F09C8.1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
pgp-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
vem-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ilys-5 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
hsp-16.41 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F46G10.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
K05B2.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F10E9.12 UP in 'RPW-24 70 micromolar' vs 'DMSO'
(Sample) organism/Caenorhabditis elegans
fmo-2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
gst-21 UP in 'RPW-24 70 micromolar' vs 'DMSO'
catp-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nspe-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ttr-26 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-13B1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F16F9.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T24C4.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
acr-18 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-45 UP in 'RPW-24 70 micromolar' vs 'DMSO'
R05F9.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
spp-4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
clec-70 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
F09B12.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
R01H10.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y54G2A.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
E04F6.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F35E12.10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
asns-2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C49C8.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
apy-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F19B2.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
gst-5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ZC395.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
D2007.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F35E12.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-131 UP in 'RPW-24 70 micromolar' vs 'DMSO'
fbxa-69 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T01G5.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F49C12.7 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
clec-53 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
F55G11.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-142 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-57 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F10D2.12 UP in 'RPW-24 70 micromolar' vs 'DMSO'
K10D6.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
R09A1.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cnc-2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
Y38E10A.14 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F39E9.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
tag-10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-37 UP in 'RPW-24 70 micromolar' vs 'DMSO'
asp-12 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-16 UP in 'RPW-24 70 micromolar' vs 'DMSO'
bca-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
fipr-26 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-174 UP in 'RPW-24 70 micromolar' vs 'DMSO'
scrm-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C44C1.5 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
T16G12.1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
gba-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y49E10.18 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
alh-12 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
ifc-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
poml-2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
lips-11 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-56 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-39 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C08D8.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T25D10.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y53F4B.45 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lips-14 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
W01B11.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T01D3.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-29A2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C24B9.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
mul-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
mtl-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F53A9.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
gst-29 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
gale-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-58 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F13D12.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F58G6.7 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
T24F1.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F13H6.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pgp-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cpr-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T16G1.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F58A6.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pcyt-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
tts-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
srp-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-33 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35A2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
oac-6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
sid-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
drh-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
W02F12.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T28D9.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F54B8.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
kqt-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F55A4.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lys-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C29F7.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C42D4.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
mrp-5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y38H6C.17 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dnj-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
gst-33 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T19B10.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C50B6.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-22 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lys-6 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
F53C11.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
aqp-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
scav-6 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C52A10.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
K08D8.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clc-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F42A10.7 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
D2063.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
M02D8.5 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
M60.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T12D8.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
asp-14 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
F45D3.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
acs-2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
T28C12.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35A1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F20D6.5 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
clec-206 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T19H5.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
acdh-2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C30G12.2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-16 UP in 'RPW-24 70 micromolar' vs 'DMSO'
tir-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
tsp-10 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-45 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y39B6A.1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
F35E12.9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
irg-3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C50F4.9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F27D9.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
swt-6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pdi-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
tat-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F53A9.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F28H7.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
F27D9.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y18D10A.23 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F13H6.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C18E9.9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
smd-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ilys-3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
hsp-16.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F19C6.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y51F10.7 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
T22B7.7 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
bcat-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C31C9.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pho-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
T28F3.4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
ifp-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lips-10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cgt-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pssy-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C29F7.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F14E5.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lys-4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
kel-8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y37A1B.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-205 UP in 'RPW-24 70 micromolar' vs 'DMSO'
fmo-5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y105C5B.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cbl-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
hsp-17 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F53B2.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F53A9.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
B0238.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F15B9.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
K07G5.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y16B4A.2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
gba-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
klf-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
fbxa-14 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y73C8C.10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-201 UP in 'RPW-24 70 micromolar' vs 'DMSO'
asp-13 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
R193.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y38F1A.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
asp-10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C32H11.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-50 UP in 'RPW-24 70 micromolar' vs 'DMSO'
skr-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lbp-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
H06A10.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
swt-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
The nematode Caenorhabditis elegans offers currently untapped potential for carrying out high-throughput, live-animal screens of low molecular weight compound libraries to identify molecules that target a variety of cellular processes. We previously used a bacterial infection assay in C. elegans to identify 119 compounds that affect host-microbe interactions among 37,214 tested. We subsequently found that one of these small molecules, RPW-24, protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. Using transcriptome profiling, epistasis pathway analyses with C. elegans mutants, and an RNAi screen, we showed that RPW-24 promotes resistance to Pseudomonas aeruginosa infection by inducing the transcription of a remarkably small number of C. elegans genes (~1.3% of all genes) in a manner that partially depends on the evolutionarily-conserved p38 MAP kinase pathway and the transcription factor ATF-7. These data demonstrated that the immunostimulatory activity of RPW-24 is required for its efficacy and define a novel C. elegans-based strategy to identify compounds with activity against antibiotic-resistant bacterial pathogens. Here we present the microarray data that were used to define the genes that are differentially regulated in wild-type nematodes following exposure to RPW-24. There are six samples total that comprise three biological replicates of wild-type animals exposed to either 70 uM RPW-24 or DMSO for 15 hours at 15°C. For a given biological replicate, N2 C. elegans animals in the late L4 larval stage were exposed to RPW-24 or DMSO in parallel to each other.
