ASPM UP in 'current smoker' vs 'never smoked'
CDCA3 UP in 'current smoker' vs 'never smoked'
SGOL2 UP in 'current smoker' vs 'never smoked'
ZNF697 UP in 'current smoker' vs 'never smoked'
FAM150B DOWN in 'current smoker' vs 'never smoked'
GMFB UP in 'current smoker' vs 'never smoked'
CCNA2 UP in 'current smoker' vs 'never smoked'
(Factor value) CLINICAL_INFORMATION/former smoker
AC008268.1 DOWN in 'current smoker' vs 'never smoked'
(Sample) clinical information/never smoked
C1orf112 UP in 'current smoker' vs 'never smoked'
C1orf132 DOWN in 'current smoker' vs 'never smoked'
RNPC3 DOWN in 'current smoker' vs 'never smoked'
EPT1 UP in 'current smoker' vs 'never smoked'
MTHFD2 UP in 'current smoker' vs 'never smoked'
AURKA UP in 'former smoker' vs 'never smoked'
ECHDC2 DOWN in 'current smoker' vs 'never smoked'
TUBG1 UP in 'former smoker' vs 'never smoked'
FADS1 UP in 'former smoker' vs 'never smoked'
HN1 UP in 'former smoker' vs 'never smoked'
GREM1 UP in 'former smoker' vs 'never smoked'
CDKN3 UP in 'current smoker' vs 'never smoked'
CIRBP DOWN in 'current smoker' vs 'never smoked'
TPX2 UP in 'former smoker' vs 'never smoked'
CASC5 UP in 'current smoker' vs 'never smoked'
PFN2 UP in 'current smoker' vs 'never smoked'
DTL UP in 'current smoker' vs 'never smoked'
CDKN3 UP in 'former smoker' vs 'never smoked'
CCDC86 UP in 'current smoker' vs 'never smoked'
COL11A1 UP in 'former smoker' vs 'never smoked'
SLC22A3 DOWN in 'current smoker' vs 'never smoked'
TARDBP DOWN in 'current smoker' vs 'never smoked'
CDK1 UP in 'current smoker' vs 'never smoked'
CDC20 UP in 'current smoker' vs 'never smoked'
SPAG5 UP in 'current smoker' vs 'never smoked'
DTYMK UP in 'current smoker' vs 'never smoked'
FBXO9 DOWN in 'current smoker' vs 'never smoked'
DLGAP5 UP in 'current smoker' vs 'never smoked'
GPLD1 DOWN in 'current smoker' vs 'never smoked'
ECT2 UP in 'current smoker' vs 'never smoked'
PRC1 UP in 'current smoker' vs 'never smoked'
PLOD2 UP in 'current smoker' vs 'never smoked'
GGA2 DOWN in 'current smoker' vs 'never smoked'
AQP4 DOWN in 'current smoker' vs 'never smoked'
(Sample) clinical information/current smoker
TTC18 DOWN in 'former smoker' vs 'never smoked'
CA10 DOWN in 'former smoker' vs 'never smoked'
PTPRG DOWN in 'current smoker' vs 'never smoked'
TUBG1 UP in 'current smoker' vs 'never smoked'
FAM20A DOWN in 'current smoker' vs 'never smoked'
SLC34A2 DOWN in 'current smoker' vs 'never smoked'
SULT1C2 DOWN in 'current smoker' vs 'never smoked'
NUSAP1 UP in 'current smoker' vs 'never smoked'
UHRF1 UP in 'current smoker' vs 'never smoked'
NCAPG UP in 'former smoker' vs 'never smoked'
RP11-5C23.1 DOWN in 'current smoker' vs 'never smoked'
CEP55 UP in 'former smoker' vs 'never smoked'
NPC2 DOWN in 'current smoker' vs 'never smoked'
CDCA5 UP in 'current smoker' vs 'never smoked'
BIRC5 UP in 'current smoker' vs 'never smoked'
HN1 UP in 'current smoker' vs 'never smoked'
PBK UP in 'current smoker' vs 'never smoked'
ZWILCH UP in 'current smoker' vs 'never smoked'
HTATIP2 UP in 'current smoker' vs 'never smoked'
PARPBP UP in 'current smoker' vs 'never smoked'
KIF18B UP in 'current smoker' vs 'never smoked'
(Sample) clinical information/former smoker
