GRAP2 DOWN in 'acute rotavirus infection' vs 'normal'
CSTB DOWN in 'rotavirus infection convalescence phase' vs 'normal'
STK17B UP in 'acute rotavirus infection' vs 'normal'
SAR1A UP in 'acute rotavirus infection' vs 'normal'
IGLV1-40 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
KLF6 UP in 'rotavirus infection convalescence phase' vs 'normal'
PMAIP1 UP in 'rotavirus infection convalescence phase' vs 'normal'
GADD45B UP in 'acute rotavirus infection' vs 'normal'
PNISR DOWN in 'acute rotavirus infection' vs 'normal'
CD24 DOWN in 'acute rotavirus infection' vs 'normal'
CCR2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
NR4A1 UP in 'acute rotavirus infection' vs 'normal'
RNF10 UP in 'rotavirus infection convalescence phase' vs 'normal'
FYB DOWN in 'acute rotavirus infection' vs 'normal'
ESYT1 DOWN in 'acute rotavirus infection' vs 'normal'
LZTS3 UP in 'rotavirus infection convalescence phase' vs 'normal'
IFI44 UP in 'acute rotavirus infection' vs 'normal'
(Factor value) DISEASE/acute rotavirus infection
OASL UP in 'acute rotavirus infection' vs 'normal'
CXCL8 UP in 'rotavirus infection convalescence phase' vs 'normal'
GTF2H5 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IL1B UP in 'acute rotavirus infection' vs 'normal'
NFKB2 UP in 'rotavirus infection convalescence phase' vs 'normal'
NR4A1 UP in 'rotavirus infection convalescence phase' vs 'normal'
BTG3 UP in 'acute rotavirus infection' vs 'normal'
TNFAIP3 UP in 'rotavirus infection convalescence phase' vs 'normal'
PCNA DOWN in 'rotavirus infection convalescence phase' vs 'normal'
Rotavirus infection is the single most important cause of severe diarrhea in young children worldwide. We used Affymetrix Human U95Av2 high density oligonucleotide arrays to compare gene expression profiles in peripheral blood mononuclear cells (PBMC) of 10 children with acute rotavirus diarrhea and 8 age-matched healthy children. We also examined patterns of gene expression in 5 convalescent-phase PBMC samples from rotavirus patients. For data analysis, we imported .cel files generated by Affymetrix MAS5.0 into Genetraffic 3.1 software (Iobion) and performed robust multi-chip analysis. We considered a gene in patients differentially expressed if its level of expression was at least 1.5-fold higher or lower than the baseline (arithmetic mean) of the corresponding gene in 8 controls and if its pattern of elevated or repressed expression was observed in at least 7 of the 10 patients. Using these criteria, we identified ~1% up- and ~2% down-regulated genes in acute-phase PBMC of patients. Up-regulated genes included those involved in the differentiation, maturation, activation, and survival of B cells, as well as an array of genes with function in inflammatory and antiviral activities. We observed a pattern of repressed expression of a number of genes involved in the various stages of T-cell development and activation. On the basis of these results, we conclude that rotavirus infection induces robust inflammatory response and B-cell activation but represses T-cell response.
POP5 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
DUSP5 UP in 'acute rotavirus infection' vs 'normal'
(Factor value) DISEASE/rotavirus infection convalescence phase
ETFA DOWN in 'rotavirus infection convalescence phase' vs 'normal'
SAR1A UP in 'rotavirus infection convalescence phase' vs 'normal'
PTPRE UP in 'rotavirus infection convalescence phase' vs 'normal'
HNRNPA0 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CXCL8 UP in 'acute rotavirus infection' vs 'normal'
UCP2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CDC42 UP in 'rotavirus infection convalescence phase' vs 'normal'
EBNA1BP2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
LUC7L3 DOWN in 'acute rotavirus infection' vs 'normal'
LTB DOWN in 'acute rotavirus infection' vs 'normal'
PPM1A UP in 'rotavirus infection convalescence phase' vs 'normal'
LEF1 DOWN in 'acute rotavirus infection' vs 'normal'
CDKN1A UP in 'acute rotavirus infection' vs 'normal'
GABARAPL1 UP in 'rotavirus infection convalescence phase' vs 'normal'
ARID5A UP in 'rotavirus infection convalescence phase' vs 'normal'
Analysis of 'acute rotavirus infection' vs 'normal'
UBE2J1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CD69 UP in 'acute rotavirus infection' vs 'normal'
HSF2 UP in 'rotavirus infection convalescence phase' vs 'normal'
IL27RA DOWN in 'acute rotavirus infection' vs 'normal'
