Fyb UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.0339708003640247
refers to: Fyb

Cd68 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.6
p value: 8.50875792222702E-6
refers to: Cd68

Tyrobp UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.6
p value: 2.33067146684474E-5
refers to: Tyrobp

Dhcr24 DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.00745165570084608
refers to: Dhcr24

Itgax
type: EnsemblDatabaseReference

Tgm1
type: EnsemblDatabaseReference

Lyz2
type: EnsemblDatabaseReference

(Assay) SRR057596
type: Assay

Myo1f UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.00740085322245762
refers to: Myo1f

C1qc
type: EnsemblDatabaseReference

E-GEOD-22351
type: rnaseq mrna differential
RO_0002162: Mus musculus
description: TDP-43, a DNA/RNA binding protein involved in RNA transcription and splicing has been associated with the pathophysiology of neurodegenerative diseases, including ALS. However, the function of TDP-43 in motor neurons remains undefined. Here, we employ both gain- and loss-of-function approaches to determine roles of TDP-43 in motor neurons. Mice expressing human TDP-43 in neurons exhibited growth retardation and premature death that are characterized by abnormal intranuclear inclusions comprised of TDP-43 and Fused in Sarcoma (FUS), and massive accumulation of mitochondria in TDP-43-negative cytoplasmic inclusions in motor neurons, lack of mitochondria in motor axon terminals and immature neuromuscular junctions. Whereas elevated level of TDP-43 disrupts the normal nuclear distribution of Survival Motor Neuron (SMN)-associated Gemini of coiled bodies (GEMs) in motor neurons, its absence prevents the formation of GEMs in the nuclei of these cells. Moreover, transcriptome-wide deep sequencing analysis revealed that decrease in abundance of neurofilament transcripts contributed to the reduction of caliber of motor axons in TDP-43 mice. In concert, our findings indicate that TDP-43 participates in pathways critical for motor neuron physiology, including those that regulate the normal distributions of SMN-associated GEMs in the nucleus and mitochondria in the cytoplasm. Human TDP-43 coding region were inserted into pThy1.2 expression cassette and subsequently injected into C57BL/6;SJL hybrid mouse embryos to make human TDP-43 transgenic mice
uses data from: http://identifiers.org/pubmed/20736350

Mmp19 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.5
p value: 0.019692348883539
refers to: Mmp19

Ppl
type: EnsemblDatabaseReference

AF251705
type: EnsemblDatabaseReference

Slc11a1
type: EnsemblDatabaseReference

AF251705
type: EnsemblDatabaseReference

Gm13886 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 4.1
p value: 0.00242689269715571
refers to: Gm13886

Mpeg1 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.0
p value: 7.64932921301664E-10
refers to: Mpeg1

Mmp19
type: EnsemblDatabaseReference

Dhcr24
type: EnsemblDatabaseReference

Cd68
type: EnsemblDatabaseReference

Mpeg1
type: EnsemblDatabaseReference

Cd84
type: EnsemblDatabaseReference

Slc15a3
type: EnsemblDatabaseReference

Analysis of 'expressing human TDP-43' vs 'non transgenic'
type: RNASeqDifferentialAnalysis

Csf3r
type: EnsemblDatabaseReference

Serpina3n
type: EnsemblDatabaseReference

Csf3r UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0431803309366114
refers to: Csf3r

Cxcl10
type: EnsemblDatabaseReference

Csf3r
type: EnsemblDatabaseReference

Tgm1 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.1
p value: 0.0278718835184711
refers to: Tgm1

Ldlr
type: EnsemblDatabaseReference

Tyrobp
type: EnsemblDatabaseReference

Fcer1g UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4
p value: 0.019910763437934
refers to: Fcer1g

C1qa
type: EnsemblDatabaseReference

(Sample) genotype/non transgenic
type: EFO_0000001
property type: genotype
property value: non transgenic

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Lgals3
type: EnsemblDatabaseReference

Cd84 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.5
p value: 0.0497413852022122
refers to: Cd84

