Pklr DOWN in 'fenofibrate diet' vs 'control diet'
Nt5e UP in 'fenofibrate diet' vs 'control diet'
Cyp7a1 DOWN in 'fenofibrate diet' vs 'control diet'
Serpine2 DOWN in 'fenofibrate diet' vs 'control diet'
Cyp4a31 UP in 'fish oil diet' vs 'control diet'
Slc22a7 DOWN in 'fenofibrate diet' vs 'control diet'
Msmo1 DOWN in 'fish oil diet' vs 'control diet'
Med12l UP in 'fenofibrate diet' vs 'control diet'
Vldlr UP in 'fenofibrate diet' vs 'control diet'
Krt23 UP in 'fish oil diet' vs 'control diet'
Cyp2c54 DOWN in 'fenofibrate diet' vs 'control diet'
Dnaic1 UP in 'fenofibrate diet' vs 'control diet'
Pdzk1ip1 DOWN in 'fish oil diet' vs 'control diet'
Rab30 UP in 'fenofibrate diet' vs 'control diet'
Slco1a1 DOWN in 'fenofibrate diet' vs 'control diet'
Cd36 UP in 'fenofibrate diet' vs 'control diet'
Enho DOWN in 'fenofibrate diet' vs 'control diet'
Serpina11 DOWN in 'fenofibrate diet' vs 'control diet'
Nrp2 UP in 'fenofibrate diet' vs 'control diet'
Elovl6 DOWN in 'fish oil diet' vs 'control diet'
Sdr9c7 DOWN in 'fenofibrate diet' vs 'control diet'
9130409I23Rik UP in 'fenofibrate diet' vs 'control diet'
Sqle DOWN in 'fish oil diet' vs 'control diet'
Hsd17b11 UP in 'fish oil diet' vs 'control diet'
Serpina4-ps1 DOWN in 'fenofibrate diet' vs 'control diet'
Acyp2 UP in 'fenofibrate diet' vs 'control diet'
Slc27a1 UP in 'fenofibrate diet' vs 'control diet'
Tpm2 UP in 'fenofibrate diet' vs 'control diet'
Gsta2 UP in 'fish oil diet' vs 'control diet'
Acot1 UP in 'fish oil diet' vs 'control diet'
Serpina3k DOWN in 'fenofibrate diet' vs 'control diet'
Slc35f2 UP in 'fenofibrate diet' vs 'control diet'
Casc4 UP in 'fenofibrate diet' vs 'control diet'
Rdh11 DOWN in 'fish oil diet' vs 'control diet'
Gstm2 DOWN in 'fish oil diet' vs 'control diet'
Clec2h UP in 'fish oil diet' vs 'control diet'
Hsd17b11 UP in 'fenofibrate diet' vs 'control diet'
Acly DOWN in 'fish oil diet' vs 'control diet'
Retsat UP in 'fish oil diet' vs 'control diet'
Hao2 UP in 'fenofibrate diet' vs 'control diet'
Defb1 UP in 'fenofibrate diet' vs 'control diet'
Sulf2 UP in 'fenofibrate diet' vs 'control diet'
Rdh16 UP in 'fenofibrate diet' vs 'control diet'
Qpct UP in 'fenofibrate diet' vs 'control diet'
Pltp DOWN in 'fish oil diet' vs 'control diet'
Cyp2c70 DOWN in 'fenofibrate diet' vs 'control diet'
Ly6e DOWN in 'fenofibrate diet' vs 'control diet'
Ccnd1 DOWN in 'fish oil diet' vs 'control diet'
F11 DOWN in 'fenofibrate diet' vs 'control diet'
Cyp39a1 DOWN in 'fish oil diet' vs 'control diet'
C4bp DOWN in 'fenofibrate diet' vs 'control diet'
Car2 UP in 'fenofibrate diet' vs 'control diet'
Cyp17a1 DOWN in 'fish oil diet' vs 'control diet'
Pnldc1 UP in 'fenofibrate diet' vs 'control diet'
Rdh5 DOWN in 'fenofibrate diet' vs 'control diet'
Vwa8 UP in 'fenofibrate diet' vs 'control diet'
Spc25 UP in 'fenofibrate diet' vs 'control diet'
Idi1 DOWN in 'fish oil diet' vs 'control diet'
Gsta2 UP in 'fenofibrate diet' vs 'control diet'
Apoa4 DOWN in 'fish oil diet' vs 'control diet'
Cyp4a10 UP in 'fenofibrate diet' vs 'control diet'
Ephx1 UP in 'fish oil diet' vs 'control diet'
Lepr UP in 'fenofibrate diet' vs 'control diet'
Abcd2 UP in 'fenofibrate diet' vs 'control diet'
Abhd6 UP in 'fenofibrate diet' vs 'control diet'
Ehhadh UP in 'fenofibrate diet' vs 'control diet'
Vnn1 UP in 'fenofibrate diet' vs 'control diet'
Lss DOWN in 'fish oil diet' vs 'control diet'
