RP11-479G22.8 DOWN in '24 hour, IL28B' vs 'none'
C4orf33 UP in '24 hour, IL28B' vs 'none'
KLHL23 DOWN in '24 hour, IL28B' vs 'none'
RP11-391M1.4 DOWN in '24 hour, IL28B' vs 'none'
TNFRSF11A UP in '6 hour; IL28B' vs 'none'
RABGAP1L UP in '6 hour; IL28B' vs 'none'
FRMD6 DOWN in '24 hour, IL28B' vs 'none'
ANGPTL1 UP in '24 hour, IL28B' vs 'none'
RAD21-AS1 DOWN in '24 hour; IFN' vs 'none'
YIPF4 DOWN in '24 hour, IL28B' vs 'none'
USP30-AS1 UP in '24 hour, IL28B' vs 'none'
ZC3HAV1 UP in '24 hour, IL28B' vs 'none'
HAUS2 DOWN in '24 hour, IL28B' vs 'none'
PALLD DOWN in '24 hour, IL28B' vs 'none'
PLCE1 DOWN in '24 hour, IL28B' vs 'none'
SLC6A16 UP in '24 hour, IL28B' vs 'none'
SMKR1 DOWN in '24 hour, IL28B' vs 'none'
MAPK14 DOWN in '24 hour, IL28B' vs 'none'
PEG10 DOWN in '24 hour, IL28B' vs 'none'
PCDH9 DOWN in '24 hour, IL28B' vs 'none'
GPATCH11 DOWN in '6 hour; IFN' vs 'none'
MED21 DOWN in '24 hour, IL28B' vs 'none'
HNRNPD DOWN in '24 hour, IL28B' vs 'none'
NUDT21 DOWN in '24 hour, IL28B' vs 'none'
RBBP4 DOWN in '24 hour, IL28B' vs 'none'
ZFYVE26 UP in '24 hour, IL28B' vs 'none'
SERPINE2 DOWN in '6 hour; IL28B' vs 'none'
ITGAE DOWN in '24 hour, IL28B' vs 'none'
ANKRD50 DOWN in '24 hour, IL28B' vs 'none'
PPIP5K2 DOWN in '24 hour, IL28B' vs 'none'
CXCL2 DOWN in '24 hour, IL28B' vs 'none'
PAXIP1OS UP in '24 hour, IL28B' vs 'none'
FAM129A DOWN in '24 hour, IL28B' vs 'none'
NUCKS1 DOWN in '24 hour, IL28B' vs 'none'
CEP83 DOWN in '24 hour, IL28B' vs 'none'
LGALS3BP UP in '24 hour, IL28B' vs 'none'
CTD-2095E4.5 UP in '24 hour, IL28B' vs 'none'
ZFHX4-AS1 UP in '24 hour, IL28B' vs 'none'
TRUB1 DOWN in '24 hour, IL28B' vs 'none'
CEP78 DOWN in '24 hour, IL28B' vs 'none'
UBE4B DOWN in '24 hour, IL28B' vs 'none'
RP11-635N19.1 UP in '24 hour, IL28B' vs 'none'
DNAH5 DOWN in '24 hour, IL28B' vs 'none'
SLC2A12 UP in '24 hour, IL28B' vs 'none'
SNHG14 DOWN in '24 hour, IL28B' vs 'none'
PCBD2 DOWN in '24 hour, IL28B' vs 'none'
APOBEC3G UP in '24 hour, IL28B' vs 'none'
PSMB8-AS1 UP in '24 hour; IFN' vs 'none'
CH17-38B12.2 UP in '24 hour, IL28B' vs 'none'
ADPRHL2 UP in '24 hour, IL28B' vs 'none'
RP11-552M11.8 DOWN in '24 hour, IL28B' vs 'none'
IL12RB1 UP in '24 hour, IL28B' vs 'none'
RABGAP1L UP in '24 hour, IL28B' vs 'none'
FKBP14 DOWN in '24 hour, IL28B' vs 'none'
SLC9A7 DOWN in '24 hour, IL28B' vs 'none'
C19orf80 UP in '24 hour, IL28B' vs 'none'
ZFY-AS1 UP in '24 hour, IL28B' vs 'none'
NEAT1 DOWN in '24 hour, IL28B' vs 'none'
