Nfib UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0098998378239
p value: 0.023139533871674
refers to: 1438245_at
refers to: Nfib
t statistic: 5.70852333679057

Ugt2b5 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 2.70388869496126
p value: 0.023139533871674
refers to: 1419622_at
refers to: Ugt2b5
t statistic: 5.65455732241962

Adra2a
type: EnsemblDatabaseReference

Ces1g
type: EnsemblDatabaseReference

(Assay) GSM515510
type: Assay
has participant: A-AFFY-45

Ces1g
type: EnsemblDatabaseReference

Mal
type: EnsemblDatabaseReference

(Factor value) TIME/0
type: EFO_0000001
property type: TIME
property value: 0

1438245_at
type: EFO_0005072
part of: A-AFFY-45

9030619P08Rik DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -2.50288394728213
p value: 0.0321324440468283
refers to: 9030619P08Rik
refers to: 1443889_at
t statistic: -4.9336492282595

Hoxd13
type: EnsemblDatabaseReference

1449375_at
type: EFO_0005072
part of: A-AFFY-45

1450952_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM515498
type: Assay
has participant: A-AFFY-45

1454849_x_at
type: EFO_0005072
part of: A-AFFY-45

Ighm
type: EnsemblDatabaseReference

Btla
type: EnsemblDatabaseReference

1449475_at
type: EFO_0005072
part of: A-AFFY-45

Cxcl13 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13287292344909
p value: 0.00363925269845506
refers to: Cxcl13
refers to: 1448859_at
t statistic: -10.0259242775274

Analysis of 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '0 day'
type: MicroarrayDifferentialExpressionAnalysis

Ces2a
type: EnsemblDatabaseReference

Rgs2
type: EnsemblDatabaseReference

Acaa1b UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.71091893512711
p value: 0.0329459380624977
refers to: 1424451_at
refers to: Acaa1b
t statistic: 4.78797231945675

Ccl20 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11517641650793
p value: 0.023139533871674
refers to: Ccl20
refers to: 1422029_at
t statistic: -5.68055729126346

Greb1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.10439611714081
p value: 0.0210092273978689
refers to: 1419593_at
refers to: Greb1
t statistic: 5.89116500065836

Cpn1
type: EnsemblDatabaseReference

(Assay) GSM515512
type: Assay
has participant: A-AFFY-45

Cldn8 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04131408054103
p value: 0.023139533871674
refers to: 1449091_at
refers to: Cldn8
t statistic: -5.68680961405039

Colec10 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.77057005073176
p value: 0.0285582450293976
refers to: 1457871_at
refers to: Colec10
t statistic: 5.25724336363936

Slc37a2
type: EnsemblDatabaseReference

1418626_a_at
type: EFO_0005072
part of: A-AFFY-45

Capn13
type: EnsemblDatabaseReference

Tnni1
type: EnsemblDatabaseReference

Prap1
type: EnsemblDatabaseReference

9030619P08Rik
type: EnsemblDatabaseReference

Capn13
type: EnsemblDatabaseReference

1448859_at
type: EFO_0005072
part of: A-AFFY-45

Car12
type: EnsemblDatabaseReference

(Assay) GSM515508
type: Assay
has participant: A-AFFY-45

(Assay) GSM515503
type: Assay
has participant: A-AFFY-45

Cpn1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.95205424652209
p value: 0.0128729216835165
refers to: 1417745_at
refers to: Cpn1
t statistic: 7.15306578375897

1436279_at
type: EFO_0005072
part of: A-AFFY-45

1453070_at
type: EFO_0005072
part of: A-AFFY-45

1437665_at
type: EFO_0005072
part of: A-AFFY-45

1425900_at
type: EFO_0005072
part of: A-AFFY-45

1431922_at
type: EFO_0005072
part of: A-AFFY-45

Crisp3
type: EnsemblDatabaseReference

Prap1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.29004002007877
p value: 0.0493786802459849
refers to: 1419167_at
refers to: Prap1
t statistic: 3.97565018577739

