Cidea
type: EnsemblDatabaseReference

1425291_at
type: EFO_0005072
part of: A-AFFY-36

Scgb3a2
type: EnsemblDatabaseReference

1448734_at
type: EFO_0005072
part of: A-AFFY-36

Cdhr1
type: EnsemblDatabaseReference

Adam8
type: EnsemblDatabaseReference

Lrrc46 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13747961835248
p value: 0.0421006069451611
refers to: Lrrc46
refers to: 1424909_at
t statistic: -3.76199985424284

Gabrp DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.04679057121876
p value: 0.010715507595137
refers to: Gabrp
refers to: 1424647_at
t statistic: -5.4937567948913

Ifitm6
type: EnsemblDatabaseReference

Morn3
type: EnsemblDatabaseReference

1425767_a_at
type: EFO_0005072
part of: A-AFFY-36

Slc23a1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.22498993059247
p value: 0.0361378184780344
refers to: Slc23a1
refers to: 1450404_at
t statistic: -4.02732456862935

Ighg2b
type: EnsemblDatabaseReference

St6galnac2
type: EnsemblDatabaseReference

1423719_at
type: EFO_0005072
part of: A-AFFY-36

Tnfrsf11b UP in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2465526298043
p value: 0.00655761144458008
refers to: Tnfrsf11b
refers to: 1449033_at
t statistic: 6.35480731986089

1426174_s_at
type: EFO_0005072
part of: A-AFFY-36

Fam46c DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.06287873226012
p value: 0.0459914706617731
refers to: Fam46c
refers to: 1448021_at
t statistic: -3.55667913612763

Tppp3
type: EnsemblDatabaseReference

1420395_a_at
type: EFO_0005072
part of: A-AFFY-36

1419699_at
type: EFO_0005072
part of: A-AFFY-36

Tekt1
type: EnsemblDatabaseReference

Bpifa2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.63244678905371
p value: 0.0326417333968839
refers to: 1419348_at
refers to: Bpifa2
t statistic: -4.15597855467144

1427626_at
type: EFO_0005072
part of: A-AFFY-36

1422873_at
type: EFO_0005072
part of: A-AFFY-36

1450974_at
type: EFO_0005072
part of: A-AFFY-36

Slc23a1
type: EnsemblDatabaseReference

Scgb3a1
type: EnsemblDatabaseReference

Map3k6 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.24334211080748
p value: 0.0498789155533637
refers to: Map3k6
refers to: 1449901_a_at
t statistic: -3.45221913910968

Aoc1
type: EnsemblDatabaseReference

1422448_at
type: EFO_0005072
part of: A-AFFY-36

Meig1
type: EnsemblDatabaseReference

1450009_at
type: EFO_0005072
part of: A-AFFY-36

Tff2
type: EnsemblDatabaseReference

Slc5a1
type: EnsemblDatabaseReference

Aoc1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.74692906182819
p value: 0.00754725702238711
refers to: Aoc1
refers to: 1424600_at
t statistic: -5.94799427162314

1419057_at
type: EFO_0005072
part of: A-AFFY-36

Mak
type: EnsemblDatabaseReference

1449476_at
type: EFO_0005072
part of: A-AFFY-36

Vpreb3 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.58763628675643
p value: 0.0421006069451611
refers to: 1422921_at
refers to: Vpreb3
t statistic: -3.78247391517783

Analysis of 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: MicroarrayDifferentialExpressionAnalysis

Pklr
type: EnsemblDatabaseReference

Pklr DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.29136421905254
p value: 0.0459914706617731
refers to: Pklr
refers to: 1438711_at
t statistic: -3.57211699773045

Lrrc46
type: EnsemblDatabaseReference

Agr3
type: EnsemblDatabaseReference

1450060_at
type: EFO_0005072
part of: A-AFFY-36

Syt5 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.27990210686625
p value: 0.0279618214013342
refers to: Syt5
refers to: 1422531_at
t statistic: -4.48882456699847

