CRISPLD2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FGF13 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CDK6 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FAM107B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ADM DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
THRSP UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PMAIP1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
YPEL3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ADM DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SEPP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PGR UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
C11orf54 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RAB31 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
COBLL1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SESN3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ID4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SYTL5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PGR UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GSTM3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 12hr timepoint - Untreated control - biological rep3
12hr timepoint - Untreated control - biological rep3
ADRB1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SOCS2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TIPARP UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
H19 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CCNA1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
MYO1B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
BIK DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
KCTD12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ST8SIA4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
IL27RA UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
GPATCH2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SACS UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FST UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BCAS1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-774O3.3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
MPPED2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
THRSP UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LYN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SRM UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PGLYRP2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
IL1R1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DOCK8 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SLC3A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MAFF UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
KAT2B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DRD1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CXCL12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SOCS3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CEACAM5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SOCS2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
GATA4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
KLHL24 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TFPI DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CYP4B1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SIAH2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
IGFBP4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
EGR3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-400K9.4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ASCL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ACKR3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DUSP4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CALB2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NEDD9 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FAM171B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
KCNK6 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TMEM194A UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ST8SIA4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SUSD3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
IGF2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
KCNK6 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
IGFBP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CREBRF DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RAB31 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SYTL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CELSR2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SGK223 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MYBL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ABCA1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-356J5.12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
Analysis of '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MAOB UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 12hr timepoint - E2 treated - biological rep3
12hr timepoint - E2 treated - biological rep3
ANK3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC1A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FHL1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FHL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
HSPB8 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NRIP1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
LYN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RAB26 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TP53INP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ASCL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
N4BP2L1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
YPEL3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CXCR4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RET UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AKR1C3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
BLNK DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
IL20 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RP11-279F6.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
PPM1K UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP11-61L23.2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC1A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SLC26A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TMPRSS3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TMPRSS3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DAB2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FAM84A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
IGF2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP5-1092A3.4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GABBR2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TH UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NRIP1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CLEC2D DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MME DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
HMCN1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
BCAS1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SLC26A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CENPE UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
HSPB8 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CELSR2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CRISPLD2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CEACAM6 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
B3GNT5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RAPGEFL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
MYO1B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 24hr timepoint - E2 treated - biological rep3
24hr timepoint - E2 treated - biological rep3
EGR3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FAM83A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
PEG10 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PDLIM3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
WISP2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PGLYRP2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FGFBP2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ESF1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PTGES UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GPR160 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 12hr timepoint - Untreated control - biological rep2
12hr timepoint - Untreated control - biological rep2
PEG10 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SLC2A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MSMB UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LYAR UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
KCTD12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
DRD1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AKR1C3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ADRB1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RPS6KA5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SHC4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DOK7 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
PRSS23 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ERBB4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FAM83B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MALAT1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
EPHA4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TIPARP UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RFTN1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TNS3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RBL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PTP4A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
COLEC12 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CMAHP DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC7A11 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RFTN1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BCAS1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FGF13 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
VAT1L DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ASCL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CDK6 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
QKI DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LIMCH1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FRAS1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RAPGEFL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP5-1092A3.4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NTN4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MARCKS DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC7A5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DGAT2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
BTG2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TCF7L2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC26A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RPS6KA3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP3-523K23.2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
C14orf182 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
EPHX4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NTN1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SGCG DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SPINK4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DYNLT3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CEMIP DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CCNG2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CXCL12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NFAT5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FAM84A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TMEM45B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PPP1R3C DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SMOC2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