AI854703
type: EnsemblDatabaseReference

Isx
type: EnsemblDatabaseReference

1452492_a_at
type: EFO_0005072
part of: A-AFFY-45

H2-Ob DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03885190777031
p value: 0.0249226561691446
refers to: H2-Ob
refers to: 1440837_at
t statistic: -5.51660614863658

Greb1
type: EnsemblDatabaseReference

Prkacb
type: EnsemblDatabaseReference

Tnni1 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.06343449324199
p value: 0.0249365448622625
refers to: 1450813_a_at
refers to: Tnni1
t statistic: -5.50954134070214

(Assay) GSM515506
type: Assay
has participant: A-AFFY-45

Rgs2 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.09295935391951
p value: 0.0365219793253771
refers to: Rgs2
refers to: 1447830_s_at
t statistic: 4.55705056624486

Crisp3 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.8021621864126
p value: 0.0422846860124895
refers to: 1449838_at
refers to: Crisp3
t statistic: -4.22839846087085

Atp12a
type: EnsemblDatabaseReference

Clu
type: EnsemblDatabaseReference

Acaa1b
type: EnsemblDatabaseReference

Etv3
type: EnsemblDatabaseReference

(Assay) GSM515511
type: Assay
has participant: A-AFFY-45

Cd79b
type: EnsemblDatabaseReference

1455656_at
type: EFO_0005072
part of: A-AFFY-45

Cd79b
type: EnsemblDatabaseReference

Csta1
type: EnsemblDatabaseReference

Wdfy1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 2.53265488532854
p value: 1.02763384378644E-5
refers to: Wdfy1
refers to: 1437358_at
t statistic: 24.3843714357734

1435048_at
type: EFO_0005072
part of: A-AFFY-45

1450813_a_at
type: EFO_0005072
part of: A-AFFY-45

Cd79b DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.36176231079659
p value: 0.006294079834659
refers to: Cd79b
refers to: 1417640_at
t statistic: -8.45747072903841

1451991_at
type: EFO_0005072
part of: A-AFFY-45

1419167_at
type: EFO_0005072
part of: A-AFFY-45

1449091_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM515499
type: Assay
has participant: A-AFFY-45

Hkdc1
type: EnsemblDatabaseReference

Il22ra2
type: EnsemblDatabaseReference

Ces1f
type: EnsemblDatabaseReference

1418635_at
type: EFO_0005072
part of: A-AFFY-45

Car12 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.12449277650097
p value: 0.019057874520064
refers to: 1428485_at
refers to: Car12
t statistic: 6.11772291382668

(Factor value) GENOTYPE/wild type genotype
type: EFO_0000001
property type: GENOTYPE
property value: wild type genotype

Slc37a2 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -2.48869376262829
p value: 0.00943917171133933
refers to: Slc37a2
refers to: 1452492_a_at
t statistic: -7.73133353931101

Clu DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.55947556754016
p value: 0.00185657340768453
refers to: 1418626_a_at
refers to: Clu
t statistic: -11.3592667573477

Clu DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2493531913517
p value: 0.0101072436081071
refers to: 1454849_x_at
refers to: Clu
t statistic: -7.62625918021986

1417851_at
type: EFO_0005072
part of: A-AFFY-45

Btla DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15201236710786
p value: 0.00523099798831199
refers to: 1455656_at
refers to: Btla
t statistic: -8.79403357426667

Glycam1
type: EnsemblDatabaseReference

Nfib
type: EnsemblDatabaseReference

1440626_at
type: EFO_0005072
part of: A-AFFY-45

1423359_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM515509
type: Assay
has participant: A-AFFY-45

(Factor value) TIME/7
type: EFO_0000001
property type: TIME
property value: 7

1447830_s_at
type: EFO_0005072
part of: A-AFFY-45

Epha7 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.01290286354172
p value: 0.0133501692893094
refers to: Epha7
refers to: 1451991_at
t statistic: 7.01059596499002

(Sample) organism/Mus musculus
type: Mus musculus
property type: organism
property value: Mus musculus