Tctex1d4
type: EnsemblDatabaseReference

1424647_at
type: EFO_0005072
part of: A-AFFY-36

Ifitm6
type: EnsemblDatabaseReference

Cldn10 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.38647378573152
p value: 0.0373452570864494
refers to: 1426147_s_at
refers to: Cldn10
t statistic: -3.97701488654417

1417494_a_at
type: EFO_0005072
part of: A-AFFY-36

Cpn2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11956400614678
p value: 0.0376145186496448
refers to: Cpn2
refers to: 1427459_at
t statistic: -3.90270236079636

1423566_a_at
type: EFO_0005072
part of: A-AFFY-36

Klk11
type: EnsemblDatabaseReference

1425738_at
type: EFO_0005072
part of: A-AFFY-36

Igkv3-12 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.61922468774425
p value: 0.0427638045690597
refers to: Igkv3-12
refers to: 1425738_at
t statistic: -3.73708956543868

Steap4
type: EnsemblDatabaseReference

1455490_at
type: EFO_0005072
part of: A-AFFY-36

Muc5b
type: EnsemblDatabaseReference

Scgb3a1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.75295858774228
p value: 0.0279618214013342
refers to: Scgb3a1
refers to: 1419699_at
t statistic: -4.51454192295491

1500015O10Rik DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.45363835158424
p value: 0.0421006069451611
refers to: 1500015O10Rik
refers to: 1423261_at
t statistic: -3.78706642027978

Kif9
type: EnsemblDatabaseReference

Six4 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3976123088717
p value: 0.0316682568269674
refers to: Six4
refers to: 1425767_a_at
t statistic: -4.31248344545472

Syt5
type: EnsemblDatabaseReference

Tppp3
type: EnsemblDatabaseReference

Pigr
type: EnsemblDatabaseReference

Drc1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.0024622688437
p value: 0.0376145186496448
refers to: 1455279_at
refers to: Drc1
t statistic: -3.94036752996654

Cpn2
type: EnsemblDatabaseReference

Cp DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.29607602631583
p value: 0.0453356689208945
refers to: Cp
refers to: 1417494_a_at
t statistic: -3.69335706805083

1423261_at
type: EFO_0005072
part of: A-AFFY-36

Nme5
type: EnsemblDatabaseReference

Resp18 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.05647040937567
p value: 0.0498789155533637
refers to: Resp18
refers to: 1417988_at
t statistic: -3.46339757213961

Mus musculus
type: OBI_0100026

Sncg
type: EnsemblDatabaseReference

4933434E20Rik
type: EnsemblDatabaseReference

Slc27a2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.37739046720401
p value: 0.0106971468758017
refers to: Slc27a2
refers to: 1416316_at
t statistic: -5.65654804832323

1420569_at
type: EFO_0005072
part of: A-AFFY-36

1422846_at
type: EFO_0005072
part of: A-AFFY-36

1417788_at
type: EFO_0005072
part of: A-AFFY-36

Prg2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.468828197813
p value: 0.0459914706617731
refers to: 1422873_at
refers to: Prg2
t statistic: -3.63532707655947

Reg3g
type: EnsemblDatabaseReference

1434777_at
type: EFO_0005072
part of: A-AFFY-36

Aoc1
type: EnsemblDatabaseReference

1424600_at
type: EFO_0005072
part of: A-AFFY-36

Fank1
type: EnsemblDatabaseReference

Pon1
type: EnsemblDatabaseReference

1449177_at
type: EFO_0005072
part of: A-AFFY-36

Cp DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.48000116191255
p value: 0.0279618214013342
refers to: 1448734_at
refers to: Cp
t statistic: -4.45530327314029

1419431_at
type: EFO_0005072
part of: A-AFFY-36

Slco1a5 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.66158831660345
p value: 0.0125652605503361
refers to: Slco1a5
refers to: 1449203_at
t statistic: -5.24622465274283

Mak DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.48682565185162
p value: 0.0476340897469849
refers to: Mak
refers to: 1422725_at
t statistic: -3.52825476390099

