SLC39A8 UP in 'ovarian cancer' vs 'normal'
RAP2B UP in 'ovarian cancer' vs 'normal'
INOS DOWN in 'ovarian cancer' vs 'normal'
LGI1 DOWN in 'ovarian cancer' vs 'normal'
OVALY UP in 'ovarian cancer' vs 'normal'
HSD3B2 DOWN in 'ovarian cancer' vs 'normal'
SPINK7 UP in 'ovarian cancer' vs 'normal'
ATP6V1C2 UP in 'ovarian cancer' vs 'normal'
KCNK2 DOWN in 'ovarian cancer' vs 'normal'
MYOZ2 DOWN in 'ovarian cancer' vs 'normal'
CAPSL UP in 'ovarian cancer' vs 'normal'
TMEM68 DOWN in 'ovarian cancer' vs 'normal'
FAM20A UP in 'ovarian cancer' vs 'normal'
RIN3 DOWN in 'ovarian cancer' vs 'normal'
AMER2 UP in 'ovarian cancer' vs 'normal'
GOLPH3L UP in 'ovarian cancer' vs 'normal'
CENPO DOWN in 'ovarian cancer' vs 'normal'
KRT20 UP in 'ovarian cancer' vs 'normal'
CLIC6 UP in 'ovarian cancer' vs 'normal'
ENSGALG00000010203 UP in 'ovarian cancer' vs 'normal'
SLC16A10 DOWN in 'ovarian cancer' vs 'normal'
Ovarian cancer has a high mortality rate due, in part, to the lack of early detection and incomplete understanding of the origin of the disease. The hen is the only spontaneous model of ovarian cancer, and can therefore aid in the identification and testing of early detection strategies and therapeutics. To our knowledge, no studies to date have examined global gene expression in ovarian cancer of the hen. Our aim was to combine the use of the hen animal model and microarray technology to identify differentially expressed genes in ovarian tissue from normal hens compared to hens with ovarian cancer. Ovarian tissue samples from whole ovaries were collected from hens for RNA extraction and hybridization on Affymetrix microarrays. Hens were matched for age and laying status. Normal hens (n=3) showed no gross or histopathological evidence of ovarian cancer, while cancer specimens (n=3) had tumors that were stage 2 (restricted to the ovary and observable at necropsy) or 3 (ovarian tumor with abdominal seeding). Total RNA was extracted using TRIZOL according to the manufacturer's instructions.
INHBB DOWN in 'ovarian cancer' vs 'normal'
TINAG UP in 'ovarian cancer' vs 'normal'
SLC2A9 DOWN in 'ovarian cancer' vs 'normal'
P4HA1 DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000005956 UP in 'ovarian cancer' vs 'normal'
SYTL2 UP in 'ovarian cancer' vs 'normal'
PRKCH DOWN in 'ovarian cancer' vs 'normal'
FAM3B UP in 'ovarian cancer' vs 'normal'
PALMD UP in 'ovarian cancer' vs 'normal'
PLEK2 UP in 'ovarian cancer' vs 'normal'
PLCB4 UP in 'ovarian cancer' vs 'normal'
CYP19A1 DOWN in 'ovarian cancer' vs 'normal'
SLC9A2 UP in 'ovarian cancer' vs 'normal'
COL4A4 DOWN in 'ovarian cancer' vs 'normal'
MTSS1 DOWN in 'ovarian cancer' vs 'normal'
FGL2 DOWN in 'ovarian cancer' vs 'normal'
PARP8 DOWN in 'ovarian cancer' vs 'normal'
PLEKHH1 DOWN in 'ovarian cancer' vs 'normal'
CRIM1 DOWN in 'ovarian cancer' vs 'normal'
ABCC9 DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000028422 UP in 'ovarian cancer' vs 'normal'
FBN2 DOWN in 'ovarian cancer' vs 'normal'
NRCAM UP in 'ovarian cancer' vs 'normal'
GNS DOWN in 'ovarian cancer' vs 'normal'
PPDPF UP in 'ovarian cancer' vs 'normal'
GAL11 UP in 'ovarian cancer' vs 'normal'
CYP17A1 DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000005812 UP in 'ovarian cancer' vs 'normal'
ATP13A4 UP in 'ovarian cancer' vs 'normal'
SLC34A2 UP in 'ovarian cancer' vs 'normal'
BEND4 DOWN in 'ovarian cancer' vs 'normal'
SPDEF UP in 'ovarian cancer' vs 'normal'
PDLIM4 UP in 'ovarian cancer' vs 'normal'
HEP21 UP in 'ovarian cancer' vs 'normal'
AMH DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000000357 UP in 'ovarian cancer' vs 'normal'
