NEDD9
type: EnsemblDatabaseReference

NME7
type: EnsemblDatabaseReference

204607_at
type: EFO_0005072
part of: A-AFFY-44

MAPT UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.49135618301132
p value: 0.0387364967660599
refers to: MAPT
refers to: 206401_s_at
t statistic: 3.92642000281426

NME7 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.56178651558507
p value: 0.0423211306423042
refers to: 227556_at
refers to: NME7
t statistic: 3.6948315332592

PMEPA1
type: EnsemblDatabaseReference

ZFP36L1
type: EnsemblDatabaseReference

204855_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547778
type: Assay
has participant: A-AFFY-44

243952_at
type: EFO_0005072
part of: A-AFFY-44

TCN1
type: EnsemblDatabaseReference

LTF UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 3.41973371873402
p value: 0.0387364967660599
refers to: LTF
refers to: 202018_s_at
t statistic: 3.90528430328466

NTN4 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 2.06836359137561
p value: 0.0423211306423042
refers to: 223315_at
refers to: NTN4
t statistic: 3.69315863151261

222449_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547806
type: Assay
has participant: A-AFFY-44

(Assay) GSM547791
type: Assay
has participant: A-AFFY-44

VTCN1
type: EnsemblDatabaseReference

(Sample) biosource provider/breast tumors were excised from women at the Rene Huguenin Hospital (Saint-Cloud, France) from 1978 to 2008
type: EFO_0000001
property type: biosource provider
property value: breast tumors were excised from women at the Rene Huguenin Hospital (Saint-Cloud, France) from 1978 to 2008

(Sample) age/73
type: EFO_0000001
property type: age
property value: 73

213425_at
type: EFO_0005072
part of: A-AFFY-44

219232_s_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547775
type: Assay
has participant: A-AFFY-44

(Sample) age/46
type: EFO_0000001
property type: age
property value: 46

LIMCH1
type: EnsemblDatabaseReference

LTF
type: EnsemblDatabaseReference

222900_at
type: EFO_0005072
part of: A-AFFY-44

232968_at
type: EFO_0005072
part of: A-AFFY-44

ID4 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.58690073016946
p value: 0.0328370014960435
refers to: 209292_at
refers to: ID4
t statistic: 4.18846579156112

WNT5A UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.50712908749949
p value: 0.0328370014960435
refers to: 213425_at
refers to: WNT5A
t statistic: 4.0868096086998

(Assay) GSM547788
type: Assay
has participant: A-AFFY-44

TCF7L2
type: EnsemblDatabaseReference

(Sample) age/62
type: EFO_0000001
property type: age
property value: 62

TNFRSF11B UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.09201532662122
p value: 0.0459192093251029
refers to: 204932_at
refers to: TNFRSF11B
t statistic: 3.60734471636758

VTCN1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 2.44568396426813
p value: 0.0423211306423042
refers to: VTCN1
refers to: 219768_at
t statistic: 3.75452543200982

(Factor value) GENOTYPE/estrogen receptor alpha mutation: positive; PIK3CA mutation: negative
type: EFO_0000001
property type: GENOTYPE
property value: estrogen receptor alpha mutation: positive; PIK3CA mutation: negative

212327_at
type: EFO_0005072
part of: A-AFFY-44

PPL
type: EnsemblDatabaseReference

ID4
type: EnsemblDatabaseReference

CYP4B1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 2.04133306133777
p value: 0.0459192093251029
refers to: 210096_at
refers to: CYP4B1
t statistic: 3.59487021317781

HMGCS2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 2.46908748581573
p value: 0.0328370014960435
refers to: 204607_at
refers to: HMGCS2
t statistic: 4.02042997918646

TPTEP1
type: EnsemblDatabaseReference

(Assay) GSM547798
type: Assay
has participant: A-AFFY-44

ALOX5
type: EnsemblDatabaseReference

PIK3R1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02423983723184
p value: 0.0387364967660599
refers to: PIK3R1
refers to: 212239_at
t statistic: 3.90342358573608

HMGCS2
type: EnsemblDatabaseReference

(Sample) age/67
type: EFO_0000001
property type: age
property value: 67

ENC1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.00165037431586
p value: 0.0328370014960435
refers to: ENC1
refers to: 201340_s_at
t statistic: 4.25086218931945

201242_s_at
type: EFO_0005072
part of: A-AFFY-44

VANGL2
type: EnsemblDatabaseReference

(Assay) GSM547793
type: Assay
has participant: A-AFFY-44

DGKH
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/estrogen receptor alpha mutation: positive; PIK3CA mutation: positive
type: EFO_0000001
property type: GENOTYPE
property value: estrogen receptor alpha mutation: positive; PIK3CA mutation: positive

