Slc13a2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.01324871500508
p value: 0.00476598135465834
refers to: Slc13a2
refers to: 10388834
t statistic: 5.81742675201889

Gm22717 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2788372904232
p value: 0.00133299673202003
refers to: Gm22717
refers to: 10587776
t statistic: -7.67088203794312

Gm4956
type: EnsemblDatabaseReference

G0s2
type: EnsemblDatabaseReference

Cidec UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.22407912295645
p value: 6.18364141139997E-5
refers to: Cidec
refers to: 10546929
t statistic: 14.0017021900679

Atp6v0d2
type: EnsemblDatabaseReference

Atp6v0d2
type: EnsemblDatabaseReference

Tubb2a
type: EnsemblDatabaseReference

Orm3
type: EnsemblDatabaseReference

10546929
type: EFO_0005072
part of: A-AFFY-130

Tubb2a
type: EnsemblDatabaseReference

Orm3
type: EnsemblDatabaseReference

Aldoc
type: EnsemblDatabaseReference

(Assay) GSM637441
type: Assay
has participant: A-AFFY-130

10429588
type: EFO_0005072
part of: A-AFFY-130

Car14 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4339509183425
p value: 3.87527366690802E-5
refers to: 10500283
refers to: Car14
t statistic: 16.0192254994075

10458461
type: EFO_0005072
part of: A-AFFY-130

10454105
type: EFO_0005072
part of: A-AFFY-130

Hdac3
type: EnsemblDatabaseReference

Slc16a5
type: EnsemblDatabaseReference

Hsd3b5 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17627680079941
p value: 0.00285021351910925
refers to: Hsd3b5
refers to: 10500545
t statistic: -6.62092903871221

(Sample) organism part/liver
type: UBERON_0002107
property type: organism part
property value: liver

Hp1bp3
type: EnsemblDatabaseReference

Abcc4
type: EnsemblDatabaseReference

10587639
type: EFO_0005072
part of: A-AFFY-130

Hp1bp3
type: EnsemblDatabaseReference

Nnmt DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.06366822972572
p value: 9.11908323719938E-4
refers to: 10593219
refers to: Nnmt
t statistic: -8.23502928824084

Nox4
type: EnsemblDatabaseReference

9030619P08Rik
type: EnsemblDatabaseReference

10554752
type: EFO_0005072
part of: A-AFFY-130

Nt5e UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.04292742901611
p value: 1.69828984029254E-4
refers to: Nt5e
refers to: 10587639
t statistic: 11.6150776656711

10353450
type: EFO_0005072
part of: A-AFFY-130

Serpina7
type: EnsemblDatabaseReference

Defb1
type: EnsemblDatabaseReference

G6pdx
type: EnsemblDatabaseReference

Cidec
type: EnsemblDatabaseReference

Defb1
type: EnsemblDatabaseReference

4930485B16Rik
type: EnsemblDatabaseReference

Aqp8
type: EnsemblDatabaseReference

10570741
type: EFO_0005072
part of: A-AFFY-130

Serpine2 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08001265153175
p value: 0.00178738807350578
refers to: 10355984
refers to: Serpine2
t statistic: -7.27609726401386

(Assay) GSM637443
type: Assay
has participant: A-AFFY-130

A-AFFY-130
type: EFO_0000269

G6pdx UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.13707628196841
p value: 1.44716001162799E-4
refers to: 10605338
refers to: G6pdx
t statistic: 11.9105268860707

Car14
type: EnsemblDatabaseReference

10557300
type: EFO_0005072
part of: A-AFFY-130

10587776
type: EFO_0005072
part of: A-AFFY-130

10505445
type: EFO_0005072
part of: A-AFFY-130

Hsd3b5
type: EnsemblDatabaseReference

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Abcc4 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12461213812482
p value: 1.78184459382844E-4
refers to: 10422280
refers to: Abcc4
t statistic: 11.4724914588039

(Assay) GSM637436
type: Assay
has participant: A-AFFY-130

Susd4
type: EnsemblDatabaseReference

(Sample) sex/male
type: EFO_0001266
property type: sex
property value: male

Slc13a2
type: EnsemblDatabaseReference

(Assay) GSM637438
type: Assay
has participant: A-AFFY-130

Itch
type: EnsemblDatabaseReference

Itch
type: EnsemblDatabaseReference

Itch DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11108751989898
p value: 0.0415277485801904
refers to: Itch
refers to: 10338948
t statistic: -3.48175731170921

Aqp8 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.29803948031794
p value: 6.88013320889583E-4
refers to: Aqp8
refers to: 10557300
t statistic: 8.80140215135371

