SNORA80E UP in 'MALT lymphoma' vs 'normal'
SH3BP5 UP in 'MALT lymphoma' vs 'normal'
ABLIM3 UP in 'MALT lymphoma' vs 'normal'
KCNJ15 UP in 'MALT lymphoma' vs 'normal'
GPR155 UP in 'MALT lymphoma' vs 'normal'
HORMAD1 UP in 'MALT lymphoma' vs 'normal'
FCER1A DOWN in 'MALT lymphoma' vs 'normal'
RFX8 DOWN in 'MALT lymphoma' vs 'normal'
SUCLG2 UP in 'MALT lymphoma' vs 'normal'
FCER1G UP in 'MALT lymphoma' vs 'normal'
IGHV4OR15-8 UP in 'MALT lymphoma' vs 'normal'
JAKMIP2 DOWN in 'MALT lymphoma' vs 'normal'
RPS13 DOWN in 'MALT lymphoma' vs 'normal'
IGLV9-49 UP in 'MALT lymphoma' vs 'normal'
SH3D19 UP in 'MALT lymphoma' vs 'normal'
PIEZO2 UP in 'MALT lymphoma' vs 'normal'
KIAA0513 UP in 'MALT lymphoma' vs 'normal'
KARS DOWN in 'MALT lymphoma' vs 'normal'
IGKV1D-27 UP in 'MALT lymphoma' vs 'normal'
GPR146 UP in 'MALT lymphoma' vs 'normal'
CXCL12 UP in 'MALT lymphoma' vs 'normal'
FCGR2A UP in 'MALT lymphoma' vs 'normal'
ZNF502 DOWN in 'MALT lymphoma' vs 'normal'
CYP1B1 UP in 'MALT lymphoma' vs 'normal'
IGHV3-33 UP in 'MALT lymphoma' vs 'normal'
C1orf186 DOWN in 'MALT lymphoma' vs 'normal'
SLC4A1 UP in 'MALT lymphoma' vs 'normal'
FRMD4A UP in 'MALT lymphoma' vs 'normal'
RPL11 DOWN in 'MALT lymphoma' vs 'normal'
RPS24 DOWN in 'MALT lymphoma' vs 'normal'
IGKV1-9 UP in 'MALT lymphoma' vs 'normal'
ZNF253 DOWN in 'MALT lymphoma' vs 'normal'
FAM198B UP in 'MALT lymphoma' vs 'normal'
FAM214B UP in 'MALT lymphoma' vs 'normal'
ADORA3 UP in 'MALT lymphoma' vs 'normal'
TNFSF10 UP in 'MALT lymphoma' vs 'normal'
LGALS3 UP in 'MALT lymphoma' vs 'normal'
RNU1-87P UP in 'MALT lymphoma' vs 'normal'
MFAP4 DOWN in 'MALT lymphoma' vs 'normal'
SLC2A14 UP in 'MALT lymphoma' vs 'normal'
ERRFI1 UP in 'MALT lymphoma' vs 'normal'
ANAPC5 DOWN in 'MALT lymphoma' vs 'normal'
TRIM10 UP in 'MALT lymphoma' vs 'normal'
CRYGD DOWN in 'MALT lymphoma' vs 'normal'
HNRNPK DOWN in 'MALT lymphoma' vs 'normal'
ILF2 DOWN in 'MALT lymphoma' vs 'normal'
Comparison of gene expression profiling analysis of bone marrow isolated CD34+ cells from patients with MALT lymphoma vs. healthy individuals revealed a large number of differentially expressed genes that included NF-kB target genes, genes involved in inflamatory signalling and immunoglobulin genes, suggesting an early lymphoid B-cell priming. Chromosomal translocations involving MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. However, targeting these translocations to mouse B-cells has failed to reproduce human disease. Here, we induced MALT1 expression in mouse Sca1+Lin- hematopoietic stem/progenitor cells (HS/PCs), leading to the development of tumors recapitulating the clinical, histopathological and molecular features of human MALT lymphomas. Ablation of the p53 gene induced transformation of MALT lymphoma to diffuse large-cell lymphoma of activated B-cell type (ABC-DLBCL). Human CD34+ cells isolated from MALT lymphoma patients displayed an abnormal transcriptional program that was shared by MALT lymphoma cells, transgenic mouse Sca1+Lin- cells and Sca1-MALT1-induced lymphomas. Our study shows that MALT lymphoma can be modeled in mice by targeting MALT1 oncogene to HS/PCs. 10 samples were analyzed of which 5 are CD34+ cells sorted from the bone marrow of MALT patients and are compared to the other 5 CD34+ cells sorted from the bone marrow of healthy donors.