Aox3 DOWN in 'fenofibrate diet' vs 'control diet'
Fam47e DOWN in 'fenofibrate diet' vs 'control diet'
Pdk4 UP in 'fenofibrate diet' vs 'control diet'
Dct DOWN in 'fenofibrate diet' vs 'control diet'
Cyp7b1 DOWN in 'fenofibrate diet' vs 'control diet'
Lpl UP in 'fenofibrate diet' vs 'control diet'
Osbpl3 UP in 'fenofibrate diet' vs 'control diet'
Agpat9 UP in 'fenofibrate diet' vs 'control diet'
Fasn DOWN in 'fish oil diet' vs 'control diet'
Cyp1a2 DOWN in 'fenofibrate diet' vs 'control diet'
Eci1 UP in 'fenofibrate diet' vs 'control diet'
Egfr DOWN in 'fenofibrate diet' vs 'control diet'
Acot2 UP in 'fenofibrate diet' vs 'control diet'
B3galt1 DOWN in 'fenofibrate diet' vs 'control diet'
Fgf21 DOWN in 'fish oil diet' vs 'control diet'
Mvd DOWN in 'fish oil diet' vs 'control diet'
Gulo DOWN in 'fenofibrate diet' vs 'control diet'
Ttc39c DOWN in 'fenofibrate diet' vs 'control diet'
Cidea UP in 'fenofibrate diet' vs 'control diet'
RP23-181K4.2 DOWN in 'fish oil diet' vs 'control diet'
Clec2h DOWN in 'fenofibrate diet' vs 'control diet'
Retsat UP in 'fenofibrate diet' vs 'control diet'
Egr1 DOWN in 'fenofibrate diet' vs 'control diet'
Apoa4 DOWN in 'fenofibrate diet' vs 'control diet'
Pmm1 UP in 'fenofibrate diet' vs 'control diet'
Rcan2 UP in 'fenofibrate diet' vs 'control diet'
Ucp2 UP in 'fenofibrate diet' vs 'control diet'
Prodh DOWN in 'fenofibrate diet' vs 'control diet'
P2ry14 UP in 'fenofibrate diet' vs 'control diet'
Cyp2b10 UP in 'fenofibrate diet' vs 'control diet'
Nsdhl DOWN in 'fish oil diet' vs 'control diet'
Peg3 UP in 'fenofibrate diet' vs 'control diet'
Slc22a5 UP in 'fenofibrate diet' vs 'control diet'
Tmem98 UP in 'fenofibrate diet' vs 'control diet'
Slc16a13 UP in 'fenofibrate diet' vs 'control diet'
Il6ra DOWN in 'fenofibrate diet' vs 'control diet'
Gna14 DOWN in 'fenofibrate diet' vs 'control diet'
Insig1 DOWN in 'fish oil diet' vs 'control diet'
Slc22a29 UP in 'fenofibrate diet' vs 'control diet'
Esr1 DOWN in 'fish oil diet' vs 'control diet'
Scara5 DOWN in 'fenofibrate diet' vs 'control diet'
Fads2 DOWN in 'fish oil diet' vs 'control diet'
Gpld1 DOWN in 'fenofibrate diet' vs 'control diet'
Lgals1 UP in 'fenofibrate diet' vs 'control diet'
Me1 UP in 'fenofibrate diet' vs 'control diet'
Sugct UP in 'fenofibrate diet' vs 'control diet'
Analysis of 'fenofibrate diet' vs 'control diet'
Pex11a UP in 'fenofibrate diet' vs 'control diet'
Crat UP in 'fenofibrate diet' vs 'control diet'
Abcc3 UP in 'fenofibrate diet' vs 'control diet'
Cyp4a14 UP in 'fish oil diet' vs 'control diet'
Nnmt DOWN in 'fenofibrate diet' vs 'control diet'
Chkb UP in 'fenofibrate diet' vs 'control diet'
Ugt2b1 DOWN in 'fenofibrate diet' vs 'control diet'
Fitm1 UP in 'fenofibrate diet' vs 'control diet'
Hsd17b6 UP in 'fish oil diet' vs 'control diet'
Aldoc DOWN in 'fish oil diet' vs 'control diet'
BC089597 DOWN in 'fenofibrate diet' vs 'control diet'
Mogat1 UP in 'fenofibrate diet' vs 'control diet'
Pltp UP in 'fenofibrate diet' vs 'control diet'
Cyp2c50 DOWN in 'fenofibrate diet' vs 'control diet'
Elovl5 DOWN in 'fish oil diet' vs 'control diet'
Pla2g6 UP in 'fenofibrate diet' vs 'control diet'
Hamp2 DOWN in 'fish oil diet' vs 'control diet'
Mmd2 DOWN in 'fenofibrate diet' vs 'control diet'
Slco1a4 DOWN in 'fish oil diet' vs 'control diet'
Cyp2b9 UP in 'fenofibrate diet' vs 'control diet'
C8b DOWN in 'fenofibrate diet' vs 'control diet'
