KITLG DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
ATAD2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RAD51AP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
ANKRD9 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
THAP2 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
BRCA1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CHAF1A DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
(Factor value) COMPOUND/IGF-IR monoclonal antibody - 10H5 5
MYBL1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
TK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CDC6 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
MCM10 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
TEX15 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
HELLS DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CREBRF UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CHEK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CCNE2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
BRCA2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
DTL DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RRM2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CHAC2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
E2F1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CDC25A DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RAD51 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
UHRF1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
KLHL24 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RAD54L DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
E2F8 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CDCA5 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
FEN1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
Analysis of '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
FANCD2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
MCM4 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
MTFR2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
DHCR24 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
WDR76 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
LRR1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
HIST1H2AC UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
GMNN DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CCNE1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RFC5 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
(Sample) xenograft/SK-N-AS neuroblastoma xenografts implanted in nude mouse
SK-N-AS neuroblastoma xenografts implanted in nude mouse
SLC39A8 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RFWD3 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
PCNA DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
GINS2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
EXO1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
CDC45 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
ZNF367 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
MCM6 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
ASF1B DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
TOX2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
UGT8 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
The insulin-like growth factor (IGF) system consists of two ligands (IGF-I and IGF-II), which both signal through type I IGF receptor (IGF-IR) to stimulate proliferation and inhibit apoptosis, with activity contributing to malignant growth of many types of human cancers. We have developed a humanized, affinity-matured anti-human IGF-IR monoclonal antibody (h10H5), which binds with high affinity and specificity to the extracellular domain. h10H5 inhibits IGF-IR-mediated signaling by blocking IGF-I and IGF-IIbinding and by inducing cell surface receptor down-regulation via internalization and degradation. In vitro, h10H5 exhibits anti-proliferative effects on cancer cell lines. In vivo, h10H5 demonstrates single-agent anti-tumor efficacy in human SK-N-AS neuroblastoma and SW527 breast cancer xenograft models, and even greater efficacy in combination with the chemotherapeutic agent Docetaxel or an anti-VEGF antibody. Anti-tumor activity of h10H5 is associated with decreased AKT activation and glucose uptake, and a 316-gene transcription profile with significant changes involving DNA metabolic and cell cycle machineries. These data support the clinical testing of h10H5 as a biotherapeutic for IGF-IR-dependent human tumors. Experiment Overall Design: Two treatment groups with four tumor samples per group are collected and analyzed,
SDC1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
FANCI DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
MYBL2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
BRIP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
SPC25 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
SHCBP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
TYMS DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
E2F2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
VRK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
MCM5 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
PSMC3IP DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
POLA2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
E2F7 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RP11-303E16.2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
RP11-196G18.24 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
N4BP2L1 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
PMAIP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
GINS1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
LDLR DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'