ZFP36L1
type: EnsemblDatabaseReference

(Assay) GSM547784
type: Assay
has participant: A-AFFY-44

204932_at
type: EFO_0005072
part of: A-AFFY-44

201243_s_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547801
type: Assay
has participant: A-AFFY-44

(Assay) GSM547805
type: Assay
has participant: A-AFFY-44

209598_at
type: EFO_0005072
part of: A-AFFY-44

204541_at
type: EFO_0005072
part of: A-AFFY-44

FANK1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02510758252865
p value: 0.0423211306423042
refers to: FANK1
refers to: 232968_at
t statistic: 3.7012609801916

212249_at
type: EFO_0005072
part of: A-AFFY-44

SERPINB5
type: EnsemblDatabaseReference

203407_at
type: EFO_0005072
part of: A-AFFY-44

ALOX5 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.14041544130362
p value: 0.0328370014960435
refers to: ALOX5
refers to: 204446_s_at
t statistic: 4.0161565416179

(Assay) GSM547790
type: Assay
has participant: A-AFFY-44

TNFRSF11B
type: EnsemblDatabaseReference

216511_s_at
type: EFO_0005072
part of: A-AFFY-44

SERPINB5 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.59384075138209
p value: 0.0339867839496031
refers to: SERPINB5
refers to: 204855_at
t statistic: 3.99465204975633

(Sample) age/72
type: EFO_0000001
property type: age
property value: 72

TPTEP1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12967343957113
p value: 0.0423211306423042
refers to: TPTEP1
refers to: 243952_at
t statistic: 3.70371033817959

ATP1B1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.44812697266954
p value: 0.0328370014960435
refers to: ATP1B1
refers to: 201243_s_at
t statistic: 4.1653649626663

REEP1
type: EnsemblDatabaseReference

(Assay) GSM547807
type: Assay
has participant: A-AFFY-44

PIK3R1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.22595736677225
p value: 0.0328370014960435
refers to: PIK3R1
refers to: 212249_at
t statistic: 4.18584603487321

NKAIN1 DOWN in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: DecreasedDifferentialExpressionRatio
fold change: -1.84258586847116
p value: 0.0387364967660599
refers to: 219438_at
refers to: NKAIN1
t statistic: -3.8287723586901

ID4 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.55269540590251
p value: 0.0274102420869758
refers to: 209291_at
refers to: ID4
t statistic: 4.59469259847512

202018_s_at
type: EFO_0005072
part of: A-AFFY-44

209292_at
type: EFO_0005072
part of: A-AFFY-44

A-AFFY-44
type: EFO_0000269

SEC14L2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.77123381841486
p value: 0.0328370014960435
refers to: SEC14L2
refers to: 230316_at
t statistic: 4.14462230265042

(Sample) age/75
type: EFO_0000001
property type: age
property value: 75

(Assay) GSM547792
type: Assay
has participant: A-AFFY-44

FANK1
type: EnsemblDatabaseReference

TCF7L2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12203826160967
p value: 0.0191997563683314
refers to: TCF7L2
refers to: 212762_s_at
t statistic: 4.76146056221933

TCN1
type: EnsemblDatabaseReference

(Assay) GSM547795
type: Assay
has participant: A-AFFY-44

(Sample) age/76
type: EFO_0000001
property type: age
property value: 76

226806_s_at
type: EFO_0005072
part of: A-AFFY-44

THBD
type: EnsemblDatabaseReference

FAM46B
type: EnsemblDatabaseReference

206401_s_at
type: EFO_0005072
part of: A-AFFY-44

PPL
type: EnsemblDatabaseReference

ID4
type: EnsemblDatabaseReference

MSX2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12519460177403
p value: 0.0455451166271407
refers to: MSX2
refers to: 210319_x_at
t statistic: 3.6243872588091

TPTEP1
type: EnsemblDatabaseReference

PNMA2
type: EnsemblDatabaseReference

NFIA
type: EnsemblDatabaseReference

TCF7L2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.11309465241636
p value: 0.0102328865245688
refers to: 216511_s_at
refers to: TCF7L2
t statistic: 5.02277713041887

PIK3R1
type: EnsemblDatabaseReference

(Assay) GSM547796
type: Assay
has participant: A-AFFY-44

LIMCH1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.55646455175993
p value: 0.0328370014960435
refers to: LIMCH1
refers to: 212325_at
t statistic: 4.09655559004712