Pla2g3
type: EnsemblDatabaseReference

Tmprss5
type: EnsemblDatabaseReference

Gm15512 DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -2.7
p value: 7.82299520802438E-5
refers to: Gm15512

Prg4
type: EnsemblDatabaseReference

Cd109
type: EnsemblDatabaseReference

Cyba
type: EnsemblDatabaseReference

Cst7
type: EnsemblDatabaseReference

Gm13886
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/non transgenic
type: EFO_0000001
property type: GENOTYPE
property value: non transgenic

Tm7sf2
type: EnsemblDatabaseReference

Pla2g3 DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -1.6
p value: 0.00148577601680263
refers to: Pla2g3

Wisp2
type: EnsemblDatabaseReference

Wisp2
type: EnsemblDatabaseReference

Lss
type: EnsemblDatabaseReference

Mybpc3
type: EnsemblDatabaseReference

Ctss
type: EnsemblDatabaseReference

Ccl4 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 3.3
p value: 0.00148577601680263
refers to: Ccl4

Fmod
type: EnsemblDatabaseReference

Fcer1g
type: EnsemblDatabaseReference

Fmod
type: EnsemblDatabaseReference

Fcer1g
type: EnsemblDatabaseReference

Fcrls
type: EnsemblDatabaseReference

Fcrls
type: EnsemblDatabaseReference

(Assay) SRR057601
type: Assay

Ppl UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.2
p value: 0.0369073529797722
refers to: Ppl

Serpinf2
type: EnsemblDatabaseReference

Lpl
type: EnsemblDatabaseReference

Ccl3
type: EnsemblDatabaseReference

Lpl
type: EnsemblDatabaseReference

Ccl3
type: EnsemblDatabaseReference

Gpnmb
type: EnsemblDatabaseReference

Ccl4
type: EnsemblDatabaseReference

Comp UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.6
p value: 0.00308456633344341
refers to: Comp

Gpnmb
type: EnsemblDatabaseReference

Serpinf2 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.8
p value: 0.027594800994316
refers to: Serpinf2

Ptprc
type: EnsemblDatabaseReference

Fyb
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/expressing human TDP-43
type: EFO_0000001
property type: GENOTYPE
property value: expressing human TDP-43

Itgax
type: EnsemblDatabaseReference

Comp
type: EnsemblDatabaseReference

Timp1
type: EnsemblDatabaseReference

Plek
type: EnsemblDatabaseReference

Tgm1
type: EnsemblDatabaseReference

Lyz2
type: EnsemblDatabaseReference

(Sample) strain/C57BL/6;SJL
type: EFO_0000001
property type: strain
property value: C57BL/6;SJL

Myo1f
type: EnsemblDatabaseReference

Timp1 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.2
p value: 0.0246608350884287
refers to: Timp1

Slc11a1
type: EnsemblDatabaseReference

Ch25h
type: EnsemblDatabaseReference

Atf3
type: EnsemblDatabaseReference

Mmp19
type: EnsemblDatabaseReference

Mpeg1
type: EnsemblDatabaseReference

Cd84
type: EnsemblDatabaseReference

Serpina3n
type: EnsemblDatabaseReference

(Sample) organism part/spinal cord
type: UBERON_0002240
property type: organism part
property value: spinal cord

Tyrobp
type: EnsemblDatabaseReference

Prg4 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.6
p value: 0.0237655935983919
refers to: Prg4

C1qc
type: EnsemblDatabaseReference

Cst7 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 3.8
p value: 2.36149593991301E-10
refers to: Cst7

C1qa
type: EnsemblDatabaseReference

(Sample) age/21
type: EFO_0000001
property type: age
property value: 21

Tmprss5 DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2
p value: 0.019910763437934
refers to: Tmprss5

Ppl
type: EnsemblDatabaseReference

Lgals3
type: EnsemblDatabaseReference

Tmprss5
type: EnsemblDatabaseReference

C1qc UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.4
p value: 1.74101774993554E-4
refers to: C1qc

Slc11a1 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0431505753767837
refers to: Slc11a1