Tubb2a UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.00809197587439
p value: 2.89395428804846E-4
refers to: Tubb2a
refers to: 10408610
t statistic: 10.384047386695

(Assay) GSM637440
type: Assay
has participant: A-AFFY-130

Cdkn1a
type: EnsemblDatabaseReference

10352439
type: EFO_0005072
part of: A-AFFY-130

Gm4956 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19744163224216
p value: 5.08481479020244E-4
refers to: Gm4956
refers to: 10353450
t statistic: -9.33721137114191

10511779
type: EFO_0005072
part of: A-AFFY-130

4930485B16Rik UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02165619882584
p value: 0.00624927455616606
refers to: 10371942
refers to: 4930485B16Rik
t statistic: 5.53025455474616

(Factor value) PHENOTYPE/wild type HDAC3
type: EFO_0000001
property type: PHENOTYPE
property value: wild type HDAC3

Gm22717
type: EnsemblDatabaseReference

Dsg1c
type: EnsemblDatabaseReference

Pcp4l1
type: EnsemblDatabaseReference

Nnmt
type: EnsemblDatabaseReference

10360053
type: EFO_0005072
part of: A-AFFY-130

Cabyr
type: EnsemblDatabaseReference

10388834
type: EFO_0005072
part of: A-AFFY-130

Acnat2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.20740469717886
p value: 0.00152533924324219
refers to: Acnat2
refers to: 10512886
t statistic: 7.52082511842026

10361246
type: EFO_0005072
part of: A-AFFY-130

10408610
type: EFO_0005072
part of: A-AFFY-130

Nt5e
type: EnsemblDatabaseReference

Nox4 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.30920275571079
p value: 7.8622378847364E-5
refers to: Nox4
refers to: 10554752
t statistic: -13.2313185043764

10443463
type: EFO_0005072
part of: A-AFFY-130

10379153
type: EFO_0005072
part of: A-AFFY-130

Gm4956
type: EnsemblDatabaseReference

(Factor value) PHENOTYPE/liver-specific depletion of HDAC3
type: EFO_0000001
property type: PHENOTYPE
property value: liver-specific depletion of HDAC3

Serpine2
type: EnsemblDatabaseReference

(Assay) GSM637437
type: Assay
has participant: A-AFFY-130

Aldoc
type: EnsemblDatabaseReference

10355984
type: EFO_0005072
part of: A-AFFY-130

Dsg1c DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10859015440019
p value: 0.00159346558878935
refers to: 10454105
refers to: Dsg1c
t statistic: -7.44420788702382

Acnat2
type: EnsemblDatabaseReference

Hdac3 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.34381113517161
p value: 1.6151801944958E-5
refers to: Hdac3
refers to: 10458461
t statistic: -19.9074154806984

Atp6v0d2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.49387894244459
p value: 0.00171181295586207
refers to: Atp6v0d2
refers to: 10511779
t statistic: 7.34229595890823

Hdac3
type: EnsemblDatabaseReference

Slc16a5
type: EnsemblDatabaseReference

10500545
type: EFO_0005072
part of: A-AFFY-130

10606928
type: EFO_0005072
part of: A-AFFY-130

Abcc4
type: EnsemblDatabaseReference

G0s2
type: EnsemblDatabaseReference

(Sample) genotype/HDAC3 fl/fl
type: EFO_0000001
property type: genotype
property value: HDAC3 fl/fl

10605338
type: EFO_0005072
part of: A-AFFY-130

10454030
type: EFO_0005072
part of: A-AFFY-130

(Assay) GSM637435
type: Assay
has participant: A-AFFY-130

Cabyr DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.46746233570924
p value: 0.0130440707123334
refers to: Cabyr
refers to: 10454030
t statistic: -4.71621326382346

4930485B16Rik
type: EnsemblDatabaseReference

Pcp4l1 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17644430954031
p value: 3.60961861776091E-4
refers to: Pcp4l1
refers to: 10360053
t statistic: -9.95755104430207

(Assay) GSM637442
type: Assay
has participant: A-AFFY-130

10382532
type: EFO_0005072
part of: A-AFFY-130

Car14
type: EnsemblDatabaseReference

10512886
type: EFO_0005072
part of: A-AFFY-130

Hsd3b5
type: EnsemblDatabaseReference

Ssr3
type: EnsemblDatabaseReference

9030619P08Rik UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 2.22886003658783
p value: 4.5526024703196E-5
refers to: 9030619P08Rik
refers to: 10429588
t statistic: 15.1629028397292

