GIMAP2 UP in 'Dhori virus' vs 'none' at '48 hour'
BCO1 UP in 'Dhori virus' vs 'none' at '48 hour'
RNF213 UP in 'Dhori virus' vs 'none' at '48 hour'
CCL5 UP in 'Dhori virus' vs 'none' at '48 hour'
RSAD2 UP in 'SARS-CoV' vs 'none' at '48 hour'
ETS2 UP in 'Dhori virus' vs 'none' at '48 hour'
TAP2 UP in 'Dhori virus' vs 'none' at '48 hour'
RTP4 UP in 'Dhori virus' vs 'none' at '24 hour'
OASL UP in 'SARS-CoV' vs 'none' at '48 hour'
ARL4C DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TNFSF10 UP in 'Dhori virus' vs 'none' at '48 hour'
HINT3 DOWN in 'Dhori virus' vs 'none' at '48 hour'
TMED4 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
JAK2 UP in 'Dhori virus' vs 'none' at '48 hour'
ETV5 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
NEB DOWN in 'Dhori virus' vs 'none' at '48 hour'
KAT6A DOWN in 'Dhori virus' vs 'none' at '48 hour'
CLIP1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
BNIP3L DOWN in 'SARS-CoV' vs 'none' at '48 hour'
NDUFS1 DOWN in 'Dhori virus' vs 'none' at '12 hour'
KLHL24 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
MPHOSPH9 DOWN in 'Dhori virus' vs 'none' at '48 hour'
CTSS UP in 'Dhori virus' vs 'none' at '48 hour'
TNFSF10 UP in 'SARS-CoV' vs 'none' at '48 hour'
CXCL8 UP in 'SARS-CoV' vs 'none' at '48 hour'
HELZ2 UP in 'Dhori virus' vs 'none' at '48 hour'
EPSTI1 UP in 'Dhori virus' vs 'none' at '24 hour'
CASP1 UP in 'SARS-CoV' vs 'none' at '48 hour'
CYS1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
SEC62 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CASP1 UP in 'Dhori virus' vs 'none' at '48 hour'
NCOA7 UP in 'Dhori virus' vs 'none' at '48 hour'
TRIM69 UP in 'SARS-CoV' vs 'none' at '48 hour'
GBP4 UP in 'Dhori virus' vs 'none' at '48 hour'
DDX60L UP in 'Dhori virus' vs 'none' at '24 hour'
OAS3 UP in 'Dhori virus' vs 'none' at '48 hour'
STAT2 UP in 'Dhori virus' vs 'none' at '48 hour'
PMAIP1 UP in 'Dhori virus' vs 'none' at '48 hour'
QSER1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
SP110 UP in 'Dhori virus' vs 'none' at '48 hour'
LPGAT1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
NDUFS1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
INHBA UP in 'SARS-CoV' vs 'none' at '48 hour'
FRMD3 UP in 'Dhori virus' vs 'none' at '48 hour'
MX2 UP in 'SARS-CoV' vs 'none' at '48 hour'
VIM DOWN in 'SARS-CoV' vs 'none' at '48 hour'
DDX17 DOWN in 'Dhori virus' vs 'none' at '48 hour'
PLEKHS1 UP in 'Dhori virus' vs 'none' at '48 hour'
FAM46A UP in 'Dhori virus' vs 'none' at '48 hour'
DUSP16 UP in 'SARS-CoV' vs 'none' at '48 hour'
MT1H UP in 'SARS-CoV' vs 'none' at '48 hour'
DUSP1 UP in 'SARS-CoV' vs 'none' at '48 hour'
CCL20 UP in 'SARS-CoV' vs 'none' at '48 hour'
SAMHD1 UP in 'Dhori virus' vs 'none' at '48 hour'
IFIT3 UP in 'SARS-CoV' vs 'none' at '48 hour'
IFIH1 UP in 'SARS-CoV' vs 'none' at '48 hour'
DDX60 UP in 'Dhori virus' vs 'none' at '48 hour'
CMTM4 DOWN in 'Dhori virus' vs 'none' at '48 hour'
MX2 UP in 'Dhori virus' vs 'none' at '48 hour'
CLN8 DOWN in 'Dhori virus' vs 'none' at '48 hour'
JUN UP in 'SARS-CoV' vs 'none' at '24 hour'
DUSP4 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IFNL1 UP in 'Dhori virus' vs 'none' at '48 hour'
BST2 UP in 'Dhori virus' vs 'none' at '48 hour'
STAT1 UP in 'Dhori virus' vs 'none' at '48 hour'
ETV7 UP in 'Dhori virus' vs 'none' at '48 hour'
TRIM22 UP in 'SARS-CoV' vs 'none' at '48 hour'
EGR1 UP in 'SARS-CoV' vs 'none' at '48 hour'
OASL UP in 'Dhori virus' vs 'none' at '24 hour'
IFIT1 UP in 'Dhori virus' vs 'none' at '48 hour'
TRAFD1 UP in 'Dhori virus' vs 'none' at '48 hour'
TMEM33 DOWN in 'Dhori virus' vs 'none' at '48 hour'
MT1X UP in 'SARS-CoV' vs 'none' at '48 hour'
Analysis of 'Dhori virus' vs 'none' at '48 hour'
SPAG9 DOWN in 'Dhori virus' vs 'none' at '48 hour'
EPSTI1 UP in 'Dhori virus' vs 'none' at '48 hour'
ABHD2 DOWN in 'Dhori virus' vs 'none' at '48 hour'
HLA-DPA1 UP in 'Dhori virus' vs 'none' at '48 hour'
AP1S1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
ERGIC1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
DDX60L UP in 'SARS-CoV' vs 'none' at '48 hour'
NFE2L3 UP in 'Dhori virus' vs 'none' at '48 hour'
HIST1H4C DOWN in 'Dhori virus' vs 'none' at '48 hour'