Lss DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0
p value: 0.0497413852022122
refers to: Lss

Prg4
type: EnsemblDatabaseReference

Dhcr24
type: EnsemblDatabaseReference

Slc15a3
type: EnsemblDatabaseReference

Cd68
type: EnsemblDatabaseReference

Cyba
type: EnsemblDatabaseReference

Gpnmb UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.7
p value: 3.1945979250332E-13
refers to: Gpnmb

Cst7
type: EnsemblDatabaseReference

Gm13886
type: EnsemblDatabaseReference

Cxcl10
type: EnsemblDatabaseReference

Ldlr
type: EnsemblDatabaseReference

Serpina3n UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.6
p value: 1.73227266337492E-6
refers to: Serpina3n

Tm7sf2
type: EnsemblDatabaseReference

(Assay) SRR057600
type: Assay

Ldlr DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1
p value: 0.0237655935983919
refers to: Ldlr

(Assay) SRR057598
type: Assay

Mybpc3 DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -2.4
p value: 0.0193994039649633
refers to: Mybpc3

Itgax UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 3.6
p value: 7.64932921301664E-10
refers to: Itgax

Mybpc3
type: EnsemblDatabaseReference

Cxcl10 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.7
p value: 0.0419140559944555
refers to: Cxcl10

Ch25h UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 3.0
p value: 1.41604780730339E-6
refers to: Ch25h

Ctss
type: EnsemblDatabaseReference

Atf3 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.9
p value: 0.00491308376978753
refers to: Atf3

AF251705 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.7
p value: 0.0350139026618933
refers to: AF251705

Pla2g3
type: EnsemblDatabaseReference

Wisp2 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.5
p value: 0.0344542356118673
refers to: Wisp2

Mus musculus
type: OBI_0100026

Gm15512
type: EnsemblDatabaseReference

Cyba UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.0200984508155136
refers to: Cyba

Gm15512
type: EnsemblDatabaseReference

Cd109
type: EnsemblDatabaseReference

Ctss UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.00242689269715571
refers to: Ctss

Serpinf2
type: EnsemblDatabaseReference

(Sample) genotype/expressing human TDP-43
type: EFO_0000001
property type: genotype
property value: expressing human TDP-43

Lyz2 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.00491308376978753
refers to: Lyz2

Lpl UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.9
p value: 5.43926424890006E-7
refers to: Lpl

Slc15a3 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.5
p value: 0.00107325956175187
refers to: Slc15a3

C1qa UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.5
p value: 5.36415043180316E-5
refers to: C1qa

Tm7sf2 DOWN in 'expressing human TDP-43' vs 'non transgenic'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2
p value: 0.0164733584734116
refers to: Tm7sf2

Lss
type: EnsemblDatabaseReference

Cd109 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.7
p value: 2.74887183007007E-4
refers to: Cd109

Fyb
type: EnsemblDatabaseReference

Fmod UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.6
p value: 6.31526363673722E-6
refers to: Fmod

Ptprc UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2
p value: 0.0438250672096716
refers to: Ptprc

(Assay) SRR057597
type: Assay

Comp
type: EnsemblDatabaseReference

Timp1
type: EnsemblDatabaseReference

Plek
type: EnsemblDatabaseReference

(Assay) SRR057599
type: Assay

Fcrls UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.3
p value: 0.00232307366031061
refers to: Fcrls

Lgals3 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 2.6
p value: 5.43926424890006E-7
refers to: Lgals3

Myo1f
type: EnsemblDatabaseReference

Ccl3 UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 3.2
p value: 0.0311246526278442
refers to: Ccl3

Ccl4
type: EnsemblDatabaseReference

Ch25h
type: EnsemblDatabaseReference

Plek UP in 'expressing human TDP-43' vs 'non transgenic'
type: IncreasedDifferentialExpressionRatio
fold change: 1.5
p value: 0.00224385353755261
refers to: Plek

Atf3
type: EnsemblDatabaseReference

Ptprc
type: EnsemblDatabaseReference