1700019G17Rik UP in '6 week' vs '0 week'
1500009L16Rik UP in '6 week' vs '0 week'
2810417H13Rik UP in '6 week' vs '0 week'
2210407C18Rik UP in '6 week' vs '0 week'
2210407C18Rik UP in '4 week' vs '0 week'
1100001G20Rik UP in '6 week' vs '0 week'
5330417C22Rik DOWN in '6 week' vs '0 week'
5330417C22Rik DOWN in '4 week' vs '0 week'
A430093F15Rik UP in '6 week' vs '0 week'
4632427E13Rik DOWN in '6 week' vs '0 week'
0610005C13Rik DOWN in '4 week' vs '0 week'
(Sample) disease/T cell transfer-induced colitis
2310034C09Rik UP in '4 week' vs '0 week'
Temporal geneome profiling of T cell transfer colitis model T cells critically regulate clinical inflammatory bowel diseases and T cell dependent experimental colitis models have gained prominent favor as useful models to identify potential pathogenic mechanisms. The naÃÂ¯ve CD4+CD45Rbhigh cell transfer model into recombinase activating gene-1 deficient (RAG-/-) mice induces both colitis and small bowel inflammation reflecting Crohn's disease with unclear pathogenic mechanisms. Given the pathological similarities between the T cell transfer model of colitis and clinical disease, we sought to identify changes in whole genome expression profiles over time during the delelopment of colitis. Male RAG-1-/- C57BL/6 mice were injected with a half million CD4+CD45RBhigh T cells from healthy wild type C57BL/6 male mice. The colon tissue from individual cohorts were collected at weeks 0, 2, 4 and 6. Total RNA were extracted from the colon tissue and detected by Affymetrix GeneChip Mouse Genome 430 2.0 Array.
4632434I11Rik UP in '4 week' vs '0 week'
2810417H13Rik UP in '4 week' vs '0 week'
E130012A19Rik DOWN in '2 week' vs '0 week'