cyp-35C1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-14 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ncx-6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F20G2.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nspe-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F38B6.4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-63 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Analysis of 'RPW-24 70 micromolar' vs 'DMSO'
D1044.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C33H5.13 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35B3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pgp-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F15E6.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
K08D8.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T15B7.1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
ZC196.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C45B2.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C17H12.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F25D1.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-51 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-203 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cdr-4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cgt-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
asm-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-21 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F35E12.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C29F7.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y51A2D.13 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dod-23 UP in 'RPW-24 70 micromolar' vs 'DMSO'
npa-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C35B1.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
oac-14 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F30F8.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
gsto-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C32H11.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
gst-6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C14C6.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ZK970.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-42 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y73C8B.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-51 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
mth-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-41 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-107 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dhs-25 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
W01F3.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-187 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T10B10.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-67 UP in 'RPW-24 70 micromolar' vs 'DMSO'
H20E11.2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
nspe-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pdi-6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
E02C12.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
spp-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
clec-186 UP in 'RPW-24 70 micromolar' vs 'DMSO'
asp-8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F20C5.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F20G2.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ttr-44 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
pmp-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
aex-6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dhs-23 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C50F7.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F01D5.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T16G1.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
R05H10.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F08G5.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F10C2.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C05D2.8 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
nlp-17 UP in 'RPW-24 70 micromolar' vs 'DMSO'
spin-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
prx-11 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-49 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
K08D8.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-54 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F35E12.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
bre-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
alh-13 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
T28C6.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F53E10.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
K09C4.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
H25K10.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ras-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F49F1.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-14A4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lys-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C15A11.7 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
ZK228.4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C29F3.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C32H11.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ttr-18 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cdf-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
gst-10 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
gbh-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F53C11.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cth-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
dod-19 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F44G3.2 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
K09D9.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dsc-4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
fat-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-227 UP in 'RPW-24 70 micromolar' vs 'DMSO'
hrg-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
math-27 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C15C7.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lmp-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ver-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-36A1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y41C4A.11 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-29A3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
amt-1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35B1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y77E11A.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y73F4A.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C14C6.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C23H5.8 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cdo-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C05D9.9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T10B5.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C18A11.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-65 UP in 'RPW-24 70 micromolar' vs 'DMSO'
catp-3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C35A5.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-43A1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
R05D8.9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F21C10.9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
W05H9.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-47 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cytb-5.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y32F6B.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y46D2A.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-33A1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F49F1.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lec-11 UP in 'RPW-24 70 micromolar' vs 'DMSO'
AC3.5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F11E6.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
D2021.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T14G8.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ttr-37 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F53A9.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-150 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
K10B2.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-202 UP in 'RPW-24 70 micromolar' vs 'DMSO'
H23N18.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F58G6.9 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
clec-52 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ckb-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T27D12.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C39E9.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C42D4.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pud-4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35A3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F01D5.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
lys-10 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cTel55X.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
mrp-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-103 UP in 'RPW-24 70 micromolar' vs 'DMSO'
swt-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-62 UP in 'RPW-24 70 micromolar' vs 'DMSO'
alh-10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C38H2.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F59B1.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-48 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C03D6.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F13D11.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F49E2.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y94H6A.10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F59B1.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-13 UP in 'RPW-24 70 micromolar' vs 'DMSO'
rft-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
spp-12 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-34A9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35A4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dhs-21 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-25A1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
F26E4.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
alh-5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ctg-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ptr-22 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cept-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y37D8A.16 UP in 'RPW-24 70 micromolar' vs 'DMSO'
comt-4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
comt-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F40F12.7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F54E2.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C06B3.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
fbxa-105 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-7 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-265 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pho-11 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C29G2.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T28H10.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
E02C12.12 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nstp-2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C16B8.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F55G11.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
D1086.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
W01A11.1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F21D5.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dhs-4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cdd-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
hsp-70 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F41B4.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-237 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
fat-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
D1053.3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nlp-39 UP in 'RPW-24 70 micromolar' vs 'DMSO'
drr-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nhr-11 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F23F12.12 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
spp-23 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
Y42A5A.3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
pgp-13 UP in 'RPW-24 70 micromolar' vs 'DMSO'
hpo-6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
odc-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
hrg-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-25 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35A5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T05E7.1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35B2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
far-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F41C3.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ptr-14 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ZK6.8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-21 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pud-3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
clec-5 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cdr-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C14B9.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
hrg-4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lec-10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
hsp-3 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F49E12.10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
gbh-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C27H5.4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
daf-22 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C34H4.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-26 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
(Factor value) COMPOUND/2-N-(3-chloro-4-methylphenyl) quinazoline-2,4-diamine (RPW-24) 70
2-N-(3-chloro-4-methylphenyl) quinazoline-2,4-diamine (RPW-24) 70
gba-4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C09B8.4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
aco-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
T05B11.4 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
C18H9.6 UP in 'RPW-24 70 micromolar' vs 'DMSO'
srr-4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
F20A1.10 UP in 'RPW-24 70 micromolar' vs 'DMSO'
lec-8 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-33C9 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-41 UP in 'RPW-24 70 micromolar' vs 'DMSO'
C55F2.1 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'
cyp-35D1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
clec-72 UP in 'RPW-24 70 micromolar' vs 'DMSO'
cah-4 UP in 'RPW-24 70 micromolar' vs 'DMSO'
nspe-5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
dct-18 UP in 'RPW-24 70 micromolar' vs 'DMSO'
acp-5 UP in 'RPW-24 70 micromolar' vs 'DMSO'
Y40D12A.2 UP in 'RPW-24 70 micromolar' vs 'DMSO'
ugt-1 UP in 'RPW-24 70 micromolar' vs 'DMSO'
pcp-3 DOWN in 'RPW-24 70 micromolar' vs 'DMSO'