Pi4k2b DOWN in 'Alkbh1-/-' vs 'wild type'
2210409E12Rik UP in 'Alkbh1-/-' vs 'wild type'
Adamts1 DOWN in 'Alkbh1-/-' vs 'wild type'
Pipox DOWN in 'Alkbh1-/-' vs 'wild type'
Bmp2k DOWN in 'Alkbh1-/-' vs 'wild type'
Serpina3m DOWN in 'Alkbh1-/-' vs 'wild type'
Foxp1 DOWN in 'Alkbh1-/-' vs 'wild type'
Snai3 DOWN in 'Alkbh1-/-' vs 'wild type'
Rapgef3 UP in 'Alkbh1-/-' vs 'wild type'
N6amt2 DOWN in 'Alkbh1-/-' vs 'wild type'
Sema3e DOWN in 'Alkbh1-/-' vs 'wild type'
Gm14820 UP in 'Alkbh1-/-' vs 'wild type'
Cnksr1 DOWN in 'Alkbh1-/-' vs 'wild type'
Dnmt3a DOWN in 'Alkbh1-/-' vs 'wild type'
Slc35g1 UP in 'Alkbh1-/-' vs 'wild type'
Mapk4 DOWN in 'Alkbh1-/-' vs 'wild type'
Soat1 DOWN in 'Alkbh1-/-' vs 'wild type'
Dcaf12l1 UP in 'Alkbh1-/-' vs 'wild type'
Gramd3 DOWN in 'Alkbh1-/-' vs 'wild type'
Cachd1 DOWN in 'Alkbh1-/-' vs 'wild type'
Slc40a1 DOWN in 'Alkbh1-/-' vs 'wild type'
Ddx3y DOWN in 'Alkbh1-/-' vs 'wild type'
Marveld3 DOWN in 'Alkbh1-/-' vs 'wild type'
1700029P11Rik UP in 'Alkbh1-/-' vs 'wild type'
Cldn7 DOWN in 'Alkbh1-/-' vs 'wild type'
Dnmt3b DOWN in 'Alkbh1-/-' vs 'wild type'
Lgals9 DOWN in 'Alkbh1-/-' vs 'wild type'
Zfhx3 DOWN in 'Alkbh1-/-' vs 'wild type'
Sestd1 DOWN in 'Alkbh1-/-' vs 'wild type'
Klhl7 DOWN in 'Alkbh1-/-' vs 'wild type'
Rab11fip5 UP in 'Alkbh1-/-' vs 'wild type'
Serpini1 DOWN in 'Alkbh1-/-' vs 'wild type'
Calml4 DOWN in 'Alkbh1-/-' vs 'wild type'
Rimklb DOWN in 'Alkbh1-/-' vs 'wild type'
Slc5a5 DOWN in 'Alkbh1-/-' vs 'wild type'
Stap2 DOWN in 'Alkbh1-/-' vs 'wild type'
Hmgxb4 DOWN in 'Alkbh1-/-' vs 'wild type'
Rabgap1l DOWN in 'Alkbh1-/-' vs 'wild type'
Apobec2 UP in 'Alkbh1-/-' vs 'wild type'
Rspo1 DOWN in 'Alkbh1-/-' vs 'wild type'
Anxa3 DOWN in 'Alkbh1-/-' vs 'wild type'
Tex21 DOWN in 'Alkbh1-/-' vs 'wild type'
Phlda2 DOWN in 'Alkbh1-/-' vs 'wild type'
2310043M15Rik UP in 'Alkbh1-/-' vs 'wild type'
Prss8 DOWN in 'Alkbh1-/-' vs 'wild type'
Hmgn5 DOWN in 'Alkbh1-/-' vs 'wild type'
Trim2 DOWN in 'Alkbh1-/-' vs 'wild type'
C430039J16Rik DOWN in 'Alkbh1-/-' vs 'wild type'
4930519F16Rik UP in 'Alkbh1-/-' vs 'wild type'
Slc7a7 DOWN in 'Alkbh1-/-' vs 'wild type'
Sox11 DOWN in 'Alkbh1-/-' vs 'wild type'
Grb10 DOWN in 'Alkbh1-/-' vs 'wild type'
Sult6b1 UP in 'Alkbh1-/-' vs 'wild type'
Cgrrf1 DOWN in 'Alkbh1-/-' vs 'wild type'
D630039A03Rik UP in 'Alkbh1-/-' vs 'wild type'
Mapk13 DOWN in 'Alkbh1-/-' vs 'wild type'
Igfbp3 DOWN in 'Alkbh1-/-' vs 'wild type'
