RFC5
type: EnsemblDatabaseReference

TK1
type: EnsemblDatabaseReference

TOX2
type: EnsemblDatabaseReference

220651_s_at
type: EFO_0005072
part of: A-AFFY-44

1554696_s_at
type: EFO_0005072
part of: A-AFFY-44

KITLG DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10870467323425
p value: 0.00127630898209055
refers to: KITLG
refers to: 226534_at
t statistic: -8.3094667795449

ATAD2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.62758530163183
p value: 6.70196186784597E-4
refers to: ATAD2
refers to: 235266_at
t statistic: -9.50239682043439

CDC25A
type: EnsemblDatabaseReference

RAD51AP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13497669985605
p value: 2.82970141215356E-4
refers to: RAD51AP1
refers to: 204146_at
t statistic: -11.5975522652934

(Factor value) COMPOUND/vehicle control
type: EFO_0000001
property type: COMPOUND
property value: vehicle control

E2F7
type: EnsemblDatabaseReference

235117_at
type: EFO_0005072
part of: A-AFFY-44

ANKRD9 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04155274648947
p value: 0.00129848139491634
refers to: ANKRD9
refers to: 230972_at
t statistic: -8.2613916155909

THAP2 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: IncreasedDifferentialExpressionRatio
fold change: 1.14794209489918
p value: 0.00174770632802156
refers to: THAP2
refers to: 223588_at
t statistic: 7.85217871000146

(Assay) vehicle, biological replicate 2
type: Assay
identifier: vehicle, biological replicate 2
has participant: A-AFFY-44

221521_s_at
type: EFO_0005072
part of: A-AFFY-44

MCM4
type: EnsemblDatabaseReference

RFWD3
type: EnsemblDatabaseReference

GINS2
type: EnsemblDatabaseReference

THAP2
type: EnsemblDatabaseReference

222036_s_at
type: EFO_0005072
part of: A-AFFY-44

SDC1
type: EnsemblDatabaseReference

RAD51AP1
type: EnsemblDatabaseReference

228361_at
type: EFO_0005072
part of: A-AFFY-44

BRCA1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00764298245811
p value: 2.00006912094647E-4
refers to: 204531_s_at
refers to: BRCA1
t statistic: -12.4079937418167

CHAF1A DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.02019464340418
p value: 1.4053285713058E-4
refers to: CHAF1A
refers to: 214426_x_at
t statistic: -15.262902269611

LDLR
type: EnsemblDatabaseReference

205519_at
type: EFO_0005072
part of: A-AFFY-44

212141_at
type: EFO_0005072
part of: A-AFFY-44

242560_at
type: EFO_0005072
part of: A-AFFY-44

TK1
type: EnsemblDatabaseReference

226534_at
type: EFO_0005072
part of: A-AFFY-44

204285_s_at
type: EFO_0005072
part of: A-AFFY-44

(Factor value) COMPOUND/IGF-IR monoclonal antibody - 10H5 5
type: EFO_0000001
property type: COMPOUND
property value: IGF-IR monoclonal antibody - 10H5 5

FEN1
type: EnsemblDatabaseReference

ATAD2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3190637309548
p value: 2.00006912094647E-4
refers to: 228401_at
refers to: ATAD2
t statistic: -12.4773787495412

MYBL1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.18722767240738
p value: 1.76643625620715E-4
refers to: MYBL1
refers to: 213906_at
t statistic: -12.8808836447865

CHAC2
type: EnsemblDatabaseReference

TK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0891344568098
p value: 6.69386131821198E-4
refers to: 1554408_a_at
refers to: TK1
t statistic: -9.57332569731728

(Assay) 24 hr 10H5, replicate 2
type: Assay
identifier: 24 hr 10H5, replicate 2
has participant: A-AFFY-44

202338_at
type: EFO_0005072
part of: A-AFFY-44

CDC6 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.74637819912491
p value: 1.4053285713058E-4
refers to: 203968_s_at
refers to: CDC6
t statistic: -15.0544006985759

MCM10 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.35129099718182
p value: 1.92239438997006E-4
refers to: 223570_at
refers to: MCM10
t statistic: -12.6782577950396

CHAF1A DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.22202478775061
p value: 2.00006912094647E-4
refers to: CHAF1A
refers to: 203976_s_at
t statistic: -12.4616671999049

(Assay) 24 hr 10H5, replicate 4
type: Assay
identifier: 24 hr 10H5, replicate 4
has participant: A-AFFY-44