CFDP1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
ST6GAL1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
UBAP2L UP in 'rotavirus infection convalescence phase' vs 'normal'
NFKBIA UP in 'rotavirus infection convalescence phase' vs 'normal'
NFIL3 UP in 'acute rotavirus infection' vs 'normal'
MTSS1 DOWN in 'acute rotavirus infection' vs 'normal'
FCER1A DOWN in 'acute rotavirus infection' vs 'normal'
DUSP2 UP in 'rotavirus infection convalescence phase' vs 'normal'
IL27RA DOWN in 'rotavirus infection convalescence phase' vs 'normal'
H3F3B UP in 'rotavirus infection convalescence phase' vs 'normal'
SLC2A3 UP in 'rotavirus infection convalescence phase' vs 'normal'
ICAM2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
PER1 UP in 'rotavirus infection convalescence phase' vs 'normal'
RGS1 UP in 'rotavirus infection convalescence phase' vs 'normal'
BCL6 UP in 'rotavirus infection convalescence phase' vs 'normal'
PHLDA2 UP in 'acute rotavirus infection' vs 'normal'
DDIT3 UP in 'acute rotavirus infection' vs 'normal'
IL1B UP in 'rotavirus infection convalescence phase' vs 'normal'
BST2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
DDIT4 UP in 'acute rotavirus infection' vs 'normal'
TCL1A DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IL16 DOWN in 'acute rotavirus infection' vs 'normal'
KRAS UP in 'rotavirus infection convalescence phase' vs 'normal'
PPBP DOWN in 'acute rotavirus infection' vs 'normal'
TALDO1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
RAB21 UP in 'rotavirus infection convalescence phase' vs 'normal'
(Sample) disease/acute rotavirus infection
CD24 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IGHM DOWN in 'rotavirus infection convalescence phase' vs 'normal'
TMED10 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
Analysis of 'rotavirus infection convalescence phase' vs 'normal'
TRAF3IP3 DOWN in 'acute rotavirus infection' vs 'normal'
FAIM3 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
ZNF91 DOWN in 'acute rotavirus infection' vs 'normal'
RALBP1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
LRRN3 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IFITM2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
RGS1 UP in 'acute rotavirus infection' vs 'normal'
LRRN3 DOWN in 'acute rotavirus infection' vs 'normal'
KHNYN UP in 'rotavirus infection convalescence phase' vs 'normal'
NR4A2 UP in 'acute rotavirus infection' vs 'normal'
SPARC DOWN in 'acute rotavirus infection' vs 'normal'
(Sample) disease/rotavirus infection convalescence phase
IDS UP in 'rotavirus infection convalescence phase' vs 'normal'
SLC2A3 UP in 'acute rotavirus infection' vs 'normal'
KLF9 UP in 'rotavirus infection convalescence phase' vs 'normal'
SETX DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CLNS1A DOWN in 'rotavirus infection convalescence phase' vs 'normal'
UBE2L6 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
TRAC DOWN in 'acute rotavirus infection' vs 'normal'
BCL2L11 UP in 'acute rotavirus infection' vs 'normal'
RSRP1 DOWN in 'acute rotavirus infection' vs 'normal'
BCL2A1 UP in 'acute rotavirus infection' vs 'normal'
DUSP4 UP in 'rotavirus infection convalescence phase' vs 'normal'
CNPY2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IL6 UP in 'acute rotavirus infection' vs 'normal'
ESYT1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IL7R DOWN in 'acute rotavirus infection' vs 'normal'
SEPT6 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
ANXA6 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IL16 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CORO1A DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IL1RN UP in 'acute rotavirus infection' vs 'normal'
RBL2 DOWN in 'acute rotavirus infection' vs 'normal'
NRGN DOWN in 'acute rotavirus infection' vs 'normal'
RGS19 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
FAIM3 DOWN in 'acute rotavirus infection' vs 'normal'
TIPARP UP in 'acute rotavirus infection' vs 'normal'
DUSP8 UP in 'rotavirus infection convalescence phase' vs 'normal'
CX3CR1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CD83 UP in 'acute rotavirus infection' vs 'normal'
PSMB9 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
G0S2 UP in 'acute rotavirus infection' vs 'normal'
ERF UP in 'rotavirus infection convalescence phase' vs 'normal'
UBE2J1 UP in 'acute rotavirus infection' vs 'normal'
DDX17 DOWN in 'acute rotavirus infection' vs 'normal'