KLK11 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SGCG DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FHL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RAB26 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BCL2L11 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HEY2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-356J5.12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CLMN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NR5A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ADORA1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
C5AR2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CTNND2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SASH1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RAB27B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SCD UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LINC00052 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PCED1B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TMEM64 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
EGR3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP3-428L16.2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FUT9 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ACOX2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ERBB4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LRP8 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ZNF704 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NEAT1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CCNG2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ITGB6 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BTG2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TH UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GREB1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
GREB1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SPINK4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TMC5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC24A3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FGFBP2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
JAK2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PLEKHF2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NPY1R UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SMTNL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
KIAA0513 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CDKN2B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DAB2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NPNT DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PP14571 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SGK1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
PRSS23 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CCNG2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
DAB2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CDKN2B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SDK2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MYO1B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ST8SIA4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CLIP4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SGK3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CDKN2B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NPY1R UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
(Assay) 48hr timepoint - Untreated control - biological rep1
48hr timepoint - Untreated control - biological rep1
TIMP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RAB27B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PMAIP1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ZMYM2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RPS6KA3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FOXC1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
IL20 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MPPED2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SLC7A5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GEM UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TMC5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CA12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GREB1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
BYSL UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TSC22D3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GPRC5A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NEDD9 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AREG UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MYB UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
POLR3G UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SACS UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ZFP36L2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PIK3R1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ABCC5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HERC5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
HMCN1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
LOXL4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
GSAP DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ENPP5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PSD3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
Analysis of '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CLIP4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
C15orf59 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TNS3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RIN2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
BIK DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RP11-710C12.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FUT9 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-774O3.3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CEMIP DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
KLHL24 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FOSL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RAB30 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
EPB41L4A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SMOC2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CTPS1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HEY2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
C8orf46 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
LHFP DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
B4GALT1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
EFEMP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GATA4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NAB2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CLMN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TRERF1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FOSL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CHMP4B UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
LHFP DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PKIB UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
DDIT4L DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FABP6 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SGK1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
(Assay) 48hr timepoint - E2 treated - biological rep1
48hr timepoint - E2 treated - biological rep1
BIK DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FOSL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ERP27 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CYP1A1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
KCNJ8 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LIMCH1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RBM24 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DDIT4L DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
WDR4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FTX DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MPPED2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TFPI DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
C14orf182 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CEMIP DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TMEM164 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
KCNMA1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ARNT2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
GABBR2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CA12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
YPEL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SERPINB1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP3-428L16.2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
UGT2B15 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PRSS23 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ISG20 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AC008268.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
C14orf182 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TP53INP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GRB14 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CORO2A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NR5A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FAM107B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SELENBP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SIAH2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FADS1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ABCC5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TNRC6B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC9A7 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ANTXR1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
IGFBP4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
AHRR DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
IGSF5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC6A6 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ACOX2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CAB39L DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FAM3B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ADORA1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FDFT1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TMEM64 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CLCA2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP4-781B1.5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RIF1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DOK7 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LMBR1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NATD1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NAV2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
(Assay) 48hr timepoint - E2 treated - biological rep2
48hr timepoint - E2 treated - biological rep2
RET UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NBEA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
APELA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 12hr timepoint - E2 treated - biological rep1
12hr timepoint - E2 treated - biological rep1
SOCS2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
B3GNT5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
LNX1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
UTRN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PPFIBP2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TRIM55 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PPFIBP2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FAIM3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FRK UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HILPDA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FRK UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NBEA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ID2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
