Jag1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Tshr DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ets1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Tie1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
F13a1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
B3galt2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Prps1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Pfdn5 DOWN in 'undernutrition during pregnancy, ad libitum chow during suckling' vs 'ad libitum chow during pregnancy and suckling'
Anxa6 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Vim DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Hp DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Clybl DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Emp1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Trp53inp2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Lgals3bp DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Sdpr DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ccdc80 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Paip1 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
(Factor value) ENVIRONMENTAL_HISTORY/ad libitum chow during pregnancy and suckling
ad libitum chow during pregnancy and suckling
Pfkfb3 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Fmr1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Cib2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ttr UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Fbn1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Abcd2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Sod3 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Adipoq DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ghr DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Pnpla3 UP in 'undernutrition during pregnancy, ad libitum chow during suckling' vs 'ad libitum chow during pregnancy and suckling'
Abca1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Edem1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
C2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Gabarapl1 DOWN in 'undernutrition during pregnancy, ad libitum chow during suckling' vs 'ad libitum chow during pregnancy and suckling'
C1qc DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Analysis of 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Net1 DOWN in 'undernutrition during pregnancy, ad libitum chow during suckling' vs 'ad libitum chow during pregnancy and suckling'
C1qb DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
S100a6 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Cidec DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Serpinh1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Tm6sf1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Serpina3c DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Adrb3 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Tmem27 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Acp5 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
(Factor value) ENVIRONMENTAL_HISTORY/undernutrition during pregnancy, ad libitum chow during suckling
undernutrition during pregnancy, ad libitum chow during suckling
Npr3 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Mmd DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Chp1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Lpgat1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
OBJECTIVE: To characterize the hormonal milieu and adipose gene expression in response to catch-up growth (CUG), a growth pattern associated with obesity and diabetes risk, in a mouse model of low birth weight (LBW). RESEARCH DESIGN AND METHODS: ICR mice were food restricted by 50% from gestational days 12.5-18.5, reducing offspring birth weight by 25%. During the suckling period, dams were either fed ad libitum, permitting CUG in offspring, or food restricted, preventing CUG. Offspring were killed at age 3 weeks, and gonadal fat was removed for RNA extraction, array analysis, RT-PCR, and evaluation of cell size and number. Serum insulin, thyroxine (T4), corticosterone, and adipokines were measured. RESULTS: At age 3 weeks, LBW mice with CUG (designated U-C) had body weight comparable with controls (designated C-C); weight was reduced by 49% in LBW mice without CUG (designated U-U). Adiposity was altered by postnatal nutrition, with gonadal fat increased by 50% in U-C and decreased by 58% in U-U mice (P < 0.05 vs. C-C mice). Adipose expression of the lipogenic genes Fasn, AccI, Lpin1, and Srebf1 was significantly increased in U-C compared with both C-C and U-U mice (P < 0.05). Mitochondrial DNA copy number was reduced by >50% in U-C versus U-U mice (P = 0.014). Although cell numbers did not differ, mean adipocyte diameter was increased in U-C and reduced in U-U mice (P < 0.01). CONCLUSIONS: CUG results in increased adipose tissue lipogenic gene expression and adipocyte diameter but not increased cellularity, suggesting that catch-up fat is primarily associated with lipogenesis rather than adipogenesis in this murine model. Epididymal fat samples were obtained at age 3 weeks from 5 control mice (CC), 5 mice exposed to in utero undernutrition (UC), and 4 mice exposed to undernutrition in utero and during suckling (UU).
Per2 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Tenm4 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Med20 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
(Factor value) ENVIRONMENTAL_HISTORY/undernutrition during pregnancy and suckling
undernutrition during pregnancy and suckling
Satb1 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Nid2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Sulf2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Lyz2 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ankrd40 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Clec10a DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
C1qa DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ccng1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Chpt1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
H19 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ccl6 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Steap4 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Glo1 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ccl9 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Sucnr1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Pla2g7 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Mest DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Igf1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Eepd1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Sh3rf1 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ogn DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Analysis of 'undernutrition during pregnancy, ad libitum chow during suckling' vs 'ad libitum chow during pregnancy and suckling'
Aspn DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Alcam DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ttc7b DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Retnla DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Pank3 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Mrc1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Hmgcs1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Dram1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Pzp UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Ctsz DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Lamb1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Deptor DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Fn1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Slc16a1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Prnp DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Serpina1b DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Rpgrip1 UP in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Plbd1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Prelp DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'
Itgb1bp1 DOWN in 'undernutrition during pregnancy and suckling' vs 'ad libitum chow during pregnancy and suckling'