NTN4
type: EnsemblDatabaseReference

(Sample) age/61
type: EFO_0000001
property type: age
property value: 61

(Sample) age/65
type: EFO_0000001
property type: age
property value: 65

(Sample) age/64
type: EFO_0000001
property type: age
property value: 64

(Sample) age/79
type: EFO_0000001
property type: age
property value: 79

202149_at
type: EFO_0005072
part of: A-AFFY-44

LIMCH1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.31242750770806
p value: 0.0423211306423042
refers to: 212327_at
refers to: LIMCH1
t statistic: 3.70776636972197

REEP1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.71947760250028
p value: 0.0387364967660599
refers to: REEP1
refers to: 204364_s_at
t statistic: 3.8413104160892

202888_s_at
type: EFO_0005072
part of: A-AFFY-44

VANGL2
type: EnsemblDatabaseReference

203908_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) age/69
type: EFO_0000001
property type: age
property value: 69

Homo sapiens
type: OBI_0100026

(Assay) GSM547794
type: Assay
has participant: A-AFFY-44

DGKH
type: EnsemblDatabaseReference

(Assay) GSM547800
type: Assay
has participant: A-AFFY-44

ANPEP UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.77122070510593
p value: 0.0459192093251029
refers to: 202888_s_at
refers to: ANPEP
t statistic: 3.59760846799261

SEC14L2
type: EnsemblDatabaseReference

(Assay) GSM547772
type: Assay
has participant: A-AFFY-44

THBD UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12897112094895
p value: 0.0387364967660599
refers to: 203887_s_at
refers to: THBD
t statistic: 3.81189680065858

212240_s_at
type: EFO_0005072
part of: A-AFFY-44

219557_s_at
type: EFO_0005072
part of: A-AFFY-44

EGLN3 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.1255190611298
p value: 0.0387364967660599
refers to: EGLN3
refers to: 219232_s_at
t statistic: 3.87727328302034

SERPINB5
type: EnsemblDatabaseReference

AK5
type: EnsemblDatabaseReference

PMEPA1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.14825920197582
p value: 0.0326298381948889
refers to: PMEPA1
refers to: 222450_at
t statistic: 4.4921564467627

MSX2
type: EnsemblDatabaseReference

212762_s_at
type: EFO_0005072
part of: A-AFFY-44

NKAIN1
type: EnsemblDatabaseReference

201340_s_at
type: EFO_0005072
part of: A-AFFY-44

ALOX5
type: EnsemblDatabaseReference

206385_s_at
type: EFO_0005072
part of: A-AFFY-44

ANK3
type: EnsemblDatabaseReference

(Assay) GSM547777
type: Assay
has participant: A-AFFY-44

(Sample) age/70
type: EFO_0000001
property type: age
property value: 70

WNT5A
type: EnsemblDatabaseReference

(Sample) genotype/estrogen receptor alpha mutation: positive; PIK3CA mutation: negative
type: EFO_0000001
property type: genotype
property value: estrogen receptor alpha mutation: positive; PIK3CA mutation: negative

REEP1
type: EnsemblDatabaseReference

(Assay) GSM547799
type: Assay
has participant: A-AFFY-44

204446_s_at
type: EFO_0005072
part of: A-AFFY-44

MAPT
type: EnsemblDatabaseReference

ANPEP
type: EnsemblDatabaseReference

NRIP3
type: EnsemblDatabaseReference

(Assay) GSM547785
type: Assay
has participant: A-AFFY-44

212239_at
type: EFO_0005072
part of: A-AFFY-44

210319_x_at
type: EFO_0005072
part of: A-AFFY-44

FANK1
type: EnsemblDatabaseReference

(Sample) age/53
type: EFO_0000001
property type: age
property value: 53

PIK3R1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.30319492034868
p value: 0.0102328865245688
refers to: PIK3R1
refers to: 212240_s_at
t statistic: 5.07881005402292

EGLN3
type: EnsemblDatabaseReference

219768_at
type: EFO_0005072
part of: A-AFFY-44

FAM46B
type: EnsemblDatabaseReference

SLC4A4
type: EnsemblDatabaseReference

210096_at
type: EFO_0005072
part of: A-AFFY-44

WNT5A UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.48780264445559
p value: 0.0328370014960435
refers to: 205990_s_at
refers to: WNT5A
t statistic: 4.25994611819893

219438_at
type: EFO_0005072
part of: A-AFFY-44

229518_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) age/74
type: EFO_0000001
property type: age
property value: 74

PNMA2
type: EnsemblDatabaseReference

NFIA
type: EnsemblDatabaseReference

ATP1B1
type: EnsemblDatabaseReference

(Sample) genotype/estrogen receptor alpha mutation: positive; PIK3CA mutation: positive
type: EFO_0000001
property type: genotype
property value: estrogen receptor alpha mutation: positive; PIK3CA mutation: positive