RPL37 DOWN in '24 hour, IL28B' vs 'none'
MAP1B DOWN in '24 hour, IL28B' vs 'none'
MTHFD2 DOWN in '6 hour; IL28B' vs 'none'
TTC33 DOWN in '24 hour, IL28B' vs 'none'
HBS1L DOWN in '24 hour, IL28B' vs 'none'
CEACAM1 UP in '24 hour, IL28B' vs 'none'
SEC62 DOWN in '24 hour, IL28B' vs 'none'
SERPINB9P1 UP in '6 hour; IL28B' vs 'none'
RP5-1039K5.17 DOWN in '24 hour, IL28B' vs 'none'
CYP2E1 DOWN in '24 hour, IL28B' vs 'none'
RASSF6 DOWN in '24 hour, IL28B' vs 'none'
PSMB8-AS1 UP in '24 hour, IL28B' vs 'none'
SLC27A3 UP in '24 hour, IL28B' vs 'none'
LRFN5 DOWN in '24 hour, IL28B' vs 'none'
RP1-93H18.6 UP in '6 hour; IFN' vs 'none'
CCDC146 UP in '24 hour, IL28B' vs 'none'
FAM172A DOWN in '24 hour, IL28B' vs 'none'
LMCD1 DOWN in '24 hour, IL28B' vs 'none'
RP1-152L7.5 DOWN in '24 hour, IL28B' vs 'none'
CTC-429P9.3 DOWN in '24 hour, IL28B' vs 'none'
MTHFD2L DOWN in '24 hour, IL28B' vs 'none'
CTD-2095E4.5 UP in '6 hour; IFN' vs 'none'
THBS1 DOWN in '24 hour, IL28B' vs 'none'
APAF1 DOWN in '24 hour, IL28B' vs 'none'
NUAK2 DOWN in '24 hour, IL28B' vs 'none'
TMEM116 UP in '24 hour, IL28B' vs 'none'
MAPKAP1 DOWN in '24 hour, IL28B' vs 'none'
FILIP1L DOWN in '24 hour, IL28B' vs 'none'
SLC25A24 DOWN in '24 hour, IL28B' vs 'none'
ANXA3 DOWN in '24 hour, IL28B' vs 'none'
RP11-617F23.1 DOWN in '24 hour, IL28B' vs 'none'
TMEM158 DOWN in '6 hour; IL28B' vs 'none'
C19orf12 UP in '24 hour, IL28B' vs 'none'
BCL2L14 UP in '24 hour, IL28B' vs 'none'
USP9Y DOWN in '24 hour, IL28B' vs 'none'
GFPT1 DOWN in '24 hour, IL28B' vs 'none'
BLCAP DOWN in '24 hour, IL28B' vs 'none'
COTL1 DOWN in '24 hour, IL28B' vs 'none'
LINC00487 UP in '24 hour, IL28B' vs 'none'
RPL27A DOWN in '24 hour, IL28B' vs 'none'
RPS6KA2 DOWN in '24 hour, IL28B' vs 'none'
HMBOX1 DOWN in '24 hour, IL28B' vs 'none'
HNRNPA1 DOWN in '24 hour, IL28B' vs 'none'
POU2AF1 DOWN in '24 hour, IL28B' vs 'none'
SLC25A28 UP in '6 hour; IL28B' vs 'none'
SLC4A4 DOWN in '24 hour, IL28B' vs 'none'
DIAPH3 DOWN in '24 hour, IL28B' vs 'none'
ANKRD1 DOWN in '6 hour; IL28B' vs 'none'
SCN9A DOWN in '24 hour, IL28B' vs 'none'
TNFRSF21 DOWN in '24 hour, IL28B' vs 'none'
SLC15A3 UP in '24 hour, IL28B' vs 'none'
PANK3 DOWN in '24 hour, IL28B' vs 'none'
EIF2AK2 UP in '24 hour, IL28B' vs 'none'
RP11-288L9.1 UP in '6 hour; IFN' vs 'none'
RP3-508I15.21 UP in '6 hour; IL28B' vs 'none'
PRKAA2 DOWN in '24 hour, IL28B' vs 'none'
RP11-10L7.1 UP in '6 hour; IL28B' vs 'none'
MRPL30 DOWN in '24 hour, IL28B' vs 'none'
