Slc13a2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Gm22717 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Cidec UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Car14 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Hsd3b5 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Nnmt DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Nt5e UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Serpine2 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
G6pdx UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Abcc4 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Itch DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Aqp8 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Tubb2a UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Gm4956 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
4930485B16Rik UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
(Factor value) PHENOTYPE/wild type HDAC3
Acnat2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Nox4 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
(Factor value) PHENOTYPE/liver-specific depletion of HDAC3
Dsg1c DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Hdac3 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Atp6v0d2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Cabyr DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Pcp4l1 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
9030619P08Rik UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Slc16a5 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Ssr3 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Cdkn1a UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Susd4 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Analysis of 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Serpina7 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Hp1bp3 DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Liver-specific depletion of HDAC3 leads to liver steatosis (fatty liver), suggesting disregulation of lipid metabolism. This is correlated with changes in lipid metabolic gene expression. Livers depleted of HDAC3 were removed from 12 week old male HDAC3 fl/fl mice (loxP sites flanking exon 4 to 7 of the HDAC3 gene encoding the catalytic domain of HDAC3) one week after the injection of AAV2/8-Tbg-Cre virus. Livers from the HDAC3 fl/fl mice injected with AAV2/8-Tbg-GFP were used as normal controls. mRNA was extracted from 100mg mouse liver samples and hybridized to Affymetrix microarrays. For each group (HDAC3 depleted liver and normal liver), we have 5 samples from different mice.
(Sample) phenotype/liver-specific depletion of HDAC3
Aldoc DOWN in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Defb1 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
G0s2 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'
Orm3 UP in 'liver-specific depletion of HDAC3' vs 'wild type HDAC3'