1426147_s_at
type: EFO_0005072
part of: A-AFFY-36

(Factor value) GENOTYPE/wild type HIF2alpha
type: EFO_0000001
property type: GENOTYPE
property value: wild type HIF2alpha

1422727_at
type: EFO_0005072
part of: A-AFFY-36

Iglv1
type: EnsemblDatabaseReference

1424631_a_at
type: EFO_0005072
part of: A-AFFY-36

Rbp2
type: EnsemblDatabaseReference

Ltf
type: EnsemblDatabaseReference

1440865_at
type: EFO_0005072
part of: A-AFFY-36

1418109_at
type: EFO_0005072
part of: A-AFFY-36

1424909_at
type: EFO_0005072
part of: A-AFFY-36

Bpifb1
type: EnsemblDatabaseReference

Steap4
type: EnsemblDatabaseReference

Igha DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08903713727053
p value: 0.0459914706617731
refers to: Igha
refers to: 1425763_x_at
t statistic: -3.65394106395461

1455393_at
type: EFO_0005072
part of: A-AFFY-36

Vpreb3
type: EnsemblDatabaseReference

Chad
type: EnsemblDatabaseReference

Mlf1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.92315531981055
p value: 0.0453020555755683
refers to: 1418589_a_at
refers to: Mlf1
t statistic: -3.70120587963962

(Sample) organism part/lung
type: UBERON_0002048
property type: organism part
property value: lung

Ereg
type: EnsemblDatabaseReference

(Assay) GSM560303
type: Assay
has participant: A-AFFY-36

Igha
type: EnsemblDatabaseReference

Tnfrsf11b
type: EnsemblDatabaseReference

(Assay) GSM560301
type: Assay
has participant: A-AFFY-36

Foxj1
type: EnsemblDatabaseReference

A-AFFY-36
type: EFO_0000269

1425763_x_at
type: EFO_0005072
part of: A-AFFY-36

1432075_a_at
type: EFO_0005072
part of: A-AFFY-36

Igkv3-12
type: EnsemblDatabaseReference

Mycl
type: EnsemblDatabaseReference

4933434E20Rik
type: EnsemblDatabaseReference

Prg2
type: EnsemblDatabaseReference

S100b
type: EnsemblDatabaseReference

1417988_at
type: EFO_0005072
part of: A-AFFY-36

Anxa8
type: EnsemblDatabaseReference

Dnajb13 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19378161843748
p value: 0.0459914706617731
refers to: Dnajb13
refers to: 1431119_at
t statistic: -3.57010038017453

1429907_at
type: EFO_0005072
part of: A-AFFY-36

Ltf DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -5.16483593573278
p value: 0.010715507595137
refers to: 1450009_at
refers to: Ltf
t statistic: -5.54569046229552

Mlf1
type: EnsemblDatabaseReference

Foxj1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.27797259391161
p value: 0.0224320703634686
refers to: Foxj1
refers to: 1425291_at
t statistic: -4.7181479364018

Nme5 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.94288306978821
p value: 0.0326417333968839
refers to: Nme5
refers to: 1422727_at
t statistic: -4.18962921629315

Dnajb13
type: EnsemblDatabaseReference

Cdhr1
type: EnsemblDatabaseReference

(Assay) GSM560309
type: Assay
has participant: A-AFFY-36

Tff2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -3.78492051018074
p value: 0.0219990445969804
refers to: Tff2
refers to: 1422448_at
t statistic: -4.80799470214594

1417956_at
type: EFO_0005072
part of: A-AFFY-36

Slco1a5
type: EnsemblDatabaseReference

Cp
type: EnsemblDatabaseReference

Vpreb3
type: EnsemblDatabaseReference

Calml4
type: EnsemblDatabaseReference

Ereg
type: EnsemblDatabaseReference

1448181_at
type: EFO_0005072
part of: A-AFFY-36

Six4
type: EnsemblDatabaseReference

1500015O10Rik
type: EnsemblDatabaseReference

Slc27a2
type: EnsemblDatabaseReference

Aqp4
type: EnsemblDatabaseReference

(Assay) GSM560296
type: Assay
has participant: A-AFFY-36

1419079_at
type: EFO_0005072
part of: A-AFFY-36

Mycl
type: EnsemblDatabaseReference

Klf15 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.25475959279386
p value: 0.0459914706617731
refers to: 1448181_at
refers to: Klf15
t statistic: -3.57368492864487