PTPN14 DOWN in '24 hour, IL28B' vs 'none'
SERINC5 DOWN in '24 hour, IL28B' vs 'none'
EIF3F DOWN in '24 hour, IL28B' vs 'none'
KCNAB1 DOWN in '24 hour, IL28B' vs 'none'
VPS13A DOWN in '24 hour, IL28B' vs 'none'
SOCS2 DOWN in '24 hour, IL28B' vs 'none'
COL16A1 DOWN in '24 hour, IL28B' vs 'none'
SLC25A16 DOWN in '24 hour, IL28B' vs 'none'
RP11-305K5.1 DOWN in '24 hour, IL28B' vs 'none'
RP11-432J24.5 UP in '24 hour, IL28B' vs 'none'
C17orf100 UP in '24 hour, IL28B' vs 'none'
BTBD11 DOWN in '24 hour, IL28B' vs 'none'
ASAP2 DOWN in '24 hour, IL28B' vs 'none'
OTUD6B-AS1 DOWN in '24 hour, IL28B' vs 'none'
RP11-766F14.2 DOWN in '24 hour, IL28B' vs 'none'
PLA2G12A DOWN in '24 hour, IL28B' vs 'none'
CXCL8 DOWN in '24 hour, IL28B' vs 'none'
MRPL42 DOWN in '24 hour, IL28B' vs 'none'
CD109 DOWN in '24 hour, IL28B' vs 'none'
PRKDC DOWN in '24 hour, IL28B' vs 'none'
CYP11A1 UP in '24 hour, IL28B' vs 'none'
HRASLS2 UP in '24 hour, IL28B' vs 'none'
TGFB2 DOWN in '24 hour, IL28B' vs 'none'
RP11-295H24.4 DOWN in '24 hour, IL28B' vs 'none'
OSBPL10 DOWN in '6 hour; IL28B' vs 'none'
C1orf168 DOWN in '24 hour, IL28B' vs 'none'
JMJD6 DOWN in '24 hour, IL28B' vs 'none'
SCAMP1-AS1 UP in '24 hour, IL28B' vs 'none'
DLGAP5 DOWN in '6 hour; IL28B' vs 'none'
RP3-508I15.21 UP in '6 hour; IFN' vs 'none'
TNFRSF11A UP in '24 hour, IL28B' vs 'none'
SLC16A10 DOWN in '24 hour, IL28B' vs 'none'
GPALPP1 DOWN in '24 hour, IL28B' vs 'none'
GXYLT1 DOWN in '24 hour, IL28B' vs 'none'
SLC2A13 DOWN in '24 hour, IL28B' vs 'none'
CYR61 DOWN in '24 hour, IL28B' vs 'none'
ZNF850 DOWN in '6 hour; IL28B' vs 'none'
CTD-2095E4.5 UP in '6 hour; IL28B' vs 'none'
RASAL2 DOWN in '24 hour, IL28B' vs 'none'
TAGLN DOWN in '24 hour, IL28B' vs 'none'
RNU1-70P DOWN in '24 hour, IL28B' vs 'none'
RP11-305E6.4 DOWN in '24 hour, IL28B' vs 'none'
AC009948.5 UP in '24 hour, IL28B' vs 'none'
AHNAK2 DOWN in '24 hour, IL28B' vs 'none'
DOCK7 DOWN in '24 hour, IL28B' vs 'none'
CRLS1 DOWN in '24 hour, IL28B' vs 'none'
C19orf66 UP in '6 hour; IL28B' vs 'none'
RP11-145M9.4 UP in '24 hour, IL28B' vs 'none'
AKAP12 DOWN in '24 hour, IL28B' vs 'none'
FAM102B DOWN in '24 hour, IL28B' vs 'none'
SPTLC3 DOWN in '24 hour, IL28B' vs 'none'
MAB21L2 UP in '24 hour, IL28B' vs 'none'
RPS6KA6 DOWN in '24 hour, IL28B' vs 'none'
L3MBTL4 DOWN in '24 hour, IL28B' vs 'none'
PREPL DOWN in '24 hour, IL28B' vs 'none'
PKI55 DOWN in '24 hour, IL28B' vs 'none'
RP11-164P12.4 DOWN in '24 hour, IL28B' vs 'none'