LIFR UP in 'Dhori virus' vs 'none' at '48 hour'
IFNL2 UP in 'SARS-CoV' vs 'none' at '48 hour'
SYNE2 DOWN in 'Dhori virus' vs 'none' at '24 hour'
CCL5 UP in 'SARS-CoV' vs 'none' at '48 hour'
UBE2L6 UP in 'Dhori virus' vs 'none' at '48 hour'
PCGF5 UP in 'Dhori virus' vs 'none' at '48 hour'
APOL6 UP in 'SARS-CoV' vs 'none' at '48 hour'
ACHE UP in 'Dhori virus' vs 'none' at '48 hour'
CD274 UP in 'SARS-CoV' vs 'none' at '48 hour'
NUB1 UP in 'Dhori virus' vs 'none' at '48 hour'
SSR1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
HECTD1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
RTP4 UP in 'SARS-CoV' vs 'none' at '48 hour'
CLN8 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
LGMN UP in 'Dhori virus' vs 'none' at '48 hour'
IFIT2 UP in 'Dhori virus' vs 'none' at '24 hour'
TRAK2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
BTN3A3 UP in 'Dhori virus' vs 'none' at '48 hour'
SLC28A3 UP in 'Dhori virus' vs 'none' at '48 hour'
ANP32B DOWN in 'Dhori virus' vs 'none' at '48 hour'
PIK3R1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
MXD1 UP in 'Dhori virus' vs 'none' at '48 hour'
SAMD9 UP in 'Dhori virus' vs 'none' at '48 hour'
LONRF2 DOWN in 'Dhori virus' vs 'none' at '48 hour'
PML UP in 'Dhori virus' vs 'none' at '48 hour'
Analysis of 'Dhori virus' vs 'none' at '24 hour'
MASTL UP in 'Dhori virus' vs 'none' at '48 hour'
PLEKHA4 UP in 'Dhori virus' vs 'none' at '48 hour'
TTC3 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
DIRAS3 UP in 'Dhori virus' vs 'none' at '48 hour'
SORL1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
RP4-781L3.1 UP in 'Dhori virus' vs 'none' at '48 hour'
IFNL1 UP in 'SARS-CoV' vs 'none' at '48 hour'
CD69 UP in 'SARS-CoV' vs 'none' at '48 hour'
PMAIP1 UP in 'SARS-CoV' vs 'none' at '48 hour'
TNRC6B DOWN in 'SARS-CoV' vs 'none' at '48 hour'
BTC UP in 'Dhori virus' vs 'none' at '48 hour'
PARP10 UP in 'Dhori virus' vs 'none' at '48 hour'
SP140L UP in 'Dhori virus' vs 'none' at '48 hour'
IL33 UP in 'Dhori virus' vs 'none' at '48 hour'
ASPM DOWN in 'Dhori virus' vs 'none' at '24 hour'
OAS1 UP in 'Dhori virus' vs 'none' at '48 hour'
MOV10 UP in 'Dhori virus' vs 'none' at '48 hour'
SPTBN1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
PARP12 UP in 'Dhori virus' vs 'none' at '48 hour'
MLKL UP in 'Dhori virus' vs 'none' at '48 hour'
TYMP UP in 'Dhori virus' vs 'none' at '48 hour'
FAS UP in 'Dhori virus' vs 'none' at '48 hour'
HLA-DRB1 UP in 'Dhori virus' vs 'none' at '48 hour'
WARS UP in 'Dhori virus' vs 'none' at '48 hour'
RICTOR UP in 'Dhori virus' vs 'none' at '48 hour'
CXCL1 UP in 'Dhori virus' vs 'none' at '48 hour'
TNFSF15 UP in 'Dhori virus' vs 'none' at '48 hour'
ZC3HAV1 UP in 'Dhori virus' vs 'none' at '48 hour'
TBL1XR1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
SOD2 UP in 'Dhori virus' vs 'none' at '48 hour'
HCG11 DOWN in 'Dhori virus' vs 'none' at '48 hour'
GBP4 UP in 'SARS-CoV' vs 'none' at '48 hour'
SECISBP2L DOWN in 'Dhori virus' vs 'none' at '48 hour'
EGR4 UP in 'SARS-CoV' vs 'none' at '48 hour'
CXCL8 UP in 'Dhori virus' vs 'none' at '48 hour'
MTF2 UP in 'Dhori virus' vs 'none' at '48 hour'
RABGAP1L UP in 'Dhori virus' vs 'none' at '48 hour'
IFIH1 UP in 'Dhori virus' vs 'none' at '48 hour'
MALAT1 DOWN in 'Dhori virus' vs 'none' at '12 hour'
ARIH1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
MAP3K8 UP in 'Dhori virus' vs 'none' at '48 hour'
RBBP6 UP in 'Dhori virus' vs 'none' at '48 hour'
DDX17 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TNFSF13B UP in 'Dhori virus' vs 'none' at '48 hour'
C19orf66 UP in 'Dhori virus' vs 'none' at '48 hour'
C1S UP in 'Dhori virus' vs 'none' at '48 hour'
STAT1 UP in 'SARS-CoV' vs 'none' at '48 hour'
ATF3 UP in 'SARS-CoV' vs 'none' at '48 hour'
GBP1 UP in 'Dhori virus' vs 'none' at '48 hour'
NEFL DOWN in 'Dhori virus' vs 'none' at '48 hour'
CD274 UP in 'Dhori virus' vs 'none' at '48 hour'
ZNFX1 UP in 'Dhori virus' vs 'none' at '48 hour'
HSH2D UP in 'Dhori virus' vs 'none' at '48 hour'
ATF3 UP in 'Dhori virus' vs 'none' at '48 hour'
CEACAM1 UP in 'Dhori virus' vs 'none' at '48 hour'
CARD16 UP in 'SARS-CoV' vs 'none' at '48 hour'
HELZ2 UP in 'SARS-CoV' vs 'none' at '48 hour'
