Ighg2b UP in 'B6.Sle1a.1' vs 'wild type'
Col5a1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Coro2b UP in 'B6.Sle1a.1' vs 'wild type'
Pla2g6 UP in 'B6.Sle1a.1' vs 'wild type'
Ank3 DOWN in 'B6.Sle1a.1' vs 'wild type'
Zfp420 UP in 'B6.Sle1a.1' vs 'wild type'
C230052I12Rik UP in 'B6.Sle1a.1' vs 'wild type'
4931406P16Rik UP in 'B6.Sle1a.1' vs 'wild type'
Ubash3b UP in 'B6.Sle1a.1' vs 'wild type'
Syce2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Sle1a.1 is part of the Sle1a lupus susceptibility locus which results in the production of activated and autoreactive CD4+ T cells as well as a reduction in the peripheral regulatory T cell (Treg) pool. Sle1a.1 CD4+ T cells showed a defective response to retinoic acid (RA) expansion of TGFÃÂÃÂ²-induced Tregs. At the molecular level, Sle1a.1 corresponds to an increased expression of a novel splice isoform of Pbx1, Pbx1-d. Pbx1-d over-expression is sufficient to induce an activated/inflammatory phenotype in Jurkat T cells, and to decrease their apoptotic response to RA. PBX1-d is expressed more frequently in lupus patients than in healthy controls, and its presence correlates with an increased memory T cell population. These findings indicate that Pbx1 is a novel lupus susceptibility gene that regulates T cell activation and tolerance. Total RNA from CD4+ T cells from C57BL/6 (B6) and B6.Sle1a.1 (Sle) mice was isolated, with 4 biological replicates each. Gene expression data from C57BL/6 mice were compared with data from B6.Sle2c1 mice.
Tfr2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Tal1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Zfp386 UP in 'B6.Sle1a.1' vs 'wild type'
Tmprss13 UP in 'B6.Sle1a.1' vs 'wild type'
Abcb4 DOWN in 'B6.Sle1a.1' vs 'wild type'
Fabp4 DOWN in 'B6.Sle1a.1' vs 'wild type'
Cenpe DOWN in 'B6.Sle1a.1' vs 'wild type'
Tgm2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Wdfy1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Zfp28 DOWN in 'B6.Sle1a.1' vs 'wild type'
Psmg3 DOWN in 'B6.Sle1a.1' vs 'wild type'
Podxl DOWN in 'B6.Sle1a.1' vs 'wild type'
Ccdc91 UP in 'B6.Sle1a.1' vs 'wild type'
Kctd14 DOWN in 'B6.Sle1a.1' vs 'wild type'
Ypel4 DOWN in 'B6.Sle1a.1' vs 'wild type'
Poldip2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Dapk2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Tmem40 DOWN in 'B6.Sle1a.1' vs 'wild type'
Ighg2c UP in 'B6.Sle1a.1' vs 'wild type'
Ptdss2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Optn DOWN in 'B6.Sle1a.1' vs 'wild type'
Itsn1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Gfi1b DOWN in 'B6.Sle1a.1' vs 'wild type'
Cd163l1 UP in 'B6.Sle1a.1' vs 'wild type'
Plek2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Tmem177 DOWN in 'B6.Sle1a.1' vs 'wild type'
Scn2b DOWN in 'B6.Sle1a.1' vs 'wild type'
Tspan8 DOWN in 'B6.Sle1a.1' vs 'wild type'
Speer7-ps1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Ephx2 DOWN in 'B6.Sle1a.1' vs 'wild type'
E2f1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Pik3r6 UP in 'B6.Sle1a.1' vs 'wild type'
Sorl1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Nupl2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Apol11b DOWN in 'B6.Sle1a.1' vs 'wild type'
Gramd1a DOWN in 'B6.Sle1a.1' vs 'wild type'
Ank1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Zdhhc14 DOWN in 'B6.Sle1a.1' vs 'wild type'
Aqp1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Slc22a23 DOWN in 'B6.Sle1a.1' vs 'wild type'
Zfp790 UP in 'B6.Sle1a.1' vs 'wild type'
Gipc1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Arel1 DOWN in 'B6.Sle1a.1' vs 'wild type'
March1 DOWN in 'B6.Sle1a.1' vs 'wild type'
Nt5dc2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Them4 DOWN in 'B6.Sle1a.1' vs 'wild type'
(Factor value) GENOTYPE/wild type genotype
Plekha5 DOWN in 'B6.Sle1a.1' vs 'wild type'
Glce DOWN in 'B6.Sle1a.1' vs 'wild type'
Cars2 DOWN in 'B6.Sle1a.1' vs 'wild type'
Zfp386 DOWN in 'B6.Sle1a.1' vs 'wild type'
Zfand2a DOWN in 'B6.Sle1a.1' vs 'wild type'