RN7SL368P UP in 'MALT lymphoma' vs 'normal'
MTND6P5 UP in 'MALT lymphoma' vs 'normal'
FRMD4B UP in 'MALT lymphoma' vs 'normal'
IGFBP5 UP in 'MALT lymphoma' vs 'normal'
ITM2A DOWN in 'MALT lymphoma' vs 'normal'
GIMAP5 UP in 'MALT lymphoma' vs 'normal'
TGFBR3 UP in 'MALT lymphoma' vs 'normal'
SIGLEC7 UP in 'MALT lymphoma' vs 'normal'
SRGAP1 UP in 'MALT lymphoma' vs 'normal'
RILPL1 UP in 'MALT lymphoma' vs 'normal'
CLDN10 DOWN in 'MALT lymphoma' vs 'normal'
ZNF726 DOWN in 'MALT lymphoma' vs 'normal'
MIR22HG UP in 'MALT lymphoma' vs 'normal'
KDELC1 DOWN in 'MALT lymphoma' vs 'normal'
RNU6-637P DOWN in 'MALT lymphoma' vs 'normal'
SLC9A9 UP in 'MALT lymphoma' vs 'normal'
PIK3R5 UP in 'MALT lymphoma' vs 'normal'
TMBIM1 UP in 'MALT lymphoma' vs 'normal'
PRSS57 DOWN in 'MALT lymphoma' vs 'normal'
TSPAN15 UP in 'MALT lymphoma' vs 'normal'
SLC16A6 UP in 'MALT lymphoma' vs 'normal'
RPL30 DOWN in 'MALT lymphoma' vs 'normal'
ZNF391 DOWN in 'MALT lymphoma' vs 'normal'
ZNF667-AS1 DOWN in 'MALT lymphoma' vs 'normal'
SLC22A23 UP in 'MALT lymphoma' vs 'normal'
IGKV1D-16 UP in 'MALT lymphoma' vs 'normal'
CDC42BPB UP in 'MALT lymphoma' vs 'normal'
(Sample) disease/mucosa-associated lymphoid tissue lymphoma
mucosa-associated lymphoid tissue lymphoma
HFM1 DOWN in 'MALT lymphoma' vs 'normal'
IGHV1OR15-1 UP in 'MALT lymphoma' vs 'normal'
LILRB2 UP in 'MALT lymphoma' vs 'normal'
PFKFB3 UP in 'MALT lymphoma' vs 'normal'
NREP DOWN in 'MALT lymphoma' vs 'normal'
KIAA1598 UP in 'MALT lymphoma' vs 'normal'
CRISP3 UP in 'MALT lymphoma' vs 'normal'
TYROBP UP in 'MALT lymphoma' vs 'normal'
CEACAM8 UP in 'MALT lymphoma' vs 'normal'
GAS5 DOWN in 'MALT lymphoma' vs 'normal'
CAMSAP2 UP in 'MALT lymphoma' vs 'normal'
RPL19 DOWN in 'MALT lymphoma' vs 'normal'
LGALSL UP in 'MALT lymphoma' vs 'normal'
ATP1B2 UP in 'MALT lymphoma' vs 'normal'
IGLV6-57 UP in 'MALT lymphoma' vs 'normal'
RAB3IL1 UP in 'MALT lymphoma' vs 'normal'
SLC6A9 UP in 'MALT lymphoma' vs 'normal'
S100A11 UP in 'MALT lymphoma' vs 'normal'
RASSF4 UP in 'MALT lymphoma' vs 'normal'
ATP6V0A1 UP in 'MALT lymphoma' vs 'normal'
PPAP2B UP in 'MALT lymphoma' vs 'normal'
LILRA6 UP in 'MALT lymphoma' vs 'normal'
TBC1D8 UP in 'MALT lymphoma' vs 'normal'
ARHGEF12 UP in 'MALT lymphoma' vs 'normal'
DPY19L2P2 DOWN in 'MALT lymphoma' vs 'normal'
SLC15A3 UP in 'MALT lymphoma' vs 'normal'
ENTPD1 UP in 'MALT lymphoma' vs 'normal'
TMEM150B UP in 'MALT lymphoma' vs 'normal'
GABARAPL1 UP in 'MALT lymphoma' vs 'normal'
DENND2C UP in 'MALT lymphoma' vs 'normal'
MARCH2 UP in 'MALT lymphoma' vs 'normal'
SCPEP1 UP in 'MALT lymphoma' vs 'normal'
IGKV2D-18 UP in 'MALT lymphoma' vs 'normal'
