Zcchc3 DOWN in 'MMTV-Myc in E2F1 null background' vs 'MMTV-Myc'
type: DecreasedDifferentialExpressionRatio
fold change: -1.086978195
p value: 1.10388065747596E-4
refers to: 1428402_at
refers to: Zcchc3
t statistic: -6.66868054095773

(Assay) GSM606154
type: Assay
has participant: A-AFFY-36

(Assay) GSM606197
type: Assay
has participant: A-AFFY-36

Analysis of 'MMTV-Myc in E2F1 null background' vs 'MMTV-Myc'
type: MicroarrayDifferentialExpressionAnalysis

(Assay) GSM606175
type: Assay
has participant: A-AFFY-36

(Assay) GSM606151
type: Assay
has participant: A-AFFY-36

(Assay) GSM606193
type: Assay
has participant: A-AFFY-36

(Assay) GSM606148
type: Assay
has participant: A-AFFY-36

(Assay) GSM606176
type: Assay
has participant: A-AFFY-36

(Assay) GSM606217
type: Assay
has participant: A-AFFY-36

(Assay) GSM606219
type: Assay
has participant: A-AFFY-36

Mapre1 DOWN in 'MMTV-Myc in E2F1 null background' vs 'MMTV-Myc'
type: DecreasedDifferentialExpressionRatio
fold change: -1.31925954
p value: 9.929892581597E-7
refers to: Mapre1
refers to: 1428820_at
t statistic: -8.49976696602241

(Assay) GSM606192
type: Assay
has participant: A-AFFY-36

Zcchc3
type: EnsemblDatabaseReference

(Assay) GSM606206
type: Assay
has participant: A-AFFY-36

(Sample) strain/FVB
type: EFO_0000001
property type: strain
property value: FVB

(Sample) genotype/MMTV-Myc in E2F3 heterozygous background
type: EFO_0000001
property type: genotype
property value: MMTV-Myc in E2F3 heterozygous background

(Assay) GSM606205
type: Assay
has participant: A-AFFY-36

(Assay) GSM606180
type: Assay
has participant: A-AFFY-36

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

(Assay) GSM606201
type: Assay
has participant: A-AFFY-36

1428402_at
type: EFO_0005072
part of: A-AFFY-36

(Assay) GSM606178
type: Assay
has participant: A-AFFY-36

(Assay) GSM606210
type: Assay
has participant: A-AFFY-36

(Sample) organism part/mammary gland
type: UBERON_0001911
property type: organism part
property value: mammary gland

1455900_x_at
type: EFO_0005072
part of: A-AFFY-36

(Factor value) GENOTYPE/MMTV-Myc in E2F3 heterozygous background
type: EFO_0000001
property type: GENOTYPE
property value: MMTV-Myc in E2F3 heterozygous background

(Sample) genotype/MMTV-Myc in E2F1 null background
type: EFO_0000001
property type: genotype
property value: MMTV-Myc in E2F1 null background

(Sample) genotype/MMTV-Myc in E2F2 null background
type: EFO_0000001
property type: genotype
property value: MMTV-Myc in E2F2 null background

(Assay) GSM606167
type: Assay
has participant: A-AFFY-36

A-AFFY-36
type: EFO_0000269

(Assay) GSM606156
type: Assay
has participant: A-AFFY-36

(Assay) GSM606216
type: Assay
has participant: A-AFFY-36

(Assay) GSM606163
type: Assay
has participant: A-AFFY-36

(Assay) GSM606188
type: Assay
has participant: A-AFFY-36

(Assay) GSM606170
type: Assay
has participant: A-AFFY-36

(Assay) GSM606191
type: Assay
has participant: A-AFFY-36

(Factor value) GENOTYPE/MMTV-Myc in E2F1 null background
type: EFO_0000001
property type: GENOTYPE
property value: MMTV-Myc in E2F1 null background

(Factor value) GENOTYPE/MMTV-Myc in E2F2 null background
type: EFO_0000001
property type: GENOTYPE
property value: MMTV-Myc in E2F2 null background

(Assay) GSM606184
type: Assay
has participant: A-AFFY-36

(Assay) GSM606159
type: Assay
has participant: A-AFFY-36

(Assay) GSM606158
type: Assay
has participant: A-AFFY-36

(Assay) GSM606221
type: Assay
has participant: A-AFFY-36

(Assay) GSM606171
type: Assay
has participant: A-AFFY-36

Mus musculus
type: OBI_0100026

(Assay) GSM606208
type: Assay
has participant: A-AFFY-36

(Assay) GSM606174
type: Assay
has participant: A-AFFY-36

(Assay) GSM606182
type: Assay
has participant: A-AFFY-36

Tgm2
type: EnsemblDatabaseReference

(Assay) GSM606202
type: Assay
has participant: A-AFFY-36

(Assay) GSM606169
type: Assay
has participant: A-AFFY-36

(Assay) GSM606214
type: Assay
has participant: A-AFFY-36

(Assay) GSM606166
type: Assay
has participant: A-AFFY-36

(Assay) GSM606179
type: Assay
has participant: A-AFFY-36

(Assay) GSM606162
type: Assay
has participant: A-AFFY-36

(Assay) GSM606149
type: Assay
has participant: A-AFFY-36

(Assay) GSM606181
type: Assay
has participant: A-AFFY-36

(Sample) genotype/MMTV-Myc
type: EFO_0000001
property type: genotype
property value: MMTV-Myc

