Lactbl1 UP in 'non-pregnant' vs 'pregnant'
Pycr1 UP in 'non-pregnant' vs 'pregnant'
Ggact UP in 'non-pregnant' vs 'pregnant'
(Factor value) CLINICAL_INFORMATION/non-pregnant
Hspa1b DOWN in 'non-pregnant' vs 'pregnant'
Gpr26 UP in 'non-pregnant' vs 'pregnant'
Csrnp1 DOWN in 'non-pregnant' vs 'pregnant'
Cntn3 UP in 'non-pregnant' vs 'pregnant'
(Factor value) CLINICAL_INFORMATION/pregnant
Lonrf3 UP in 'non-pregnant' vs 'pregnant'
Npas4 DOWN in 'non-pregnant' vs 'pregnant'
Socs2 UP in 'non-pregnant' vs 'pregnant'
Cldn8 UP in 'non-pregnant' vs 'pregnant'
Pcsk1 UP in 'non-pregnant' vs 'pregnant'
Rgs2 DOWN in 'non-pregnant' vs 'pregnant'
Ehhadh UP in 'non-pregnant' vs 'pregnant'
Disp2 UP in 'non-pregnant' vs 'pregnant'
Hsph1 DOWN in 'non-pregnant' vs 'pregnant'
Txnrd2 UP in 'non-pregnant' vs 'pregnant'
Dnmt3b UP in 'non-pregnant' vs 'pregnant'
Ogdhl UP in 'non-pregnant' vs 'pregnant'
Prkd1 UP in 'non-pregnant' vs 'pregnant'
Tnfrsf11b UP in 'non-pregnant' vs 'pregnant'
Sptbn2 UP in 'non-pregnant' vs 'pregnant'
Itga6 UP in 'non-pregnant' vs 'pregnant'
D630039A03Rik UP in 'non-pregnant' vs 'pregnant'
(Sample) clinical history/13 to 15 days post conception
1110038B12Rik DOWN in 'non-pregnant' vs 'pregnant'
Cartpt UP in 'non-pregnant' vs 'pregnant'
Kirrel3 UP in 'non-pregnant' vs 'pregnant'
Gm27168 UP in 'non-pregnant' vs 'pregnant'
Synpr UP in 'non-pregnant' vs 'pregnant'
Gm16314 UP in 'non-pregnant' vs 'pregnant'
Tsc22d3 DOWN in 'non-pregnant' vs 'pregnant'
Gyltl1b UP in 'non-pregnant' vs 'pregnant'
mt-Rnr2 DOWN in 'non-pregnant' vs 'pregnant'
1300002E11Rik UP in 'non-pregnant' vs 'pregnant'
Hapln4 UP in 'non-pregnant' vs 'pregnant'
Junb DOWN in 'non-pregnant' vs 'pregnant'
Slc6a8 UP in 'non-pregnant' vs 'pregnant'
Hsbp1 UP in 'non-pregnant' vs 'pregnant'
Mctp1 UP in 'non-pregnant' vs 'pregnant'
Cttnbp2 UP in 'non-pregnant' vs 'pregnant'
Tmem255a UP in 'non-pregnant' vs 'pregnant'
Gabbr2 UP in 'non-pregnant' vs 'pregnant'
Syce2 UP in 'non-pregnant' vs 'pregnant'
Dnaja1 DOWN in 'non-pregnant' vs 'pregnant'
Rab3d UP in 'non-pregnant' vs 'pregnant'
Igfbp5 UP in 'non-pregnant' vs 'pregnant'
Nupr1 UP in 'non-pregnant' vs 'pregnant'
Reg3d UP in 'non-pregnant' vs 'pregnant'
D10Bwg1379e UP in 'non-pregnant' vs 'pregnant'
D5Ertd579e UP in 'non-pregnant' vs 'pregnant'
Nr4a1 DOWN in 'non-pregnant' vs 'pregnant'
Analysis of 'non-pregnant' vs 'pregnant'
Arc DOWN in 'non-pregnant' vs 'pregnant'
Grhl1 UP in 'non-pregnant' vs 'pregnant'
Aldh9a1 UP in 'non-pregnant' vs 'pregnant'
Rnf150 UP in 'non-pregnant' vs 'pregnant'
Ikzf4 UP in 'non-pregnant' vs 'pregnant'
Lrrc55 UP in 'non-pregnant' vs 'pregnant'
Gm16315 UP in 'non-pregnant' vs 'pregnant'
(Sample) clinical information/non-pregnant
Glp1r UP in 'non-pregnant' vs 'pregnant'
Igfals UP in 'non-pregnant' vs 'pregnant'
Reg3a UP in 'non-pregnant' vs 'pregnant'
Matn2 UP in 'non-pregnant' vs 'pregnant'
Ovol2 UP in 'non-pregnant' vs 'pregnant'
Znrf2 UP in 'non-pregnant' vs 'pregnant'