Klb
type: EnsemblDatabaseReference

Ccl20
type: EnsemblDatabaseReference

H2-Ob
type: EnsemblDatabaseReference

H2-Ob
type: EnsemblDatabaseReference

Pln
type: EnsemblDatabaseReference

Klb
type: EnsemblDatabaseReference

(Assay) GSM515505
type: Assay
has participant: A-AFFY-45

1450912_at
type: EFO_0005072
part of: A-AFFY-45

Ms4a1
type: EnsemblDatabaseReference

1449568_at
type: EFO_0005072
part of: A-AFFY-45

Mt2
type: EnsemblDatabaseReference

(Factor value) GENOTYPE/CD4-CRE+ (PPAR g null)
type: EFO_0000001
property type: GENOTYPE
property value: CD4-CRE+ (PPAR g null)

Colec10
type: EnsemblDatabaseReference

Tsc22d3 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.18758800844842
p value: 0.0134348565597749
refers to: Tsc22d3
refers to: 1425281_a_at
t statistic: -6.92813105934557

Rps4l
type: EnsemblDatabaseReference

Ugt2b5
type: EnsemblDatabaseReference

Epha7
type: EnsemblDatabaseReference

Adra2a UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.39028063161649
p value: 0.0422846860124895
refers to: Adra2a
refers to: 1433600_at
t statistic: 4.23031133953458

1437358_at
type: EFO_0005072
part of: A-AFFY-45

Ms4a1 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.27756664236002
p value: 0.00185657340768453
refers to: Ms4a1
refers to: 1450912_at
t statistic: -11.3599475673953

1443889_at
type: EFO_0005072
part of: A-AFFY-45

Epha7
type: EnsemblDatabaseReference

1437960_at
type: EFO_0005072
part of: A-AFFY-45

Pcdh17 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0407558065972
p value: 0.0377009904585776
refers to: 1453070_at
refers to: Pcdh17
t statistic: 4.46906960208963

1435760_at
type: EFO_0005072
part of: A-AFFY-45

1435588_at
type: EFO_0005072
part of: A-AFFY-45

1425281_a_at
type: EFO_0005072
part of: A-AFFY-45

Mal
type: EnsemblDatabaseReference

Cxcl13 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.66765706596434
p value: 6.42851507177034E-4
refers to: Cxcl13
refers to: 1417851_at
t statistic: -13.772980219419

1460332_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM515500
type: Assay
has participant: A-AFFY-45

Pcdh17
type: EnsemblDatabaseReference

Hoxd13
type: EnsemblDatabaseReference

1424825_a_at
type: EFO_0005072
part of: A-AFFY-45

Cxcl13
type: EnsemblDatabaseReference

Slc26a7
type: EnsemblDatabaseReference

Slc26a7
type: EnsemblDatabaseReference

Analysis of 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: MicroarrayDifferentialExpressionAnalysis

Pln UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.06848923275857
p value: 0.0434615424057602
refers to: 1450952_at
refers to: Pln
t statistic: 4.17949582541081

Ms4a1 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -2.66242171017532
p value: 1.02763384378644E-5
refers to: 1423226_at
refers to: Ms4a1
t statistic: -25.5784965189171

1433600_at
type: EFO_0005072
part of: A-AFFY-45

Btla
type: EnsemblDatabaseReference

Tsc22d3
type: EnsemblDatabaseReference

Best2
type: EnsemblDatabaseReference

1437458_x_at
type: EFO_0005072
part of: A-AFFY-45

Cldn8
type: EnsemblDatabaseReference

(Sample) cell type/colonic mucosal CD4+ T cell
type: EFO_0000001
property type: cell type
property value: colonic mucosal CD4+ T cell

Adra2a
type: EnsemblDatabaseReference

Wdfy1
type: EnsemblDatabaseReference

Ighm DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.60295201248214
p value: 0.0422846860124895
refers to: Ighm
refers to: 1427329_a_at
t statistic: -4.2273973241571