FMNL2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
THEMIS2 UP in 'Dhori virus' vs 'none' at '48 hour'
SIDT1 UP in 'Dhori virus' vs 'none' at '48 hour'
LYZ DOWN in 'SARS-CoV' vs 'none' at '48 hour'
HECTD1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IFIT1 UP in 'Dhori virus' vs 'none' at '24 hour'
SLC16A7 DOWN in 'Dhori virus' vs 'none' at '48 hour'
RAB8B UP in 'Dhori virus' vs 'none' at '48 hour'
CMPK2 UP in 'Dhori virus' vs 'none' at '48 hour'
RHOBTB3 DOWN in 'Dhori virus' vs 'none' at '48 hour'
LTN1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
LIPA UP in 'Dhori virus' vs 'none' at '48 hour'
FOSB UP in 'SARS-CoV' vs 'none' at '48 hour'
CBX5 DOWN in 'Dhori virus' vs 'none' at '48 hour'
TRIM69 UP in 'Dhori virus' vs 'none' at '48 hour'
PER1 UP in 'SARS-CoV' vs 'none' at '48 hour'
HCG11 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
BTN3A1 UP in 'Dhori virus' vs 'none' at '48 hour'
IFNB1 UP in 'SARS-CoV' vs 'none' at '48 hour'
CX3CL1 UP in 'SARS-CoV' vs 'none' at '48 hour'
DDX58 UP in 'Dhori virus' vs 'none' at '48 hour'
CCL20 UP in 'Dhori virus' vs 'none' at '48 hour'
EPSTI1 UP in 'SARS-CoV' vs 'none' at '48 hour'
BATF2 UP in 'Dhori virus' vs 'none' at '48 hour'
DTX3L UP in 'Dhori virus' vs 'none' at '48 hour'
PSMB9 UP in 'SARS-CoV' vs 'none' at '48 hour'
LPGAT1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IFIT3 UP in 'Dhori virus' vs 'none' at '24 hour'
PRKAA2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
KIF1A DOWN in 'Dhori virus' vs 'none' at '24 hour'
RNF213 UP in 'Dhori virus' vs 'none' at '24 hour'
TMEM159 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
SECISBP2L DOWN in 'SARS-CoV' vs 'none' at '48 hour'
HERC5 UP in 'Dhori virus' vs 'none' at '48 hour'
IFIT3 UP in 'Dhori virus' vs 'none' at '48 hour'
TMED4 DOWN in 'Dhori virus' vs 'none' at '48 hour'
DYNC1H1 DOWN in 'Dhori virus' vs 'none' at '12 hour'
IFITM2 UP in 'Dhori virus' vs 'none' at '48 hour'
OPTN UP in 'Dhori virus' vs 'none' at '48 hour'
ARIH1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
IFI44 UP in 'Dhori virus' vs 'none' at '24 hour'
GAS5 UP in 'Dhori virus' vs 'none' at '48 hour'
TNFAIP3 UP in 'Dhori virus' vs 'none' at '48 hour'
SLC16A7 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CD47 UP in 'Dhori virus' vs 'none' at '48 hour'
ABI3BP DOWN in 'SARS-CoV' vs 'none' at '48 hour'
ISG20 UP in 'Dhori virus' vs 'none' at '48 hour'
AHNAK DOWN in 'Dhori virus' vs 'none' at '48 hour'
HSPA4 DOWN in 'Dhori virus' vs 'none' at '24 hour'
CCR1 UP in 'Dhori virus' vs 'none' at '48 hour'
DNAJB4 UP in 'Dhori virus' vs 'none' at '48 hour'
ODF3B UP in 'Dhori virus' vs 'none' at '48 hour'
THBS1 UP in 'SARS-CoV' vs 'none' at '48 hour'
DDX58 UP in 'SARS-CoV' vs 'none' at '48 hour'
MUC13 UP in 'Dhori virus' vs 'none' at '48 hour'
PSMB8 UP in 'Dhori virus' vs 'none' at '48 hour'
IL15 UP in 'Dhori virus' vs 'none' at '48 hour'
OAS2 UP in 'Dhori virus' vs 'none' at '48 hour'
PAPSS2 DOWN in 'Dhori virus' vs 'none' at '48 hour'
TRIM38 UP in 'Dhori virus' vs 'none' at '48 hour'
XRN1 UP in 'SARS-CoV' vs 'none' at '48 hour'
IL1A UP in 'Dhori virus' vs 'none' at '48 hour'
SLC15A3 UP in 'Dhori virus' vs 'none' at '48 hour'
NDUFS1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
SMG1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
MMP1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IFITM1 UP in 'SARS-CoV' vs 'none' at '48 hour'
CXCL8 UP in 'SARS-CoV' vs 'none' at '24 hour'
PRR11 DOWN in 'Dhori virus' vs 'none' at '48 hour'
TRIM31 UP in 'Dhori virus' vs 'none' at '48 hour'
ARRDC3 UP in 'SARS-CoV' vs 'none' at '48 hour'
PLAUR UP in 'Dhori virus' vs 'none' at '48 hour'
CFLAR UP in 'Dhori virus' vs 'none' at '48 hour'
SMCHD1 UP in 'Dhori virus' vs 'none' at '48 hour'
RIMKLB UP in 'Dhori virus' vs 'none' at '48 hour'
KIF1A DOWN in 'Dhori virus' vs 'none' at '12 hour'
CASP7 UP in 'Dhori virus' vs 'none' at '48 hour'
BIRC3 UP in 'Dhori virus' vs 'none' at '48 hour'
INHBA UP in 'Dhori virus' vs 'none' at '48 hour'
PLA1A UP in 'Dhori virus' vs 'none' at '48 hour'
IFIT2 UP in 'Dhori virus' vs 'none' at '48 hour'
SAMHD1 UP in 'SARS-CoV' vs 'none' at '48 hour'
