Tpd52l1 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
LOC100912195 UP in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Nmrk2 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Thrsp DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Cd24 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Dcxr DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle. Diaphragm and sternohyoid muscle from Zucker diabetic fatty (ZDF) rats were analyzed with Affymetrix gene expression arrays. The two muscles had 97 and 102 genes, respectively, with at least ÃÂ±1.5-fold significantly changed expression with diabetes, and these were assigned to gene ontology groups based on over-representation analysis. Several significantly changed groups were common to both muscles, including lipid metabolism, carbohydrate metabolism, muscle contraction, ion transport and collagen, although the number of genes and the specific genes involved differed considerably for the two muscles. In both muscles there was a shift in metabolism gene expression from carbohydrate metabolism toward lipid metabolism, but the shift was greater and involved more genes in diabetic diaphragm than diabetic sternohyoid muscle. Groups present in only diaphragm were blood circulation and oxidoreductase activity. Groups present in only sternohyoid were immune & inflammation and response to stress & wounding, with complement genes being a prominent component. In conclusion, type 2 diabetes-induced gene expression changes in respiratory muscles has both similarities and differences relative to previous data on type 1 diabetes gene expression. Furthermore, the diabetic alterations in gene expression differ between diaphragm and sternohyoid. 18-week-old Zucker diabetic fatty rats: 6 normal and 5 diabetic diaphragms and sternohyoids.
Mybph UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Nmrk2 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Fcna DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Acot1 UP in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Dyrk2 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Decr1 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Fcgr2b UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
(Factor value) DISEASE/type 2 diabetes, obesity
Pln DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Col1a1 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Bst2 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Myl6b UP in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Analysis of 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Myh4 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Crot UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Aqp7 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Analysis of 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Ankrd1 UP in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Mybph UP in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Nudt7 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
RT1-CE5 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
(Factor value) ORGANISM_PART/sternohyoid
Rrad UP in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
S100a4 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
(Sample) disease/type 2 diabetes, obesity
Il13ra2 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Thrsp DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
S100a9 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Casq2 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Myl6b DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Ces1d DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Hopx DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Mpv17l DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Gpd1 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Lgals3 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Neu2 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Csrp3 UP in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Phyhd1 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Slc41a3 DOWN in 'type 2 diabetes, obesity' vs 'normal' in 'diaphragm'
Atp1b4 UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'
Gpnmb UP in 'type 2 diabetes, obesity' vs 'normal' in 'sternohyoid'