Drc1
type: EnsemblDatabaseReference

Timp4 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.34678441165127
p value: 0.0459914706617731
refers to: Timp4
refers to: 1450974_at
t statistic: -3.56204015588429

Slc23a1
type: EnsemblDatabaseReference

Scgb3a1
type: EnsemblDatabaseReference

1427459_at
type: EFO_0005072
part of: A-AFFY-36

Ifitm6 UP in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: IncreasedDifferentialExpressionRatio
fold change: 1.10812000365465
p value: 0.0419263297464225
refers to: Ifitm6
refers to: 1440865_at
t statistic: 3.81236072946834

1422750_a_at
type: EFO_0005072
part of: A-AFFY-36

Tff2
type: EnsemblDatabaseReference

Steap4 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.07300684214306
p value: 0.0498789155533637
refers to: Steap4
refers to: 1460197_a_at
t statistic: -3.46845337968351

Scnn1g
type: EnsemblDatabaseReference

Klf15
type: EnsemblDatabaseReference

Scgb3a2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.42434645348978
p value: 0.0498789155533637
refers to: Scgb3a2
refers to: 1425218_a_at
t statistic: -3.4429966250218

Tppp3 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.80386566048291
p value: 0.0326417333968839
refers to: Tppp3
refers to: 1416713_at
t statistic: -4.1534723647097

1448021_at
type: EFO_0005072
part of: A-AFFY-36

Mak
type: EnsemblDatabaseReference

Agr3
type: EnsemblDatabaseReference

Fbxo36
type: EnsemblDatabaseReference

Resp18
type: EnsemblDatabaseReference

1450404_at
type: EFO_0005072
part of: A-AFFY-36

1417495_x_at
type: EFO_0005072
part of: A-AFFY-36

Kcnmb4
type: EnsemblDatabaseReference

Klk11
type: EnsemblDatabaseReference

Kcnmb4 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.33333122266695
p value: 0.0295367660642548
refers to: 1449471_at
refers to: Kcnmb4
t statistic: -4.40226821491925

Muc5b
type: EnsemblDatabaseReference

1419201_at
type: EFO_0005072
part of: A-AFFY-36

Mycl DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.41403500839097
p value: 0.0326417333968839
refers to: 1434777_at
refers to: Mycl
t statistic: -4.243926957468

Spag6
type: EnsemblDatabaseReference

Calml4 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.57043788374572
p value: 0.0459914706617731
refers to: 1424713_at
refers to: Calml4
t statistic: -3.63758605539057

Ccna1
type: EnsemblDatabaseReference

Timp4
type: EnsemblDatabaseReference

Syt5
type: EnsemblDatabaseReference

Zmynd10
type: EnsemblDatabaseReference

Pigr
type: EnsemblDatabaseReference

Pigr DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.29504058939643
p value: 0.0376145186496448
refers to: Pigr
refers to: 1455490_at
t statistic: -3.96081518589849

1418304_at
type: EFO_0005072
part of: A-AFFY-36

Gabrp
type: EnsemblDatabaseReference

1422531_at
type: EFO_0005072
part of: A-AFFY-36

Nme5
type: EnsemblDatabaseReference

1416316_at
type: EFO_0005072
part of: A-AFFY-36

Ifitm1
type: EnsemblDatabaseReference

Slc5a1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15308807467587
p value: 0.0421006069451611
refers to: 1419057_at
refers to: Slc5a1
t statistic: -3.75346275742006

Sncg
type: EnsemblDatabaseReference

Iglv1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.66272029021581
p value: 0.0476340897469849
refers to: Iglv1
refers to: 1430523_s_at
t statistic: -3.52962163711219