DYNC1H1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
ERAP2 UP in 'Dhori virus' vs 'none' at '48 hour'
Analysis of 'SARS-CoV' vs 'none' at '48 hour'
NKX3-1 UP in 'Dhori virus' vs 'none' at '48 hour'
PTX3 UP in 'Dhori virus' vs 'none' at '48 hour'
SOCS1 UP in 'Dhori virus' vs 'none' at '48 hour'
QSER1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
BATF2 UP in 'SARS-CoV' vs 'none' at '48 hour'
ARRDC3 UP in 'Dhori virus' vs 'none' at '48 hour'
GSDMB UP in 'Dhori virus' vs 'none' at '48 hour'
HECTD1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
RNF213 UP in 'SARS-CoV' vs 'none' at '48 hour'
SAMD9L UP in 'SARS-CoV' vs 'none' at '48 hour'
TNFAIP3 UP in 'SARS-CoV' vs 'none' at '24 hour'
LYSMD2 UP in 'Dhori virus' vs 'none' at '48 hour'
IFI16 UP in 'Dhori virus' vs 'none' at '48 hour'
DNAJC3 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
DIS3 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
OASL UP in 'Dhori virus' vs 'none' at '48 hour'
RSAD2 UP in 'Dhori virus' vs 'none' at '48 hour'
MAP2K6 UP in 'Dhori virus' vs 'none' at '48 hour'
SLFN5 UP in 'Dhori virus' vs 'none' at '48 hour'
IFITM3 UP in 'Dhori virus' vs 'none' at '48 hour'
APOBEC3G UP in 'Dhori virus' vs 'none' at '48 hour'
EGFR UP in 'SARS-CoV' vs 'none' at '48 hour'
ARL5B UP in 'Dhori virus' vs 'none' at '48 hour'
GEM UP in 'SARS-CoV' vs 'none' at '48 hour'
ETV1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
SMAD5 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IRF1 UP in 'Dhori virus' vs 'none' at '48 hour'
PPM1K UP in 'Dhori virus' vs 'none' at '48 hour'
Analysis of 'SARS-CoV' vs 'none' at '12 hour'
HCP5 UP in 'Dhori virus' vs 'none' at '48 hour'
MT1H UP in 'Dhori virus' vs 'none' at '48 hour'
SAMD9L UP in 'Dhori virus' vs 'none' at '48 hour'
PTX3 UP in 'SARS-CoV' vs 'none' at '48 hour'
IFNA1 UP in 'Dhori virus' vs 'none' at '48 hour'
CD74 UP in 'Dhori virus' vs 'none' at '48 hour'
APOL6 UP in 'Dhori virus' vs 'none' at '48 hour'
TNFAIP3 UP in 'SARS-CoV' vs 'none' at '48 hour'
SAMD9L UP in 'Dhori virus' vs 'none' at '24 hour'
SEC22C DOWN in 'Dhori virus' vs 'none' at '48 hour'
OR52K3P UP in 'Dhori virus' vs 'none' at '48 hour'
PDGFRL UP in 'Dhori virus' vs 'none' at '48 hour'
BLZF1 UP in 'Dhori virus' vs 'none' at '48 hour'
KCTD12 DOWN in 'Dhori virus' vs 'none' at '48 hour'
HSD17B2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
HLA-DRA UP in 'Dhori virus' vs 'none' at '48 hour'
NIPBL DOWN in 'Dhori virus' vs 'none' at '24 hour'
BAZ1A UP in 'Dhori virus' vs 'none' at '48 hour'
TGM2 UP in 'Dhori virus' vs 'none' at '48 hour'
RP11-145M9.4 UP in 'Dhori virus' vs 'none' at '48 hour'
TTC3 DOWN in 'Dhori virus' vs 'none' at '48 hour'
CLCN5 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IL6 UP in 'Dhori virus' vs 'none' at '48 hour'
MAP2 UP in 'Dhori virus' vs 'none' at '48 hour'
SAT1 UP in 'Dhori virus' vs 'none' at '48 hour'
XAF1 UP in 'Dhori virus' vs 'none' at '48 hour'
TRANK1 UP in 'Dhori virus' vs 'none' at '48 hour'
HES4 UP in 'Dhori virus' vs 'none' at '48 hour'
REL UP in 'SARS-CoV' vs 'none' at '48 hour'
XPO1 UP in 'Dhori virus' vs 'none' at '48 hour'
RRAD UP in 'SARS-CoV' vs 'none' at '48 hour'
SPAG9 DOWN in 'Dhori virus' vs 'none' at '24 hour'
CLIP1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
ERGIC1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
CXCL10 UP in 'SARS-CoV' vs 'none' at '48 hour'
ASPM DOWN in 'Dhori virus' vs 'none' at '48 hour'
HLA-E UP in 'Dhori virus' vs 'none' at '48 hour'
DDX58 UP in 'Dhori virus' vs 'none' at '24 hour'
SEC22C DOWN in 'SARS-CoV' vs 'none' at '48 hour'
KLHDC7B UP in 'Dhori virus' vs 'none' at '48 hour'
PSD3 DOWN in 'Dhori virus' vs 'none' at '48 hour'
GIMAP2 UP in 'SARS-CoV' vs 'none' at '48 hour'
RSAD2 UP in 'Dhori virus' vs 'none' at '24 hour'
CX3CL1 UP in 'Dhori virus' vs 'none' at '48 hour'
CPEB3 UP in 'Dhori virus' vs 'none' at '48 hour'
ETV7 UP in 'SARS-CoV' vs 'none' at '48 hour'
BATF2 UP in 'Dhori virus' vs 'none' at '24 hour'
TMEM159 DOWN in 'Dhori virus' vs 'none' at '48 hour'
CSTB DOWN in 'SARS-CoV' vs 'none' at '48 hour'
ARL4C DOWN in 'Dhori virus' vs 'none' at '48 hour'
MSI2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