CEACAM6 UP in '24 hour, IL28B' vs 'none'
FAM122C UP in '24 hour, IL28B' vs 'none'
SPECC1 DOWN in '24 hour, IL28B' vs 'none'
TMCO3 DOWN in '24 hour, IL28B' vs 'none'
RPS20 DOWN in '24 hour, IL28B' vs 'none'
MARVELD3 UP in '24 hour, IL28B' vs 'none'
NUDT3 DOWN in '24 hour, IL28B' vs 'none'
KIAA0040 UP in '24 hour, IL28B' vs 'none'
SERPINB2 DOWN in '6 hour; IL28B' vs 'none'
AC005355.2 UP in '24 hour, IL28B' vs 'none'
NANOS1 DOWN in '6 hour; IL28B' vs 'none'
SBNO1 DOWN in '24 hour, IL28B' vs 'none'
AKR1D1 DOWN in '24 hour, IL28B' vs 'none'
ANKRD1 DOWN in '24 hour, IL28B' vs 'none'
KLHL20 DOWN in '6 hour; IL28B' vs 'none'
ZNF850 DOWN in '24 hour, IL28B' vs 'none'
RP11-498C9.15 DOWN in '24 hour, IL28B' vs 'none'
RAB27B DOWN in '24 hour, IL28B' vs 'none'
SLC16A7 DOWN in '24 hour, IL28B' vs 'none'
SESN3 DOWN in '24 hour, IL28B' vs 'none'
LINC00938 DOWN in '24 hour, IL28B' vs 'none'
LINC00862 DOWN in '24 hour, IL28B' vs 'none'
LINC00205 DOWN in '24 hour, IL28B' vs 'none'
DCAF17 DOWN in '24 hour, IL28B' vs 'none'
C19orf66 UP in '24 hour, IL28B' vs 'none'
APOBEC3F UP in '24 hour, IL28B' vs 'none'
RP11-145M9.4 UP in '6 hour; IFN' vs 'none'
PHACTR4 UP in '24 hour, IL28B' vs 'none'
LONRF2 DOWN in '24 hour, IL28B' vs 'none'
KIAA1217 UP in '24 hour, IL28B' vs 'none'
SLC30A2 UP in '24 hour, IL28B' vs 'none'
SPATA18 DOWN in '24 hour, IL28B' vs 'none'
ANGPTL6 UP in '24 hour, IL28B' vs 'none'
HEATR5A DOWN in '24 hour, IL28B' vs 'none'
TMEM229B UP in '24 hour, IL28B' vs 'none'
MARCKSL1 UP in '24 hour, IL28B' vs 'none'
ZMAT3 DOWN in '24 hour, IL28B' vs 'none'
RP11-845C23.3 UP in '24 hour, IL28B' vs 'none'
RP11-342K6.1 DOWN in '24 hour, IL28B' vs 'none'
C2orf76 DOWN in '24 hour, IL28B' vs 'none'
SPPL2A DOWN in '24 hour, IL28B' vs 'none'
XPNPEP3 DOWN in '24 hour, IL28B' vs 'none'
MALAT1 DOWN in '24 hour, IL28B' vs 'none'
AC009948.5 UP in '6 hour; IL28B' vs 'none'
STK38L DOWN in '24 hour, IL28B' vs 'none'
ONECUT2 DOWN in '24 hour, IL28B' vs 'none'
ARRDC3 DOWN in '24 hour, IL28B' vs 'none'
PWAR6 DOWN in '24 hour, IL28B' vs 'none'
FAM199X DOWN in '24 hour, IL28B' vs 'none'
ABCC1 DOWN in '24 hour, IL28B' vs 'none'
NANOS1 DOWN in '24 hour, IL28B' vs 'none'
PSMB8-AS1 UP in '6 hour; IL28B' vs 'none'
PLEKHA4 UP in '24 hour, IL28B' vs 'none'
TIMP3 DOWN in '24 hour, IL28B' vs 'none'
CTD-3025N20.3 DOWN in '24 hour, IL28B' vs 'none'
APOBEC3G UP in '6 hour; IL28B' vs 'none'
CLASP2 DOWN in '24 hour, IL28B' vs 'none'
ITGB6 DOWN in '24 hour, IL28B' vs 'none'