KIF4A UP in 'current smoker' vs 'never smoked'
TLR5 DOWN in 'current smoker' vs 'never smoked'
FEN1 UP in 'former smoker' vs 'never smoked'
CENPN UP in 'current smoker' vs 'never smoked'
TEAD4 UP in 'current smoker' vs 'never smoked'
CKAP2L UP in 'former smoker' vs 'never smoked'
WWC1 DOWN in 'current smoker' vs 'never smoked'
CASC5 UP in 'former smoker' vs 'never smoked'
KIF18B UP in 'former smoker' vs 'never smoked'
PHLDA2 UP in 'former smoker' vs 'never smoked'
RQCD1 UP in 'current smoker' vs 'never smoked'
FEN1 UP in 'current smoker' vs 'never smoked'
TIMM50 UP in 'current smoker' vs 'never smoked'
ESPL1 UP in 'current smoker' vs 'never smoked'
RAD51AP1 UP in 'former smoker' vs 'never smoked'
COL4A3 DOWN in 'current smoker' vs 'never smoked'
TUFT1 UP in 'current smoker' vs 'never smoked'
MMP28 DOWN in 'current smoker' vs 'never smoked'
SEPP1 DOWN in 'former smoker' vs 'never smoked'
DBF4 UP in 'current smoker' vs 'never smoked'
PRKAB2 UP in 'current smoker' vs 'never smoked'
ITSN2 DOWN in 'current smoker' vs 'never smoked'
ZWINT UP in 'former smoker' vs 'never smoked'
GTSE1 UP in 'current smoker' vs 'never smoked'
GTPBP4 UP in 'current smoker' vs 'never smoked'
FNDC1 UP in 'former smoker' vs 'never smoked'
NUSAP1 UP in 'former smoker' vs 'never smoked'
POLE2 UP in 'current smoker' vs 'never smoked'
DPH3 UP in 'current smoker' vs 'never smoked'
RAD51 UP in 'current smoker' vs 'never smoked'
HJURP UP in 'current smoker' vs 'never smoked'
TMEM206 UP in 'current smoker' vs 'never smoked'
MCM10 UP in 'current smoker' vs 'never smoked'
RASGRF1 DOWN in 'current smoker' vs 'never smoked'
CLK4 DOWN in 'former smoker' vs 'never smoked'
NFIA DOWN in 'current smoker' vs 'never smoked'
SUSD2 DOWN in 'current smoker' vs 'never smoked'
TK1 UP in 'former smoker' vs 'never smoked'
KIF2C UP in 'former smoker' vs 'never smoked'
CEP55 UP in 'current smoker' vs 'never smoked'
PRTFDC1 UP in 'current smoker' vs 'never smoked'
KIF14 UP in 'former smoker' vs 'never smoked'
TROAP UP in 'current smoker' vs 'never smoked'
DEPDC1B UP in 'former smoker' vs 'never smoked'
CISH DOWN in 'current smoker' vs 'never smoked'
SEPP1 DOWN in 'current smoker' vs 'never smoked'
MMP11 UP in 'current smoker' vs 'never smoked'
RP4-635E18.8 DOWN in 'current smoker' vs 'never smoked'
ESPL1 UP in 'former smoker' vs 'never smoked'
AURKA UP in 'current smoker' vs 'never smoked'
(Factor value) CLINICAL_INFORMATION/never smoked
RPAIN DOWN in 'current smoker' vs 'never smoked'
BYSL UP in 'current smoker' vs 'never smoked'
BLM UP in 'current smoker' vs 'never smoked'
RP11-664D7.4 DOWN in 'current smoker' vs 'never smoked'
H2AFX UP in 'current smoker' vs 'never smoked'
CDC6 UP in 'current smoker' vs 'never smoked'
NCAPG UP in 'current smoker' vs 'never smoked'
(Factor value) CLINICAL_INFORMATION/current smoker
MRPS12 UP in 'current smoker' vs 'never smoked'
ADAMTS5 UP in 'former smoker' vs 'never smoked'
ZWINT UP in 'current smoker' vs 'never smoked'
DTL UP in 'former smoker' vs 'never smoked'
MYBL2 UP in 'former smoker' vs 'never smoked'
GPI UP in 'current smoker' vs 'never smoked'
EPT1 UP in 'former smoker' vs 'never smoked'
STYK1 UP in 'former smoker' vs 'never smoked'
