DNAJB1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ISG12(B) UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
STC1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
SDS UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RAB8B UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CDC42EP2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CD40 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PLAC8 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ANGPTL4 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
GRO1 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
PPP1R3C UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TRIB2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MX1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CASP13 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
IFIT5 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL1B UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
GTF2B UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
SLC25A28 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MAFF UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PRICKLE1 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
KLF4 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
LRIG3 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NR4A2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
GRO1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
RASL11B DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
EFNA4 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RND1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CCL2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
RND1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
NFKBIZ UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
CCL5 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
GDAP2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000027513 UP in 'heat inactivated S. aureus' at '6 hour' vs 'control' at '0 hour'
ZNF292 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MAP3K8 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
CXCL3 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MX1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
GRO1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
MAGEF1 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PLAT UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TLR2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
TIFA UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
IFIT2 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
ABHD2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
GRO1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NFKB2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
FBXO33 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
GRO1 UP in 'heat inactivated S. aureus' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000046307 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
TNFSF13B UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RELB UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL18BP UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
LGP2 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
IRF1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
SDS UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ANGPTL4 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CXCL3 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
ENSBTAG00000037799 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
C27H8orf4 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
INOS UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ARRDC2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
PGHS-2 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
RASGEF1A DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL1B UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
IPMK UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL1A UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
USP18 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
RASSF1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MYB UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
LGALS9 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
NFKB1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
TRIM25 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PLIN2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
IFI44 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
ARRDC2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MXI1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
NFKBIE UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
EGR1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
PHLDA1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NFKB1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CIART UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RND1 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
BCL2A1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL1A UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000027513 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
USP18 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MMP9 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
EDN2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
INOS UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CCDC8 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RTP4 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
SAA3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RND1 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
PPAP2B UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ZC3H12A UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
SP140L UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000027513 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
ENSBTAG00000045822 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ZC3H12A UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ENSBTAG00000027513 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
DAPP1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
TIFA UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NAB1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
EIF2AK2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
HCK UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
IRF1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ZC3H12A UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
GRO1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CXCL6 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CXCL10 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ENSBTAG00000037465 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CYP1A1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MAFF UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MX1 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
TNFSF13B UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
FBXO33 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL18BP UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CASP13 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ZC3H12A UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
GSE1 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ITGA2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
S100A9 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
SDS UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
KLK10 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
BIKBA UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
JARID2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
S100A9 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CASP13 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
CCL2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
DEPDC7 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
LPO UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ERO1L UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
RSAD2 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
TIPARP UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
SLCO4A1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
CCL20 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
RSAD2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
IL6 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
BLNK DOWN in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
SMTNL2 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
AGPAT9 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RNF144B UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
STC1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
LTB UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
BMP2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
DNAJB9 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
GRAMD1C UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
HP UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
DNAJB1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
PTGER2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TTC14 DOWN in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
CD40 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CRYM UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
CCL2 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
LAP UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
BCOR DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ADM UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PLAUR UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CYP1A1 UP in 'heat inactivated S. aureus' at '1 hour' vs 'control' at '0 hour'
PLAC8 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