SMAD5 DOWN in 'Dhori virus' vs 'none' at '24 hour'
HRASLS2 UP in 'Dhori virus' vs 'none' at '48 hour'
STK4 DOWN in 'Dhori virus' vs 'none' at '24 hour'
CTD-2521M24.9 UP in 'Dhori virus' vs 'none' at '48 hour'
IL15RA UP in 'Dhori virus' vs 'none' at '48 hour'
CXCL1 UP in 'SARS-CoV' vs 'none' at '48 hour'
IL7 UP in 'Dhori virus' vs 'none' at '48 hour'
PRDX5 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
HDGFRP3 DOWN in 'Dhori virus' vs 'none' at '48 hour'
CXCL10 UP in 'Dhori virus' vs 'none' at '24 hour'
CMPK2 UP in 'Dhori virus' vs 'none' at '24 hour'
IDO1 UP in 'SARS-CoV' vs 'none' at '48 hour'
DYNC2LI1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TOR1B UP in 'Dhori virus' vs 'none' at '48 hour'
MBTD1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CLCN5 DOWN in 'Dhori virus' vs 'none' at '48 hour'
PSMB9 UP in 'Dhori virus' vs 'none' at '48 hour'
NEFL DOWN in 'SARS-CoV' vs 'none' at '48 hour'
RASGRP3 UP in 'Dhori virus' vs 'none' at '48 hour'
NFKBIA UP in 'SARS-CoV' vs 'none' at '24 hour'
TNFSF13B UP in 'SARS-CoV' vs 'none' at '48 hour'
MT2A UP in 'Dhori virus' vs 'none' at '48 hour'
CXCL2 UP in 'Dhori virus' vs 'none' at '48 hour'
ZCCHC2 UP in 'Dhori virus' vs 'none' at '48 hour'
EGR4 UP in 'SARS-CoV' vs 'none' at '24 hour'
TMEM184A DOWN in 'SARS-CoV' vs 'none' at '48 hour'
PRKD2 UP in 'Dhori virus' vs 'none' at '48 hour'
ADAM28 UP in 'Dhori virus' vs 'none' at '48 hour'
SERPINB9 UP in 'Dhori virus' vs 'none' at '48 hour'
TMEM140 UP in 'Dhori virus' vs 'none' at '48 hour'
XAF1 UP in 'SARS-CoV' vs 'none' at '48 hour'
IDO1 UP in 'Dhori virus' vs 'none' at '24 hour'
SEC62 DOWN in 'SARS-CoV' vs 'none' at '24 hour'
BCL2L14 UP in 'Dhori virus' vs 'none' at '48 hour'
GABRE UP in 'Dhori virus' vs 'none' at '48 hour'
IFNA2 UP in 'Dhori virus' vs 'none' at '48 hour'
PIK3AP1 UP in 'Dhori virus' vs 'none' at '48 hour'
XAF1 UP in 'Dhori virus' vs 'none' at '24 hour'
XRN1 UP in 'Dhori virus' vs 'none' at '48 hour'
CXCL11 UP in 'Dhori virus' vs 'none' at '48 hour'
CH25H UP in 'SARS-CoV' vs 'none' at '48 hour'
LAMP3 UP in 'Dhori virus' vs 'none' at '48 hour'
AKR1B10 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
NEB DOWN in 'SARS-CoV' vs 'none' at '48 hour'
SPEN DOWN in 'Dhori virus' vs 'none' at '48 hour'
BX322557.10 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
PNPT1 UP in 'Dhori virus' vs 'none' at '48 hour'
OAS1 UP in 'SARS-CoV' vs 'none' at '48 hour'
SSR1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CXCL2 UP in 'SARS-CoV' vs 'none' at '48 hour'
IFI27 UP in 'Dhori virus' vs 'none' at '48 hour'
RP3-508I15.21 UP in 'Dhori virus' vs 'none' at '48 hour'
ASPM DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TRIM14 UP in 'Dhori virus' vs 'none' at '48 hour'
IRF1 UP in 'SARS-CoV' vs 'none' at '48 hour'
TBL1X DOWN in 'Dhori virus' vs 'none' at '48 hour'
CREB5 UP in 'SARS-CoV' vs 'none' at '48 hour'
JADE2 UP in 'Dhori virus' vs 'none' at '48 hour'
NFKBIA UP in 'SARS-CoV' vs 'none' at '48 hour'
HNRNPA2B1 UP in 'Dhori virus' vs 'none' at '24 hour'
LAP3 UP in 'Dhori virus' vs 'none' at '48 hour'
BTN3A2 UP in 'Dhori virus' vs 'none' at '48 hour'
RP11-400K9.4 UP in 'Dhori virus' vs 'none' at '48 hour'
CCDC186 DOWN in 'Dhori virus' vs 'none' at '12 hour'
UHMK1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
MT1F UP in 'Dhori virus' vs 'none' at '48 hour'
PSD3 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CXCL11 UP in 'SARS-CoV' vs 'none' at '48 hour'
PSMB8-AS1 UP in 'Dhori virus' vs 'none' at '48 hour'
IFIH1 UP in 'Dhori virus' vs 'none' at '24 hour'
SP100 UP in 'Dhori virus' vs 'none' at '48 hour'
QSER1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CPM DOWN in 'Dhori virus' vs 'none' at '48 hour'
ETS2 UP in 'SARS-CoV' vs 'none' at '48 hour'
ANPEP DOWN in 'SARS-CoV' vs 'none' at '48 hour'
EGR1 UP in 'SARS-CoV' vs 'none' at '12 hour'
IFI44 UP in 'SARS-CoV' vs 'none' at '48 hour'
IFI44 UP in 'Dhori virus' vs 'none' at '48 hour'
EGR4 UP in 'SARS-CoV' vs 'none' at '12 hour'
NFKBIA UP in 'Dhori virus' vs 'none' at '48 hour'
C5orf24 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
JUN UP in 'SARS-CoV' vs 'none' at '48 hour'
EGR4 UP in 'Dhori virus' vs 'none' at '48 hour'
