MME UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
(Sample) clinical information/response to Infliximab treatment
SLC25A37 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CREB5 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
C10orf99 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
IGFBP5 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
BCL2A1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
GPR27 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MYO1F UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FCGR3B UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CSGALNACT1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
STEAP4 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CEMIP UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
P2RY13 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
WNT5A UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TWIST2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
HCK UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ALOX5AP UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL24 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SLC2A3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PTGS2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
KCNJ2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
COL7A1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TMEM71 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
HSD11B1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
NFE2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TLR1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
KIAA1551 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL1RN UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CXCL11 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TLR2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
COL12A1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FGR UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
KCNJ15 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
OLFM1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SOD2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CXCL14 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
HGF UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MMP3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
HAPLN1 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
CCR1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
Analysis of 'no response to Infliximab' vs 'response to Infliximab treatment'
BCL6 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
LCP2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
GCA UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TAGAP UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FCER1G UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ALPL UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to respond to treatment. Consequently, about 40% of patients do not respond. This study analyzed mucosal gene expression from patients enrolled in ACT1 to provide a predictive response signature for infliximab treatment. Experiment Overall Design: Twenty-two patients underwent colonoscopy with biopsy before infliximab treatment. Response to infliximab was defined as endoscopic and histologic healing at week 8 (P2, 5, 9, 10, 14, 15, 16, 17, 24, 27, 36, and 45 as responders; P3, 12, 13, 19, 28, 29, 32, 33, 34, and 47 as non-responders). Messenger RNA was isolated from pre-infliximab biopsies, labeled and hybridized to Affymetrix HGU133Plus_2.0 Array. The predictive response signature was verified by an independent data set.
CLEC4E UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SOSTDC1 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
MASP1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
DOK3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
(Factor value) CLINICAL_INFORMATION/response to Infliximab treatment
GBP5 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CMTM2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TNFAIP6 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CLEC7A UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
APOBEC3A UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ANPEP UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TLR4 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TNFRSF11B UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SAMSN1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ACSL1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SOCS3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PI15 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MMP25 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FPR2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
B3GNT7 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
LILRA5 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
OSM UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FPR1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
HAL UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SLC11A1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TFPI2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TNFAIP3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL18RAP UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
(Sample) clinical information/no response to Infliximab
RGS18 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SPP1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SERPINB2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FAM129A UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CHI3L1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IFIT3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
THBS2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CTHRC1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
NAMPT UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
GPR97 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FST UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL13RA2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
RP3-428L16.2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
WFDC2 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
RP11-373D23.2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SELL UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PTPRO DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
CYP4F3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ITGAX UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
GAS1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SLC22A4 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TREM1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
G0S2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
LILRB2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FCN1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
HLA-DQA1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SLC16A6 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TFPI UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MCEMP1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CSF3R UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
RNF144B UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
GIPC2 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
F5 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
LILRA2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
NRCAM UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CNTN3 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
SATB2 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
PFKFB3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL11 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
OLR1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FCAR UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TNFRSF10C UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PTGES UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ZFP36 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
DUSP1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL6 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
BASP1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PYY DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
IFIT2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CTB-167B5.2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
C5AR1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PRR16 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL1B UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SIRPB1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SRGN UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CXCL5 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MCTP1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CXCL8 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
HOXD11 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
PAPPA UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
WISP1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CDHR1 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
GLIS3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
RGS2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
STC1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SERPINE1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ACSL4 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SELE UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
KIAA1324 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
GBP2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
INHBA UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
LRRK2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MX2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SLC16A10 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
S100A9 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
KYNU UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
GPR84 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CLEC4D UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IGSF6 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IL1A UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ZEB2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SLC16A4 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
EMR2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TWIST1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
GK UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
LGR5 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
NCF2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
S100A12 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FAP UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
DGAT2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PLEK UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
AQP9 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
TLR8 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
COL8A1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PDE4B UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MNDA UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
EREG UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PKIB DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
CYP26B1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
FGF2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MGAM UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
NFIL3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
KLK10 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
IDO1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CSF2RB UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
MMP19 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CCL4 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
S100A8 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ELOVL6 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
(Factor value) CLINICAL_INFORMATION/no response to Infliximab
PROK2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
AOX1 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
SLITRK6 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
VNN2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
ITGAM UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
PTCH1 DOWN in 'no response to Infliximab' vs 'response to Infliximab treatment'
FFAR2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CXCR2 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'
CSF3 UP in 'no response to Infliximab' vs 'response to Infliximab treatment'