FSTL1 DOWN in 'ovarian cancer' vs 'normal'
LPL DOWN in 'ovarian cancer' vs 'normal'
ARHGEF28 UP in 'ovarian cancer' vs 'normal'
CLK1 DOWN in 'ovarian cancer' vs 'normal'
GJA5 DOWN in 'ovarian cancer' vs 'normal'
ZP3 DOWN in 'ovarian cancer' vs 'normal'
PLBD1 DOWN in 'ovarian cancer' vs 'normal'
SLC9A9 DOWN in 'ovarian cancer' vs 'normal'
KCNK1 UP in 'ovarian cancer' vs 'normal'
KIF14 DOWN in 'ovarian cancer' vs 'normal'
CLDN10 UP in 'ovarian cancer' vs 'normal'
HSD17B4 UP in 'ovarian cancer' vs 'normal'
GAL12 UP in 'ovarian cancer' vs 'normal'
PCSK5 DOWN in 'ovarian cancer' vs 'normal'
MYO10 DOWN in 'ovarian cancer' vs 'normal'
SERPINB14 UP in 'ovarian cancer' vs 'normal'
CMTM8 UP in 'ovarian cancer' vs 'normal'
AXIN1 UP in 'ovarian cancer' vs 'normal'
ENSGALG00000009953 UP in 'ovarian cancer' vs 'normal'
VSNL1 DOWN in 'ovarian cancer' vs 'normal'
TAF1D UP in 'ovarian cancer' vs 'normal'
BCAS1 UP in 'ovarian cancer' vs 'normal'
SEMA3A DOWN in 'ovarian cancer' vs 'normal'
COL24A1 DOWN in 'ovarian cancer' vs 'normal'
CLDN3 UP in 'ovarian cancer' vs 'normal'
PDIA5 UP in 'ovarian cancer' vs 'normal'
COTL1 DOWN in 'ovarian cancer' vs 'normal'
STAR DOWN in 'ovarian cancer' vs 'normal'
ZPD DOWN in 'ovarian cancer' vs 'normal'
GPR149 DOWN in 'ovarian cancer' vs 'normal'
GPR137B UP in 'ovarian cancer' vs 'normal'
NPDC1 UP in 'ovarian cancer' vs 'normal'
COL4A3 DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000026433 DOWN in 'ovarian cancer' vs 'normal'
TUFT1 UP in 'ovarian cancer' vs 'normal'
TSPAN8 UP in 'ovarian cancer' vs 'normal'
ENSGALG00000012416 UP in 'ovarian cancer' vs 'normal'
COL12A1 DOWN in 'ovarian cancer' vs 'normal'
VCAN DOWN in 'ovarian cancer' vs 'normal'
TBC1D8 UP in 'ovarian cancer' vs 'normal'
ENSGALG00000006565 UP in 'ovarian cancer' vs 'normal'
SULF1 UP in 'ovarian cancer' vs 'normal'
DTL DOWN in 'ovarian cancer' vs 'normal'
DCTD DOWN in 'ovarian cancer' vs 'normal'
COL4A5 DOWN in 'ovarian cancer' vs 'normal'
F2RL1 UP in 'ovarian cancer' vs 'normal'
MRPL51 DOWN in 'ovarian cancer' vs 'normal'
COLEC12 DOWN in 'ovarian cancer' vs 'normal'
ZFPM2 DOWN in 'ovarian cancer' vs 'normal'
BRT-1 DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000015722 DOWN in 'ovarian cancer' vs 'normal'
MME DOWN in 'ovarian cancer' vs 'normal'
CCDC109B UP in 'ovarian cancer' vs 'normal'
ESRP2 UP in 'ovarian cancer' vs 'normal'
TMEM117 DOWN in 'ovarian cancer' vs 'normal'
STEAP3 UP in 'ovarian cancer' vs 'normal'
SLC6A2 DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000018733 UP in 'ovarian cancer' vs 'normal'
MTCL1 DOWN in 'ovarian cancer' vs 'normal'
ALX-4 DOWN in 'ovarian cancer' vs 'normal'
AOAH DOWN in 'ovarian cancer' vs 'normal'
ENSGALG00000014252 UP in 'ovarian cancer' vs 'normal'
HOXB5 UP in 'ovarian cancer' vs 'normal'
NR5A1 DOWN in 'ovarian cancer' vs 'normal'
NES DOWN in 'ovarian cancer' vs 'normal'
SLC22A4 UP in 'ovarian cancer' vs 'normal'
ZGRF1 DOWN in 'ovarian cancer' vs 'normal'
STT3A DOWN in 'ovarian cancer' vs 'normal'
NPLOC4 UP in 'ovarian cancer' vs 'normal'
FBN3 DOWN in 'ovarian cancer' vs 'normal'
NID2 DOWN in 'ovarian cancer' vs 'normal'
DPYSL4 UP in 'ovarian cancer' vs 'normal'
RERG DOWN in 'ovarian cancer' vs 'normal'
MAP1B DOWN in 'ovarian cancer' vs 'normal'
TSPAN1 UP in 'ovarian cancer' vs 'normal'
ENSGALG00000027090 DOWN in 'ovarian cancer' vs 'normal'
E2F8 DOWN in 'ovarian cancer' vs 'normal'
Analysis of 'ovarian cancer' vs 'normal'
GRP DOWN in 'ovarian cancer' vs 'normal'
IGFBP5 DOWN in 'ovarian cancer' vs 'normal'
COL4A6 DOWN in 'ovarian cancer' vs 'normal'