LONRF2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
SLC25A28 UP in 'Dhori virus' vs 'none' at '48 hour'
FYB UP in 'Dhori virus' vs 'none' at '48 hour'
OAS2 UP in 'SARS-CoV' vs 'none' at '48 hour'
EGR1 UP in 'SARS-CoV' vs 'none' at '24 hour'
ATRX DOWN in 'Dhori virus' vs 'none' at '12 hour'
PCYOX1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
NMI UP in 'Dhori virus' vs 'none' at '48 hour'
TRIM21 UP in 'SARS-CoV' vs 'none' at '48 hour'
IL1A UP in 'SARS-CoV' vs 'none' at '24 hour'
FAM122C UP in 'Dhori virus' vs 'none' at '48 hour'
THRAP3 DOWN in 'Dhori virus' vs 'none' at '12 hour'
FOS UP in 'SARS-CoV' vs 'none' at '24 hour'
SIX1 UP in 'Dhori virus' vs 'none' at '48 hour'
CCNL1 UP in 'Dhori virus' vs 'none' at '48 hour'
RHBDF2 UP in 'Dhori virus' vs 'none' at '48 hour'
GMPR UP in 'Dhori virus' vs 'none' at '48 hour'
NLRC5 UP in 'SARS-CoV' vs 'none' at '48 hour'
SEMA3A UP in 'Dhori virus' vs 'none' at '48 hour'
VIM DOWN in 'Dhori virus' vs 'none' at '48 hour'
CDC42BPA DOWN in 'SARS-CoV' vs 'none' at '48 hour'
DUSP8 UP in 'SARS-CoV' vs 'none' at '48 hour'
CCDC186 DOWN in 'Dhori virus' vs 'none' at '24 hour'
SECTM1 UP in 'Dhori virus' vs 'none' at '48 hour'
TRIM22 UP in 'Dhori virus' vs 'none' at '48 hour'
ZC3HAV1 UP in 'SARS-CoV' vs 'none' at '48 hour'
CEP57 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
NDRG1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
EIF1 UP in 'Dhori virus' vs 'none' at '48 hour'
PCYOX1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
GAREM DOWN in 'SARS-CoV' vs 'none' at '48 hour'
PTX3 UP in 'SARS-CoV' vs 'none' at '24 hour'
CCL20 UP in 'SARS-CoV' vs 'none' at '24 hour'
CDC42BPA DOWN in 'Dhori virus' vs 'none' at '24 hour'
ICAM1 UP in 'Dhori virus' vs 'none' at '48 hour'
KLF13 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TAGAP UP in 'Dhori virus' vs 'none' at '48 hour'
OAS2 UP in 'Dhori virus' vs 'none' at '24 hour'
MYH10 DOWN in 'Dhori virus' vs 'none' at '48 hour'
IFIT1 UP in 'SARS-CoV' vs 'none' at '48 hour'
IFNB1 UP in 'Dhori virus' vs 'none' at '48 hour'
RIF1 DOWN in 'Dhori virus' vs 'none' at '12 hour'
NPFFR2 UP in 'SARS-CoV' vs 'none' at '48 hour'
LGALS9 UP in 'Dhori virus' vs 'none' at '48 hour'
LMO2 UP in 'Dhori virus' vs 'none' at '48 hour'
NUPR1 UP in 'Dhori virus' vs 'none' at '48 hour'
IFIT2 UP in 'SARS-CoV' vs 'none' at '48 hour'
IL11 UP in 'SARS-CoV' vs 'none' at '48 hour'
TRIM21 UP in 'Dhori virus' vs 'none' at '48 hour'
PAH DOWN in 'SARS-CoV' vs 'none' at '48 hour'
DDX17 DOWN in 'Dhori virus' vs 'none' at '24 hour'
HNRNPA2B1 UP in 'Dhori virus' vs 'none' at '48 hour'
NOSTRIN DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TLR3 UP in 'Dhori virus' vs 'none' at '48 hour'
TMEM106B DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CXCL11 UP in 'Dhori virus' vs 'none' at '24 hour'
CXCL3 UP in 'Dhori virus' vs 'none' at '48 hour'
HERC5 UP in 'SARS-CoV' vs 'none' at '48 hour'
SMARCE1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
NLRC5 UP in 'Dhori virus' vs 'none' at '48 hour'
MX2 UP in 'Dhori virus' vs 'none' at '24 hour'
RASEF DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CTD-2095E4.5 UP in 'Dhori virus' vs 'none' at '48 hour'
UHMK1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
HERC6 UP in 'Dhori virus' vs 'none' at '48 hour'
HPGD DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IGF1R DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TTC3 DOWN in 'Dhori virus' vs 'none' at '24 hour'
TAP1 UP in 'SARS-CoV' vs 'none' at '48 hour'
CEACAM7 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
ATF3 UP in 'SARS-CoV' vs 'none' at '24 hour'
TMEM27 UP in 'Dhori virus' vs 'none' at '48 hour'
PAPSS2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TDRD7 UP in 'Dhori virus' vs 'none' at '48 hour'
ITGAM UP in 'SARS-CoV' vs 'none' at '48 hour'
CXCL10 UP in 'Dhori virus' vs 'none' at '48 hour'
IRF7 UP in 'Dhori virus' vs 'none' at '48 hour'
Analysis of 'SARS-CoV' vs 'none' at '24 hour'
IFI44L UP in 'Dhori virus' vs 'none' at '48 hour'
MYD88 UP in 'Dhori virus' vs 'none' at '48 hour'
TRIM22 UP in 'Dhori virus' vs 'none' at '24 hour'
TMEM159 DOWN in 'Dhori virus' vs 'none' at '24 hour'