MAGEF1 DOWN in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RCAN1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
TIFA UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
HAS3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
GRK5 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IRF7 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CD83 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
MGC165862 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TNIP1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL18BP UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
NAV3 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
CCL20 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
BCL2A1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PRSS22 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CD14 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
(Factor value) STIMULUS/heat inactivated S. aureus
TNIP1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
PDE4B UP in 'heat inactivated S. aureus' at '1 hour' vs 'control' at '0 hour'
PGHS-2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CXCL8 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ZC3H12A UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ST3GAL6 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
KLK10 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ISG15 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RTP4 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
OVOL1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
BIKBA UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ZC3H12A UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
MAP3K8 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RNF34 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CASP3 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PPP1R3C UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ENSBTAG00000004994 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
BIRC3 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
GBP4 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
PARP8 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RSAD2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IFNAR2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IFIH1 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
IFIH1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CXCL6 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ISG20 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
HP UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
FOSL1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
(Factor value) STIMULUS/heat inactivated E. coli
BACE2 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
NFKB1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RND1 UP in 'heat inactivated S. aureus' at '6 hour' vs 'control' at '0 hour'
STRA6 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000045588 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MMP9 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ARMCX6 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
GBP4 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
NFKBIZ UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
FLIP UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CD14 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CXCL3 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
PTGER2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
DMBT1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PGHS-2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
CXCL6 UP in 'heat inactivated S. aureus' at '6 hour' vs 'control' at '0 hour'
CITED1 DOWN in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
CA4 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MXI1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RCAN1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
TNIP1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TNF UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
SLC6A14 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
PARP14 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
NCOA7 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NFKB2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
DKK1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MUC1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
S100A9 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TRIM25 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PPP1R3C UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ATF3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NFKBIZ UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
DKK1 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RND1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CPNE8 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
BCL2A1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
CCL20 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
CA4 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000037799 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
PLAT UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
BMP2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
AREG UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
SMTNL2 DOWN in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CASP3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PPP1R15A UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
JUN UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
TIEG2 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ETS1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
BIRC3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CCL20 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
KCTD11 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
HIVEP2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CCL5 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
SAA3 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ARRDC2 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
SAA3 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000027513 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PPP1R3C UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PANK1 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CXCL8 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
NR4A2 UP in 'heat inactivated S. aureus' at '1 hour' vs 'control' at '0 hour'
ABHD2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ENSBTAG00000027513 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
DAPP1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ISG12(B) UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
PNPT1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MGC165862 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CXCL3 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
TIPARP UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
LGP2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
SLC6A14 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MXI1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
BIRC3 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RTP4 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MAP3K8 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
CYP1A1 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
SMURF2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ENSBTAG00000027513 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
FZD2 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
L2HGDH UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
AGPAT9 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CXCL3 UP in 'heat inactivated S. aureus' at '6 hour' vs 'control' at '0 hour'
SLC6A14 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
FAM46B DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
Infections of the udder by Escherichia coli very often elicit acute inflammation, while Staphylococcus aureus infections tend to cause mild, subclinical inflammation and persistent infections. The molecular causes undercovering the different disease patterns are poorly understood. We therefore profiled kinetics and extent of global changes in the transcriptome of primary bovine mammary epithelia cells (MEC) subsequent to challenging them with heat inactivated preparations of E. coli or S. aureus pathogens. E. coli swiftly and strongly induced expression of cytokines and bactericidal factors. S. aureus elicited a retarded response and failed to quickly induce expression of bactericidal factors. Both pathogens induced a similar pattern of chemokines for cell recruitment into the udder, but E. coli stimulated their synthesis much faster and stronger. The genes which are exclusively and most strongly up-regulated by E. coli may be clustered into a regulatory network with Tumor necrosis factor alpha (TNF-a) and Interleukin 1 (IL-1) in a central position. In contrast, the expression of these master cytokines is barely regulated by S. aureus. Both pathogens quickly trigger enhanced expression of IL-6. This is still possible after completely abrogating MyD88 dependent TLR-signalling in MEC. The E. coli specific strong induction of TNF-a and IL-1 expression may be causative for the severe inflammatory symptoms of animals suffering from E. coli mastitis while avoidance to quickly induce synthesis of bactericidal factors may support persistent survival of S. aureus within the udder. We suggest that S. aureus subverts MyD88-dependent activation of immune gene expression in MEC. We challenged pbMEC cultures with 1E+07 particles per ml of heat inactivated E. coli strain 1303 for 1, 3, 6, and 24 h and compared their transcriptomes to that of untreated control cells. The experiment included three biological replicas (rep1, rep2, rep3), each from a different cow We challenged pbMEC cultures with 1E+07 particles per ml of heat inactivated S. aureus strain 1027 for 1, 3, 6, and 24 h and compared their transcriptomes to that of untreated control cells. The experiment included three biological replicas (rep1, rep2, rep3), each from a different cow