Sdf2l1 UP in 'non-pregnant' vs 'pregnant'
Prok1 UP in 'non-pregnant' vs 'pregnant'
Crispld2 UP in 'non-pregnant' vs 'pregnant'
Cspg5 UP in 'non-pregnant' vs 'pregnant'
Enpp2 UP in 'non-pregnant' vs 'pregnant'
Sftpd UP in 'non-pregnant' vs 'pregnant'
Dnah8 UP in 'non-pregnant' vs 'pregnant'
Dhcr7 UP in 'non-pregnant' vs 'pregnant'
Aldh1l2 UP in 'non-pregnant' vs 'pregnant'
Mdm1 DOWN in 'non-pregnant' vs 'pregnant'
During pregnancy, the energy requirements of the fetus impose changes in maternal metabolism. Increasing insulin resistance in the mother maintains nutrient flow to the growing fetus, while prolactin and placental lactogen counterbalance this resistance and prevent maternal hyperglycemia by driving expansion of the maternal population of insulin-producing beta-cells. However, the exact mechanisms by which the lactogenic hormones drive beta-cell expansion remain uncertain. Here we show that serotonin acts downstream of lactogen signaling to drive beta-cell proliferation. Serotonin synthetic enzyme Tph1 and serotonin production increased sharply in beta-cells during pregnancy or after treatment with lactogens in vitro. Inhibition of serotonin synthesis by dietary tryptophan restriction or Tph inhibition blocked beta-cell expansion and induced glucose intolerance in pregnant mice without affecting insulin sensitivity. Expression of the Gq-linked serotonin receptor Htr2b in maternal islets increased during pregnancy and normalized just prior to parturition, while expression of the Gi-linked receptor Htr1d increased at the end of pregnancy and postpartum. Blocking Htr2b signaling in pregnant mice also blocked beta-cell expansion and caused glucose intolerance. These studies reveal an integrated signaling pathway linking beta-cell mass to anticipated insulin need during pregnancy. Modulators of this pathway, including medications and diet, may affect the risk of gestational diabetes. Analysis of poly(A)+ RNA from 3 biological replicates of pancreatic islets isolated from normal female and pregnant female mice
Fosb DOWN in 'non-pregnant' vs 'pregnant'
Rnf182 UP in 'non-pregnant' vs 'pregnant'
Hspa1a DOWN in 'non-pregnant' vs 'pregnant'
Chst11 UP in 'non-pregnant' vs 'pregnant'
Kirrel3os UP in 'non-pregnant' vs 'pregnant'
Serinc5 UP in 'non-pregnant' vs 'pregnant'
Slc2a13 UP in 'non-pregnant' vs 'pregnant'
Dnajb1 DOWN in 'non-pregnant' vs 'pregnant'
Gm13716 UP in 'non-pregnant' vs 'pregnant'
Lgals12 UP in 'non-pregnant' vs 'pregnant'
Acvr1c UP in 'non-pregnant' vs 'pregnant'
B3galnt1 UP in 'non-pregnant' vs 'pregnant'
Fam155a UP in 'non-pregnant' vs 'pregnant'
Wipi1 UP in 'non-pregnant' vs 'pregnant'
Slc40a1 UP in 'non-pregnant' vs 'pregnant'
Fkbp11 UP in 'non-pregnant' vs 'pregnant'
Gm17040 UP in 'non-pregnant' vs 'pregnant'
Dusp1 DOWN in 'non-pregnant' vs 'pregnant'
Reg3b UP in 'non-pregnant' vs 'pregnant'
Derl3 UP in 'non-pregnant' vs 'pregnant'
Apobec1 UP in 'non-pregnant' vs 'pregnant'