MME DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FHL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LIMA1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CXCL12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ESR1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PSD3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FAM171B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RAB31 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ACKR3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
IKZF2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CRISPLD2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SMTNL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PMP22 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TMEM164 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TMPRSS3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CELSR2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
HSD17B11 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DOCK11 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CRACR2A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
BMPER UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RET UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CTNND2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FAM84A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ANTXR1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PPP1R3C DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP11-1399P15.1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SASH1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FAIM3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
GEM UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
PGM5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LINC01293 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SLC3A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
C6orf141 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
(Assay) 24hr timepoint - E2 treated - biological rep1
24hr timepoint - E2 treated - biological rep1
CA12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ZNF704 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PCOLCE2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ARNT2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ABCG1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
VTCN1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ATP8A1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PTP4A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SGK1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RHEBL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LRP8 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CALB2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SACS UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PGR UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ST3GAL1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-710C12.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ADAMTS19 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SVOPL DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ZFP36L2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
(Assay) 48hr timepoint - E2 treated - biological rep3
48hr timepoint - E2 treated - biological rep3
FAIM3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FOXC1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TMEM30A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
POLR3G UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TP53INP2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TIMP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP4-781B1.5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ID1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TMEM64 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CITED2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CLEC3A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
COL12A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ITGB6 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RAI14 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
MAOA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
(Assay) 48hr timepoint - Untreated control - biological rep3
48hr timepoint - Untreated control - biological rep3
CLU DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ELOVL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CRACR2A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TIMP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FOXA1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
Analysis of '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
EPHA4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ARHGEF37 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
BLNK DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
MAP1B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
VAT1L DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
(Assay) 48hr timepoint - Untreated control - biological rep2
48hr timepoint - Untreated control - biological rep2
TNS3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TACC1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ABCG1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
B4GALT1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
STARD4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
C12orf60 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LYAR UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
HOMER3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SMARCA1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
B4GALT1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
AC013394.2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
VAT1L DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP11-44F14.8 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SERPINA1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ITGB6 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
TPBG UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SUSD3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CDK6 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NAV2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
C8orf46 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ERC2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NEIL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 24hr timepoint - E2 treated - biological rep2
24hr timepoint - E2 treated - biological rep2
EFEMP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RNF144B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
BTG1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ID1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
LAMB2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BAMBI DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AC008268.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HCAR1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ADORA1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
INPP4B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AQP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
KLF9 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC1A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SERPINA1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
MYBL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PGM5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RP5-1159O4.2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SGK3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
UGT2B15 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ABCG1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
C2CD4A UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RIN2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CAMK1D DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NAV2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ABCC5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RP11-663N22.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BCAR3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LDLRAD4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
KAT2B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ARHGEF37 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PPP1R3C DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
ID2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SUSD3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ARNT2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PNPLA7 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PDLIM3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CAB39L DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DRAM1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ELOVL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
C1orf226 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
GRB14 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SYBU UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
LYN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
S100A7A UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TCN1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SEPP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PTGES UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SOX3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CORO2A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ARL4D DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-279F6.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
EPB41L5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NUPL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SPINK4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ELOVL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
(Assay) 24hr timepoint - Untreated control - biological rep3
24hr timepoint - Untreated control - biological rep3
IRX2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SYTL5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ARHGAP18 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ACSS3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LDLRAD4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NR5A2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RP11-710C12.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MRTO4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CREBRF DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PTGES UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ERP27 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SVOPL DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ELF5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NPHP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DGAT2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NTN4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FAM216A UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FGFBP2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
C1orf85 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RNF144B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CLMN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
H19 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-279F6.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
IL1R1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
C6orf141 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RHOBTB1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LONRF2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NTN4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ST6GAL1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