Susd4
type: EnsemblDatabaseReference

Ssr3
type: EnsemblDatabaseReference

Nox4
type: EnsemblDatabaseReference

9030619P08Rik
type: EnsemblDatabaseReference

Serpina7
type: EnsemblDatabaseReference

G6pdx
type: EnsemblDatabaseReference

Cidec
type: EnsemblDatabaseReference

Slc16a5 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.45908847312277
p value: 0.00131256420480433
refers to: 10382532
refers to: Slc16a5
t statistic: 7.74455079352787

(Sample) phenotype/wild type HDAC3
type: EFO_0000001
property type: phenotype
property value: wild type HDAC3

Aqp8
type: EnsemblDatabaseReference

Ssr3 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.23772807453562
p value: 6.50195065246332E-4
refers to: Ssr3
refers to: 10344222
t statistic: -8.96457654988646

Cdkn1a UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.81820661046724
p value: 0.00172775622495173
refers to: 10443463
refers to: Cdkn1a
t statistic: 7.31135342841201

10371942
type: EFO_0005072
part of: A-AFFY-130

Susd4 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03230592535952
p value: 8.19088020546863E-4
refers to: Susd4
refers to: 10352439
t statistic: -8.50808824610231

Cdkn1a
type: EnsemblDatabaseReference

(Sample) infect/AAV2/8-Tbg-GFP virus
type: EFO_0000001
property type: infect
property value: AAV2/8-Tbg-GFP virus

Gm22717
type: EnsemblDatabaseReference

Analysis of 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: MicroarrayDifferentialExpressionAnalysis

Serpina7 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08314187128257
p value: 9.04940776084896E-4
refers to: Serpina7
refers to: 10606928
t statistic: 8.25572236252971

Mus musculus
type: OBI_0100026

Nnmt
type: EnsemblDatabaseReference

10339562
type: EFO_0005072
part of: A-AFFY-130

Slc13a2
type: EnsemblDatabaseReference

Hp1bp3 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01427128248079
p value: 0.0404619161299553
refers to: Hp1bp3
refers to: 10339562
t statistic: -3.5099641801499

E-GEOD-25937
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: Liver-specific depletion of HDAC3 leads to liver steatosis (fatty liver), suggesting disregulation of lipid metabolism. This is correlated with changes in lipid metabolic gene expression. Livers depleted of HDAC3 were removed from 12 week old male HDAC3 fl/fl mice (loxP sites flanking exon 4 to 7 of the HDAC3 gene encoding the catalytic domain of HDAC3) one week after the injection of AAV2/8-Tbg-Cre virus. Livers from the HDAC3 fl/fl mice injected with AAV2/8-Tbg-GFP were used as normal controls. mRNA was extracted from 100mg mouse liver samples and hybridized to Affymetrix microarrays. For each group (HDAC3 depleted liver and normal liver), we have 5 samples from different mice.
uses data from: http://identifiers.org/pubmed/21393543
uses data from: http://identifiers.org/pubmed/22474260

(Assay) GSM637439
type: Assay
has participant: A-AFFY-130

(Sample) phenotype/liver-specific depletion of HDAC3
type: EFO_0000001
property type: phenotype
property value: liver-specific depletion of HDAC3

Aldoc DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0920724682426
p value: 7.80712500825092E-5
refers to: Aldoc
refers to: 10379153
t statistic: -13.4427295643905

(Sample) infect/AAV2/8-Tbg-Cre
type: EFO_0000001
property type: infect
property value: AAV2/8-Tbg-Cre

Serpine2
type: EnsemblDatabaseReference

Defb1 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.07302684807644
p value: 6.64179347271676E-4
refers to: Defb1
refers to: 10570741
t statistic: 8.88314711874199

Dsg1c
type: EnsemblDatabaseReference

10338948
type: EFO_0005072
part of: A-AFFY-130

10422280
type: EFO_0005072
part of: A-AFFY-130

Pcp4l1
type: EnsemblDatabaseReference

G0s2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.11825282066589
p value: 0.00715871996708702
refers to: G0s2
refers to: 10361246
t statistic: 5.38152611848191

10500283
type: EFO_0005072
part of: A-AFFY-130

Acnat2
type: EnsemblDatabaseReference

10344222
type: EFO_0005072
part of: A-AFFY-130

10593219
type: EFO_0005072
part of: A-AFFY-130

Cabyr
type: EnsemblDatabaseReference

Orm3 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
type: IncreasedDifferentialExpressionRatio
fold change: 1.27372908548002
p value: 0.0032118549609119
refers to: Orm3
refers to: 10505445
t statistic: 6.45225726557456

(Sample) strain/C57BL/6
type: EFO_0004472
property type: strain
property value: C57BL/6

(Assay) GSM637434
type: Assay
has participant: A-AFFY-130

Nt5e
type: EnsemblDatabaseReference