Acot4 UP in 'fenofibrate diet' vs 'control diet'
Anxa2 UP in 'fenofibrate diet' vs 'control diet'
Aqp8 DOWN in 'fish oil diet' vs 'control diet'
Nt5dc2 UP in 'fenofibrate diet' vs 'control diet'
Trpm4 UP in 'fenofibrate diet' vs 'control diet'
Avpr1a DOWN in 'fenofibrate diet' vs 'control diet'
Ppp1r3g UP in 'fenofibrate diet' vs 'control diet'
9130409I23Rik UP in 'fish oil diet' vs 'control diet'
Plxnb1 DOWN in 'fenofibrate diet' vs 'control diet'
Serpina12 DOWN in 'fenofibrate diet' vs 'control diet'
Pdzrn3 UP in 'fenofibrate diet' vs 'control diet'
Fabp4 UP in 'fenofibrate diet' vs 'control diet'
Pstpip2 DOWN in 'fish oil diet' vs 'control diet'
Acsl3 DOWN in 'fish oil diet' vs 'control diet'
Vnn1 UP in 'fish oil diet' vs 'control diet'
Ugt2b38 DOWN in 'fenofibrate diet' vs 'control diet'
Cyp51 DOWN in 'fish oil diet' vs 'control diet'
Acot3 UP in 'fenofibrate diet' vs 'control diet'
Enpp2 DOWN in 'fenofibrate diet' vs 'control diet'
Ptp4a3 UP in 'fenofibrate diet' vs 'control diet'
Decr1 UP in 'fenofibrate diet' vs 'control diet'
Bcl6 DOWN in 'fenofibrate diet' vs 'control diet'
Rab30 UP in 'fish oil diet' vs 'control diet'
Hsd11b1 DOWN in 'fenofibrate diet' vs 'control diet'
Acacb DOWN in 'fish oil diet' vs 'control diet'
Aldh3a2 UP in 'fenofibrate diet' vs 'control diet'
Bhlhb9 UP in 'fenofibrate diet' vs 'control diet'
Chchd6 UP in 'fenofibrate diet' vs 'control diet'
Cidec UP in 'fenofibrate diet' vs 'control diet'
Elevated circulating triglycerides, which are considered a risk factor for cardiovascular disease, can be targeted by treatment with fenofibrate or fish oil. To gain insight into underlying mechanisms, we carried out a comparative transcriptomics and metabolomics analysis of the effect of 2 week treatment withfenofibrate and fish oil in mice. Plasma triglycerides were significantly decreased byfenofibrate (-49.1%) and fish oil (-21.8%), whereas plasma cholesterol was increased by fenofibrate (+29.9%) and decreased by fish oil (-32.8%). Levels of various phospholipid species were specifically decreased by fish oil, while levels of Krebs cycle intermediates were increased specifically by fenofibrate. Plasma levels of many amino acids were altered by fenofibrate and to a lesser extent by fish oil. Both fenofibrate and fish oil upregulated genes involved in fatty acid metabolism, and downregulated genes involved in blood coagulation and fibrinolysis. Significant overlap in gene regulation by fenofibrate and fish oil was observed, reflecting their property as high or low affinity agonist for PPARÃÂ±, respectively. Fenofibrate specifically downregulated genes involved in complement cascade and inflammatory response. Fish oil specifically downregulated genes involved in cholesterol and fatty acid biosynthesis, and upregulated genes involved in amino acid and arachidonic acid metabolism. Taken together, the data indicate that despite being similarly potent towards modulating plasma free fatty acids, cholesterol and triglyceride levels, fish oil causes modest changes in gene expression likely via activation of multiple mechanistic pathways, whereas fenofibrate causes pronounced gene expression changes via a single pathway, reflecting the key difference between nutritional and pharmacological intervention. Expression profiling of liver from mice fed control diet, fish oil or fenofibrate for 2 weeks.