(Assay) vehicle, biological replicate 3
type: Assay
identifier: vehicle, biological replicate 3
has participant: A-AFFY-44

214727_at
type: EFO_0005072
part of: A-AFFY-44

TEX15 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.573032967598
p value: 4.07655769214028E-4
refers to: 232760_at
refers to: TEX15
t statistic: -10.6821808900844

205024_s_at
type: EFO_0005072
part of: A-AFFY-44

E2F8
type: EnsemblDatabaseReference

DTL
type: EnsemblDatabaseReference

HELLS DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17714694254436
p value: 0.00903252865052839
refers to: HELLS
refers to: 227350_at
t statistic: -5.53794532943622

CREBRF UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: IncreasedDifferentialExpressionRatio
fold change: 1.25605112610134
p value: 0.00795634278263067
refers to: 225956_at
refers to: CREBRF
t statistic: 5.71857428077638

CHEK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20658217530648
p value: 0.0013524883527018
refers to: CHEK1
refers to: 205393_s_at
t statistic: -8.20549325359869

SPC25
type: EnsemblDatabaseReference

CCNE1
type: EnsemblDatabaseReference

228069_at
type: EFO_0005072
part of: A-AFFY-44

CCNE2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.28861462714191
p value: 0.00216664625500047
refers to: 211814_s_at
refers to: CCNE2
t statistic: -7.55693098272644

BRCA2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.25780755494356
p value: 0.00510859946205949
refers to: BRCA2
refers to: 214727_at
t statistic: -6.30445910287554

223588_at
type: EFO_0005072
part of: A-AFFY-44

DHCR24
type: EnsemblDatabaseReference

TOX2
type: EnsemblDatabaseReference

MCM6
type: EnsemblDatabaseReference

218585_s_at
type: EFO_0005072
part of: A-AFFY-44

DTL DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.56990165401118
p value: 1.4053285713058E-4
refers to: 218585_s_at
refers to: DTL
t statistic: -13.6809084349301

RRM2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.44575600340887
p value: 6.70196186784597E-4
refers to: 209773_s_at
refers to: RRM2
t statistic: -9.48980479233254

CHAC2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.54443079252583
p value: 4.18850038216554E-4
refers to: CHAC2
refers to: 235117_at
t statistic: -10.5958738363959

1555772_a_at
type: EFO_0005072
part of: A-AFFY-44

TEX15
type: EnsemblDatabaseReference

ATAD2
type: EnsemblDatabaseReference

E2F1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.23081337041667
p value: 1.4053285713058E-4
refers to: E2F1
refers to: 204947_at
t statistic: -15.3187597987281

CREBRF
type: EnsemblDatabaseReference

MCM4
type: EnsemblDatabaseReference

THAP2
type: EnsemblDatabaseReference

UHRF1
type: EnsemblDatabaseReference

CDC25A DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -2.08168168624953
p value: 9.85483232937113E-5
refers to: CDC25A
refers to: 1555772_a_at
t statistic: -18.6227038695363

MCM10 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.57005205146436
p value: 1.4053285713058E-4
refers to: 222962_s_at
refers to: MCM10
t statistic: -15.5869637748707

RAD51AP1
type: EnsemblDatabaseReference

209773_s_at
type: EFO_0005072
part of: A-AFFY-44

HELLS DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.31032568804642
p value: 0.00139214664567198
refers to: HELLS
refers to: 220085_at
t statistic: -8.16769796624982

RAD51 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.20384364990584
p value: 0.00181287388881742
refers to: RAD51
refers to: 205024_s_at
t statistic: -7.78530799602156

(Sample) organism/Homo sapiens
type: Homo sapiens
property type: organism
property value: Homo sapiens

ASF1B
type: EnsemblDatabaseReference

RP11-303E16.2
type: EnsemblDatabaseReference

RRM2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.7074482460258
p value: 6.05751681043801E-5
refers to: RRM2
refers to: 201890_at
t statistic: -21.1356133154252

UHRF1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.16314142895715
p value: 2.04593155095548E-4
refers to: 225655_at
refers to: UHRF1
t statistic: -12.3393345800392

204767_s_at
type: EFO_0005072
part of: A-AFFY-44

KLHL24 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: IncreasedDifferentialExpressionRatio
fold change: 1.21967144435322
p value: 0.0150745742691043
refers to: 242088_at
refers to: KLHL24
t statistic: 4.88643776818925