1439568_at
type: EFO_0005072
part of: A-AFFY-45

1436920_at
type: EFO_0005072
part of: A-AFFY-45

Hmgcs2
type: EnsemblDatabaseReference

Wdfy1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 2.52083681774085
p value: 1.02763384378644E-5
refers to: 1424749_at
refers to: Wdfy1
t statistic: 26.2021968425451

Wdfy1
type: EnsemblDatabaseReference

Wdfy1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '0 day'
type: IncreasedDifferentialExpressionRatio
fold change: 2.58909599294935
p value: 0.00274892466278235
refers to: 1424749_at
refers to: Wdfy1
t statistic: 15.1714977992424

Hmgcs2
type: EnsemblDatabaseReference

Car12
type: EnsemblDatabaseReference

(Assay) GSM515501
type: Assay
has participant: A-AFFY-45

1422029_at
type: EFO_0005072
part of: A-AFFY-45

Slc35d1
type: EnsemblDatabaseReference

Hmgcs2 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.07069476473288
p value: 0.0150167155184245
refers to: 1431833_a_at
refers to: Hmgcs2
t statistic: 6.50883128605077

Slc35d1
type: EnsemblDatabaseReference

Csta1 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03937649339452
p value: 0.0363524275595929
refers to: 1435760_at
refers to: Csta1
t statistic: -4.58210431425625

Ces1f UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.24399679756463
p value: 0.0313318097032932
refers to: Ces1f
refers to: 1424266_s_at
t statistic: 4.99604062307182

Wdfy1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '0 day'
type: IncreasedDifferentialExpressionRatio
fold change: 2.71931728781932
p value: 0.00279650975977356
refers to: Wdfy1
refers to: 1437358_at
t statistic: 14.2800875698633

Pln UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.08573993885174
p value: 0.0377009904585776
refers to: 1423359_at
refers to: Pln
t statistic: 4.46287511604112

1440837_at
type: EFO_0005072
part of: A-AFFY-45

Ighm
type: EnsemblDatabaseReference

1420610_at
type: EFO_0005072
part of: A-AFFY-45

Capn13 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.40999960375173
p value: 0.0295574327245869
refers to: Capn13
refers to: 1437960_at
t statistic: -5.1393864449505

(Assay) GSM515497
type: Assay
has participant: A-AFFY-45

Prkacb
type: EnsemblDatabaseReference

Ces1g UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.01568930466628
p value: 0.0467284051569193
refers to: Ces1g
refers to: 1449486_at
t statistic: 4.06143187829435

Glycam1 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.26694241339549
p value: 0.0276676883855045
refers to: Glycam1
refers to: 1424825_a_at
t statistic: -5.31000059746999

Ces2a
type: EnsemblDatabaseReference

Rgs2
type: EnsemblDatabaseReference

1417275_at
type: EFO_0005072
part of: A-AFFY-45

Atp12a
type: EnsemblDatabaseReference

Cpn1
type: EnsemblDatabaseReference

Clu
type: EnsemblDatabaseReference

Etv3
type: EnsemblDatabaseReference

Acaa1b
type: EnsemblDatabaseReference

Pln UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.04737117739134
p value: 0.0316696328014579
refers to: 1460332_at
refers to: Pln
t statistic: 4.96092572321587

1419593_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM515507
type: Assay
has participant: A-AFFY-45

(Sample) genotype/wild type genotype
type: EFO_0000001
property type: genotype
property value: wild type genotype

Slc37a2
type: EnsemblDatabaseReference

Wdfy1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '0 day'
type: IncreasedDifferentialExpressionRatio
fold change: 2.78386320938344
p value: 0.00195017558535433
refers to: Wdfy1
refers to: 1435588_at
t statistic: 17.5864295771519

Tnni1
type: EnsemblDatabaseReference

Rps4l DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '0 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.22857096585272
p value: 0.0190340481595184
refers to: 1452730_at
refers to: Rps4l
t statistic: -10.0295119296037

Prap1
type: EnsemblDatabaseReference

9030619P08Rik
type: EnsemblDatabaseReference

Ces2a UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.05982078392799
p value: 0.0317765414803957
refers to: Ces2a
refers to: 1449375_at
t statistic: 4.9499972674172

