TUBB2A UP in 'parathyroid hormone' vs 'saline'
SMOC2 UP in 'parathyroid hormone' vs 'saline'
TSPAN11 UP in 'parathyroid hormone' vs 'saline'
FAT4 UP in 'parathyroid hormone' vs 'saline'
WNT5A UP in 'parathyroid hormone' vs 'saline'
CXCL14 UP in 'parathyroid hormone' vs 'saline'
NNMT UP in 'parathyroid hormone' vs 'saline'
NR4A2 UP in 'parathyroid hormone' vs 'saline'
ERRFI1 UP in 'parathyroid hormone' vs 'saline'
MATN2 UP in 'parathyroid hormone' vs 'saline'
ENPP2 UP in 'parathyroid hormone' vs 'saline'
SNAI2 UP in 'parathyroid hormone' vs 'saline'
MSX1 UP in 'parathyroid hormone' vs 'saline'
TNFSF11 UP in 'parathyroid hormone' vs 'saline'
ACKR3 UP in 'parathyroid hormone' vs 'saline'
INHBA UP in 'parathyroid hormone' vs 'saline'
CRISPLD2 UP in 'parathyroid hormone' vs 'saline'
SLC2A3 UP in 'parathyroid hormone' vs 'saline'
CD83 UP in 'parathyroid hormone' vs 'saline'
MAFF UP in 'parathyroid hormone' vs 'saline'
(Sample) xenograft/human bone implanted in SCID mice then engrafted with the myeloma cell line, Hg
human bone implanted in SCID mice then engrafted with the myeloma cell line, Hg
CDC42EP5 UP in 'parathyroid hormone' vs 'saline'
CEBPD UP in 'parathyroid hormone' vs 'saline'
(Factor value) COMPOUND/parathyroid hormone 80
DIRAS3 UP in 'parathyroid hormone' vs 'saline'
NR4A3 UP in 'parathyroid hormone' vs 'saline'
MGST1 DOWN in 'parathyroid hormone' vs 'saline'
Analysis of 'parathyroid hormone' vs 'saline'
CH25H UP in 'parathyroid hormone' vs 'saline'
ZNF521 UP in 'parathyroid hormone' vs 'saline'
LAPTM5 DOWN in 'parathyroid hormone' vs 'saline'
FHL2 UP in 'parathyroid hormone' vs 'saline'
PDE7B UP in 'parathyroid hormone' vs 'saline'
ANGPTL2 UP in 'parathyroid hormone' vs 'saline'
SERINC5 UP in 'parathyroid hormone' vs 'saline'
The data present global gene expression profile of whole human bones, implanted in SCID mice (SCID-hu model), then engrafted with the myeloma cell line, Hg, and treated with saline or PTH for 4 weeks. SCID-hu mice were prepared by subcutaneous implantation of human bone in SCID mice. The human myeloma cell line, Hg was injected directly into the implanted bone in SCID-hum mice. Upon establishment of myeloma growth as determined by measurement of circulating human immunoglobulins in SCID-hu mice sera, the mice were treated with saline or intermittent PTH (parathyroid hormone, 80 ug/kg/day) for 4 weeks. At the end of the experiment, the human bones from SCID-hu mice were snap frozen in liquid nitrogen. RNA extracted from these bones was subjected to global gene expression profile using Affymetrix U133-Plus microarray.
COL14A1 UP in 'parathyroid hormone' vs 'saline'
COL8A2 UP in 'parathyroid hormone' vs 'saline'
PTN UP in 'parathyroid hormone' vs 'saline'
SPON1 UP in 'parathyroid hormone' vs 'saline'
CNKSR3 UP in 'parathyroid hormone' vs 'saline'
GAS1 UP in 'parathyroid hormone' vs 'saline'
FRMD6 UP in 'parathyroid hormone' vs 'saline'
SLC30A1 UP in 'parathyroid hormone' vs 'saline'
EHD3 UP in 'parathyroid hormone' vs 'saline'
PDE4D UP in 'parathyroid hormone' vs 'saline'
METRNL UP in 'parathyroid hormone' vs 'saline'
RIN2 UP in 'parathyroid hormone' vs 'saline'
RGS2 UP in 'parathyroid hormone' vs 'saline'