LRR1
type: EnsemblDatabaseReference

RAD54L DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10212049991402
p value: 2.63792187252422E-4
refers to: 204558_at
refers to: RAD54L
t statistic: -11.7915707033545

213951_s_at
type: EFO_0005072
part of: A-AFFY-44

242088_at
type: EFO_0005072
part of: A-AFFY-44

204126_s_at
type: EFO_0005072
part of: A-AFFY-44

FEN1
type: EnsemblDatabaseReference

TYMS
type: EnsemblDatabaseReference

204441_s_at
type: EFO_0005072
part of: A-AFFY-44

CREBRF
type: EnsemblDatabaseReference

209891_at
type: EFO_0005072
part of: A-AFFY-44

CDC45
type: EnsemblDatabaseReference

CHAC2
type: EnsemblDatabaseReference

203209_at
type: EFO_0005072
part of: A-AFFY-44

201890_at
type: EFO_0005072
part of: A-AFFY-44

E2F8 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.29810380661682
p value: 8.1353189754445E-4
refers to: E2F8
refers to: 219990_at
t statistic: -9.19072048152963

204768_s_at
type: EFO_0005072
part of: A-AFFY-44

POLA2
type: EnsemblDatabaseReference

E2F8
type: EnsemblDatabaseReference

TK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17749683074884
p value: 1.48151542177702E-4
refers to: 202338_at
refers to: TK1
t statistic: -13.4267879104923

CDCA5 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.09295170689415
p value: 1.4053285713058E-4
refers to: 224753_at
refers to: CDCA5
t statistic: -14.3199878080981

235266_at
type: EFO_0005072
part of: A-AFFY-44

HELLS
type: EnsemblDatabaseReference

RRM2
type: EnsemblDatabaseReference

CCNE1
type: EnsemblDatabaseReference

FEN1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.16087317265287
p value: 1.4053285713058E-4
refers to: FEN1
refers to: 204767_s_at
t statistic: -14.0372281617584

LRR1
type: EnsemblDatabaseReference

BRIP1
type: EnsemblDatabaseReference

KITLG
type: EnsemblDatabaseReference

Analysis of '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: MicroarrayDifferentialExpressionAnalysis

ATAD2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.13686633107288
p value: 0.00106117551387658
refers to: ATAD2
refers to: 218782_s_at
t statistic: -8.59159345569935

MTFR2
type: EnsemblDatabaseReference

FANCD2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01744257103326
p value: 0.00257778298136096
refers to: 242560_at
refers to: FANCD2
t statistic: -7.30526996500435

DHCR24
type: EnsemblDatabaseReference

MCM4 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.33366847722706
p value: 1.4053285713058E-4
refers to: MCM4
refers to: 222036_s_at
t statistic: -15.8374734276636

202589_at
type: EFO_0005072
part of: A-AFFY-44

N4BP2L1
type: EnsemblDatabaseReference

MTFR2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0392834402222
p value: 1.4053285713058E-4
refers to: 228069_at
refers to: MTFR2
t statistic: -15.0908522054583

MCM6
type: EnsemblDatabaseReference

RP11-196G18.24
type: EnsemblDatabaseReference

TEX15
type: EnsemblDatabaseReference

ATAD2
type: EnsemblDatabaseReference

228559_at
type: EFO_0005072
part of: A-AFFY-44

DHCR24 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.58342252705455
p value: 5.6631695393953E-4
refers to: 200862_at
refers to: DHCR24
t statistic: -9.95089336368296

PSMC3IP
type: EnsemblDatabaseReference

WDR76 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.18853783500534
p value: 5.80285712821053E-4
refers to: 239680_at
refers to: WDR76
t statistic: -9.89009958887138

POLA2
type: EnsemblDatabaseReference

BRCA2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.33414591566941
p value: 1.48151542177702E-4
refers to: BRCA2
refers to: 208368_s_at
t statistic: -13.4431713082663

RAD54L
type: EnsemblDatabaseReference

UHRF1
type: EnsemblDatabaseReference

ATAD2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.42271720214658
p value: 1.56982547288591E-4
refers to: 222740_at
refers to: ATAD2
t statistic: -13.2042410794966

230972_at
type: EFO_0005072
part of: A-AFFY-44

214426_x_at
type: EFO_0005072
part of: A-AFFY-44

ASF1B
type: EnsemblDatabaseReference

RP11-303E16.2
type: EnsemblDatabaseReference

LRR1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.25241390338259
p value: 3.96177117276963E-4
refers to: LRR1
refers to: 235113_at
t statistic: -10.7729386998012