RP11-996F15.2 UP in '24 hour, IL28B' vs 'none'
ANXA1 DOWN in '24 hour, IL28B' vs 'none'
PNPLA4 DOWN in '24 hour, IL28B' vs 'none'
RP11-10L7.1 UP in '6 hour; IFN' vs 'none'
PTPRG DOWN in '24 hour, IL28B' vs 'none'
MORC4 DOWN in '24 hour, IL28B' vs 'none'
SLC13A5 UP in '24 hour, IL28B' vs 'none'
PDE5A DOWN in '24 hour, IL28B' vs 'none'
ABCC4 DOWN in '24 hour, IL28B' vs 'none'
RP11-766F14.2 DOWN in '6 hour; IL28B' vs 'none'
RP11-305K5.1 DOWN in '24 hour; IFN' vs 'none'
DPY19L4 DOWN in '24 hour; IFN' vs 'none'
FARP1 DOWN in '24 hour, IL28B' vs 'none'
EXOC5 DOWN in '24 hour, IL28B' vs 'none'
RP11-326I11.3 UP in '24 hour, IL28B' vs 'none'
ATXN7L1 UP in '24 hour, IL28B' vs 'none'
BICC1 DOWN in '24 hour, IL28B' vs 'none'
MARVELD3 UP in '6 hour; IL28B' vs 'none'
SLC6A6 DOWN in '24 hour, IL28B' vs 'none'
RP11-134L10.1 UP in '6 hour; IFN' vs 'none'
SLC2A2 DOWN in '24 hour, IL28B' vs 'none'
RASGRP3 UP in '24 hour, IL28B' vs 'none'
KIF1C DOWN in '24 hour, IL28B' vs 'none'
IFT80 DOWN in '24 hour, IL28B' vs 'none'
APOOL DOWN in '24 hour, IL28B' vs 'none'
AC005224.2 UP in '24 hour, IL28B' vs 'none'
PRR11 DOWN in '24 hour, IL28B' vs 'none'
RP11-1069G10.2 DOWN in '24 hour, IL28B' vs 'none'
MAD2L1 DOWN in '24 hour, IL28B' vs 'none'
C5orf56 UP in '24 hour, IL28B' vs 'none'
PTPN14 DOWN in '6 hour; IL28B' vs 'none'
TMEM178B DOWN in '24 hour, IL28B' vs 'none'
CTA-384D8.35 UP in '24 hour, IL28B' vs 'none'
CMTM4 DOWN in '24 hour, IL28B' vs 'none'
RP11-288L9.1 UP in '24 hour; IFN' vs 'none'
CNKSR3 DOWN in '24 hour, IL28B' vs 'none'
CASC7 DOWN in '24 hour, IL28B' vs 'none'
RHOBTB3 DOWN in '24 hour, IL28B' vs 'none'
DLGAP5 DOWN in '24 hour, IL28B' vs 'none'
FAM9B DOWN in '24 hour, IL28B' vs 'none'
RP11-134L10.1 UP in '6 hour; IL28B' vs 'none'
LINC00862 DOWN in '6 hour; IL28B' vs 'none'
AC009133.12 UP in '24 hour, IL28B' vs 'none'
RBM26 DOWN in '24 hour, IL28B' vs 'none'
CCNA2 DOWN in '24 hour, IL28B' vs 'none'
BIRC5 DOWN in '24 hour, IL28B' vs 'none'
SLCO5A1 UP in '24 hour, IL28B' vs 'none'
PRKCI DOWN in '24 hour, IL28B' vs 'none'
RP11-288L9.1 UP in '6 hour; IL28B' vs 'none'
VPS53 DOWN in '24 hour, IL28B' vs 'none'
SFT2D2 DOWN in '24 hour, IL28B' vs 'none'
CTC-459F4.3 DOWN in '24 hour, IL28B' vs 'none'
HERC3 DOWN in '24 hour, IL28B' vs 'none'
LDLRAD3 DOWN in '24 hour, IL28B' vs 'none'
B4GALT6 DOWN in '24 hour, IL28B' vs 'none'
OR52K3P UP in '24 hour, IL28B' vs 'none'
BCL2L13 UP in '24 hour, IL28B' vs 'none'
SRD5A2 DOWN in '24 hour, IL28B' vs 'none'