IFI35 UP in 'Dhori virus' vs 'none' at '48 hour'
IFIT5 UP in 'Dhori virus' vs 'none' at '48 hour'
SGK2 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
ACO1 DOWN in 'Dhori virus' vs 'none' at '48 hour'
TMEM33 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
NUPL1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
AHNAK2 DOWN in 'Dhori virus' vs 'none' at '48 hour'
ST3GAL1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
ZBP1 UP in 'Dhori virus' vs 'none' at '48 hour'
SERPING1 UP in 'Dhori virus' vs 'none' at '48 hour'
GBP1 UP in 'SARS-CoV' vs 'none' at '48 hour'
DUSP1 UP in 'SARS-CoV' vs 'none' at '24 hour'
DRD1 UP in 'SARS-CoV' vs 'none' at '48 hour'
NR1D1 UP in 'SARS-CoV' vs 'none' at '48 hour'
TULP4 DOWN in 'Dhori virus' vs 'none' at '48 hour'
DDX17 DOWN in 'Dhori virus' vs 'none' at '12 hour'
IDO1 UP in 'Dhori virus' vs 'none' at '48 hour'
HELZ2 UP in 'Dhori virus' vs 'none' at '24 hour'
RASSF6 DOWN in 'Dhori virus' vs 'none' at '24 hour'
RNF19B UP in 'Dhori virus' vs 'none' at '48 hour'
NT5DC1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CTSZ DOWN in 'Dhori virus' vs 'none' at '48 hour'
HIF3A UP in 'SARS-CoV' vs 'none' at '48 hour'
IL1A UP in 'SARS-CoV' vs 'none' at '48 hour'
C11orf54 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
FAM65B UP in 'Dhori virus' vs 'none' at '48 hour'
FMNL2 DOWN in 'Dhori virus' vs 'none' at '48 hour'
PNPT1 UP in 'SARS-CoV' vs 'none' at '48 hour'
SCYL3 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
KLF6 UP in 'Dhori virus' vs 'none' at '48 hour'
DDX60L UP in 'Dhori virus' vs 'none' at '48 hour'
CDC42BPA DOWN in 'Dhori virus' vs 'none' at '12 hour'
CYS1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
HSPA4 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
PXK UP in 'Dhori virus' vs 'none' at '48 hour'
PSD3 DOWN in 'Dhori virus' vs 'none' at '24 hour'
NDUFS1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
ISG15 UP in 'Dhori virus' vs 'none' at '48 hour'
CD55 UP in 'Dhori virus' vs 'none' at '48 hour'
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection causes an immune-mediated disease. We have recently shown that SARS-CoV-induced epithelial Calu-3 cytokines could exacerbate and dampen host inflammatory and T cell responses, respectively, through modulating the functions of macrophages and dendritic cells, thereby suggesting that not only are lung epithelial cells the primary cells of SARS-CoV infection, but they also involve in initiating and orchestrating the host innate and adaptive immunity. Comprehensive evaluation of the complex epithelial signaling to SARS-CoV is, thus, crucial for paving the way to better understand SARS pathogenesis and develop the innovative therapeutics against SARS. Here, based on the microarray-based functional genomics, we reported that 2B4 cells, a clonal derivative of Calu-3 cells, elicited a temporal and spatial activation of nuclear factor (NF)kappaB, activator protein (AP)-1 (ATF2/c-Jun), and interferon regulatory factor (IRF)-3/-7 at 12-, 24-, and 48-hrs post infection (p.i.), respectively, resulting in the activation of many antiviral genes, including interferon (IFN)-ÃÂÃÂ², -ÃÂÃÂ»s, SARS-related inflammatory mediators, and various IFN-stimulated genes (ISGs). While elevated responses of IFN-ÃÂÃÂ² and IFN-ÃÂÃÂ»s were not detected until 48-hrs p.i., as a consequence of a delayed IRF-3/-7 activation, we showed, for the first time, that both types of IFNs exerted previously under-described non-redundant, complementary, and/or synergistic effects on the epithelial defense against SARS-CoV. Collectively, our results highlight the molecular mechanisms of the sequential activation of virus- and IFN-dependent signaling of lung epithelial cells against SARS-CoV and identify novel cellular targets for future studies, aiming at advancing strategies against SARS. DNA microarrays were performed in the Molecular Genomics (MG) Core Facilities at UTMB. The detailed information about the procedures of microarray analysis has been posted on the MG Core Facilities website (genomics@scms.utmb.edu). To characterize the dynamic, spatial, and temporal changes of the gene