CDCA7 DOWN in 'MALT lymphoma' vs 'normal'
RPL28 DOWN in 'MALT lymphoma' vs 'normal'
STEAP4 UP in 'MALT lymphoma' vs 'normal'
TCP11L2 UP in 'MALT lymphoma' vs 'normal'
CLGN DOWN in 'MALT lymphoma' vs 'normal'
TSPAN6 UP in 'MALT lymphoma' vs 'normal'
SMNDC1 DOWN in 'MALT lymphoma' vs 'normal'
LRRC25 UP in 'MALT lymphoma' vs 'normal'
NPM1 DOWN in 'MALT lymphoma' vs 'normal'
PLD4 DOWN in 'MALT lymphoma' vs 'normal'
MARCKS UP in 'MALT lymphoma' vs 'normal'
IFIT1B UP in 'MALT lymphoma' vs 'normal'
TMEM140 UP in 'MALT lymphoma' vs 'normal'
TACSTD2 UP in 'MALT lymphoma' vs 'normal'
RPS3AP5 DOWN in 'MALT lymphoma' vs 'normal'
RPS3AP6 DOWN in 'MALT lymphoma' vs 'normal'
CYSTM1 UP in 'MALT lymphoma' vs 'normal'
AADAT DOWN in 'MALT lymphoma' vs 'normal'
SECTM1 UP in 'MALT lymphoma' vs 'normal'
LILRA5 UP in 'MALT lymphoma' vs 'normal'
TMEM63B UP in 'MALT lymphoma' vs 'normal'
CANX DOWN in 'MALT lymphoma' vs 'normal'
JAM2 DOWN in 'MALT lymphoma' vs 'normal'
SLAMF6 UP in 'MALT lymphoma' vs 'normal'
SIPA1L2 UP in 'MALT lymphoma' vs 'normal'
THEMIS2 UP in 'MALT lymphoma' vs 'normal'
SPG20OS DOWN in 'MALT lymphoma' vs 'normal'
CLEC4D UP in 'MALT lymphoma' vs 'normal'
RNU6-1003P UP in 'MALT lymphoma' vs 'normal'
CHI3L1 UP in 'MALT lymphoma' vs 'normal'
APOBEC3A UP in 'MALT lymphoma' vs 'normal'
FAM49A UP in 'MALT lymphoma' vs 'normal'
IL18RAP UP in 'MALT lymphoma' vs 'normal'
NONO DOWN in 'MALT lymphoma' vs 'normal'
NRG4 DOWN in 'MALT lymphoma' vs 'normal'
DPY19L2 DOWN in 'MALT lymphoma' vs 'normal'
CYP4F3 UP in 'MALT lymphoma' vs 'normal'
KLHL13 DOWN in 'MALT lymphoma' vs 'normal'
C1QTNF4 DOWN in 'MALT lymphoma' vs 'normal'
HSPA1A UP in 'MALT lymphoma' vs 'normal'
RASGRP4 UP in 'MALT lymphoma' vs 'normal'
AREG DOWN in 'MALT lymphoma' vs 'normal'
ZNF257 DOWN in 'MALT lymphoma' vs 'normal'
GIMAP4 UP in 'MALT lymphoma' vs 'normal'
RNASE1 UP in 'MALT lymphoma' vs 'normal'
SERPINA1 UP in 'MALT lymphoma' vs 'normal'
AL161784.1 UP in 'MALT lymphoma' vs 'normal'
FLT3 DOWN in 'MALT lymphoma' vs 'normal'
GPR160 UP in 'MALT lymphoma' vs 'normal'
FAM216A DOWN in 'MALT lymphoma' vs 'normal'
CLEC4M UP in 'MALT lymphoma' vs 'normal'
IL10RA UP in 'MALT lymphoma' vs 'normal'
PRSS3P2 DOWN in 'MALT lymphoma' vs 'normal'
SLC11A1 UP in 'MALT lymphoma' vs 'normal'
CLEC7A UP in 'MALT lymphoma' vs 'normal'
TNFAIP6 UP in 'MALT lymphoma' vs 'normal'
BCL2L1 UP in 'MALT lymphoma' vs 'normal'
FAXDC2 UP in 'MALT lymphoma' vs 'normal'
ZFYVE16 UP in 'MALT lymphoma' vs 'normal'
FCGR2B UP in 'MALT lymphoma' vs 'normal'
ZNF486 DOWN in 'MALT lymphoma' vs 'normal'
GGTA1P UP in 'MALT lymphoma' vs 'normal'
MARCH1 UP in 'MALT lymphoma' vs 'normal'