CH17-38B12.2 UP in '6 hour; IFN' vs 'none'
EIF4EBP2 DOWN in '24 hour, IL28B' vs 'none'
BRWD1 DOWN in '24 hour, IL28B' vs 'none'
AC009948.5 UP in '6 hour; IFN' vs 'none'
BCAT1 DOWN in '24 hour, IL28B' vs 'none'
KIAA0040 UP in '6 hour; IL28B' vs 'none'
RP11-278C7.5 DOWN in '24 hour, IL28B' vs 'none'
TMEM2 DOWN in '24 hour, IL28B' vs 'none'
SLC6A12 UP in '24 hour, IL28B' vs 'none'
SERPINE2 DOWN in '24 hour, IL28B' vs 'none'
PRKCQ-AS1 UP in '24 hour, IL28B' vs 'none'
PPP2R2D DOWN in '24 hour, IL28B' vs 'none'
COL12A1 DOWN in '24 hour, IL28B' vs 'none'
TNFRSF10D DOWN in '24 hour, IL28B' vs 'none'
SLC37A4 UP in '24 hour, IL28B' vs 'none'
FAM173B DOWN in '24 hour, IL28B' vs 'none'
KIF4A DOWN in '24 hour, IL28B' vs 'none'
RAB3B DOWN in '24 hour, IL28B' vs 'none'
ZDHHC21 DOWN in '6 hour; IL28B' vs 'none'
TSPAN12 DOWN in '24 hour, IL28B' vs 'none'
AC013275.2 DOWN in '24 hour, IL28B' vs 'none'
RP11-356J5.12 DOWN in '24 hour, IL28B' vs 'none'
HELLS DOWN in '24 hour, IL28B' vs 'none'
TNFSF10 UP in '24 hour, IL28B' vs 'none'
VPS41 DOWN in '24 hour, IL28B' vs 'none'
LINC01192 DOWN in '24 hour; IFN' vs 'none'
ELAVL1 DOWN in '24 hour, IL28B' vs 'none'
C17orf67 UP in '6 hour; IL28B' vs 'none'
RBMS2 DOWN in '24 hour, IL28B' vs 'none'
MXRA7 DOWN in '24 hour, IL28B' vs 'none'
FSTL1 DOWN in '24 hour, IL28B' vs 'none'
TGFBR1 DOWN in '24 hour, IL28B' vs 'none'
SCAMP1-AS1 UP in '6 hour; IFN' vs 'none'
SLC25A36 DOWN in '6 hour; IL28B' vs 'none'
TMEM178B DOWN in '6 hour; IL28B' vs 'none'
TMEM140 UP in '24 hour, IL28B' vs 'none'
RP11-288L9.1 UP in '24 hour, IL28B' vs 'none'
PTPN11 DOWN in '24 hour, IL28B' vs 'none'
TRIM45 DOWN in '24 hour, IL28B' vs 'none'
KLHDC7B UP in '24 hour, IL28B' vs 'none'
NHLRC2 DOWN in '24 hour, IL28B' vs 'none'
MCUR1 DOWN in '24 hour, IL28B' vs 'none'
RAPH1 DOWN in '24 hour, IL28B' vs 'none'
ZDHHC21 DOWN in '24 hour, IL28B' vs 'none'
DDHD2 DOWN in '24 hour, IL28B' vs 'none'
BRI3BP DOWN in '24 hour, IL28B' vs 'none'
TMEM168 DOWN in '24 hour, IL28B' vs 'none'
ARL17A DOWN in '24 hour, IL28B' vs 'none'
ZNF704 DOWN in '24 hour, IL28B' vs 'none'
GLIPR1 DOWN in '6 hour; IL28B' vs 'none'
STRBP DOWN in '24 hour, IL28B' vs 'none'
TMEM158 DOWN in '24 hour, IL28B' vs 'none'
GPATCH11 DOWN in '6 hour; IL28B' vs 'none'
SLC25A36 DOWN in '24 hour, IL28B' vs 'none'
CENPA DOWN in '24 hour, IL28B' vs 'none'
CACNA1A UP in '24 hour, IL28B' vs 'none'
KLHL36 DOWN in '24 hour, IL28B' vs 'none'
GS1-358P8.4 DOWN in '24 hour, IL28B' vs 'none'