E-GEOD-20523
type: microarray 1colour mrna differential
RO_0002162: Mus musculus
description: BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion of PPAR g in T cells modulates the severity of dextran-sodium sulfate (DSS)-induced colitis, immune cell distribution and global gene expression. METHODS: Wild-type (WT) or PPAR g flfl; CD4 Cre+ (CD4cre) mice in a C57BL/6 background were challenged with 2.5% DSS in their drinking water for 0, 2, or 7 days. Mice were scored on disease severity both clinically and histopathologically. Flow cytometry was used to assess lymphocyte and macrophage populations in the blood, spleen, and mesenteric lymph nodes (MLN). Global gene expression in colonic mucosa was profiled using Affymetrix microarrays. RESULTS: Both disease severity and inflammation-related body weight loss were accelerated by the deficiency of PPAR g in T cells. Examination of colon histopathology revealed significantly greater epithelial erosion, leukocyte infiltration, and mucosal thickening in the CD4cre mice on day 7. CD4cre mice had more CD8+ T cells than wt mice and fewer CD4+FoxP3+ regulatory T cells (Treg) and IL10+CD4+ T cells in blood and MLN, respectively. Transcriptomic profiling revealed around 3000 genes being transcriptionally altered as a result of DSS challenge in CD4cre mice. These included up-regulated adhesion molecules on day 7 and proinflammatory cytokines interleukin-6 (IL-6) and IL-1b, and suppressor of cytokine signaling 3 (SOCS-3) mRNA expression. CONCLUSIONS: These findings suggest that T cell PPAR g down-regulates inflammation during DSS colitis by inhibiting colonic expression of inflammatory mediators and increasing MLN Treg. Colonic mucosa from wt and CD4cre mice were sampled at 0 (no DSS), 2, and 7 days of DSS-induced experimental colitis
uses data from: http://identifiers.org/pubmed/20537136

Csta1
type: EnsemblDatabaseReference

Isx UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.54633849826027
p value: 0.0329610815123976
refers to: 1431922_at
refers to: Isx
t statistic: 4.7812253294613

1433595_at
type: EFO_0005072
part of: A-AFFY-45

1427329_a_at
type: EFO_0005072
part of: A-AFFY-45

Hkdc1
type: EnsemblDatabaseReference

1417745_at
type: EFO_0005072
part of: A-AFFY-45

Atp12a DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -4.31938905158762
p value: 0.00143626361517518
refers to: Atp12a
refers to: 1449475_at
t statistic: -12.1697879442813

Ces1f
type: EnsemblDatabaseReference

Crisp3
type: EnsemblDatabaseReference

A-AFFY-45
type: EFO_0000269

Isx
type: EnsemblDatabaseReference

AI854703
type: EnsemblDatabaseReference

Clu DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.28371772437488
p value: 0.0185550023265544
refers to: Clu
refers to: 1437458_x_at
t statistic: -6.16364263302891

Greb1
type: EnsemblDatabaseReference

AI854703 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.62993235416899
p value: 0.0286101439245372
refers to: 1435048_at
refers to: AI854703
t statistic: -5.22514721148494

(Sample) genotype/CD4-CRE+ (PPAR g null)
type: EFO_0000001
property type: genotype
property value: CD4-CRE+ (PPAR g null)

Clu DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.54246219672236
p value: 0.0133501692893094
refers to: Clu
refers to: 1437689_x_at
t statistic: -7.08598978074356

Il22ra2 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.05184839780826
p value: 0.00378777528380827
refers to: Il22ra2
refers to: 1437665_at
t statistic: -9.73675259937617

(Assay) GSM515496
type: Assay
has participant: A-AFFY-45

Wdfy1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 2.80150236801588
p value: 1.33836888111152E-5
refers to: Wdfy1
refers to: 1435588_at
t statistic: 22.8000821994488

Mus musculus
type: OBI_0100026

Ms4a1
type: EnsemblDatabaseReference

Etv3 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11862779203667
p value: 0.00523099798831199
refers to: Etv3
refers to: 1418635_at
t statistic: -8.71804398236462