UBE2T UP in 'current smoker' vs 'never smoked'
TTK UP in 'current smoker' vs 'never smoked'
CFLAR DOWN in 'current smoker' vs 'never smoked'
OIP5 UP in 'current smoker' vs 'never smoked'
NFIX DOWN in 'current smoker' vs 'never smoked'
BUB1B UP in 'current smoker' vs 'never smoked'
C1orf132 DOWN in 'former smoker' vs 'never smoked'
AGPS UP in 'current smoker' vs 'never smoked'
FAM83A UP in 'former smoker' vs 'never smoked'
MTHFD2 UP in 'former smoker' vs 'never smoked'
TPX2 UP in 'current smoker' vs 'never smoked'
CENPA UP in 'former smoker' vs 'never smoked'
ASPM UP in 'former smoker' vs 'never smoked'
DEPDC1 UP in 'current smoker' vs 'never smoked'
FANCI UP in 'current smoker' vs 'never smoked'
ADAMTS9-AS2 DOWN in 'former smoker' vs 'never smoked'
MELK UP in 'current smoker' vs 'never smoked'
UCK2 UP in 'former smoker' vs 'never smoked'
NEK2 UP in 'former smoker' vs 'never smoked'
BORA UP in 'current smoker' vs 'never smoked'
DIO2 UP in 'former smoker' vs 'never smoked'
(Sample) clinical information/smoking status not available
S100P UP in 'current smoker' vs 'never smoked'
RP4-635E18.8 DOWN in 'former smoker' vs 'never smoked'
PPIL1 UP in 'current smoker' vs 'never smoked'
TDO2 UP in 'current smoker' vs 'never smoked'
NDC80 UP in 'current smoker' vs 'never smoked'
ANLN UP in 'former smoker' vs 'never smoked'
CEBPG UP in 'current smoker' vs 'never smoked'
PRR11 UP in 'former smoker' vs 'never smoked'
SLC47A1 DOWN in 'current smoker' vs 'never smoked'
TYMS UP in 'current smoker' vs 'never smoked'
CDC20 UP in 'former smoker' vs 'never smoked'
RHPN2 UP in 'current smoker' vs 'never smoked'
HILPDA UP in 'current smoker' vs 'never smoked'
GREM1 UP in 'current smoker' vs 'never smoked'
CPAMD8 DOWN in 'current smoker' vs 'never smoked'
SLC2A1 UP in 'current smoker' vs 'never smoked'
CENPF UP in 'former smoker' vs 'never smoked'
CHRDL1 DOWN in 'current smoker' vs 'never smoked'
KIF14 UP in 'current smoker' vs 'never smoked'
CLK4 DOWN in 'current smoker' vs 'never smoked'
TMTC3 UP in 'current smoker' vs 'never smoked'
ADAMTS9-AS2 DOWN in 'current smoker' vs 'never smoked'
MELK UP in 'former smoker' vs 'never smoked'
Analysis of 'former smoker' vs 'never smoked'
TRIP13 UP in 'current smoker' vs 'never smoked'
ROS1 DOWN in 'current smoker' vs 'never smoked'
ANLN UP in 'current smoker' vs 'never smoked'
POLE2 UP in 'former smoker' vs 'never smoked'
(Sample) disease/lung cancer (pathology not available)
RHPN2 UP in 'former smoker' vs 'never smoked'
UHRF1 UP in 'former smoker' vs 'never smoked'
MYBL2 UP in 'current smoker' vs 'never smoked'
ECT2 UP in 'former smoker' vs 'never smoked'
This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are likely to play a role in carcinogenesis. The observed mutational profiles correlate with clinical features, smoking status, and DNA repair defects. These results are complemented by data integration including SNP array data and gene expression array data (deposited here). Our findings shed further light on several key signaling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment. Experiment Overall Design: A subset of 75 RNAs from a corresponding set of 188 lung adenocarcinomas DNAs were resequenced across 623 genes.