BRIP1
type: EnsemblDatabaseReference

PMAIP1
type: EnsemblDatabaseReference

220085_at
type: EFO_0005072
part of: A-AFFY-44

RP11-196G18.24
type: EnsemblDatabaseReference

(Assay) 24 hr 10H5, replicate 1
type: Assay
identifier: 24 hr 10H5, replicate 1
has participant: A-AFFY-44

E2F1
type: EnsemblDatabaseReference

SLC39A8
type: EnsemblDatabaseReference

MYBL1
type: EnsemblDatabaseReference

218564_at
type: EFO_0005072
part of: A-AFFY-44

204146_at
type: EFO_0005072
part of: A-AFFY-44

TYMS
type: EnsemblDatabaseReference

HIST1H2AC UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: IncreasedDifferentialExpressionRatio
fold change: 1.0315985434721
p value: 6.70196186784597E-4
refers to: HIST1H2AC
refers to: 215071_s_at
t statistic: 9.50032530081355

GMNN DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00254083907715
p value: 3.33717491606217E-4
refers to: GMNN
refers to: 218350_s_at
t statistic: -11.2075538208128

PCNA
type: EnsemblDatabaseReference

ANKRD9
type: EnsemblDatabaseReference

225956_at
type: EFO_0005072
part of: A-AFFY-44

CCNE1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.25670940655419
p value: 3.86478540031108E-4
refers to: 213523_at
refers to: CCNE1
t statistic: -10.9225218475524

CDC45
type: EnsemblDatabaseReference

RAD54L
type: EnsemblDatabaseReference

201286_at
type: EFO_0005072
part of: A-AFFY-44

CDC6 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.96755664537987
p value: 1.4053285713058E-4
refers to: CDC6
refers to: 203967_at
t statistic: -16.1425803567289

RFC5 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11518198588336
p value: 0.001258158591168
refers to: RFC5
refers to: 203209_at
t statistic: -8.34190449617249

206102_at
type: EFO_0005072
part of: A-AFFY-44

MCM10
type: EnsemblDatabaseReference

CDCA5
type: EnsemblDatabaseReference

204695_at
type: EFO_0005072
part of: A-AFFY-44

HELLS
type: EnsemblDatabaseReference

213906_at
type: EFO_0005072
part of: A-AFFY-44

(Sample) xenograft/SK-N-AS neuroblastoma xenografts implanted in nude mouse
type: EFO_0000001
property type: xenograft
property value: SK-N-AS neuroblastoma xenografts implanted in nude mouse

RRM2
type: EnsemblDatabaseReference

203967_at
type: EFO_0005072
part of: A-AFFY-44

KITLG
type: EnsemblDatabaseReference

202068_s_at
type: EFO_0005072
part of: A-AFFY-44

203968_s_at
type: EFO_0005072
part of: A-AFFY-44

MTFR2
type: EnsemblDatabaseReference

SLC39A8
type: EnsemblDatabaseReference

KLHL24
type: EnsemblDatabaseReference

CCNE2
type: EnsemblDatabaseReference

N4BP2L1
type: EnsemblDatabaseReference

SLC39A8 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08897791791314
p value: 0.00310713162030577
refers to: SLC39A8
refers to: 209267_s_at
t statistic: -7.00459623133307

RFWD3 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.02580214251659
p value: 1.56982547288591E-4
refers to: RFWD3
refers to: 218564_at
t statistic: -13.1875941058556

PCNA DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.1493268475006
p value: 1.4053285713058E-4
refers to: PCNA
refers to: 201202_at
t statistic: -13.8361100375692

FEN1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.15043255820024
p value: 1.88804416458461E-4
refers to: 204768_s_at
refers to: FEN1
t statistic: -12.7443538353366

GMNN
type: EnsemblDatabaseReference

PSMC3IP
type: EnsemblDatabaseReference

213375_s_at
type: EFO_0005072
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GINS2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.21118208420994
p value: 4.76870008789719E-4
refers to: GINS2
refers to: 221521_s_at
t statistic: -10.3159879119819

Homo sapiens
type: OBI_0100026

222680_s_at
type: EFO_0005072
part of: A-AFFY-44

MCM10 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.56055277691788
p value: 1.4053285713058E-4
refers to: 220651_s_at
refers to: MCM10
t statistic: -13.9953722676971