SELENBP1 UP in 'MALT lymphoma' vs 'normal'
DPY19L2P1 DOWN in 'MALT lymphoma' vs 'normal'
SLC7A7 UP in 'MALT lymphoma' vs 'normal'
(Factor value) DISEASE/mucosa-associated lymphoid tissue lymphoma
SLAMF7 UP in 'MALT lymphoma' vs 'normal'
CREBL2 UP in 'MALT lymphoma' vs 'normal'
GLT1D1 UP in 'MALT lymphoma' vs 'normal'
UGT3A2 DOWN in 'MALT lymphoma' vs 'normal'
ZNF804A DOWN in 'MALT lymphoma' vs 'normal'
RPS26P15 DOWN in 'MALT lymphoma' vs 'normal'
NCKAP1 UP in 'MALT lymphoma' vs 'normal'
CEACAM1 UP in 'MALT lymphoma' vs 'normal'
CADPS2 UP in 'MALT lymphoma' vs 'normal'
S100A8 UP in 'MALT lymphoma' vs 'normal'
ZNF404 DOWN in 'MALT lymphoma' vs 'normal'
TMEM40 UP in 'MALT lymphoma' vs 'normal'
TNFRSF17 UP in 'MALT lymphoma' vs 'normal'
SLC25A37 UP in 'MALT lymphoma' vs 'normal'
P2RY12 UP in 'MALT lymphoma' vs 'normal'
SPINK2 DOWN in 'MALT lymphoma' vs 'normal'
BAALC DOWN in 'MALT lymphoma' vs 'normal'
SNORD20 DOWN in 'MALT lymphoma' vs 'normal'
S100A16 UP in 'MALT lymphoma' vs 'normal'
RUNX2 DOWN in 'MALT lymphoma' vs 'normal'
RPS7 DOWN in 'MALT lymphoma' vs 'normal'
GIMAP7 UP in 'MALT lymphoma' vs 'normal'
ZNF93 DOWN in 'MALT lymphoma' vs 'normal'
FAM26E UP in 'MALT lymphoma' vs 'normal'
PROM1 DOWN in 'MALT lymphoma' vs 'normal'
CYTL1 DOWN in 'MALT lymphoma' vs 'normal'
CD200R1 UP in 'MALT lymphoma' vs 'normal'
TUBA4A UP in 'MALT lymphoma' vs 'normal'
RPP40 DOWN in 'MALT lymphoma' vs 'normal'
TBC1D9 UP in 'MALT lymphoma' vs 'normal'
LY6G6F UP in 'MALT lymphoma' vs 'normal'
DUSP10 DOWN in 'MALT lymphoma' vs 'normal'
TMEM56 UP in 'MALT lymphoma' vs 'normal'
RP11-162A23.5 DOWN in 'MALT lymphoma' vs 'normal'
SNORD27 DOWN in 'MALT lymphoma' vs 'normal'
MS4A6A UP in 'MALT lymphoma' vs 'normal'
TM6SF1 UP in 'MALT lymphoma' vs 'normal'
LILRB1 UP in 'MALT lymphoma' vs 'normal'
(Sample) cell type/CD34+ cells from bone marrow
EPB41L4A UP in 'MALT lymphoma' vs 'normal'
CLEC4A UP in 'MALT lymphoma' vs 'normal'
TREML1 UP in 'MALT lymphoma' vs 'normal'
RNPS1 DOWN in 'MALT lymphoma' vs 'normal'
SIGLEC9 UP in 'MALT lymphoma' vs 'normal'
CLEC4E UP in 'MALT lymphoma' vs 'normal'
S100A12 UP in 'MALT lymphoma' vs 'normal'
TNFAIP2 UP in 'MALT lymphoma' vs 'normal'
B4GALT6 DOWN in 'MALT lymphoma' vs 'normal'
BCL2L11 UP in 'MALT lymphoma' vs 'normal'
SDK2 DOWN in 'MALT lymphoma' vs 'normal'
IGFBP4 UP in 'MALT lymphoma' vs 'normal'
ADAM19 UP in 'MALT lymphoma' vs 'normal'
TANGO2 UP in 'MALT lymphoma' vs 'normal'
S100A10 UP in 'MALT lymphoma' vs 'normal'
SEPT10 UP in 'MALT lymphoma' vs 'normal'
MARCH8 UP in 'MALT lymphoma' vs 'normal'
EREG DOWN in 'MALT lymphoma' vs 'normal'
SEC14L4 UP in 'MALT lymphoma' vs 'normal'