Mok
type: EnsemblDatabaseReference

Tctex1d4 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.62451114668985
p value: 0.0405977884167458
refers to: Tctex1d4
refers to: 1436653_at
t statistic: -3.85525892885673

Drc1
type: EnsemblDatabaseReference

1419383_at
type: EFO_0005072
part of: A-AFFY-36

Cldn10
type: EnsemblDatabaseReference

Zmynd10 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.73240603432455
p value: 0.0459914706617731
refers to: Zmynd10
refers to: 1422750_a_at
t statistic: -3.56374454476249

Cidea
type: EnsemblDatabaseReference

1448872_at
type: EFO_0005072
part of: A-AFFY-36

1424713_at
type: EFO_0005072
part of: A-AFFY-36

(Assay) GSM560298
type: Assay
has participant: A-AFFY-36

Fank1
type: EnsemblDatabaseReference

Fank1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.96350228280857
p value: 0.0459914706617731
refers to: Fank1
refers to: 1419567_at
t statistic: -3.58449330645936

Scnn1g
type: EnsemblDatabaseReference

Bpifb1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -3.84795901357571
p value: 0.0360392691403403
refers to: Bpifb1
refers to: 1423719_at
t statistic: -4.06020943712104

Scgb3a2
type: EnsemblDatabaseReference

1422725_at
type: EFO_0005072
part of: A-AFFY-36

Adam8
type: EnsemblDatabaseReference

(Sample) genotype/floxed HIF2alpha
type: EFO_0000001
property type: genotype
property value: floxed HIF2alpha

1418589_a_at
type: EFO_0005072
part of: A-AFFY-36

1438711_at
type: EFO_0005072
part of: A-AFFY-36

1416713_at
type: EFO_0005072
part of: A-AFFY-36

Ighg2b
type: EnsemblDatabaseReference

(Assay) GSM560300
type: Assay
has participant: A-AFFY-36

Fbxo36
type: EnsemblDatabaseReference

Bpifa2
type: EnsemblDatabaseReference

1436653_at
type: EFO_0005072
part of: A-AFFY-36

(Factor value) GENOTYPE/floxed HIF2alpha
type: EFO_0000001
property type: GENOTYPE
property value: floxed HIF2alpha

E-GEOD-22575
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. The oxygen-sensitive Hypoxia Inducible Factor (HIF) transcriptional regulators HIF-1ÃÂÃÂ± and HIF-2ÃÂÃÂ± are overexpressed in many human NSCLCs, and constitutive HIF-2ÃÂÃÂ± activity can promote murine lung tumor progression, suggesting that HIF proteins may be effective NSCLC therapeutic targets. To investigate the consequences of inhibiting HIF activity in lung cancers, we deleted Hif-1ÃÂÃÂ± or Hif-2ÃÂÃÂ± in an established KrasG12D-driven murine NSCLC model. Deletion of Hif-1ÃÂÃÂ± had no obvious effect on tumor growth, whereas Hif-2ÃÂÃÂ± deletion resulted in an unexpected increase in tumor burden that correlated with reduced expression of the candidate tumor suppressor gene Scgb3a1 (HIN-1). Here, we identify Scgb3a1 as a direct HIF-2ÃÂÃÂ± target gene, and demonstrate that HIF-2ÃÂÃÂ± regulates Scgb3a1 expression and tumor formation in human KrasG12D-driven NSCLC cells. AKT pathway activity, reported to be repressed by Scgb3a1, was enhanced in HIF-2ÃÂÃÂ± deficient human NSCLC cells and xenografts. Finally, a direct correlation between HIF-2ÃÂÃÂ± and SCGB3a1 expression was observed in approximately 70% of human NSCLC samples analyzed. These data suggest that whereas HIF-2ÃÂÃÂ± overexpression can contribute to NSCLC progression, therapeutic inhibition of HIF-2ÃÂÃÂ± below a critical threshold may paradoxically promote tumor growth by reducing expression of tumor suppressor genes, including Scgb3a1. RNA was isolated from tumors of experimental (Hif2alpha deficient) mice and control mice (seven for each group).
uses data from: pubmed