Crmp1 DOWN in 'Alkbh1-/-' vs 'wild type'
Fosl1 DOWN in 'Alkbh1-/-' vs 'wild type'
Csrnp3 DOWN in 'Alkbh1-/-' vs 'wild type'
Dnajb13 UP in 'Alkbh1-/-' vs 'wild type'
Atp10a DOWN in 'Alkbh1-/-' vs 'wild type'
Plcxd1 DOWN in 'Alkbh1-/-' vs 'wild type'
Elmo1 DOWN in 'Alkbh1-/-' vs 'wild type'
Fam49a DOWN in 'Alkbh1-/-' vs 'wild type'
Zc3hav1 UP in 'Alkbh1-/-' vs 'wild type'
Tmem2 DOWN in 'Alkbh1-/-' vs 'wild type'
Glipr2 DOWN in 'Alkbh1-/-' vs 'wild type'
Pla2g4c UP in 'Alkbh1-/-' vs 'wild type'
2810002D19Rik DOWN in 'Alkbh1-/-' vs 'wild type'
Gm21967 DOWN in 'Alkbh1-/-' vs 'wild type'
Dmrt1 DOWN in 'Alkbh1-/-' vs 'wild type'
2610037D02Rik DOWN in 'Alkbh1-/-' vs 'wild type'
Slc15a2 DOWN in 'Alkbh1-/-' vs 'wild type'
Arhgef16 DOWN in 'Alkbh1-/-' vs 'wild type'
Itpr1 DOWN in 'Alkbh1-/-' vs 'wild type'
Frem2 DOWN in 'Alkbh1-/-' vs 'wild type'
Pcolce2 UP in 'Alkbh1-/-' vs 'wild type'
Eif2s3y DOWN in 'Alkbh1-/-' vs 'wild type'
Mctp2 DOWN in 'Alkbh1-/-' vs 'wild type'
Neurod1 DOWN in 'Alkbh1-/-' vs 'wild type'
Slc38a4 DOWN in 'Alkbh1-/-' vs 'wild type'
Tmem30b DOWN in 'Alkbh1-/-' vs 'wild type'
(Sample) developmental stage/day 0, undifferentiated
Nkx6-3 DOWN in 'Alkbh1-/-' vs 'wild type'
2300002M23Rik UP in 'Alkbh1-/-' vs 'wild type'
9130008F23Rik DOWN in 'Alkbh1-/-' vs 'wild type'
(Factor value) GENOTYPE/wild type genotype
Serpinb6c UP in 'Alkbh1-/-' vs 'wild type'
Cdcp1 DOWN in 'Alkbh1-/-' vs 'wild type'
AI662270 DOWN in 'Alkbh1-/-' vs 'wild type'
Pwwp2b DOWN in 'Alkbh1-/-' vs 'wild type'
Eif4g3 DOWN in 'Alkbh1-/-' vs 'wild type'
Slc13a5 UP in 'Alkbh1-/-' vs 'wild type'
Prom1 DOWN in 'Alkbh1-/-' vs 'wild type'
St6gal1 DOWN in 'Alkbh1-/-' vs 'wild type'
Fancd2os UP in 'Alkbh1-/-' vs 'wild type'
Calcoco2 UP in 'Alkbh1-/-' vs 'wild type'
Kdm5d DOWN in 'Alkbh1-/-' vs 'wild type'
Gm15698 UP in 'Alkbh1-/-' vs 'wild type'
Gm13889 UP in 'Alkbh1-/-' vs 'wild type'
AA986860 DOWN in 'Alkbh1-/-' vs 'wild type'
Lypd6b DOWN in 'Alkbh1-/-' vs 'wild type'
Rhbdf1 DOWN in 'Alkbh1-/-' vs 'wild type'
Lphn2 DOWN in 'Alkbh1-/-' vs 'wild type'
Laptm4b DOWN in 'Alkbh1-/-' vs 'wild type'
A930004D18Rik UP in 'Alkbh1-/-' vs 'wild type'
Enpp2 DOWN in 'Alkbh1-/-' vs 'wild type'
Tspan32 UP in 'Alkbh1-/-' vs 'wild type'
Crlf1 DOWN in 'Alkbh1-/-' vs 'wild type'
Zfp647 DOWN in 'Alkbh1-/-' vs 'wild type'
Kcnk1 DOWN in 'Alkbh1-/-' vs 'wild type'
Gm16233 DOWN in 'Alkbh1-/-' vs 'wild type'
Insm1 DOWN in 'Alkbh1-/-' vs 'wild type'