SUV39H2 UP in 'current smoker' vs 'never smoked'
GCLC UP in 'current smoker' vs 'never smoked'
NEK2 UP in 'current smoker' vs 'never smoked'
CDCA5 UP in 'former smoker' vs 'never smoked'
EME1 UP in 'current smoker' vs 'never smoked'
CDCA2 UP in 'current smoker' vs 'never smoked'
TUSC3 UP in 'current smoker' vs 'never smoked'
AC025171.1 DOWN in 'current smoker' vs 'never smoked'
UCK2 UP in 'current smoker' vs 'never smoked'
CTSH DOWN in 'current smoker' vs 'never smoked'
RRM2 UP in 'former smoker' vs 'never smoked'
LONP2 DOWN in 'current smoker' vs 'never smoked'
(Sample) disease/large cell neuroendocrine carcinoma
CHEK1 UP in 'current smoker' vs 'never smoked'
CIRBP DOWN in 'former smoker' vs 'never smoked'
ACADSB DOWN in 'current smoker' vs 'never smoked'
STYK1 UP in 'current smoker' vs 'never smoked'
DIRAS3 DOWN in 'current smoker' vs 'never smoked'
CDC6 UP in 'former smoker' vs 'never smoked'
ACTL6A UP in 'current smoker' vs 'never smoked'
CAMK2D DOWN in 'current smoker' vs 'never smoked'
AL591069.1 DOWN in 'current smoker' vs 'never smoked'
NAPSB DOWN in 'current smoker' vs 'never smoked'
RP11-295G20.2 UP in 'current smoker' vs 'never smoked'
ATP13A4 DOWN in 'current smoker' vs 'never smoked'
FAM64A UP in 'current smoker' vs 'never smoked'
PRR11 UP in 'current smoker' vs 'never smoked'
FAM83D UP in 'former smoker' vs 'never smoked'
TMEM206 UP in 'former smoker' vs 'never smoked'
SORCS2 DOWN in 'current smoker' vs 'never smoked'
PAFAH1B3 UP in 'current smoker' vs 'never smoked'
FOXM1 UP in 'current smoker' vs 'never smoked'
MTMR2 UP in 'former smoker' vs 'never smoked'
PTS UP in 'current smoker' vs 'never smoked'
C16orf89 DOWN in 'current smoker' vs 'never smoked'
STEAP1 UP in 'current smoker' vs 'never smoked'
KIF2C UP in 'current smoker' vs 'never smoked'
KIAA0101 UP in 'current smoker' vs 'never smoked'
KIAA0101 UP in 'former smoker' vs 'never smoked'
FAM83D UP in 'current smoker' vs 'never smoked'
CSE1L UP in 'current smoker' vs 'never smoked'
CENPA UP in 'current smoker' vs 'never smoked'
(Factor value) CLINICAL_INFORMATION/smoking status not available
UBE2T UP in 'former smoker' vs 'never smoked'
Analysis of 'current smoker' vs 'never smoked'
CTSV UP in 'current smoker' vs 'never smoked'
LINC00888 UP in 'current smoker' vs 'never smoked'
FOLR1 DOWN in 'current smoker' vs 'never smoked'
NUF2 UP in 'current smoker' vs 'never smoked'
(Sample) disease/squamous cell lung carcinoma
CREM UP in 'current smoker' vs 'never smoked'
KIF4A UP in 'former smoker' vs 'never smoked'
SLC18A2 DOWN in 'current smoker' vs 'never smoked'
ERVK13-1 DOWN in 'current smoker' vs 'never smoked'
MTFR2 UP in 'current smoker' vs 'never smoked'
CDC45 UP in 'current smoker' vs 'never smoked'
PIGR DOWN in 'former smoker' vs 'never smoked'
TOP2A UP in 'current smoker' vs 'never smoked'
CENPF UP in 'current smoker' vs 'never smoked'