Mt2
type: EnsemblDatabaseReference

Slc26a7 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11915824457106
p value: 0.0362695283665789
refers to: Slc26a7
refers to: 1436279_at
t statistic: -4.59927484222499

1457871_at
type: EFO_0005072
part of: A-AFFY-45

1424266_s_at
type: EFO_0005072
part of: A-AFFY-45

1425729_at
type: EFO_0005072
part of: A-AFFY-45

1428942_at
type: EFO_0005072
part of: A-AFFY-45

Hkdc1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.27686571223856
p value: 0.0329459380624977
refers to: 1425900_at
refers to: Hkdc1
t statistic: 4.79345387331642

Hoxd13 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.61681159231275
p value: 0.015891302405362
refers to: Hoxd13
refers to: 1440626_at
t statistic: -6.39300527035037

Mal UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.57317358932167
p value: 0.04722849279854
refers to: Mal
refers to: 1417275_at
t statistic: 4.03062986827509

Mt2 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.55238624109767
p value: 0.0296614408853338
refers to: 1428942_at
refers to: Mt2
t statistic: 5.12723380917648

Il22ra2
type: EnsemblDatabaseReference

1437689_x_at
type: EFO_0005072
part of: A-AFFY-45

Klb DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09032570360364
p value: 0.0357213481233565
refers to: Klb
refers to: 1449568_at
t statistic: -4.62255879049333

1452730_at
type: EFO_0005072
part of: A-AFFY-45

1424451_at
type: EFO_0005072
part of: A-AFFY-45

Glycam1
type: EnsemblDatabaseReference

1428485_at
type: EFO_0005072
part of: A-AFFY-45

Nfib
type: EnsemblDatabaseReference

Prkacb DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.28411998549043
p value: 0.0422846860124895
refers to: 1420610_at
refers to: Prkacb
t statistic: -4.22871979312191

Slc35d1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.00382865371453
p value: 0.0464594726239185
refers to: Slc35d1
refers to: 1433595_at
t statistic: 4.0882386564988

1449486_at
type: EFO_0005072
part of: A-AFFY-45

(Factor value) TIME/2
type: EFO_0000001
property type: TIME
property value: 2

1423226_at
type: EFO_0005072
part of: A-AFFY-45

Pcdh17 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.2599672488117
p value: 0.0344722977225165
refers to: Pcdh17
refers to: 1436920_at
t statistic: 4.6807954619346

Best2 DOWN in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: DecreasedDifferentialExpressionRatio
fold change: -1.21806341782562
p value: 0.0377009904585776
refers to: 1425729_at
refers to: Best2
t statistic: -4.44989927901158

Ccl20
type: EnsemblDatabaseReference

Pln
type: EnsemblDatabaseReference

1431833_a_at
type: EFO_0005072
part of: A-AFFY-45

(Assay) GSM515504
type: Assay
has participant: A-AFFY-45

Pcdh17
type: EnsemblDatabaseReference

1419622_at
type: EFO_0005072
part of: A-AFFY-45

Cxcl13
type: EnsemblDatabaseReference

1449838_at
type: EFO_0005072
part of: A-AFFY-45

1424749_at
type: EFO_0005072
part of: A-AFFY-45

Greb1 UP in 'CD4-CRE+ (PPAR g null)' vs 'wild type genotype' at '2 day'
type: IncreasedDifferentialExpressionRatio
fold change: 1.49248125692309
p value: 0.00378777528380827
refers to: Greb1
refers to: 1439568_at
t statistic: 9.56165878365724

(Assay) GSM515502
type: Assay
has participant: A-AFFY-45

Colec10
type: EnsemblDatabaseReference

Tsc22d3
type: EnsemblDatabaseReference

Best2
type: EnsemblDatabaseReference

Rps4l
type: EnsemblDatabaseReference

Cldn8
type: EnsemblDatabaseReference

Ugt2b5
type: EnsemblDatabaseReference

1417640_at
type: EFO_0005072
part of: A-AFFY-45