Mfsd2a DOWN in 'fish oil diet' vs 'control diet'
Pcsk9 DOWN in 'fish oil diet' vs 'control diet'
Cyp2c37 DOWN in 'fenofibrate diet' vs 'control diet'
Ctse UP in 'fenofibrate diet' vs 'control diet'
C9 DOWN in 'fenofibrate diet' vs 'control diet'
Lrrc39 UP in 'fenofibrate diet' vs 'control diet'
Acot1 UP in 'fenofibrate diet' vs 'control diet'
Hsbp1l1 DOWN in 'fish oil diet' vs 'control diet'
Spon2 UP in 'fenofibrate diet' vs 'control diet'
Pmvk DOWN in 'fish oil diet' vs 'control diet'
Hsdl2 UP in 'fenofibrate diet' vs 'control diet'
Il1rn UP in 'fenofibrate diet' vs 'control diet'
Tff3 DOWN in 'fish oil diet' vs 'control diet'
2010003K11Rik DOWN in 'fish oil diet' vs 'control diet'
Nipal1 DOWN in 'fish oil diet' vs 'control diet'
Gnai1 UP in 'fenofibrate diet' vs 'control diet'
Ehhadh UP in 'fish oil diet' vs 'control diet'
Gal3st1 UP in 'fenofibrate diet' vs 'control diet'
Dhcr7 DOWN in 'fish oil diet' vs 'control diet'
Gstt2 UP in 'fenofibrate diet' vs 'control diet'
Ech1 UP in 'fenofibrate diet' vs 'control diet'
Pla1a DOWN in 'fenofibrate diet' vs 'control diet'
Csad UP in 'fenofibrate diet' vs 'control diet'
Slc39a5 UP in 'fenofibrate diet' vs 'control diet'
Cyp4a31 UP in 'fenofibrate diet' vs 'control diet'
Hsd3b5 DOWN in 'fenofibrate diet' vs 'control diet'
1500017E21Rik DOWN in 'fenofibrate diet' vs 'control diet'
G6pdx DOWN in 'fish oil diet' vs 'control diet'
Frmd4b DOWN in 'fish oil diet' vs 'control diet'
Slc3a1 DOWN in 'fenofibrate diet' vs 'control diet'
Lifr DOWN in 'fenofibrate diet' vs 'control diet'
Acss2 DOWN in 'fish oil diet' vs 'control diet'
Elovl2 DOWN in 'fish oil diet' vs 'control diet'
Analysis of 'fish oil diet' vs 'control diet'
Pknox2 UP in 'fenofibrate diet' vs 'control diet'
Cyp4a10 UP in 'fish oil diet' vs 'control diet'
9030619P08Rik DOWN in 'fish oil diet' vs 'control diet'
Chpt1 UP in 'fenofibrate diet' vs 'control diet'
C8a DOWN in 'fenofibrate diet' vs 'control diet'
Cyp2c38 UP in 'fenofibrate diet' vs 'control diet'
Zwint UP in 'fenofibrate diet' vs 'control diet'
Adh6-ps1 DOWN in 'fenofibrate diet' vs 'control diet'
Acaca DOWN in 'fish oil diet' vs 'control diet'
Cyp4f14 DOWN in 'fenofibrate diet' vs 'control diet'
Rtn4 UP in 'fenofibrate diet' vs 'control diet'
Sult1a1 DOWN in 'fenofibrate diet' vs 'control diet'
Krt23 UP in 'fenofibrate diet' vs 'control diet'
Dntt DOWN in 'fish oil diet' vs 'control diet'
Thrsp DOWN in 'fish oil diet' vs 'control diet'
Abcc3 UP in 'fish oil diet' vs 'control diet'
Serinc2 UP in 'fenofibrate diet' vs 'control diet'
C6 DOWN in 'fenofibrate diet' vs 'control diet'
Tff3 DOWN in 'fenofibrate diet' vs 'control diet'
Kdsr UP in 'fenofibrate diet' vs 'control diet'
Uap1l1 UP in 'fenofibrate diet' vs 'control diet'
Adam11 UP in 'fenofibrate diet' vs 'control diet'
Ly6d UP in 'fenofibrate diet' vs 'control diet'
Ephx1 UP in 'fenofibrate diet' vs 'control diet'
Lrrc16a DOWN in 'fenofibrate diet' vs 'control diet'
Csad UP in 'fish oil diet' vs 'control diet'
1810055G02Rik DOWN in 'fish oil diet' vs 'control diet'
Hmgcr DOWN in 'fish oil diet' vs 'control diet'
Cyp4a14 UP in 'fenofibrate diet' vs 'control diet'
Fads1 DOWN in 'fish oil diet' vs 'control diet'