AZGP1P1 UP in '24 hour, IL28B' vs 'none'
DENND2D UP in '24 hour, IL28B' vs 'none'
FLG-AS1 DOWN in '24 hour, IL28B' vs 'none'
SERPINB9P1 UP in '24 hour, IL28B' vs 'none'
RP11-111F16.2 DOWN in '24 hour, IL28B' vs 'none'
RP11-479G22.8 DOWN in '24 hour; IFN' vs 'none'
SCAMP1-AS1 UP in '6 hour; IL28B' vs 'none'
P2RX5 DOWN in '24 hour, IL28B' vs 'none'
USP30-AS1 UP in '6 hour; IL28B' vs 'none'
CXorf38 UP in '24 hour, IL28B' vs 'none'
TMEM19 DOWN in '24 hour, IL28B' vs 'none'
C17orf67 UP in '24 hour, IL28B' vs 'none'
REEP1 DOWN in '24 hour, IL28B' vs 'none'
OTUD6B-AS1 DOWN in '6 hour; IL28B' vs 'none'
SERPINB2 DOWN in '24 hour, IL28B' vs 'none'
MIS18A DOWN in '24 hour, IL28B' vs 'none'
TSPYL1 DOWN in '24 hour, IL28B' vs 'none'
SLC25A28 UP in '24 hour, IL28B' vs 'none'
ATP8B1 DOWN in '24 hour, IL28B' vs 'none'
TNFSF13B UP in '24 hour, IL28B' vs 'none'
MSRB3 DOWN in '24 hour, IL28B' vs 'none'
CKAP2 DOWN in '24 hour, IL28B' vs 'none'
CRTAP DOWN in '24 hour, IL28B' vs 'none'
IL22RA1 UP in '24 hour, IL28B' vs 'none'
TOP2A DOWN in '24 hour, IL28B' vs 'none'
MAD2L1 DOWN in '6 hour; IL28B' vs 'none'
CTB-78F1.1 UP in '6 hour; IFN' vs 'none'
NFASC DOWN in '24 hour, IL28B' vs 'none'
RARRES3 UP in '24 hour, IL28B' vs 'none'
CYP7A1 DOWN in '24 hour, IL28B' vs 'none'
CTNNBL1 UP in '24 hour, IL28B' vs 'none'
SERPINB9P1 UP in '6 hour; IFN' vs 'none'
MTHFD2 DOWN in '24 hour, IL28B' vs 'none'
PIK3AP1 UP in '24 hour, IL28B' vs 'none'
SERTAD1 UP in '24 hour, IL28B' vs 'none'
TUBE1 DOWN in '24 hour, IL28B' vs 'none'
KCNMA1 DOWN in '24 hour, IL28B' vs 'none'
RP11-981G7.6 UP in '24 hour, IL28B' vs 'none'
APPL2 DOWN in '24 hour, IL28B' vs 'none'
LINC01192 DOWN in '24 hour, IL28B' vs 'none'
NAP1L1 DOWN in '24 hour, IL28B' vs 'none'
Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III IFNs in intrinsic antiviral immunity is poorly understood. Here we show that HCV infection of primary human hepatocytes results in a robust induction of type III but not type I IFNs, leading to IFN- stimulated gene (ISG) expression. In addition, HCV infection elicits a much broader range of gene expression alterations in addition to ISG induction. The induction of type III IFNs is mediated by IRF3 and NFkB- dependent pathways. Type III IFN, aside from upregulating ISGs with a different kinetic profile, induces a distinct set of genes from type I IFN, potentially explaining the functional difference between the two types of IFNs. Chimpanzees undergoing experimental