PIK3R1
type: EnsemblDatabaseReference

NEDD9 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.31786685267567
p value: 0.0328370014960435
refers to: NEDD9
refers to: 202149_at
t statistic: 4.02959683839722

FRMD6 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.15365278333132
p value: 0.0423211306423042
refers to: FRMD6
refers to: 225464_at
t statistic: 3.66814358753425

NTN4
type: EnsemblDatabaseReference

205990_s_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) disease/primary unilateral non-metastatic breast cancer
type: EFO_0000001
property type: disease
property value: primary unilateral non-metastatic breast cancer

ZFP36L1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.09652692702146
p value: 0.0328370014960435
refers to: ZFP36L1
refers to: 211965_at
t statistic: 4.07536582848875

(Assay) GSM547783
type: Assay
has participant: A-AFFY-44

AK5 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.5796861377252
p value: 0.0423211306423042
refers to: 222862_s_at
refers to: AK5
t statistic: 3.66868847752015

(Assay) GSM547773
type: Assay
has participant: A-AFFY-44

222862_s_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547804
type: Assay
has participant: A-AFFY-44

226029_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547781
type: Assay
has participant: A-AFFY-44

(Sample) organism part/breast
type: UBERON_0000310
property type: organism part
property value: breast

SEC14L2
type: EnsemblDatabaseReference

(Assay) GSM547774
type: Assay
has participant: A-AFFY-44

(Assay) GSM547770
type: Assay
has participant: A-AFFY-44

(Assay) GSM547780
type: Assay
has participant: A-AFFY-44

(Assay) GSM547787
type: Assay
has participant: A-AFFY-44

209291_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) age/68
type: EFO_0000001
property type: age
property value: 68

ENC1
type: EnsemblDatabaseReference

223315_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547802
type: Assay
has participant: A-AFFY-44

235952_at
type: EFO_0005072
part of: A-AFFY-44

NFIA UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.01584824609116
p value: 0.0387364967660599
refers to: NFIA
refers to: 226806_s_at
t statistic: 3.86666586250562

AK5
type: EnsemblDatabaseReference

VTCN1
type: EnsemblDatabaseReference

THBD
type: EnsemblDatabaseReference

TCN1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.49236629978465
p value: 0.0459192093251029
refers to: TCN1
refers to: 205513_at
t statistic: 3.60173729086928

225481_at
type: EFO_0005072
part of: A-AFFY-44

204364_s_at
type: EFO_0005072
part of: A-AFFY-44

NRIP3 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.34612416473142
p value: 0.0459192093251029
refers to: 222900_at
refers to: NRIP3
t statistic: 3.60187892726195

NKAIN1
type: EnsemblDatabaseReference

FRMD6
type: EnsemblDatabaseReference

(Sample) age/57
type: EFO_0000001
property type: age
property value: 57

CYP4B1
type: EnsemblDatabaseReference

NEDD9
type: EnsemblDatabaseReference

WNT5A
type: EnsemblDatabaseReference

LTF
type: EnsemblDatabaseReference

NME7
type: EnsemblDatabaseReference

(Assay) GSM547769
type: Assay
has participant: A-AFFY-44

(Assay) GSM547786
type: Assay
has participant: A-AFFY-44

(Assay) GSM547771
type: Assay
has participant: A-AFFY-44

205513_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547809
type: Assay
has participant: A-AFFY-44

MAPT
type: EnsemblDatabaseReference

(Sample) age/55
type: EFO_0000001
property type: age
property value: 55

PMEPA1
type: EnsemblDatabaseReference

NRIP3
type: EnsemblDatabaseReference

211965_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547808
type: Assay
has participant: A-AFFY-44

EGLN3
type: EnsemblDatabaseReference

(Sample) age/71
type: EFO_0000001
property type: age
property value: 71

ATP1B1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.46006758769906
p value: 0.0328370014960435
refers to: 201242_s_at
refers to: ATP1B1
t statistic: 4.33056090796705

212328_at
type: EFO_0005072
part of: A-AFFY-44

NFIA UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08810653908644
p value: 0.0328370014960435
refers to: 224975_at
refers to: NFIA
t statistic: 4.02534007325091

SLC4A4
type: EnsemblDatabaseReference

203887_s_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547776
type: Assay
has participant: A-AFFY-44

