ATXN1 DOWN in 'moderate Alzheimer's disease' vs 'normal'
CYP26B1 DOWN in 'severe Alzheimer's disease' vs 'normal'
COL5A2 DOWN in 'severe Alzheimer's disease' vs 'normal'
PLCB1 DOWN in 'severe Alzheimer's disease' vs 'normal'
(Sample) clinical information/Test:MiniMental Status Examination=20-26 (incipient Alzheimer's disease)
Test:MiniMental Status Examination=20-26 (incipient Alzheimer's disease)
DZIP1 DOWN in 'severe Alzheimer's disease' vs 'normal'
EFR3A DOWN in 'severe Alzheimer's disease' vs 'normal'
(Factor value) DISEASE/severe Alzheimer's disease
Analysis of 'moderate Alzheimer's disease' vs 'normal'
(Factor value) DISEASE/incipient Alzheimer's disease
SCN3A DOWN in 'severe Alzheimer's disease' vs 'normal'
PPP3CA DOWN in 'severe Alzheimer's disease' vs 'normal'
AMFR DOWN in 'severe Alzheimer's disease' vs 'normal'
RFK DOWN in 'severe Alzheimer's disease' vs 'normal'
PCSK2 DOWN in 'severe Alzheimer's disease' vs 'normal'
FAM65B DOWN in 'severe Alzheimer's disease' vs 'normal'
LDB2 DOWN in 'severe Alzheimer's disease' vs 'normal'
Analysis of 'severe Alzheimer's disease' vs 'normal'
LRP1B DOWN in 'severe Alzheimer's disease' vs 'normal'
PTPRN2 DOWN in 'severe Alzheimer's disease' vs 'normal'
CNR1 DOWN in 'severe Alzheimer's disease' vs 'normal'
RALYL DOWN in 'severe Alzheimer's disease' vs 'normal'
SERPINI1 DOWN in 'severe Alzheimer's disease' vs 'normal'
RCAN2 DOWN in 'severe Alzheimer's disease' vs 'normal'
PRKCB DOWN in 'severe Alzheimer's disease' vs 'normal'
CLDN10 DOWN in 'severe Alzheimer's disease' vs 'normal'
ITM2A DOWN in 'severe Alzheimer's disease' vs 'normal'
TRIM36 DOWN in 'severe Alzheimer's disease' vs 'normal'
PLK2 DOWN in 'severe Alzheimer's disease' vs 'normal'
(Sample) clinical information/minimental Status Examination
(Factor value) DISEASE/moderate Alzheimer's disease
SCN1A DOWN in 'severe Alzheimer's disease' vs 'normal'
(Sample) clinical information/Test:MiniMental Status Examination=14-19 (moderate Alzheimer's disease)
Test:MiniMental Status Examination=14-19 (moderate Alzheimer's disease)
FEZF2 DOWN in 'severe Alzheimer's disease' vs 'normal'
(Sample) disease/severe Alzheimer's disease
ETV1 DOWN in 'severe Alzheimer's disease' vs 'normal'
VSNL1 DOWN in 'severe Alzheimer's disease' vs 'normal'
(Sample) disease/incipient Alzheimer's disease
CRYM DOWN in 'severe Alzheimer's disease' vs 'normal'
NETO2 DOWN in 'severe Alzheimer's disease' vs 'normal'
FRY DOWN in 'severe Alzheimer's disease' vs 'normal'
PRKAR2B DOWN in 'severe Alzheimer's disease' vs 'normal'
COL5A2 DOWN in 'moderate Alzheimer's disease' vs 'normal'
ANO3 DOWN in 'severe Alzheimer's disease' vs 'normal'
NEFH DOWN in 'severe Alzheimer's disease' vs 'normal'
SLIT2 DOWN in 'severe Alzheimer's disease' vs 'normal'
NEFM DOWN in 'severe Alzheimer's disease' vs 'normal'
PTN DOWN in 'severe Alzheimer's disease' vs 'normal'
SACS DOWN in 'severe Alzheimer's disease' vs 'normal'
MAP3K9 DOWN in 'severe Alzheimer's disease' vs 'normal'
(Sample) disease/moderate Alzheimer's disease
SATB2 DOWN in 'severe Alzheimer's disease' vs 'normal'
RGS7 DOWN in 'severe Alzheimer's disease' vs 'normal'
SHANK2 DOWN in 'severe Alzheimer's disease' vs 'normal'
For these data, we analyzed hippocampal gene expression of nine control and 22 AD subjects of varying severity on 31 separate microarrays. We then tested the correlation of each gene's expression with MiniMental Status Examination (MMSE) and neurofibrillary tangle (NFT) scores across all 31 subjects regardless of diagnosis. These tests revealed a major transcriptional response comprising thousands of genes significantly correlated with AD markers. Several hundred of these genes were also correlated with AD markers across only control and incipient AD subjects (MMSE > 20).
(Sample) clinical information/Test:MiniMental Status Examination=< 14 (severe Alzheimer's disease)
Test:MiniMental Status Examination=< 14 (severe Alzheimer's disease)
RGS4 DOWN in 'severe Alzheimer's disease' vs 'normal'
RB1CC1 DOWN in 'severe Alzheimer's disease' vs 'normal'
SYNGR3 DOWN in 'severe Alzheimer's disease' vs 'normal'
LTF UP in 'severe Alzheimer's disease' vs 'normal'
CACNG3 DOWN in 'severe Alzheimer's disease' vs 'normal'
KIAA0368 DOWN in 'severe Alzheimer's disease' vs 'normal'
PKP4 DOWN in 'severe Alzheimer's disease' vs 'normal'
FABP7 DOWN in 'severe Alzheimer's disease' vs 'normal'