HCV infection demonstrated a prompt hepatic induction of IL28, associating with ISG upregulation, but minimal type I IFN induction. Analysis of liver biopsies from HCV-infected patients supported a close correlation among hepatic expression of IL28 and ISGs, but not with type I IFNs. Our study demonstrates that HCV infection results predominantly in type III IFN induction in the liver and the level of induction correlates with hepatic ISG levels, thus providing a mechanistic explanation for the association between IL28, ISG levels and recovery from HCV infection as well as a potential therapeutic strategy for the treatment of non-responders. Samples were treated with IFN or IL28b after 6 or 24 hours with three replications
TM2D3 DOWN in '24 hour, IL28B' vs 'none'
ELOVL7 DOWN in '6 hour; IL28B' vs 'none'
RP11-134L10.1 UP in '24 hour, IL28B' vs 'none'
SWAP70 DOWN in '24 hour, IL28B' vs 'none'
RP3-508I15.21 UP in '24 hour, IL28B' vs 'none'
GSTA1 DOWN in '24 hour, IL28B' vs 'none'
PDZD8 DOWN in '24 hour, IL28B' vs 'none'
SRSF8 DOWN in '24 hour, IL28B' vs 'none'
AGPAT6 DOWN in '24 hour, IL28B' vs 'none'
DIAPH3 DOWN in '6 hour; IL28B' vs 'none'
ARHGEF19 UP in '24 hour, IL28B' vs 'none'
LECT2 DOWN in '24 hour, IL28B' vs 'none'
RP5-1092A3.4 DOWN in '24 hour, IL28B' vs 'none'
PRKAR1A DOWN in '24 hour, IL28B' vs 'none'
RAB11A DOWN in '24 hour, IL28B' vs 'none'
RP11-48B3.4 DOWN in '24 hour, IL28B' vs 'none'
GPR125 DOWN in '24 hour, IL28B' vs 'none'
MTURN DOWN in '24 hour, IL28B' vs 'none'
SLC36A4 DOWN in '24 hour, IL28B' vs 'none'
SLC35A3 DOWN in '24 hour, IL28B' vs 'none'
GPATCH11 DOWN in '24 hour, IL28B' vs 'none'
TMEM237 DOWN in '24 hour, IL28B' vs 'none'
SLC16A4 DOWN in '24 hour, IL28B' vs 'none'
C12orf49 DOWN in '24 hour, IL28B' vs 'none'
LTBP1 DOWN in '24 hour, IL28B' vs 'none'
RP11-999E24.3 DOWN in '24 hour, IL28B' vs 'none'
RP11-10L7.1 UP in '24 hour, IL28B' vs 'none'
MFSD4 DOWN in '24 hour, IL28B' vs 'none'
DNAJC6 DOWN in '24 hour, IL28B' vs 'none'
CTD-2521M24.9 UP in '24 hour, IL28B' vs 'none'
PPP2R2C DOWN in '24 hour, IL28B' vs 'none'
YTHDC2 DOWN in '24 hour, IL28B' vs 'none'
RASGEF1B UP in '24 hour, IL28B' vs 'none'
OSBPL10 DOWN in '24 hour, IL28B' vs 'none'
SLC26A2 DOWN in '24 hour, IL28B' vs 'none'
ALDH1A3 DOWN in '24 hour, IL28B' vs 'none'
SEPT8 DOWN in '24 hour, IL28B' vs 'none'
RP11-553A10.1 DOWN in '24 hour, IL28B' vs 'none'
HMGB2 DOWN in '24 hour, IL28B' vs 'none'
LIMA1 DOWN in '24 hour, IL28B' vs 'none'