IL1R1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PMP22 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
HMCN1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HMGCS1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SLC20A2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LIMA1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PGLYRP2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CRACR2A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 24hr timepoint - Untreated control - biological rep2
24hr timepoint - Untreated control - biological rep2
FRK UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
GRB14 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
EPB41L5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
AC008268.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CYBRD1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RBM24 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FAM149A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MGP UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FAM13B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
STON1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ATP8A1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TMEM164 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP5-1092A3.4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SLC7A11 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLIT1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AREG UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
(Assay) 24hr timepoint - Untreated control - biological rep1
24hr timepoint - Untreated control - biological rep1
PRRT3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PPFIBP2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
IGSF5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CHST8 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
(Assay) 12hr timepoint - Untreated control - biological rep1
12hr timepoint - Untreated control - biological rep1
AREG UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells. We identified 1,234 high confidence binding clusters of which 94% are projected to be bona fide ERalpha binding regions. Only 5% of the mapped estrogen receptor binding sites are located within 5 kb upstream of the transcriptional start sites of adjacent genes, regions containing the proximal promoters, whereas vast majority of the sites are mapped to intronic or distal locations (>5 kb from 5' and 3' ends of adjacent transcript), suggesting transcriptional regulatory mechanisms over significant physical distances. Of all the identified sites, 71% harbored putative full estrogen response elements (EREs), 25% bore ERE half sites, and only 4% had no recognizable ERE sequences. Genes in the vicinity of ERalpha binding sites were enriched for regulation by estradiol in MCF-7 cells, and their expression profiles in patient samples segregate ERalpha-positive from ERalpha-negative breast tumors. The expression dynamics of the genes adjacent to ERalpha binding sites suggest a direct induction of gene expression through binding to ERE-like sequences, whereas transcriptional repression by ERalpha appears to be through indirect mechanisms. Our analysis also indicates a number of candidate transcription factor binding sites adjacent to occupied EREs at frequencies much greater than by chance, including the previously reported FOXA1 sites, and demonstrate the potential involvement of one such putative adjacent factor, Sp1, in the global regulation of ERalpha target genes. Unexpectedly, we found that only 22%-24% of the bona fide human ERalpha binding sites were overlapping conserved regions in whole genome vertebrate alignments, which suggest limited conservation of functional binding sites. Taken together, this genome-scale analysis suggests complex but definable rules governing ERalpha binding and gene regulation. Experiment Overall Design: We used oligonucleotide expression microarrays (Affymetrix GeneChip U133 Plus 2.0) to identify estradiol (E2)-responsive genes in the estrogen-receptor positive breast cancer cell line, MCF7. MCF7 cells were grown to 30-50% confluency and exposed to 10 nM E2 (or vehicle only) at 12, 24, and 48 hours. Each timepoint was performed in triplicate (ie, biological replicates). Total RNA was isolated from cells using the Qiagen RNeasy kit, and 5 micrograms of total RNA was amplified, labeled and hybridized to the array according to the manufacturerÃÂ¢ÃÂÃÂs protocols.
HIVEP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GAL UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HEY2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
S100A7A UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ABCA1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
DOK7 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TSC22D3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
PKIB UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SYTL5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CYBRD1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RNF144B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DHRS2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RERG UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BLNK DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
CSTA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RERG UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TSC22D3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP11-356J5.12 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ERBB4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
FAM171B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
(Assay) 12hr timepoint - E2 treated - biological rep2
12hr timepoint - E2 treated - biological rep2
EPB41L4A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GEM UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LONRF2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DOCK8 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
APELA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NAB2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
MYB UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FAM216A UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CSTA DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ADRB1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
PTGER4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PGM5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RGS22 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RBM24 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
S100A9 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LAMB1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
COLEC12 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TIPARP UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SMTNL2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
IGFBP3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
TMC4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RASGRP1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DGAT2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LOXL4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
COL12A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
MYBL1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
FAM110B DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SLC16A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AHRR DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
NR3C1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NPY1R UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FNIP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
PTP4A1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
RPS6KA5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
LONRF2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SYBU UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
NPNT DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
TP53INP1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RBL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CTSD UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ALDH6A1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
GATA4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
C16orf45 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
MPP7 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LDLRAD4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BCAS3 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SOX3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
LXN DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ARHGEF37 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PP14571 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
DDIT4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CHMP4B UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ACOX2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
UGT2B15 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CLIP4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NAA15 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
IL20 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
CORO2A DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RBL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RASGRP1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
KLHL4 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SALL4 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-663N22.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
OGFRL1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
AHRR DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PDLIM3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PPM1K UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
NPR3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RASGRP1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SIAH2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PMP22 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
RP11-1399P15.1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
IGFBP5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
FOXC1 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
PLEKHF2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
RP11-490M8.1 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
LINC00052 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
ATP8B2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SOX3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
QKI DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
KLHL24 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
AGR3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
SERHL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
MGP UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SGK3 UP in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
CALB2 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
SNX24 UP in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
HERC5 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
HSPB8 UP in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
B3GNT5 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
SGCG DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
OAS2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '12 hour'
YPEL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'
BTG2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '24 hour'
ITPRIPL2 DOWN in '10 nanomolar; estradiol' vs 'vehicle' at '48 hour'