T05E12.3 UP in 'tdp-1(ok803)' vs 'wild type'
mlt-9 DOWN in 'tdp-1(ok803)' vs 'wild type'
asp-12 UP in 'tdp-1(ok803)' vs 'wild type'
cnc-2 UP in 'tdp-1(ok803)' vs 'wild type'
valv-1 UP in 'tdp-1(ok803)' vs 'wild type'
H42K12.3 DOWN in 'tdp-1(ok803)' vs 'wild type'
T24C4.4 UP in 'tdp-1(ok803)' vs 'wild type'
H03E18.1 DOWN in 'tdp-1(ok803)' vs 'wild type'
crn-6 UP in 'tdp-1(ok803)' vs 'wild type'
C14F11.6 DOWN in 'tdp-1(ok803)' vs 'wild type'
F44E2.4 DOWN in 'tdp-1(ok803)' vs 'wild type'
mtl-2 DOWN in 'tdp-1(ok803)' vs 'wild type'
dpy-10 DOWN in 'tdp-1(ok803)' vs 'wild type'
ins-7 UP in 'tdp-1(ok803)' vs 'wild type'
F08G2.5 UP in 'tdp-1(ok803)' vs 'wild type'
tdp-1 DOWN in 'tdp-1(ok803)' vs 'wild type'
(Factor value) GENOTYPE/wild type genotype
lys-4 UP in 'tdp-1(ok803)' vs 'wild type'
clec-62 UP in 'tdp-1(ok803)' vs 'wild type'
(Sample) organism/Caenorhabditis elegans
dpy-6 DOWN in 'tdp-1(ok803)' vs 'wild type'
lpr-5 DOWN in 'tdp-1(ok803)' vs 'wild type'
B0348.2 UP in 'tdp-1(ok803)' vs 'wild type'
Transactive response DNA-binding protein of 43 kDa (TDP-43), a heterogeneous nuclear ribonucleoprotein (hnRNP) with diverse activities, is a common denominator in several neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Orthologs of TDP-43 exist from mammals to invertebrates, but their functions in lower organisms remain poorly understood. Here we systematically studied mutant Caenorhabditis elegans lacking the nematode TDP-43 ortholog, TDP-1. To understand the global gene expression regulation induced by the loss of tdp-1, the C. elegans transcriptomes were compared between the N2 WT animals and the tdp-1(ok803lf) mutant. Transcriptional profiling demonstrated that the loss of TDP-1 altered expression of genes functioning in RNA processing and protein folding. These results suggest that the C. elegans TDP-1 as an RNA-processing protein may have a role in the regulation of protein homeostasis and aging. Global gene expression profiling was performed to compare the transcriptome of wild-type (N2) Caenorabditis elegans and that of tdp-1(ok803) loss-of-function mutant. We analyzed mixed stages of Caenorabditis elegans, wild-type N2 versus tdp-1(ok803), using the Affymetrix C. elegans genome array. Three biological replicates were performed.
dpy-8 DOWN in 'tdp-1(ok803)' vs 'wild type'
T16H12.2 UP in 'tdp-1(ok803)' vs 'wild type'
pud-4 DOWN in 'tdp-1(ok803)' vs 'wild type'
set-18 DOWN in 'tdp-1(ok803)' vs 'wild type'
C46C2.5 UP in 'tdp-1(ok803)' vs 'wild type'
F41B4.1 DOWN in 'tdp-1(ok803)' vs 'wild type'
Y43F8B.9 UP in 'tdp-1(ok803)' vs 'wild type'
mlt-11 DOWN in 'tdp-1(ok803)' vs 'wild type'
Y48G9A.7 UP in 'tdp-1(ok803)' vs 'wild type'
grl-7 DOWN in 'tdp-1(ok803)' vs 'wild type'
clec-60 UP in 'tdp-1(ok803)' vs 'wild type'
T03G6.1 DOWN in 'tdp-1(ok803)' vs 'wild type'
F09C8.1 UP in 'tdp-1(ok803)' vs 'wild type'
M02H5.8 UP in 'tdp-1(ok803)' vs 'wild type'
col-90 DOWN in 'tdp-1(ok803)' vs 'wild type'
bus-8 DOWN in 'tdp-1(ok803)' vs 'wild type'
nurf-1 DOWN in 'tdp-1(ok803)' vs 'wild type'
nep-14 UP in 'tdp-1(ok803)' vs 'wild type'
T19A5.3 DOWN in 'tdp-1(ok803)' vs 'wild type'
clec-86 UP in 'tdp-1(ok803)' vs 'wild type'
spp-18 UP in 'tdp-1(ok803)' vs 'wild type'
lpr-6 DOWN in 'tdp-1(ok803)' vs 'wild type'
wrt-1 DOWN in 'tdp-1(ok803)' vs 'wild type'
Y64H9A.2 DOWN in 'tdp-1(ok803)' vs 'wild type'
noah-1 DOWN in 'tdp-1(ok803)' vs 'wild type'
C04G6.5 UP in 'tdp-1(ok803)' vs 'wild type'
T14B1.1 DOWN in 'tdp-1(ok803)' vs 'wild type'
W03D2.13 UP in 'tdp-1(ok803)' vs 'wild type'
gst-24 UP in 'tdp-1(ok803)' vs 'wild type'
Y37H2A.14 UP in 'tdp-1(ok803)' vs 'wild type'
col-41 DOWN in 'tdp-1(ok803)' vs 'wild type'
clec-190 DOWN in 'tdp-1(ok803)' vs 'wild type'
sdz-24 DOWN in 'tdp-1(ok803)' vs 'wild type'
F19H8.2 DOWN in 'tdp-1(ok803)' vs 'wild type'
Y37A1B.7 DOWN in 'tdp-1(ok803)' vs 'wild type'
cuti-1 DOWN in 'tdp-1(ok803)' vs 'wild type'
F44G3.2 UP in 'tdp-1(ok803)' vs 'wild type'
lpr-3 DOWN in 'tdp-1(ok803)' vs 'wild type'
D1014.5 DOWN in 'tdp-1(ok803)' vs 'wild type'
F53B3.6 DOWN in 'tdp-1(ok803)' vs 'wild type'
F19C7.2 UP in 'tdp-1(ok803)' vs 'wild type'
pud-3 DOWN in 'tdp-1(ok803)' vs 'wild type'
K08B12.1 DOWN in 'tdp-1(ok803)' vs 'wild type'
abf-2 DOWN in 'tdp-1(ok803)' vs 'wild type'
clec-70 UP in 'tdp-1(ok803)' vs 'wild type'
K08E7.5 DOWN in 'tdp-1(ok803)' vs 'wild type'
Y102A5C.6 DOWN in 'tdp-1(ok803)' vs 'wild type'
F53A9.8 UP in 'tdp-1(ok803)' vs 'wild type'
Analysis of 'tdp-1(ok803)' vs 'wild type'
F52E1.14 UP in 'tdp-1(ok803)' vs 'wild type'
ZK896.5 UP in 'tdp-1(ok803)' vs 'wild type'
F09F9.2 DOWN in 'tdp-1(ok803)' vs 'wild type'
ech-9 UP in 'tdp-1(ok803)' vs 'wild type'