EXO1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.12758383826856
p value: 2.17356674296391E-4
refers to: EXO1
refers to: 204603_at
t statistic: -12.1335142468104

E2F2
type: EnsemblDatabaseReference

PMAIP1
type: EnsemblDatabaseReference

CDC45 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.29867555760948
p value: 2.89039448522336E-4
refers to: 204126_s_at
refers to: CDC45
t statistic: -11.475314160377

FANCI
type: EnsemblDatabaseReference

239680_at
type: EFO_0005072
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SHCBP1
type: EnsemblDatabaseReference

1554408_a_at
type: EFO_0005072
part of: A-AFFY-44

205393_s_at
type: EFO_0005072
part of: A-AFFY-44

ZNF367 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.45530943955626
p value: 4.07655769214028E-4
refers to: ZNF367
refers to: 229551_x_at
t statistic: -10.6591491953847

MCM6 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.17476530579752
p value: 4.92995314391157E-4
refers to: MCM6
refers to: 201930_at
t statistic: -10.2391475997071

MYBL1
type: EnsemblDatabaseReference

CDC25A DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19750135506291
p value: 3.86478540031108E-4
refers to: 204695_at
refers to: CDC25A
t statistic: -10.870421146503

E2F1
type: EnsemblDatabaseReference

VRK1
type: EnsemblDatabaseReference

EXO1
type: EnsemblDatabaseReference

219493_at
type: EFO_0005072
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CHEK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0649880714896
p value: 6.70196186784597E-4
refers to: 205394_at
refers to: CHEK1
t statistic: -9.49626796516722

PCNA
type: EnsemblDatabaseReference

227943_at
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ANKRD9
type: EnsemblDatabaseReference

A-AFFY-44
type: EFO_0000269

205034_at
type: EFO_0005072
part of: A-AFFY-44

MCM4 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01081694531881
p value: 3.86478540031108E-4
refers to: MCM4
refers to: 212141_at
t statistic: -10.8471920639561

224753_at
type: EFO_0005072
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204603_at
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part of: A-AFFY-44

HIST1H2AC
type: EnsemblDatabaseReference

211814_s_at
type: EFO_0005072
part of: A-AFFY-44

MCM10
type: EnsemblDatabaseReference

CDCA5
type: EnsemblDatabaseReference

218782_s_at
type: EFO_0005072
part of: A-AFFY-44

228737_at
type: EFO_0005072
part of: A-AFFY-44

GINS1
type: EnsemblDatabaseReference

ASF1B DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.00622112492739
p value: 5.47012428135416E-4
refers to: ASF1B
refers to: 218115_at
t statistic: -10.0339843968218

FANCD2
type: EnsemblDatabaseReference

228956_at
type: EFO_0005072
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TOX2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.04289511220524
p value: 0.00533152105502814
refers to: 228737_at
refers to: TOX2
t statistic: -6.23209597081281

UGT8 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01085505221047
p value: 0.0045880924018705
refers to: UGT8
refers to: 228956_at
t statistic: -6.45659928727477

KLHL24
type: EnsemblDatabaseReference

CCNE2
type: EnsemblDatabaseReference

204558_at
type: EFO_0005072
part of: A-AFFY-44

MCM5
type: EnsemblDatabaseReference

229551_x_at
type: EFO_0005072
part of: A-AFFY-44

E-GEOD-11959
type: microarray 1colour mrna differential
RO_0002162: Homo sapiens
description: The insulin-like growth factor (IGF) system consists of two ligands (IGF-I and IGF-II), which both signal through type I IGF receptor (IGF-IR) to stimulate proliferation and inhibit apoptosis, with activity contributing to malignant growth of many types of human cancers. We have developed a humanized, affinity-matured anti-human IGF-IR monoclonal antibody (h10H5), which binds with high affinity and specificity to the extracellular domain. h10H5 inhibits IGF-IR-mediated signaling by blocking IGF-I and IGF-IIbinding and by inducing cell surface receptor down-regulation via internalization and degradation. In vitro, h10H5 exhibits anti-proliferative effects on cancer cell lines. In vivo, h10H5 demonstrates single-agent anti-tumor efficacy in human SK-N-AS neuroblastoma and SW527 breast cancer xenograft models, and even greater efficacy in combination with the chemotherapeutic agent Docetaxel or an anti-VEGF antibody. Anti-tumor activity of h10H5 is associated with decreased AKT activation and glucose uptake, and a 316-gene transcription profile with significant changes involving DNA metabolic and cell cycle machineries. These data support the clinical testing of h10H5 as a biotherapeutic for IGF-IR-dependent human tumors. Experiment Overall Design: Two treatment groups with four tumor samples per group are collected and analyzed,
uses data from: http://identifiers.org/pubmed/18790743