CD14 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CDKN2AIP UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
KLF4 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
LAP UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ARL4A DOWN in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
CCL5 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
IL1A UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
IFIT2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PRDM1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NLRC5 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
IFI27 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
IFNAR2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PPAP2B UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ANTXR2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ENSBTAG00000045822 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IER3 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
HCK UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TAP1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ATF3 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ENSBTAG00000003743 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
GRO1 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
MMP9 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MAP3K8 UP in 'heat inactivated S. aureus' at '1 hour' vs 'control' at '0 hour'
NFKBIZ UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
TLR2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
TBC1D9 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
KLK10 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
NAV3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
HP UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
CCL5 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
SLCO4A1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ENSBTAG00000005339 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ISG20 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ANKRD1 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PFKFB3 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
NFKBID UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated S. aureus' at '1 hour' vs 'control' at '0 hour'
MAP3K8 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
CYP1A1 UP in 'heat inactivated S. aureus' at '6 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IFIT2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
BCL3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
BIKBA UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
HP UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
FOSL1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
TNFSF13B UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
(Sample) cell type/mammary epithelial cell
ZFP36 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
IL1A UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
DAPP1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
MX2 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
SAA3 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
PLAU UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
USP53 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
LPO UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
SERPINB2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
FAM126B UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
TOP1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
UBA7 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
ENSBTAG00000005339 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
BIKBA UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
INOS UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
RIMKLB DOWN in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
DUSP19 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
PGHS-2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
SPRY2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ENSBTAG00000045588 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
PARP9 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
CLDN3 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CCL2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CYP1A1 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
PNPT1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
DKFZP564O0823 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
USP18 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PDE4B UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ARHGEF2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL6 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CYP1A1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CXCL6 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
RND1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ISG15 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
IL6 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
CXCL6 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PRR15L DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
TMEM140 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
TIPARP UP in 'heat inactivated S. aureus' at '1 hour' vs 'control' at '0 hour'
TLR2 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
ZNFX1 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
SOCS1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CSF3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
TMEM138 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
BIRC3 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
BIKBA UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
VAV3 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CCL20 UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
CTSC UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
PLEKHH3 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CXCL8 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
ISG20 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IRF7 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
NFKBIZ UP in 'heat inactivated S. aureus' at '3 hour' vs 'control' at '0 hour'
CCL20 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
IFI27 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
CXCL3 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
AMPD2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL1B UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
PTGER2 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ZNF181 DOWN in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ZBP1 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
CXCL3 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
BCL2A1 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
BAG4 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
NAMPT UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
RNF19B UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CCL5 UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
KIAA1737 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
FBXW7 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CABLES1 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
SAA3 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
IFIT5 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
GPAM DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
INOS UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ENSBTAG00000046307 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
ETS2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
GTF2B UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
CPOX UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
SLC20A1 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
STX19 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
ERO1L UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
LTB UP in 'heat inactivated E. coli' at '6 hour' vs 'control' at '0 hour'
PLAU UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
Analysis of 'heat inactivated S. aureus' at '6 hour' vs 'control' at '0 hour'
STRA6 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MATN4 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
MYLIP DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
MAP3K8 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
C27H8orf4 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
BMP2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
LRRC8C UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
TLR2 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
CXCL6 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
EIF2AK2 UP in 'heat inactivated S. aureus' at '24 hour' vs 'control' at '0 hour'
ISG15 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
KCNJ10 DOWN in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
FAS UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RGS16 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
RASA2 UP in 'heat inactivated E. coli' at '3 hour' vs 'control' at '0 hour'
IL6 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
ADRB2 UP in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'
MGC165862 UP in 'heat inactivated E. coli' at '24 hour' vs 'control' at '0 hour'
MYC DOWN in 'heat inactivated E. coli' at '1 hour' vs 'control' at '0 hour'