Dcxr UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Analysis of 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430B Array'
Tap1 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Aurka DOWN in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Pid1 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430B Array'
Acad11 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Gas2l3 DOWN in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430B Array'
(Factor value) IRRADIATE/gamma radiation
9230114K14Rik UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430B Array'
Tmem19 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Cenpf DOWN in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Analysis of 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430B Array'
Trp53inp1 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Aurka DOWN in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Dapk1 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Dapk1 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Eda2r UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430B Array'
Ddit4l UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Arap2 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Ccnb1 DOWN in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Kif2c DOWN in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Zfp365 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430B Array'
Cdkn1a UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
1700007K13Rik UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430B Array'
Trp53inp1 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibroblasts. A number of genes associated with cellular stress exhibited altered expression. Consistent with this finding, Oct-1-deficient fibroblasts were hypersensitive to radiation, doxorubicin, and hydrogen peroxide and harbored elevated reactive oxygen species. Expression profiling identified a second group of genes dysregulated in Oct-1-deficient fibroblasts following irradiation, including many associated with oxidative and metabolic stress. A number of these genes contain octamer sequences in their immediate 5' regulatory regions, some of which are conserved in human. These results indicate that Oct-1 modulates the activity of genes important for the cellular response to stress. overall experiment design: WT,WTR,MU and MUR replicates from Affymetrix GeneChip Mouse Expression Set 430 Arrays A and B
Ano3 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430B Array'
9230114K14Rik UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430B Array'
Aspm DOWN in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Gas2l3 DOWN in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430B Array'
Tmem19 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Eda2r UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430B Array'
1700007K13Rik UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430B Array'
Tap1 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
(Factor value) GENOTYPE/wild type genotype
Mdm2 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Analysis of 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Aspm DOWN in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Notch3 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Cenpf DOWN in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Pmaip1 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Dcxr UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Plk1 DOWN in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Mdm2 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Kif2c DOWN in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Pmaip1 UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Plk1 DOWN in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Rb1 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Ccnb1 DOWN in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Arap2 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'
Zfp365 UP in 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430B Array'
Ddit4l UP in 'gamma radiation' vs 'control' in 'Oct-1 mutant' on 'Affymetrix MOE430A Array'
Analysis of 'gamma radiation' vs 'control' in 'wild type' on 'Affymetrix MOE430A Array'