Atp6ap2 UP in 'Alkbh1-/-' vs 'wild type'
Timm8a2 UP in 'Alkbh1-/-' vs 'wild type'
Actn3 DOWN in 'Alkbh1-/-' vs 'wild type'
Alkbh1 DOWN in 'Alkbh1-/-' vs 'wild type'
Pramel6 UP in 'Alkbh1-/-' vs 'wild type'
Enpp3 DOWN in 'Alkbh1-/-' vs 'wild type'
2610528J11Rik DOWN in 'Alkbh1-/-' vs 'wild type'
Gna14 DOWN in 'Alkbh1-/-' vs 'wild type'
Gm11544 UP in 'Alkbh1-/-' vs 'wild type'
Rbm47 DOWN in 'Alkbh1-/-' vs 'wild type'
Ttc21b DOWN in 'Alkbh1-/-' vs 'wild type'
Spta1 DOWN in 'Alkbh1-/-' vs 'wild type'
Prune2 DOWN in 'Alkbh1-/-' vs 'wild type'
St3gal4 UP in 'Alkbh1-/-' vs 'wild type'
Hs6st2 DOWN in 'Alkbh1-/-' vs 'wild type'
Rnf157 DOWN in 'Alkbh1-/-' vs 'wild type'
Tdrd5 DOWN in 'Alkbh1-/-' vs 'wild type'
Mapk12 DOWN in 'Alkbh1-/-' vs 'wild type'
Esrp1 DOWN in 'Alkbh1-/-' vs 'wild type'
Rilpl1 DOWN in 'Alkbh1-/-' vs 'wild type'
Qser1 DOWN in 'Alkbh1-/-' vs 'wild type'
Gadd45g DOWN in 'Alkbh1-/-' vs 'wild type'
Trib2 DOWN in 'Alkbh1-/-' vs 'wild type'
C330007P06Rik UP in 'Alkbh1-/-' vs 'wild type'
S100a13 UP in 'Alkbh1-/-' vs 'wild type'
Dpysl2 DOWN in 'Alkbh1-/-' vs 'wild type'
Serpinb1a UP in 'Alkbh1-/-' vs 'wild type'
Itga1 DOWN in 'Alkbh1-/-' vs 'wild type'
Psors1c2 DOWN in 'Alkbh1-/-' vs 'wild type'
Fam19a4 DOWN in 'Alkbh1-/-' vs 'wild type'
Pdlim7 DOWN in 'Alkbh1-/-' vs 'wild type'
Naprt1 DOWN in 'Alkbh1-/-' vs 'wild type'
Nfatc2ip UP in 'Alkbh1-/-' vs 'wild type'
E130309D14Rik DOWN in 'Alkbh1-/-' vs 'wild type'
Ufsp2 DOWN in 'Alkbh1-/-' vs 'wild type'
Smim3 DOWN in 'Alkbh1-/-' vs 'wild type'
AlkB homolog 1 (ALKBH1) is one of nine members of the AlkB homologs in mammals. Most Alkbh1-deficient mice die during embryonic development, and survivors have severe defects in tissues originating from the ectodermal lineage. We hypothesized the phenotype to rely upon aberrant epigenetic regulation and provided evidence for ALKBH1 to be a histone H2A demethylase. We used a whole genome expression microarray to detail differentially expressed genes in embryonic stem cells lacking the Alkbh1 gene and identified distinct classes of up- and down-regulated genes during this process. Wild type and Alkbh-/- embryonic stem cells were established to identify differentially expressed genes at day 0, undifferentiated cells. We sought to obtain a subset of genes possibly explaining the observed phenotype. Total RNA was extracted and hybridized on Affymetrix GeneChips. 3 parallels were analyzed from each of the two genotypes.