expression induced by SARS-CoV, confluent 2B4 cells grown in T-75 flasks were infected with SARS-CoV (MOI=0.1) or remained uninfected (as control) for 12, 24, and 48hrs. Because 2B4 cells were also permissive to the productive infection of Dhori virus (DHOV), a member of the Orthomyxoviridae family within the Thogotovirus genus, resulting in robust responses of IFNs and other pro-inflammatory mediators, we also established parallel cultures of DHOV-infected 2B4 cells (MOI=0.1) for the comparative analysis of global gene expression elicited by SARS-CoV- versus DHOV-infected 2B4 cells. To meet the minimal number required for application of statistical algorithms, we performed the study in triplicate at each time point for mock-, SARS-CoV-, and DHOV-infected cultures, yielding a total of 27 arrays. Briefly, supernatants were harvested from differentially treated cultures at 12-, 24-, and 48-hrs p.i. for subsequent analyses of viral yields and cytokine profiling, whereas the cells were subjected to total RNA extraction by using an RNAqueous-4PCR kit and following the protocol recommended by the manufacturer (Ambion, Austin, TX). Purified RNA samples were sent to our core facility for conversion to cDNA, biotin-labeled, and hybridized to 27 Affymetrix Human Genome U133 Plus 2.0 ÃÂ¢ÃÂÃÂGene ChipsÃÂ¢ÃÂÃÂ each of which contained 54,675 probe set identifiers representing more than ~47,400 transcripts that identify ~38,500 well-characterized genes, and various internal controls (Affymetrix, Santa Clara, CA). Mock-infected cells were compared to cells infected with SARS-CoV or DHOV at each time point.
IFI44L UP in 'Dhori virus' vs 'none' at '24 hour'
HLA-F UP in 'Dhori virus' vs 'none' at '48 hour'
MX1 UP in 'Dhori virus' vs 'none' at '48 hour'
Analysis of 'Dhori virus' vs 'none' at '12 hour'
GPR110 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
FAM46A UP in 'SARS-CoV' vs 'none' at '48 hour'
APOL3 UP in 'Dhori virus' vs 'none' at '48 hour'
STYK1 UP in 'Dhori virus' vs 'none' at '48 hour'
TLR3 UP in 'SARS-CoV' vs 'none' at '48 hour'
MT1X UP in 'Dhori virus' vs 'none' at '48 hour'
TMEM173 UP in 'Dhori virus' vs 'none' at '48 hour'
SMG1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
TTC3 DOWN in 'Dhori virus' vs 'none' at '12 hour'
FOS UP in 'SARS-CoV' vs 'none' at '48 hour'
IL6 UP in 'SARS-CoV' vs 'none' at '48 hour'
TAP1 UP in 'Dhori virus' vs 'none' at '48 hour'
LINC00520 UP in 'SARS-CoV' vs 'none' at '48 hour'
RTP4 UP in 'Dhori virus' vs 'none' at '48 hour'
CLIP1 DOWN in 'Dhori virus' vs 'none' at '12 hour'
LTN1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
PARP9 UP in 'Dhori virus' vs 'none' at '48 hour'
TPR DOWN in 'SARS-CoV' vs 'none' at '48 hour'
FBXO6 UP in 'Dhori virus' vs 'none' at '48 hour'
FOXC1 UP in 'Dhori virus' vs 'none' at '48 hour'
SMAD5 DOWN in 'Dhori virus' vs 'none' at '48 hour'
IFITM1 UP in 'Dhori virus' vs 'none' at '48 hour'
AC016747.3 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
SPAG9 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
RALBP1 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
CMPK2 UP in 'SARS-CoV' vs 'none' at '48 hour'
IGF1R DOWN in 'Dhori virus' vs 'none' at '48 hour'
EHF UP in 'Dhori virus' vs 'none' at '48 hour'
SPTBN1 DOWN in 'Dhori virus' vs 'none' at '12 hour'
HDGFRP3 DOWN in 'SARS-CoV' vs 'none' at '48 hour'
IL12A UP in 'Dhori virus' vs 'none' at '48 hour'
GLS DOWN in 'Dhori virus' vs 'none' at '48 hour'
CLCN5 DOWN in 'Dhori virus' vs 'none' at '24 hour'
EIF3B UP in 'Dhori virus' vs 'none' at '48 hour'
PHF11 UP in 'Dhori virus' vs 'none' at '48 hour'
CYP2J2 UP in 'Dhori virus' vs 'none' at '48 hour'
RARRES3 UP in 'Dhori virus' vs 'none' at '48 hour'
INO80D DOWN in 'SARS-CoV' vs 'none' at '48 hour'
PLAC8 UP in 'Dhori virus' vs 'none' at '48 hour'
IFNL2 UP in 'Dhori virus' vs 'none' at '48 hour'
PARP14 UP in 'Dhori virus' vs 'none' at '48 hour'
SPTBN1 DOWN in 'Dhori virus' vs 'none' at '24 hour'
MT2A UP in 'SARS-CoV' vs 'none' at '48 hour'
ZBP1 UP in 'SARS-CoV' vs 'none' at '48 hour'
DDX60 UP in 'SARS-CoV' vs 'none' at '48 hour'
TRIM5 UP in 'Dhori virus' vs 'none' at '48 hour'
NAPSB UP in 'Dhori virus' vs 'none' at '48 hour'