ALOX5AP UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CD32 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SEPT3 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
LYVE1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
OLFM1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
TLR4 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LEF1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ELP2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CD5L UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
TCF7L2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CLGN DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
TMEM144 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
AGTR1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ANGPTL4 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
DUSP1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
IFIT2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
APON DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
GPX3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SMC6 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CEBPD UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
HMGCS1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CH242-51E15.1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LIMD2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CXCL2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CAMK4 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
MT2A UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
DRAM1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SOD2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
RRM2B DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CD19 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
LXR UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SASH3 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CDC6 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000014997 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CASP1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
PPP1R21 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CDCA7 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CCDC181 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
VWA5A UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
RGS2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
GLUL UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ANXA8 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
PTGS1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ZNF318 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
STC1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
RFC3 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000026531 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SCD DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
Analysis of 'postweaning multisystemic wasting syndrome' vs 'normal'
EAF2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ASPN DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
DAPL1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
F3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SLC23A1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
DNMT3B DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
TMEM26 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CCR1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
IFIT3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
MAFB UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ACP2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000028241 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ASAH1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
PTTG1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CCNB1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
SERPINI1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
MYBL2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
STEAP4 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CD3Z DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000015700 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
PLAU UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
HK3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
RASGRP1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ABCA1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
HTRA4 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CD14 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LGALS3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SLC2A3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000012364 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
FAM65C UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SNX24 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000022111 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
NREP DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
MMP2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
MRC1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
TRIM6 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000000500 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000008205 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
LRRK2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CCL8 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CCRL2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
KIF11 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
SLC15A2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
NFIL3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CD24 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
PTX3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SMPDL3A UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000002452 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
FCER1G UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
C16orf74 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
HBA DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
AMBN UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
WFDC1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000013101 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
NUGGC DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
JUN UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
MBOAT2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
VAT1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SELENBP1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LPCAT2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LREAP1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
BF UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
PSTPIP2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
(Factor value) DISEASE/postweaning multisystemic wasting syndrome
postweaning multisystemic wasting syndrome
CCR9 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000004554 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
TINAGL1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
AFF2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
LTB DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
FOLR1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000012541 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000027872 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
LITAF UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
PTGS2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
C2orf40 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ABLIM1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
MZB1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
PDK4 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SCARB2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000008203 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
TIMP-2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
PLSCR4 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
HVCN1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
RAB8A UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LONRF3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000029414 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
AQP3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000027396 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000000423 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
STMN2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
PCD1A DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
SHISA2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ANXA1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
TOP2A DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CA2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
TGM1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENPEP UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CTSZ UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
RAC2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ISG12(A) UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
Postweaning multisystemic wasting syndrome (PMWS) is one of the pig diseases with major economic impact worldwide. Clinical, pathologic and some immunologic aspects of this disease are well-known, but the molecular mechanisms underlying pathogenic mechanisms of the disease are still poorly understood. The objective of the present study was to investigate the global changes in gene expression in the mediastinal lymph nodes from pigs naturally affected by PMWS and healthy counterparts, using the Affymetrix Porcine GenechipÃÂ®. This is the first study on gene expression in pigs naturally affected by PMWS. The present results allowed identifying potential mechanisms underlying the inflammation, lymphocyte depletion in lymphoid tissues and immune suppression, which are key features of PMWS. A total of twenty-five conventional 13 to 15-week-old pigs were used in this study. Animals were selected from three farms with historical records of PMWS and free of Porcine reproductive and respiratory syndrome virus (PRRSV) and Pseudorabies virus (PRV) infections. Twelve out of the 25 pigs fulfilled the PMWS diagnosis and were selected as cases, and the remaining thirteen pigs were selected as healthy control animals. At least one case and one control were used from each farm. 25 microarrays were used in the experiment, corresponding to the RNAs from mediastinal lymph nodes of 12 PMWS-affected pigs and 13 healthy controls.
STX11 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
NQO1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
P94 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ZC3H12D DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CLECL1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000026196 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
IL8 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
TOX DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
RHOJ UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
GLRX UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
NAGK UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000008178 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
SC5D DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
AOAH UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
GAREM DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
OGN DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
(Sample) organism part/mediastinal lymph node
PLBD1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
C2 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000027568 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000021606 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ADM UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LTF UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
TIMP1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000028141 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
(Sample) disease/postweaning multisystemic wasting syndrome
ENSSSCG00000014565 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ITIH3 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ZWINT DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
SPIDR UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CTTNBP2NL UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SWAP70 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
MAOA UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
IGFBPL1 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000015556 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CR2 DOWN in 'postweaning multisystemic wasting syndrome' vs 'normal'
CP UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
S100A9 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
ENSSSCG00000027797 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
CHPT1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
LIPG UP in 'postweaning multisystemic wasting syndrome' vs 'normal'
SCPEP1 UP in 'postweaning multisystemic wasting syndrome' vs 'normal'