Ttll3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Lair1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Slc20a1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ccnd1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cav2 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cd82 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Plxnc1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Bmper UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Timp3 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cebpd DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Insm1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cdc14a UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Sez6l2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Slc5a3 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Gsn UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Plxna2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Hsf4 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Lsamp UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
1810010H24Rik UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Fzd7 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Itgb5 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Mgll DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tbc1d4 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Emilin1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tmem2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Lpar4 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Msi1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tmem158 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ephb1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Aplp1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ccdc177 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Flrt1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Grb14 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ap1s2 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Nmb DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Gpr50 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Sfrp1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Rhbdl3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Dlx2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Gata2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Slain1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Apoc1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Rtn2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Epha7 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tgfb2 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Dnm1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Bai1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Slc6a9 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Mfi2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cd109 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cldn9 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Kcnh2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Hey2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
H19 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tspan33 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Unc119 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Meg3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cacna1g UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Pappa UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ampd2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ninl UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tox2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Gm11627 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Nkd1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Fzd9 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ggta1 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Fkbp10 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Sorcs2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tsc22d4 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Kcna6 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Fzd2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Actc1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Thbs3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Wnt7b UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Igf2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Vwa1 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Efnb1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ada UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
(Factor value) GENOTYPE/p53 null mutant; plagL2 vector
Strbp UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Serpina3n DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ccnd2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Csrp1 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Glrb UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Coro2b UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
6330403K07Rik UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Pcolce2 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Rlbp1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Trpm5 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Lztfl1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Elovl2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Mycn UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Crispld2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Arx UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Rgs4 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Dlk1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Dpp6 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Emid1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Fgfbp3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
C1qtnf1 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tmem178b UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Elavl3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Rian UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Hif3a UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Wnt6 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Chic2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Crlf1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Nr2e1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Pdgfrb UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Des UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Plin2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Syt7 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
(Sample) cell type/primary neural stem cell
Efcab1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tst DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Scara3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Grifin UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Grm4 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Dgkk UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cacna1h UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Lphn2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Map1b UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Erbb3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Slc14a1 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Car14 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ttc9b UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
D930015E06Rik UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Pou3f1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Lipg UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Gucy1a3 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Mrc2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Nol4 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Kdelr3 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Analysis of 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Nptx2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Grin2c UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cdkn1c UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
(Sample) genotype/p53 null mutant; plagL2 vector
Obsl1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Zfp423 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Mn1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ascl1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Gamt UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tiam2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Sfrp2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ncs1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Adora1 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Sdk2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Garnl3 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Fgf13 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Rasa4 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Spag5 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Plagl2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Hdc UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Slc13a3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tnfaip8 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Fat4 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Pcyt1b UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
(Sample) genotype/p53 null mutant; empty vector
Olfm1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Plce1 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Sox11 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
A hallmark feature of glioblastoma (GBM) cells is its strong self-renewal potential and immature differentiation state -- stem cell-like properties which may contribute to the plasticity and intense therapeutic resistance of GBM. The molecular basis of the immature differentiation profile remains an area of active investigation. Here, integrated genomic and biological analyses identified PLAGL2 as a potent proto-oncogene targeted for amplification/gain in malignant gliomas as well as in colorectal cancers. High level of PLAGL2 expression strongly suppresses neural stem cell (NSC) and glioma-initiating cell (GIC) differentiation while promoting their proliferation and self-renewal capacity under differentiation induction conditions. On the mechanistic level, the PLAGL2 transcriptome analysis revealed that these differentiation suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling via up-regulation of Wnt6 ligand as well as Fzd9 and Fzd2 receptor expression. Correspondingly, inhibition of Wnt signaling in PLAGL2-expressing NSC partially restores their differentiation capacity. The identification of PLAGL2 as a glioma oncogene highlights the importance of a growing class of cancer genes functioning to impart stem cell-like characteristics on malignant cells. p53-null mouse NSCs are infected with retrovirus expressing either control vector or PlagL2. Total RNA were collected upon differentiation in 1% FBS for 24 hr. 3 replicates each.
Chst8 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Kctd12 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Pnrc2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ctsh DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tnnt1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Dhrs3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Slc7a10 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Diras2 DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ier5 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Ccnd3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Paip1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Gse1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Nfkbiz DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Kcne1l UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
(Factor value) GENOTYPE/p53 null mutant; empty vector
Dlx1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Lnx1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Clcn2 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Abcg1 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Mest UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Htra3 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Mylk DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Kif5c UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cbx6 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Miat UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cdkn1a UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Tspan18 UP in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'
Cidea DOWN in 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'