Bpifb1
type: EnsemblDatabaseReference

1429381_x_at
type: EFO_0005072
part of: A-AFFY-36

1455279_at
type: EFO_0005072
part of: A-AFFY-36

Aqp4 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -3.20918967663154
p value: 0.0126234993729831
refers to: Aqp4
refers to: 1434449_at
t statistic: -5.19798123160151

Cp DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.61067360811629
p value: 0.0326417333968839
refers to: Cp
refers to: 1417496_at
t statistic: -4.26459239224126

Tekt1
type: EnsemblDatabaseReference

Chad
type: EnsemblDatabaseReference

Tnfrsf11b
type: EnsemblDatabaseReference

Morn3 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19360142764274
p value: 0.0326417333968839
refers to: Morn3
refers to: 1430970_a_at
t statistic: -4.14049599529611

Klk11 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.04798240878018
p value: 0.041357003081104
refers to: Klk11
refers to: 1419201_at
t statistic: -3.83695563551682

Ccna1
type: EnsemblDatabaseReference

Hsph1
type: EnsemblDatabaseReference

Scnn1g DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.02876810154968
p value: 0.0459914706617731
refers to: Scnn1g
refers to: 1419079_at
t statistic: -3.67794892977015

Muc5b DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.57167405569816
p value: 0.0376145186496448
refers to: Muc5b
refers to: 1427626_at
t statistic: -3.93053456316809

Pigr DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.09384402667534
p value: 0.0240475389280836
refers to: Pigr
refers to: 1450060_at
t statistic: -4.62806639616529

Igkv3-12
type: EnsemblDatabaseReference

Meig1
type: EnsemblDatabaseReference

(Sample) strain/129xC57BL/6
type: EFO_0000601
property type: strain
property value: 129xC57BL/6

Slc5a1
type: EnsemblDatabaseReference

1449033_at
type: EFO_0005072
part of: A-AFFY-36

1422921_at
type: EFO_0005072
part of: A-AFFY-36

Mok
type: EnsemblDatabaseReference

Anxa8
type: EnsemblDatabaseReference

(Assay) GSM560304
type: Assay
has participant: A-AFFY-36

Gspt2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04324300507979
p value: 0.0498789155533637
refers to: 1418109_at
refers to: Gspt2
t statistic: -3.46544550464241

Mlf1
type: EnsemblDatabaseReference

Igha DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.42985119659964
p value: 0.0376145186496448
refers to: Igha
refers to: 1429381_x_at
t statistic: -3.91558270891215

Mok DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.12583642395244
p value: 0.0421006069451611
refers to: Mok
refers to: 1449476_at
t statistic: -3.80116101476642

Spag6 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.47041467739658
p value: 0.0459914706617731
refers to: Spag6
refers to: 1417528_at
t statistic: -3.60951370758421

Lrrc46
type: EnsemblDatabaseReference

1417496_at
type: EFO_0005072
part of: A-AFFY-36

1419305_a_at
type: EFO_0005072
part of: A-AFFY-36

1425221_at
type: EFO_0005072
part of: A-AFFY-36

1439423_x_at
type: EFO_0005072
part of: A-AFFY-36

Tctex1d4
type: EnsemblDatabaseReference

Dnajb13
type: EnsemblDatabaseReference

1419348_at
type: EFO_0005072
part of: A-AFFY-36

Cdhr1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.62037019762593
p value: 0.0295367660642548
refers to: Cdhr1
refers to: 1418304_at
t statistic: -4.38589618015305

Fam46c
type: EnsemblDatabaseReference

1421653_a_at
type: EFO_0005072
part of: A-AFFY-36

1417616_at
type: EFO_0005072
part of: A-AFFY-36

1449471_at
type: EFO_0005072
part of: A-AFFY-36

Map3k6
type: EnsemblDatabaseReference

1449901_a_at
type: EFO_0005072
part of: A-AFFY-36

Bpifa2
type: EnsemblDatabaseReference

1424254_at
type: EFO_0005072
part of: A-AFFY-36

1449203_at
type: EFO_0005072
part of: A-AFFY-36

Ereg UP in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08880764799257
p value: 0.0459914706617731
refers to: Ereg
refers to: 1419431_at
t statistic: 3.59052647797658

