MAPT UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
NME7 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
LTF UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
NTN4 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
(Sample) biosource provider/breast tumors were excised from women at the Rene Huguenin Hospital (Saint-Cloud, France) from 1978 to 2008
breast tumors were excised from women at the Rene Huguenin Hospital (Saint-Cloud, France) from 1978 to 2008
ID4 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
WNT5A UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
TNFRSF11B UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
VTCN1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
(Factor value) GENOTYPE/estrogen receptor alpha mutation: positive; PIK3CA mutation: negative
estrogen receptor alpha mutation: positive; PIK3CA mutation: negative
CYP4B1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
HMGCS2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
PIK3R1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
ENC1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
(Factor value) GENOTYPE/estrogen receptor alpha mutation: positive; PIK3CA mutation: positive
estrogen receptor alpha mutation: positive; PIK3CA mutation: positive
FANK1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
ALOX5 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
SERPINB5 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
TPTEP1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
ATP1B1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
NKAIN1 DOWN in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
SEC14L2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
TCF7L2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
MSX2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
LIMCH1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
REEP1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
ANPEP UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
THBD UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
EGLN3 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
PMEPA1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
(Sample) genotype/estrogen receptor alpha mutation: positive; PIK3CA mutation: negative
(Sample) genotype/estrogen receptor alpha mutation: positive; PIK3CA mutation: positive
NEDD9 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
FRMD6 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
(Sample) disease/primary unilateral non-metastatic breast cancer
primary unilateral non-metastatic breast cancer
ZFP36L1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
AK5 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
NFIA UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
TCN1 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
NRIP3 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
SLC4A4 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
Analysis of 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the oncogene which shows the high frequency of gain-of-function mutations leading to the PI3K/AKT pathway activation in breast cancer. In particular in the ERÃÂ±-positive breast tumors PIK3CA mutations have been observed in 30% to 40%. However, genes expressed in connection to the pathway activation in breast tumorigenesis remain largely unknown. To identify downstream relevant target genes (and signaling pathways) turned on by the aberrant PI3K/AKT signal in breast tumors, we analyzed gene expression by pangenomic oligonucleotide microarray in a series of 43 ERÃÂ±-positive tumors with and without PIK3CA mutations. 43 ERÃÂ±-positive breast tumors including 14 tumors with PIK3CA mutations and 29 tumors without PIK3CA mutattions were used as screening set for microarray.
PNMA2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
DGKH UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
PPL UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
ANK3 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
FAM46B UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
VANGL2 UP in 'estrogen receptor alpha mutation: positive; PIK3CA mutation: positive' vs 'estrogen receptor alpha mutation: positive; PIK3CA mutation: negative'
(Sample) developmental stage/post menopause