SDC1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.24537645311527
p value: 2.00006912094647E-4
refers to: SDC1
refers to: 201286_at
t statistic: -12.4035037918416

MYBL2
type: EnsemblDatabaseReference

205394_at
type: EFO_0005072
part of: A-AFFY-44

GMNN
type: EnsemblDatabaseReference

CCNE2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -2.07991245205673
p value: 7.03833635363519E-4
refers to: CCNE2
refers to: 205034_at
t statistic: -9.41537230984255

HIST1H2AC
type: EnsemblDatabaseReference

218115_at
type: EFO_0005072
part of: A-AFFY-44

RAD51
type: EnsemblDatabaseReference

201930_at
type: EFO_0005072
part of: A-AFFY-44

213007_at
type: EFO_0005072
part of: A-AFFY-44

228401_at
type: EFO_0005072
part of: A-AFFY-44

ZNF367
type: EnsemblDatabaseReference

FANCI DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.22940141622615
p value: 7.35532189094096E-4
refers to: FANCI
refers to: 213007_at
t statistic: -9.31352823258072

209267_s_at
type: EFO_0005072
part of: A-AFFY-44

213523_at
type: EFO_0005072
part of: A-AFFY-44

E2F2
type: EnsemblDatabaseReference

(Assay) vehicle, biological replicate 4
type: Assay
identifier: vehicle, biological replicate 4
has participant: A-AFFY-44

203856_at
type: EFO_0005072
part of: A-AFFY-44

CHEK1
type: EnsemblDatabaseReference

FANCI
type: EnsemblDatabaseReference

222037_at
type: EFO_0005072
part of: A-AFFY-44

235113_at
type: EFO_0005072
part of: A-AFFY-44

MYBL2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08446129813675
p value: 1.4053285713058E-4
refers to: MYBL2
refers to: 201710_at
t statistic: -14.1847993798206

BRCA1
type: EnsemblDatabaseReference

SHCBP1
type: EnsemblDatabaseReference

DTL DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.46025254326725
p value: 4.07655769214028E-4
refers to: 222680_s_at
refers to: DTL
t statistic: -10.6588102436763

223570_at
type: EFO_0005072
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WDR76
type: EnsemblDatabaseReference

204947_at
type: EFO_0005072
part of: A-AFFY-44

BRIP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.03397507894424
p value: 1.42860120051829E-4
refers to: 235609_at
refers to: BRIP1
t statistic: -13.59514028937

VRK1
type: EnsemblDatabaseReference

EXO1
type: EnsemblDatabaseReference

SPC25 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.02722648087473
p value: 0.00106117551387658
refers to: SPC25
refers to: 209891_at
t statistic: -8.59992592377905

UGT8
type: EnsemblDatabaseReference

CDC6
type: EnsemblDatabaseReference

BRCA2
type: EnsemblDatabaseReference

SHCBP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.43152621823576
p value: 1.4053285713058E-4
refers to: SHCBP1
refers to: 219493_at
t statistic: -14.1328878488241

208368_s_at
type: EFO_0005072
part of: A-AFFY-44

ZNF367
type: EnsemblDatabaseReference

TYMS DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.0294106494366
p value: 2.89039448522336E-4
refers to: 202589_at
refers to: TYMS
t statistic: -11.4683958647157

222962_s_at
type: EFO_0005072
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GINS1
type: EnsemblDatabaseReference

RFC5
type: EnsemblDatabaseReference

BRCA1
type: EnsemblDatabaseReference

201202_at
type: EFO_0005072
part of: A-AFFY-44

FANCD2
type: EnsemblDatabaseReference

222740_at
type: EFO_0005072
part of: A-AFFY-44

215071_s_at
type: EFO_0005072
part of: A-AFFY-44

E2F2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10536183151356
p value: 1.4053285713058E-4
refers to: 228361_at
refers to: E2F2
t statistic: -13.7347655221003