S100b DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15358850667463
p value: 0.0498789155533637
refers to: S100b
refers to: 1419383_at
t statistic: -3.44295946277773

Kif9
type: EnsemblDatabaseReference

Slco1a5
type: EnsemblDatabaseReference

1419567_at
type: EFO_0005072
part of: A-AFFY-36

Gspt2
type: EnsemblDatabaseReference

Gabrp DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.16336348817336
p value: 0.0224320703634686
refers to: 1451424_at
refers to: Gabrp
t statistic: -4.74490701050107

Reg3g DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.66534281875949
p value: 0.0498789155533637
refers to: Reg3g
refers to: 1448872_at
t statistic: -3.4744878632241

Kif9 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1648838129487
p value: 0.0421006069451611
refers to: 1420395_a_at
refers to: Kif9
t statistic: -3.75248623973901

Cp DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.39077761643039
p value: 0.0326417333968839
refers to: Cp
refers to: 1417495_x_at
t statistic: -4.15497350456417

(Assay) GSM560307
type: Assay
has participant: A-AFFY-36

Cp
type: EnsemblDatabaseReference

Sncg DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.27772379292087
p value: 0.010715507595137
refers to: Sncg
refers to: 1417788_at
t statistic: -5.42412773595037

(Assay) GSM560302
type: Assay
has participant: A-AFFY-36

Cpn2
type: EnsemblDatabaseReference

Calml4
type: EnsemblDatabaseReference

4933434E20Rik DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04133171091435
p value: 0.0376145186496448
refers to: 4933434E20Rik
refers to: 1429907_at
t statistic: -3.90219702832039

1430523_s_at
type: EFO_0005072
part of: A-AFFY-36

1460197_a_at
type: EFO_0005072
part of: A-AFFY-36

Ccna1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.34014767533899
p value: 0.0369812245285693
refers to: 1449177_at
refers to: Ccna1
t statistic: -3.99294412032854

Hsph1
type: EnsemblDatabaseReference

Six4
type: EnsemblDatabaseReference

(Assay) GSM560299
type: Assay
has participant: A-AFFY-36

1500015O10Rik
type: EnsemblDatabaseReference

Slc27a2
type: EnsemblDatabaseReference

Reg3g
type: EnsemblDatabaseReference

Aqp4
type: EnsemblDatabaseReference

1434449_at
type: EFO_0005072
part of: A-AFFY-36

1425789_s_at
type: EFO_0005072
part of: A-AFFY-36

Pon1
type: EnsemblDatabaseReference

1431119_at
type: EFO_0005072
part of: A-AFFY-36

Hsph1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.32970184848148
p value: 0.0421006069451611
refers to: Hsph1
refers to: 1423566_a_at
t statistic: -3.77166005675907

Anxa8 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.26744844668335
p value: 0.0498789155533637
refers to: Anxa8
refers to: 1425789_s_at
t statistic: -3.45616214425109

(Assay) GSM560305
type: Assay
has participant: A-AFFY-36

Klf15
type: EnsemblDatabaseReference

(Assay) GSM560306
type: Assay
has participant: A-AFFY-36

Meig1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.16356969092119
p value: 0.0279618214013342
refers to: 1423410_at
refers to: Meig1
t statistic: -4.45838579538298

Morn3
type: EnsemblDatabaseReference

Ighg2b DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.73952100162242
p value: 0.0498789155533637
refers to: Ighg2b
refers to: 1426174_s_at
t statistic: -3.44341746268576

Iglv1
type: EnsemblDatabaseReference

1425218_a_at
type: EFO_0005072
part of: A-AFFY-36

Rbp2
type: EnsemblDatabaseReference

Adam8 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.34915056097683
p value: 0.0224320703634686
refers to: Adam8
refers to: 1416871_at
t statistic: -4.69092515327393