ATP1B1
type: EnsemblDatabaseReference

225464_at
type: EFO_0005072
part of: A-AFFY-44

MSX2
type: EnsemblDatabaseReference

SLC4A4 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 2.26645995484203
p value: 0.0387364967660599
refers to: SLC4A4
refers to: 203908_at
t statistic: 3.85889427658369

(Assay) GSM547768
type: Assay
has participant: A-AFFY-44

(Assay) GSM547803
type: Assay
has participant: A-AFFY-44

(Sample) age/60
type: EFO_0000001
property type: age
property value: 60

NRIP3 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.70923735975973
p value: 0.0328370014960435
refers to: NRIP3
refers to: 219557_s_at
t statistic: 4.10311885294871

212325_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) sex/female
type: EFO_0001265
property type: sex
property value: female

HMGCS2
type: EnsemblDatabaseReference

ANK3
type: EnsemblDatabaseReference

222450_at
type: EFO_0005072
part of: A-AFFY-44

LIMCH1
type: EnsemblDatabaseReference

Analysis of 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: MicroarrayDifferentialExpressionAnalysis

(Assay) GSM547810
type: Assay
has participant: A-AFFY-44

E-GEOD-22035
type: microarray 1colour mrna differential
RO_0002162: Homo sapiens
description: PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the oncogene which shows the high frequency of gain-of-function mutations leading to the PI3K/AKT pathway activation in breast cancer. In particular in the ERÃÂ±-positive breast tumors PIK3CA mutations have been observed in 30% to 40%. However, genes expressed in connection to the pathway activation in breast tumorigenesis remain largely unknown. To identify downstream relevant target genes (and signaling pathways) turned on by the aberrant PI3K/AKT signal in breast tumors, we analyzed gene expression by pangenomic oligonucleotide microarray in a series of 43 ERÃÂ±-positive tumors with and without PIK3CA mutations. 43 ERÃÂ±-positive breast tumors including 14 tumors with PIK3CA mutations and 29 tumors without PIK3CA mutattions were used as screening set for microarray.
uses data from: http://identifiers.org/pubmed/21209903

(Sample) age/78
type: EFO_0000001
property type: age
property value: 78

ANPEP
type: EnsemblDatabaseReference

FRMD6 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.14804487893302
p value: 0.0430934243487587
refers to: FRMD6
refers to: 225481_at
t statistic: 3.65721487084619

PNMA2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08968639853694
p value: 0.0328370014960435
refers to: PNMA2
refers to: 209598_at
t statistic: 4.21378385533967

(Sample) organism/Homo sapiens
type: Homo sapiens
property type: organism
property value: Homo sapiens

PMEPA1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.02101836199281
p value: 0.0328370014960435
refers to: PMEPA1
refers to: 222449_at
t statistic: 4.14256639910874

(Sample) age/52
type: EFO_0000001
property type: age
property value: 52

DGKH UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.01539701924305
p value: 0.0423211306423042
refers to: DGKH
refers to: 235952_at
t statistic: 3.76888518843415

ENC1
type: EnsemblDatabaseReference

PPL UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.27593530801824
p value: 0.0102328865245688
refers to: PPL
refers to: 203407_at
t statistic: 5.17321207740376

TCF7L2
type: EnsemblDatabaseReference

ANK3 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.20123580397633
p value: 0.0423211306423042
refers to: ANK3
refers to: 206385_s_at
t statistic: 3.72167255097778

FAM46B UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.24075540805478
p value: 0.0387364967660599
refers to: FAM46B
refers to: 229518_at
t statistic: 3.91001058263024

VANGL2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.32323591652385
p value: 0.0423211306423042
refers to: VANGL2
refers to: 226029_at
t statistic: 3.67674511123167

(Assay) GSM547789
type: Assay
has participant: A-AFFY-44

(Assay) GSM547797
type: Assay
has participant: A-AFFY-44

LIMCH1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.41605295606523
p value: 0.0328000837506131
refers to: LIMCH1
refers to: 212328_at
t statistic: 4.44865017697438

FRMD6
type: EnsemblDatabaseReference

TNFRSF11B
type: EnsemblDatabaseReference

230316_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) developmental stage/post menopause
type: EFO_0000001
property type: developmental stage
property value: post menopause

227556_at
type: EFO_0005072
part of: A-AFFY-44

224975_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) GSM547782
type: Assay
has participant: A-AFFY-44

SEC14L2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
type: IncreasedDifferentialExpressionRatio
fold change: 1.53617119721006
p value: 0.0387364967660599
refers to: SEC14L2
refers to: 204541_at
t statistic: 3.82121136606038

CYP4B1
type: EnsemblDatabaseReference

(Assay) GSM547779
type: Assay
has participant: A-AFFY-44