Cdc42ep3 UP in 'Alkbh1-/-' vs 'wild type'
E130012A19Rik UP in 'Alkbh1-/-' vs 'wild type'
Fam84b DOWN in 'Alkbh1-/-' vs 'wild type'
Hspb11 DOWN in 'Alkbh1-/-' vs 'wild type'
Mfap5 DOWN in 'Alkbh1-/-' vs 'wild type'
Krt18 DOWN in 'Alkbh1-/-' vs 'wild type'
Ppp1r14d UP in 'Alkbh1-/-' vs 'wild type'
Nr6a1 DOWN in 'Alkbh1-/-' vs 'wild type'
Plac8 DOWN in 'Alkbh1-/-' vs 'wild type'
Ripk4 DOWN in 'Alkbh1-/-' vs 'wild type'
Sepp1 DOWN in 'Alkbh1-/-' vs 'wild type'
Pramel7 UP in 'Alkbh1-/-' vs 'wild type'
Ap1m2 DOWN in 'Alkbh1-/-' vs 'wild type'
Marveld2 DOWN in 'Alkbh1-/-' vs 'wild type'
Ccdc91 DOWN in 'Alkbh1-/-' vs 'wild type'
Cd276 DOWN in 'Alkbh1-/-' vs 'wild type'
Tmem54 DOWN in 'Alkbh1-/-' vs 'wild type'
Mfap3l DOWN in 'Alkbh1-/-' vs 'wild type'
Wnt5a DOWN in 'Alkbh1-/-' vs 'wild type'
Tmem108 UP in 'Alkbh1-/-' vs 'wild type'
Tnfsf13os UP in 'Alkbh1-/-' vs 'wild type'
Slc38a5 UP in 'Alkbh1-/-' vs 'wild type'
Bspry DOWN in 'Alkbh1-/-' vs 'wild type'
Sorbs2 DOWN in 'Alkbh1-/-' vs 'wild type'
Galnt3 DOWN in 'Alkbh1-/-' vs 'wild type'
2410137M14Rik UP in 'Alkbh1-/-' vs 'wild type'
Nrsn1 DOWN in 'Alkbh1-/-' vs 'wild type'
Hook1 DOWN in 'Alkbh1-/-' vs 'wild type'
Lemd1 DOWN in 'Alkbh1-/-' vs 'wild type'
Pla2g16 UP in 'Alkbh1-/-' vs 'wild type'
1700019A02Rik DOWN in 'Alkbh1-/-' vs 'wild type'
Arrb1 DOWN in 'Alkbh1-/-' vs 'wild type'
C1galt1c1 UP in 'Alkbh1-/-' vs 'wild type'
Col1a1 DOWN in 'Alkbh1-/-' vs 'wild type'
Igf2bp2 UP in 'Alkbh1-/-' vs 'wild type'
3110045C21Rik UP in 'Alkbh1-/-' vs 'wild type'
Klhl5 DOWN in 'Alkbh1-/-' vs 'wild type'
Igsf9 DOWN in 'Alkbh1-/-' vs 'wild type'
Fgfbp1 DOWN in 'Alkbh1-/-' vs 'wild type'
Fndc3c1 DOWN in 'Alkbh1-/-' vs 'wild type'
Dppa3 DOWN in 'Alkbh1-/-' vs 'wild type'
A830080D01Rik UP in 'Alkbh1-/-' vs 'wild type'
Inhba DOWN in 'Alkbh1-/-' vs 'wild type'
Ppp2r2c UP in 'Alkbh1-/-' vs 'wild type'
Ceacam20 UP in 'Alkbh1-/-' vs 'wild type'
Cldn6 DOWN in 'Alkbh1-/-' vs 'wild type'
BC021614 UP in 'Alkbh1-/-' vs 'wild type'
Hormad2 UP in 'Alkbh1-/-' vs 'wild type'
Tmem87a UP in 'Alkbh1-/-' vs 'wild type'
Dclk1 DOWN in 'Alkbh1-/-' vs 'wild type'
Fam183b UP in 'Alkbh1-/-' vs 'wild type'