quercetin diet' vs 'control'
Lpin1 UP in '1.0% quercetin diet' vs 'control'
Nab2 UP in '1.0% quercetin diet' vs 'control'
Serpina4-ps1 UP in '0.5% quercetin diet' vs 'control'
Il1rap DOWN in '1.0% quercetin diet' vs 'control'
Pfkfb3 UP in '0.5% quercetin diet' vs 'control'
Thrsp UP in '0.5% quercetin diet' vs 'control'
Socs2 UP in '0.5% quercetin diet' vs 'control'
Alas1 UP in '0.5% quercetin diet' vs 'control'
Apobec1 UP in '0.5% quercetin diet' vs 'control'
Tnfaip2 DOWN in '0.5% quercetin diet' vs 'control'
We showed that diets containing 0.1% or 0.5% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma insulin levels. A cluster analysis of the hepatic gene expressions showed that 0.5% quercetin diet suppressed STZ-induced alteration of gene expression. Gene set enrichment analysis (GSEA) and quantitative RT-PCR analysis showed that the quercetin diets had their greatest suppressive effect on the STZ-induced elevation of expression of cyclin dependent kinase inhibitor p21(WAF1/Cip1) (Cdkn1a). In this experiment, we determined the effect of quercetin on healthy control BALB/c mice that were fed the AIN93G diet containing 0, 0.1, 0.5 or 1% quercetin for 2 weeks. GSEA and one-way ANOVA did not detect any significant changes in hepatic gene expression in normal mice as a result of a quercetin diet. Using a linear modeling approach and the empirical Bayes statistics, we found that Ubc were significantly reduced by both the 0.5% and 1% quercetin. Six-week-old male mice were divided into 4 groups of 6 mice each, housed in groups of 3 per cage, and fed a standard purified AIN-93G diet containing 0% (Control), 0.1% (0.1), 0.5% (0.5), or 1% quercertin (1.0) for 2 weeks.
Mettl20 UP in '0.5% quercetin diet' vs 'control'
Cers6 UP in '0.5% quercetin diet' vs 'control'
Gigyf2 UP in '0.5% quercetin diet' vs 'control'
Rlf UP in '0.5% quercetin diet' vs 'control'
Aqp4 DOWN in '1.0% quercetin diet' vs 'control'
Dbp DOWN in '0.1% quercetin diet' vs 'control'
Mt2 UP in '1.0% quercetin diet' vs 'control'
Kif1b DOWN in '1.0% quercetin diet' vs 'control'
Saa1 UP in '1.0% quercetin diet' vs 'control'
Phlda1 UP in '0.5% quercetin diet' vs 'control'
Analysis of '0.5% quercetin diet' vs 'control'
Ppp1r3b DOWN in '1.0% quercetin diet' vs 'control'
Etnppl DOWN in '0.5% quercetin diet' vs 'control'
Fam47e UP in '0.5% quercetin diet' vs 'control'
Ly6d UP in '1.0% quercetin diet' vs 'control'
Saa2 UP in '0.5% quercetin diet' vs 'control'