SETX DOWN in 'acute rotavirus infection' vs 'normal'
(Sample) cell type/peripheral blood mononuclear cell
MAFF UP in 'rotavirus infection convalescence phase' vs 'normal'
NFKBIA UP in 'acute rotavirus infection' vs 'normal'
CCT5 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
FTO DOWN in 'rotavirus infection convalescence phase' vs 'normal'
VCL DOWN in 'acute rotavirus infection' vs 'normal'
SELL DOWN in 'rotavirus infection convalescence phase' vs 'normal'
ATP5J2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
RALBP1 DOWN in 'acute rotavirus infection' vs 'normal'
DYNLL1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CHD1 UP in 'rotavirus infection convalescence phase' vs 'normal'
PCMT1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
BCL2L11 UP in 'rotavirus infection convalescence phase' vs 'normal'
CD83 UP in 'rotavirus infection convalescence phase' vs 'normal'
PPP1R15A UP in 'acute rotavirus infection' vs 'normal'
ADM UP in 'acute rotavirus infection' vs 'normal'
IFI27 UP in 'acute rotavirus infection' vs 'normal'
G0S2 UP in 'rotavirus infection convalescence phase' vs 'normal'
SRSF11 UP in 'rotavirus infection convalescence phase' vs 'normal'
F13A1 DOWN in 'acute rotavirus infection' vs 'normal'
PDHB DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IER3 UP in 'rotavirus infection convalescence phase' vs 'normal'
BTG3 UP in 'rotavirus infection convalescence phase' vs 'normal'
NECAP1 UP in 'rotavirus infection convalescence phase' vs 'normal'
SLC25A36 UP in 'rotavirus infection convalescence phase' vs 'normal'
TSC22D3 UP in 'rotavirus infection convalescence phase' vs 'normal'
KLF10 UP in 'acute rotavirus infection' vs 'normal'
MAFF UP in 'acute rotavirus infection' vs 'normal'
PHF1 UP in 'rotavirus infection convalescence phase' vs 'normal'
CD79B DOWN in 'rotavirus infection convalescence phase' vs 'normal'
PMAIP1 UP in 'acute rotavirus infection' vs 'normal'
TSPYL2 UP in 'rotavirus infection convalescence phase' vs 'normal'
YES1 UP in 'rotavirus infection convalescence phase' vs 'normal'
STK17B UP in 'rotavirus infection convalescence phase' vs 'normal'
MXD1 UP in 'acute rotavirus infection' vs 'normal'
PLAUR UP in 'acute rotavirus infection' vs 'normal'
BCL11A DOWN in 'rotavirus infection convalescence phase' vs 'normal'
SCP2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
NR4A2 UP in 'rotavirus infection convalescence phase' vs 'normal'
MAPRE2 DOWN in 'acute rotavirus infection' vs 'normal'
RFPL3S UP in 'rotavirus infection convalescence phase' vs 'normal'
FAM65B DOWN in 'rotavirus infection convalescence phase' vs 'normal'
PPP1R15A UP in 'rotavirus infection convalescence phase' vs 'normal'
ACOT13 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
IDI1 UP in 'rotavirus infection convalescence phase' vs 'normal'
FAM65B DOWN in 'acute rotavirus infection' vs 'normal'
CREB1 DOWN in 'acute rotavirus infection' vs 'normal'
MNDA DOWN in 'rotavirus infection convalescence phase' vs 'normal'
GNG11 DOWN in 'acute rotavirus infection' vs 'normal'
HIF1A UP in 'rotavirus infection convalescence phase' vs 'normal'
DUSP4 UP in 'acute rotavirus infection' vs 'normal'
ATF3 UP in 'acute rotavirus infection' vs 'normal'
CD53 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
EIF1 UP in 'rotavirus infection convalescence phase' vs 'normal'
PRDX2 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
RNF103 UP in 'rotavirus infection convalescence phase' vs 'normal'
DUSP2 UP in 'acute rotavirus infection' vs 'normal'
METTL7A DOWN in 'rotavirus infection convalescence phase' vs 'normal'
SERPINB2 UP in 'rotavirus infection convalescence phase' vs 'normal'
ARPC1B DOWN in 'rotavirus infection convalescence phase' vs 'normal'
CD52 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
TRIM14 DOWN in 'rotavirus infection convalescence phase' vs 'normal'
TCL1A DOWN in 'acute rotavirus infection' vs 'normal'
UBE2D3 UP in 'rotavirus infection convalescence phase' vs 'normal'
BCL11A DOWN in 'acute rotavirus infection' vs 'normal'
HSPA5 UP in 'acute rotavirus infection' vs 'normal'
GPRASP1 UP in 'rotavirus infection convalescence phase' vs 'normal'
CCR7 DOWN in 'acute rotavirus infection' vs 'normal'
SON UP in 'rotavirus infection convalescence phase' vs 'normal'
CD69 UP in 'rotavirus infection convalescence phase' vs 'normal'
CXCL2 UP in 'acute rotavirus infection' vs 'normal'
OAS1 DOWN in 'rotavirus infection convalescence phase' vs 'normal'