216237_s_at
type: EFO_0005072
part of: A-AFFY-44

MCM5
type: EnsemblDatabaseReference

203976_s_at
type: EFO_0005072
part of: A-AFFY-44

VRK1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01667964570769
p value: 3.86478540031108E-4
refers to: VRK1
refers to: 203856_at
t statistic: -10.8559776331782

MCM5 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.21315864107301
p value: 2.97366619500934E-4
refers to: MCM5
refers to: 216237_s_at
t statistic: -11.3744315124164

200862_at
type: EFO_0005072
part of: A-AFFY-44

RFWD3
type: EnsemblDatabaseReference

GINS2
type: EnsemblDatabaseReference

PSMC3IP DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.01195361878948
p value: 1.56982547288591E-4
refers to: PSMC3IP
refers to: 213951_s_at
t statistic: -13.2799486807203

201710_at
type: EFO_0005072
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SDC1
type: EnsemblDatabaseReference

MYBL2
type: EnsemblDatabaseReference

235609_at
type: EFO_0005072
part of: A-AFFY-44

(Assay) 24 hr 10H5, replicate 3
type: Assay
identifier: 24 hr 10H5, replicate 3
has participant: A-AFFY-44

RAD51
type: EnsemblDatabaseReference

POLA2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.10885699358091
p value: 5.39105758976906E-4
refers to: POLA2
refers to: 204441_s_at
t statistic: -10.062278908978

227350_at
type: EFO_0005072
part of: A-AFFY-44

LDLR
type: EnsemblDatabaseReference

(Assay) vehicle, biological replicate 1
type: Assay
identifier: vehicle, biological replicate 1
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E2F7 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.59442055814826
p value: 1.4053285713058E-4
refers to: E2F7
refers to: 228033_at
t statistic: -16.2205158871405

RP11-303E16.2 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.08469371325378
p value: 1.4053285713058E-4
refers to: 228559_at
refers to: RP11-303E16.2
t statistic: -13.7359976907852

CHAF1A
type: EnsemblDatabaseReference

CHEK1
type: EnsemblDatabaseReference

228033_at
type: EFO_0005072
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RP11-196G18.24 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: IncreasedDifferentialExpressionRatio
fold change: 1.16003268892042
p value: 2.07010037267017E-4
refers to: RP11-196G18.24
refers to: 227943_at
t statistic: 12.2598085650126

N4BP2L1 UP in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: IncreasedDifferentialExpressionRatio
fold change: 1.43155928416788
p value: 2.74758263508539E-4
refers to: N4BP2L1
refers to: 213375_s_at
t statistic: 11.7116984664619

PMAIP1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.02595710285038
p value: 0.00137934992285973
refers to: 204285_s_at
refers to: PMAIP1
t statistic: -8.18103975690207

225655_at
type: EFO_0005072
part of: A-AFFY-44

WDR76
type: EnsemblDatabaseReference

CDC25A
type: EnsemblDatabaseReference

E2F7
type: EnsemblDatabaseReference

MCM4 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.42651654363418
p value: 1.4053285713058E-4
refers to: 222037_at
refers to: MCM4
t statistic: -13.8283539909999

GINS1 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.3351180222983
p value: 1.4053285713058E-4
refers to: GINS1
refers to: 206102_at
t statistic: -14.253062621666

WDR76 DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.2624444888526
p value: 0.00481240222399675
refers to: WDR76
refers to: 205519_at
t statistic: -6.39093297641055

UGT8
type: EnsemblDatabaseReference

CDC6
type: EnsemblDatabaseReference

DTL
type: EnsemblDatabaseReference

BRCA2
type: EnsemblDatabaseReference

SPC25
type: EnsemblDatabaseReference

204531_s_at
type: EFO_0005072
part of: A-AFFY-44

219990_at
type: EFO_0005072
part of: A-AFFY-44

218350_s_at
type: EFO_0005072
part of: A-AFFY-44

LDLR DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.19958851615679
p value: 0.00394203020802606
refers to: LDLR
refers to: 202068_s_at
t statistic: -6.66949412852544

232760_at
type: EFO_0005072
part of: A-AFFY-44

CHAF1A
type: EnsemblDatabaseReference

TYMS DOWN in '5 milligram per kilogram IGF-IR monoclonal antibody - 10H5' vs 'vehicle control'
type: DecreasedDifferentialExpressionRatio
fold change: -1.11893598091549
p value: 0.00225897302751173
refers to: TYMS
refers to: 1554696_s_at
t statistic: -7.49514480442654