1418190_at
type: EFO_0005072
part of: A-AFFY-36

St6galnac2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00930230334269
p value: 0.0491014990250894
refers to: 1417616_at
refers to: St6galnac2
t statistic: -3.5078798148728

St6galnac2
type: EnsemblDatabaseReference

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Resp18
type: EnsemblDatabaseReference

Ltf
type: EnsemblDatabaseReference

Fam46c
type: EnsemblDatabaseReference

1430970_a_at
type: EFO_0005072
part of: A-AFFY-36

Ifitm1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.55074009727387
p value: 0.0360392691403403
refers to: 1424254_at
refers to: Ifitm1
t statistic: -4.05022995770892

(Assay) GSM560308
type: Assay
has participant: A-AFFY-36

Kcnmb4
type: EnsemblDatabaseReference

Map3k6
type: EnsemblDatabaseReference

Tekt1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.86522571393833
p value: 0.0459914706617731
refers to: Tekt1
refers to: 1432075_a_at
t statistic: -3.60618324508858

Igha
type: EnsemblDatabaseReference

Ighg2b DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.2935254506346
p value: 0.0498789155533637
refers to: Ighg2b
refers to: 1424631_a_at
t statistic: -3.44693732337674

Gspt2
type: EnsemblDatabaseReference

Fbxo36 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.28201860321329
p value: 0.00655761144458008
refers to: Fbxo36
refers to: 1419305_a_at
t statistic: -6.15135830737992

Foxj1
type: EnsemblDatabaseReference

Chad DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.0324882827786
p value: 0.0459914706617731
refers to: Chad
refers to: 1420569_at
t statistic: -3.5763525135746

Cidea DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.53040649652267
p value: 0.0360392691403403
refers to: Cidea
refers to: 1417956_at
t statistic: -4.04058910446849

Spag6
type: EnsemblDatabaseReference

Timp4
type: EnsemblDatabaseReference

1421912_at
type: EFO_0005072
part of: A-AFFY-36

1417528_at
type: EFO_0005072
part of: A-AFFY-36

Zmynd10
type: EnsemblDatabaseReference

Agr3 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.41647857227315
p value: 0.0316682568269674
refers to: Agr3
refers to: 1425221_at
t statistic: -4.31671820567851

1416871_at
type: EFO_0005072
part of: A-AFFY-36

Gabrp
type: EnsemblDatabaseReference

Cp DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17960737113625
p value: 0.0498789155533637
refers to: 1455393_at
refers to: Cp
t statistic: -3.43831542637205

Prg2
type: EnsemblDatabaseReference

S100b
type: EnsemblDatabaseReference

Igha DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04370045812967
p value: 0.0498789155533637
refers to: Igha
refers to: 1421653_a_at
t statistic: -3.45421315734049

Pon1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -2.06617712963438
p value: 0.0362196018338915
refers to: Pon1
refers to: 1418190_at
t statistic: -4.01457833635053

Ifitm1
type: EnsemblDatabaseReference

Slc23a1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.39837906724084
p value: 0.0459914706617731
refers to: 1421912_at
refers to: Slc23a1
t statistic: -3.62798756686997

1451424_at
type: EFO_0005072
part of: A-AFFY-36

Bpifb1 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -3.15935181314563
p value: 0.0415360906334994
refers to: Bpifb1
refers to: 1439423_x_at
t statistic: -3.82581142401764

1423410_at
type: EFO_0005072
part of: A-AFFY-36

(Assay) GSM560297
type: Assay
has participant: A-AFFY-36

(Sample) genotype/wild type HIF2alpha
type: EFO_0000001
property type: genotype
property value: wild type HIF2alpha

Rbp2 DOWN in 'floxed HIF2alpha' vs 'wild type HIF2alpha'
type: DecreasedDifferentialExpressionRatio
fold change: -1.53005327898179
p value: 0.0219990445969804
refers to: 1422846_at
refers to: Rbp2
t statistic: -4.79403401338844

Cldn10
type: EnsemblDatabaseReference

Pklr
type: EnsemblDatabaseReference