(Assay) GSM606218
type: Assay
has participant: A-AFFY-36

(Assay) GSM606177
type: Assay
has participant: A-AFFY-36

(Assay) GSM606200
type: Assay
has participant: A-AFFY-36

E-GEOD-24594
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: Advances in genomic signatures have begun to dissect breast cancer heterogeneity, and application of these signatures will allow the prediction of which pathways are important in tumor development. Here we used genomic signatures to predict involvement of specific E2F transcription factors in Myc-induced tumors. We genetically tested this prediction by interbreeding Myc transgenics with mice lacking various activator E2F alleles. Tumor latency decreased in the E2F1 mutant background and significantly increased in both the E2F2 and E2F3 mutants. Investigating the mechanism behind these changes revealed a reduction in apoptosis in the E2F1 knockout strain. E2F2 and E2F3 mutant backgrounds alleviated Myc effects on the mammary gland, reducing the susceptible tumor target population. Gene expression data from tumors revealed that the E2F2 knockout background resulted in fewer tumors with EMT, corresponding with a reduction in probability of Ras activation. In human breast cancer we found that a low probability of E2F2 pathway activation was associated with increased relapse-free survival time. Together these data illustrate the predictive utility of genomic signatures in deciphering the heterogeneity within breast cancer and illustrate the unique genetic requirements for individual E2Fs in mediating tumorigenesis in both mouse models and human breast cancer. MMTV-Myc tumors were generated in an E2F wild-type, E2F1 null, E2F2 null and E2F3 heterozygous background. When the primary tumor reached the endpoint, the tumors were flash frozen. 20 tumors from each genotype were selected for microarray analysis.
uses data from: http://identifiers.org/pubmed/21245101

(Assay) GSM606213
type: Assay
has participant: A-AFFY-36

(Factor value) GENOTYPE/MMTV-Myc
type: EFO_0000001
property type: GENOTYPE
property value: MMTV-Myc

Mapre1
type: EnsemblDatabaseReference

(Assay) GSM606211
type: Assay
has participant: A-AFFY-36

Tgm2 DOWN in 'MMTV-Myc in E2F1 null background' vs 'MMTV-Myc'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03710926999999
p value: 0.0439438547958864
refers to: 1455900_x_at
refers to: Tgm2
t statistic: -4.5983482951348

(Assay) GSM606195
type: Assay
has participant: A-AFFY-36

(Assay) GSM606203
type: Assay
has participant: A-AFFY-36

(Assay) GSM606189
type: Assay
has participant: A-AFFY-36

(Assay) GSM606222
type: Assay
has participant: A-AFFY-36

(Assay) GSM606157
type: Assay
has participant: A-AFFY-36

(Assay) GSM606183
type: Assay
has participant: A-AFFY-36

(Assay) GSM606209
type: Assay
has participant: A-AFFY-36

(Assay) GSM606190
type: Assay
has participant: A-AFFY-36

(Assay) GSM606160
type: Assay
has participant: A-AFFY-36

(Assay) GSM606185
type: Assay
has participant: A-AFFY-36

Tgm2
type: EnsemblDatabaseReference

(Assay) GSM606155
type: Assay
has participant: A-AFFY-36

(Assay) GSM606207
type: Assay
has participant: A-AFFY-36

(Assay) GSM606199
type: Assay
has participant: A-AFFY-36

(Assay) GSM606165
type: Assay
has participant: A-AFFY-36

(Assay) GSM606144
type: Assay
has participant: A-AFFY-36

(Assay) GSM606173
type: Assay
has participant: A-AFFY-36

(Assay) GSM606150
type: Assay
has participant: A-AFFY-36

(Assay) GSM606146
type: Assay
has participant: A-AFFY-36

(Assay) GSM606198
type: Assay
has participant: A-AFFY-36

Zcchc3
type: EnsemblDatabaseReference

(Assay) GSM606164
type: Assay
has participant: A-AFFY-36

(Assay) GSM606172
type: Assay
has participant: A-AFFY-36

(Assay) GSM606215
type: Assay
has participant: A-AFFY-36

(Assay) GSM606186
type: Assay
has participant: A-AFFY-36

(Assay) GSM606196
type: Assay
has participant: A-AFFY-36

(Assay) GSM606161
type: Assay
has participant: A-AFFY-36

1428820_at
type: EFO_0005072
part of: A-AFFY-36

(Assay) GSM606187
type: Assay
has participant: A-AFFY-36

(Assay) GSM606204
type: Assay
has participant: A-AFFY-36

(Assay) GSM606194
type: Assay
has participant: A-AFFY-36

(Assay) GSM606153
type: Assay
has participant: A-AFFY-36

(Assay) GSM606147
type: Assay
has participant: A-AFFY-36

Mapre1
type: EnsemblDatabaseReference

(Assay) GSM606212
type: Assay
has participant: A-AFFY-36

(Assay) GSM606143
type: Assay
has participant: A-AFFY-36

(Assay) GSM606168
type: Assay
has participant: A-AFFY-36

(Assay) GSM606220
type: Assay
has participant: A-AFFY-36

(Assay) GSM606145
type: Assay
has participant: A-AFFY-36

(Sample) disease/breast cancer
type: EFO_0000305
property type: disease
property value: breast cancer

(Assay) GSM606152
type: Assay
has participant: A-AFFY-36