2610018G03Rik UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Slc16a3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nrip1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Grb10 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ggh DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Limch1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Bmp7 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nid1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Abca1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gstm6 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cryz UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Slc39a8 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ldlrap1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rtp4 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Mfsd4 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ugt8a UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Mycl UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cmtm3 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Sparc UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Fgf13 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nebl DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gpr137b DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Bcl6 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ngfr UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tbx2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Itpka UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Shank3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Htr3a UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Usp18 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Prtn3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ero1lb DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
(Sample) disease/dopaminergic neuroblastoma
BC022687 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Sdpr UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Hspa1b UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tram1l1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Oprd1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Oasl1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Zfp36l1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Prrx1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Snai2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Serpinf1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ybx2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ptrf UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Celf2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Runx2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Deptor UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Fkbp10 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Lgals3 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Krt8 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nos1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Clu DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Birc5 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Qpct DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gla DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
H19 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Agtr2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ebf1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Mrc2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Prkce UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nfix UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Neurog2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Avil UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Amph DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cth UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Dnajc12 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Sh3bgr DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Padi4 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Luc7l2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Aldoc UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Aqp3 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Pkdcc UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Stmn2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Analysis of 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ccnd2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tspan5 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Itm2a DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gca DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Chrna3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Reep6 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Slc39a6 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Klf6 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Spry1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Grp UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Vdr UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Mbnl3 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Egr1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tgfbi UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Il15 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Spin4 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tead2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gulo UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Qk DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Lrr1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Trib2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Jmy DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ctsb DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Il13ra1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Agfg1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Vegfc DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
The mesencephalic dopaminergic (mDA) cell system is composed by two major groups of projecting cells in the Substantia Nigra (A9 neurons) and the Ventral Tegmental Area (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Their selective degeneration leads to Parkinsons disease (PD). We used cDNA microarrays and nanoCAGE technology coupled with Laser Capture Microdissection (LCM) to characterize the intrinsic physiological properties of A9 DA neurons. Surprisingly, we found that these cells express alpha- and beta- chains of haemoglobin. Here we report that globin-immunoreactivity decorates the majority of A9 DA neurons, a subpopulation of cortical and hippocampal astrocytes as well as mature oligodendrocytes. This pattern of expression was confirmed in different mouse strains, in rat and human. This is the first report showing that haemoglobin is expressed in the Substantia Nigra of human post mortem brain. Our data suggest that the most famed oxygen-carrying globin is not exclusively restricted to the blood, but it may play a role in the normal physiology of the brain as well as in neurodegenerative disorders. To investigate the biological effects of globin expression, alpha- and beta- chains of mouse hemoglobin were overexpressed in MN9D dopaminergic neuroblastoma cell lines. RNA from 4 replicates each of over-expressing cells and of control samples, for a total of 8 samples, were hybridized on Affymetrix GeneChip Mouse Genome 430A 2.0 Arrays. Hybridization of one of the control samples did not pass quality assessment and the sample was therefore excluded from further analysis.
Abcb1a DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Wls UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Utrn DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rnd3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rgs2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Akr1b8 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gpnmb DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Grhl2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Crlf1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Dtna DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Il6 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Thy1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Kitl DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Recql4 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Dkk1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Anpep DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ifi30 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Bik UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Slc4a10 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Egln3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Peg10 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Scara5 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
N4bp2l1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Hoxa9 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
P2rx7 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Mt1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
(Sample) genotype/overexpression of alpha- and beta- Hb chains
overexpression of alpha- and beta- Hb chains
Acyp1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
G0s2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Sh3yl1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Depdc1a UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ube2o DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Fzd7 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tspo UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ntng1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cpeb2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Mfge8 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Mt2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cdkn1b DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Stard5 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ptgs1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Dapp1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Socs2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Adora1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Igfbp6 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
C1qtnf6 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
(Factor value) GENOTYPE/overexpression of alpha- and beta- Hb chains
Selenbp1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Npnt UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
S100pbp DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
F3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Otog UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rgl1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Macrod1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Slc29a4 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Socs3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Soat1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rbfox3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tlr4 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tst UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Pkia DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rhov DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Prkg2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Hoxa5 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Pitx2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ret UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Vamp1 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ung UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nabp1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ptn UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Sfrp2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cd68 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ubxn2b DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Igfbp4 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Exoc7 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gng13 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
St6galnac5 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rrm2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Bptf DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Alpl UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Abcg2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tmem56 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Dmkn UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Trpm7 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Pcdhb3 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Stmn4 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nfib UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Pygl UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Neurl1a UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Il2rg DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Crabp2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cdk18 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Sept4 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Srp68 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Cyp4v3 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Sept6 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tha1 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Fam213b UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Rab30 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tmem30b UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Gpm6b DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Acpp DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Nrbp2 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Zfp820 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Car6 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Tnfrsf9 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Metrn UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Pcdhb15 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Syngr2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Ahnak UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Bcl2l11 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Efna3 UP in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Oasl2 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Afp DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'
Igsf5 DOWN in 'overexpression of alpha- and beta- Hb chains' vs 'control vector'