Fyb UP in 'expressing human TDP-43' vs 'non transgenic'
Cd68 UP in 'expressing human TDP-43' vs 'non transgenic'
Tyrobp UP in 'expressing human TDP-43' vs 'non transgenic'
Dhcr24 DOWN in 'expressing human TDP-43' vs 'non transgenic'
Myo1f UP in 'expressing human TDP-43' vs 'non transgenic'
TDP-43, a DNA/RNA binding protein involved in RNA transcription and splicing has been associated with the pathophysiology of neurodegenerative diseases, including ALS. However, the function of TDP-43 in motor neurons remains undefined. Here, we employ both gain- and loss-of-function approaches to determine roles of TDP-43 in motor neurons. Mice expressing human TDP-43 in neurons exhibited growth retardation and premature death that are characterized by abnormal intranuclear inclusions comprised of TDP-43 and Fused in Sarcoma (FUS), and massive accumulation of mitochondria in TDP-43-negative cytoplasmic inclusions in motor neurons, lack of mitochondria in motor axon terminals and immature neuromuscular junctions. Whereas elevated level of TDP-43 disrupts the normal nuclear distribution of Survival Motor Neuron (SMN)-associated Gemini of coiled bodies (GEMs) in motor neurons, its absence prevents the formation of GEMs in the nuclei of these cells. Moreover, transcriptome-wide deep sequencing analysis revealed that decrease in abundance of neurofilament transcripts contributed to the reduction of caliber of motor axons in TDP-43 mice. In concert, our findings indicate that TDP-43 participates in pathways critical for motor neuron physiology, including those that regulate the normal distributions of SMN-associated GEMs in the nucleus and mitochondria in the cytoplasm. Human TDP-43 coding region were inserted into pThy1.2 expression cassette and subsequently injected into C57BL/6;SJL hybrid mouse embryos to make human TDP-43 transgenic mice
Mmp19 UP in 'expressing human TDP-43' vs 'non transgenic'
Gm13886 UP in 'expressing human TDP-43' vs 'non transgenic'
Mpeg1 UP in 'expressing human TDP-43' vs 'non transgenic'
Analysis of 'expressing human TDP-43' vs 'non transgenic'
Csf3r UP in 'expressing human TDP-43' vs 'non transgenic'
Tgm1 UP in 'expressing human TDP-43' vs 'non transgenic'
Fcer1g UP in 'expressing human TDP-43' vs 'non transgenic'
Cd84 UP in 'expressing human TDP-43' vs 'non transgenic'
Gm15512 DOWN in 'expressing human TDP-43' vs 'non transgenic'
Pla2g3 DOWN in 'expressing human TDP-43' vs 'non transgenic'
Ccl4 UP in 'expressing human TDP-43' vs 'non transgenic'
Ppl UP in 'expressing human TDP-43' vs 'non transgenic'
Comp UP in 'expressing human TDP-43' vs 'non transgenic'
Serpinf2 UP in 'expressing human TDP-43' vs 'non transgenic'
(Factor value) GENOTYPE/expressing human TDP-43
Timp1 UP in 'expressing human TDP-43' vs 'non transgenic'
Prg4 UP in 'expressing human TDP-43' vs 'non transgenic'
Cst7 UP in 'expressing human TDP-43' vs 'non transgenic'
Tmprss5 DOWN in 'expressing human TDP-43' vs 'non transgenic'
C1qc UP in 'expressing human TDP-43' vs 'non transgenic'
Slc11a1 UP in 'expressing human TDP-43' vs 'non transgenic'
Lss DOWN in 'expressing human TDP-43' vs 'non transgenic'
Gpnmb UP in 'expressing human TDP-43' vs 'non transgenic'
Serpina3n UP in 'expressing human TDP-43' vs 'non transgenic'
Ldlr DOWN in 'expressing human TDP-43' vs 'non transgenic'
Mybpc3 DOWN in 'expressing human TDP-43' vs 'non transgenic'
Itgax UP in 'expressing human TDP-43' vs 'non transgenic'
Cxcl10 UP in 'expressing human TDP-43' vs 'non transgenic'
Ch25h UP in 'expressing human TDP-43' vs 'non transgenic'
Atf3 UP in 'expressing human TDP-43' vs 'non transgenic'
AF251705 UP in 'expressing human TDP-43' vs 'non transgenic'
Wisp2 UP in 'expressing human TDP-43' vs 'non transgenic'
Cyba UP in 'expressing human TDP-43' vs 'non transgenic'
Ctss UP in 'expressing human TDP-43' vs 'non transgenic'
(Sample) genotype/expressing human TDP-43
Lyz2 UP in 'expressing human TDP-43' vs 'non transgenic'
Lpl UP in 'expressing human TDP-43' vs 'non transgenic'
Slc15a3 UP in 'expressing human TDP-43' vs 'non transgenic'
C1qa UP in 'expressing human TDP-43' vs 'non transgenic'
Tm7sf2 DOWN in 'expressing human TDP-43' vs 'non transgenic'
Cd109 UP in 'expressing human TDP-43' vs 'non transgenic'
Fmod UP in 'expressing human TDP-43' vs 'non transgenic'
Ptprc UP in 'expressing human TDP-43' vs 'non transgenic'
Fcrls UP in 'expressing human TDP-43' vs 'non transgenic'
Lgals3 UP in 'expressing human TDP-43' vs 'non transgenic'
Ccl3 UP in 'expressing human TDP-43' vs 'non transgenic'
Plek UP in 'expressing human TDP-43' vs 'non transgenic'