Igfbp4 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Edil3 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Hspa1a DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Epha3 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Gzmf DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Slc20a1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Gdf10 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Gli2 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Trim12c UP in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Wif1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Cygb DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Ahr DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Gzmg DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
SERPINA1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]'
Hspa1b DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Penk DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Dkk2 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Lepr DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Il11 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Gzmc DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Reg1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
TNFRSF11B DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]'
Slco4a1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Abtb2 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Abi3bp DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Pcsk5 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Sertad4 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Analysis of '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]'
Frzb DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Cp DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Pappa UP in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Mcpt1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Col8a2 UP in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Analysis of '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Aldh1a3 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Lrig3 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Galr2 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Brinp3 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Col10a1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Bpgm DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Mpzl2 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Igfbp5 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Tnfrsf19 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Ptger3 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Four vehicle-treated and four HhAntag-treated pancreatic xenograft tumors were profiled for gene expression changes using Affymetrix U133 Plus 2.0 and Affymetrix Mouse Genome 430 2.0 arrays. Keywords: comparative gene expression, hedgehog, hh A primary human pancreatic tumor xenograft (1051178-A) was established by direct implantation of surgical material into female CD1 nu/nu mice of 6-8 weeks of age. Tumors were serially passaged into larger cohorts of mice for efficacy testing and subsequently distributed into tumor volume-matched cohorts upon tumors reaching between 200 to 350 mm3. HhAntag was resuspended in 0.5% methyl-cellulose, 0.2% Tween-80 (MCT) and administered orally twice daily at 75 mg/kg from a 10 mg/ml suspension. MCT alone served as vehicle control. Tumor xenografts (4/group) were excised following 21 days of dosing and RNA was extracted. Preparation of complementary RNA, Human Genome U133 Plus 2.0 array and Mouse Genome 430 2.0 array hybridizations, and subsequent data analysis were carried out using Affymetrix protocols, with signal intensities being determined by the MAS5.0 algorithm.
Rdh10 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
(Sample) xenograft/female CD1 nu/nu mice
St8sia2 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Olr1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Il33 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'
Hsd11b1 DOWN in '75 milligram per kilogram HhAntag' vs 'vehicle' on 'Affymetrix GeneChip Mouse Genome 430 2.0 [Mouse430_2]'